MRC Protein Phosphorylation Unit

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1-Jan-2012 In : Biochemical Journal. 441, p. 339-346, 8 p.

Research output: Contribution to journal › Article

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1-Jan-2012 In : Biochemical Journal. 441, p. 325-337, 13 p.

Research output: Contribution to journal › Article

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

Castaneda-Bueno, M., Graciela Cervantes-Perez, L., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. & Gamba, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7929-7934, 6 p.

Research output: Contribution to journal › Article

Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

Research output: Contribution to journal › Article

Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35973

Research output: Contribution to journal › Article

Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

Bacon, S., Harthill, J., Coates, J., Stewart, D., McDougall, G. & Rena, G. 2012 In : Diabetic Medicine. 29, Suppl. 1, p. 41, 1 p., P41

Research output: Contribution to journal › Meeting abstract

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Lewis, P. A. & Alessi, D. R. 2012 In : Biochemical Society Transactions. 40, 5, p. 1039-1041, 3 p.

Research output: Contribution to journal › Article

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, E. J., Lachaud, C., Appleton, P., MacArtney, T. J., Nathke, I. & Rouse, J. 2012 In : Nature Structural & Molecular Biology. 19, 11, p. 1093-1100, 8 p.

Research output: Contribution to journal › Article

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

Tinti, M., Johnson, C., Toth, R., Ferrier, D. E. K. & MacKintosh, C. 2012 In : Open Biology. 2, 7

Research output: Contribution to journal › Article