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MRC Protein Phosphorylation Unit

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  1. Improved genome editing in human cell lines using the CRISPR method

    Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C. 10 Oct 2014 In : PLoS ONE. 9, 10, 6 p.e109752

    Research output: Contribution to journalArticle

  2. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC

    Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon (Broster), K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. & Jørgensen, C. 18 Sep 2014 In : Analytical Chemistry. ASAP

    Research output: Contribution to journalArticle

  3. Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

    Nair, N., Castor, D., Macartney, T. & Rouse, J. 16 Sep 2014 In : DNA Repair.

    Research output: Contribution to journalArticle

  4. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

    Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K. 4 Aug 2014 In : Nature Communications. 5, 4535

    Research output: Contribution to journalArticle

  5. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. 1 Aug 2014 In : Biochemical Journal. 461, 3, p. 531-537 7 p.

    Research output: Contribution to journalArticle

  6. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

    Alessi, D. R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y. & Kahle, K. T. 15 Jul 2014 In : Science Signaling. 7, 334, 10 p.re3

    Research output: Contribution to journalArticle

  7. Immune diseases caused by mutations in kinases and components of the ubiquitin system

    Cohen, P. Jun 2014 In : Nature Immunology. 15, 6, p. 521-529 9 p.

    Research output: Contribution to journalArticle

  8. The TLR and IL-1 signalling network at a glance

    Cohen, P. Jun 2014 In : Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

    Research output: Contribution to journalArticle

  9. USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

    Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Ewan, R., Bruce, D., Macartney, T., Weidlich, S., Smith, J. C. & Sapkota, G. P. 21 May 2014 In : Open Biology. 4, 13 p.140065

    Research output: Contribution to journalArticle

  10. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

    Baron, Y., Pedrioli, P. G., Tyagi, K., Johnson, C., Wood, N. T., Fountaine, D., Wightman, M. & Alexandru, G. May 2014 In : BMC Biology. 12, 20 p.39

    Research output: Contribution to journalArticle

  11. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

    MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F. 15 Apr 2014 In : Cancer Research. 74, 8, p. 2246-2257 12 p.

    Research output: Contribution to journalArticle

  12. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

    Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K. 19 Mar 2014 In : Open Biology. 4, 14 p.130213

    Research output: Contribution to journalArticle

  13. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

    Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y-Y., Kolwicz, S. C., Xu, J., Sakamoto, K., Wang, W. & Tian, R. 14 Mar 2014 In : Circulation Research. 114, 6, p. 966-975 10 p.

    Research output: Contribution to journalArticle

  14. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

    Houde, V. P., Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. 15 Feb 2014 In : Biochemical Journal. 458, 1, p. 41-56 16 p.

    Research output: Contribution to journalArticle

  15. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  16. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

    Iovino, M., Pfisterer, U., Holton, J. L., Lashley, T., Swingler, R. J., Calo, L., Treacy, R., Revesz, T., Parmar, M., Goedert, M., Muqit, M. M. K. & Spillantini, M. G. Feb 2014 In : Acta Neuropathologica. 127, 2, p. 283-295

    Research output: Contribution to journalArticle

  17. AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions

    Meyer, A., Hilgen, G., Dorgau, B., Sammler, E. M., Weiler, R., Monyer, H., Dedek, K. & Hormuzdi, S. G. 2014 In : Journal of Cell Science. 127, 6, p. 1190-1202 13 p.

    Research output: Contribution to journalArticle

  18. ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

    Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C. 2014 In : Database: the Journal of Biological Databases and Curation. 2014, 15 p.bat085

    Research output: Contribution to journalArticle

  19. GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

    Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S. 2014 In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

    Research output: Contribution to journalArticle

  20. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 2014 In : Open Biology. 4, May, 16 p.140029

    Research output: Contribution to journalArticle

  21. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  22. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

    van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. 2014 In : Biochemical Journal. 460, 2, p. 165-175 11 p.

    Research output: Contribution to journalArticle

  23. Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  24. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

    Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. 2014 In : Biochemical Journal. 460, 1, p. 127-139 13 p.

    Research output: Contribution to journalArticle

  25. Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

    Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C. & Sapkota, G. P. 2014 In : Open Biology. 4, FEB

    Research output: Contribution to journalArticle

  26. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  27. Structural basis for the recruitment of glycogen synthase by glycogenin

    Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K. & Sicheri, F. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840 10 p.

    Research output: Contribution to journalArticle

  28. The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

    Herhaus, L. & Sapkota, G. P. 2014 In : Cellular Signalling. 26, 10, p. 2186-2192 7 p.

    Research output: Contribution to journalArticle

  29. Transcriptional regulation of IL-10 and its cell-specific role in vivo

    MacKenzie, K. F., Pattison, M. J. & Arthur, J. S. C. 2014 In : Critical Reviews in Immunology. 34, 4, p. 315-345 31 p.

    Research output: Contribution to journalArticle

  30. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  31. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

    Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J-D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S. & Gray, N. S. Dec 2013 In : European Journal of Medicinal Chemistry. 70, p. 758-767 10 p.

    Research output: Contribution to journalArticle

  32. TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P transactivation upstream of Rho-kinase-2 activation

    Cencetti, F., Bernacchioni, C., Tonelli, F., Roberts, E., Donati, C. & Bruni, P. Nov 2013 In : FASEB Journal. 27, 11, p. 4532-4546 15 p.

    Research output: Contribution to journalArticle

  33. Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

    Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J. 24 Oct 2013 In : Molecular Cell. 52, 2, p. 221-233 13 p.

    Research output: Contribution to journalArticle

  34. Proteomic identification of novel secreted anti-bacterial toxins of the Serratia marcescens Type VI secretion system

    Fritsch, M. J., Trunk, K., Alcoforado Diniz, J., Guo, M., Trost, M. & Coulthurst, S. J. Oct 2013 In : Molecular & Cellular Proteomics. 12, 10, p. 2735-2749

    Research output: Contribution to journalArticle

  35. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  36. Localization-dependent and -independent roles of SLX4 in regulating telomeres

    Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J. 12 Sep 2013 In : Cell Reports. 4, 5, p. 853-860 8 p.

    Research output: Contribution to journalArticle

  37. Effect of IRS4 levels on PI 3-kinase signalling.

    Hoxhaj, G., Dissanayake, K. & MacKintosh, C. 10 Sep 2013 In : PLoS ONE. 8, 9, p. e73327 9 p.

    Research output: Contribution to journalArticle

  38. Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

    Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W. 1 Sep 2013 In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

    Research output: Contribution to journalArticle

  39. Hydrophilic strong anion exchange chromatography for proteomics: what's the future outlook?

    Ritorto, M. S., Trost, M. & Cook, K. Sep 2013 In : Bioanalysis. 5, 18, p. 2219-2221 3 p.

    Research output: Contribution to journalArticle

  40. Molecular mechanism of action of metformin: old or new insights?

    Rena, G., Pearson, E. R. & Sakamoto, K. Sep 2013 In : Diabetologia. 56, 9, p. 1898-1906 9 p.

    Research output: Contribution to journalArticle

  41. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

    Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P. 23 Aug 2013 In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

    Research output: Contribution to journalArticle

  42. Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F. 11 Jul 2013 In : Bioscience Reports. 33, 5, 11 p.e00063

    Research output: Contribution to journalArticle

  43. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

    Mevissen, T. E. T., Hospenthal, M. K., Geurink, P. P., Elliott, P. R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S. M. V., Ovaa, H. & Komander, D. 3 Jul 2013 In : Cell. 154, 1, p. 169-184 16 p.

    Research output: Contribution to journalArticle

  44. X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor

    Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S. C., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. & Knapp, S. 13 Jun 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4413-4421 9 p.

    Research output: Contribution to journalArticle

  45. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

    Keusekotten, K., Elliott, P. R., Glockner, L., Fiil, B. K., Damgaard, R. B., Kulathu, Y., Wauer, T., Hospenthal, M. K., Gyrd-Hansen, M., Krappmann, D., Hofmann, K. & Komander, D. 6 Jun 2013 In : Cell. 153, 6, p. 1312-1326 15 p.

    Research output: Contribution to journalArticle

  46. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

    Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Jun 2013 In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

    Research output: Contribution to journalArticle

  47. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21 May 2013 In : FEBS Letters. 587, 10, p. 1496-1503 8 p.

    Research output: Contribution to journalArticle

  48. Structural biology: Security measures of a master regulator

    Alessi, D. R. & Kulathu, Y. 1 May 2013 In : Nature.

    Research output: Contribution to journalArticle

  49. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  50. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

    Remenyi, J., van den Bosch, M. W. M., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S. C., Frenguelli, B. G. & Pankratov, Y. 26 Apr 2013 In : PLoS ONE. 8, 4, 14 p.e62509

    Research output: Contribution to journalArticle

  51. LKB1 and AMPK and the cancer-metabolism link - ten years after

    Hardie, D. G. & Alessi, D. R. 15 Apr 2013 In : BMC Biology. 11, 11 p.36

    Research output: Contribution to journalArticle

  52. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15 Apr 2013 In : Biochemical Journal. 451, 2, p. 185-194 10 p.BJ20130026

    Research output: Contribution to journalArticle

  53. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  54. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1 Apr 2013 In : Biochemical Journal. 451, 1, p. 111-122 12 p.

    Research output: Contribution to journalArticle

  55. MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop

    MacKenzie, K. F., Van den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. E. & Arthur, J. S. C. Apr 2013 In : Molecular and Cellular Biology. 33, 7, p. 1456-1467 12 p.

    Research output: Contribution to journalArticle

  56. The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

    Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K. Apr 2013 In : Human Reproduction. 28, 4, p. 866-876 11 p.

    Research output: Contribution to journalArticle

  57. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27 Mar 2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journalArticle

  58. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22 Mar 2013 In : PLoS ONE. 8, 3, 15 p.e60086

    Research output: Contribution to journalArticle

  59. Regulation of A20 and other OTU deubiquitinases by reversible oxidation

    Kulathu, Y., Garcia, F. J., Mevissen, T. E. T., Busch, M., Arnaudo, N., Carroll, K. S., Barford, D. & Komander, D. 5 Mar 2013 In : Nature Communications. 4, 1569

    Research output: Contribution to journalArticle

  60. Ca2+ signalling through CatSper and Ca2+ stores regulate different behaviours in human sperm

    Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R. 1 Mar 2013 In : Journal of Biological Chemistry. 288, 9, p. 6248-6258 11 p.

    Research output: Contribution to journalArticle

  61. Structural insights into the activation of MST3 by MO25

    Mehellou, Y., Alessi, D. R., Macartney, T. J., Szklarz, M., Knapp, S. & Elkins, J. M. 15 Feb 2013 In : Biochemical and Biophysical Research Communications. 431, 3, p. 604-609 6 p.

    Research output: Contribution to journalArticle

  62. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

    Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J. Feb 2013 In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

    Research output: Contribution to journalArticle

  63. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 479-489 11 p.

    Research output: Contribution to journalArticle

  64. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

    Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. & Chen, S. G. 15 Jan 2013 In : Human Molecular Genetics. 22, 2, p. 328-344 17 p.

    Research output: Contribution to journalArticle

  65. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  66. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan 2013 In : Microvascular Research. 85, p. 86-92 7 p.

    Research output: Contribution to journalArticle

  67. Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

    Hau, A. M., Greenwood, J. A., Loehr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., McPhail, K. L. & Ishmael, J. E. 2013 In : PLoS ONE. 8, 6, 16 p. e65250

    Research output: Contribution to journalArticle

  68. Cross talk between the Akt and p38α pathways in macrophages downstream of toll-like receptor signaling

    McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L. E., O'Keefe, S. J., Boothby, M., Gaestel, M. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology. 33, 21, p. 4152-4165 14 p.

    Research output: Contribution to journalArticle

  69. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

    Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P-J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P. & Moechars, D. W. 2013 In : Journal of Pharmaceutical and Biomedical Analysis. 76, p. 49-58 10 p.

    Research output: Contribution to journalArticle

  70. Dual regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt promotes Thrombin-mediated Integrin alpha(IIb)beta(3) activation and granule secretion in platelets

    Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I. 2013 In : Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

    Research output: Contribution to journalArticle

  71. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journalArticle

  72. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research. 12, 6, p. 2449-2457 9 p.

    Research output: Contribution to journalArticle

  73. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

  74. Loss of iron triggers PINK1/Parkin-independent mitophagy

    Allen, G. F. G., Toth, R., James, J. & Ganley, I. G. 2013 In : EMBO Reports. 14, p. 1127-1135 9 p.

    Research output: Contribution to journalArticle

  75. Molecular control of the NEMO family of ubiquitin-binding proteins

    Clark, K., Nanda, S. & Cohen, P. 2013 In : Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

    Research output: Contribution to journalArticle

  76. N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

    Melo, Z., De Los Heros, P., Cruz-Rangel, S., Vázquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A. & Gamba, G. 2013 In : Journal of Biological Chemistry. 288, 44, p. 31468-31476 9 p.

    Research output: Contribution to journalArticle

  77. p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

    Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. & Tauro, S. 2013 In : British Journal of Cancer. 109, October, p. 2432=2444 13 p.

    Research output: Contribution to journalArticle

  78. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

    Arthur, J. S. C. & 21 others Park, J., Al-Ramahi, I., Tan, Q., Mollema, N., Diaz-Garcia, J. R., Gallego-Flores, T., Lu, H-C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L. S., Richman, R., Liu, X., Gao, Y., Shaw, C. A., Orr, H. T., Westbrook, T. F., Botas, J. & Zoghbi, H. Y. 2013 In : Nature. 498, 7454, p. 325-331 7 p.

    Research output: Contribution to journalArticle

  79. Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

    Alessi, D. R. & 21 others Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., Michalski, C. W., Schlitter, A. M., Esposito, I., Kind, A. J., Rad, L., Schnieke, A. E., Baccarini, M., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. 2013 In : Cancer Cell. 23, 3, p. 406-420 15 p.

    Research output: Contribution to journalArticle

  80. The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

    Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K. 2013 In : FEBS Journal. 280, 12, p. 2830-2841 12 p.

    Research output: Contribution to journalArticle

  81. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p.e77537

    Research output: Contribution to journalArticle

  82. The ULK1 complex Sensing nutrient signals for autophagy activation

    Wong, P-M., Puente, C., Ganley, I. G. & Jiang, X. 2013 In : Autophagy. 9, 2, p. 124-137 14 p.

    Research output: Contribution to journalArticle

  83. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  84. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec 2012 In : Neuropharmacology. 63, 7, p. 1227-1237 11 p.

    Research output: Contribution to journalArticle

  85. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

    Research output: Contribution to journalArticle

  86. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

    Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zegiraj, E., Turk, B. E. & Sakamoto, K. Nov 2012 In : Cellular Signalling. 24, 11, p. 2085-2094 10 p.

    Research output: Contribution to journalArticle

  87. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway

    Bruce, D. L., Macartney, T., Yong, W., Shou, W. & Sapkota, G. P. Nov 2012 In : Cellular Signalling. 24, 11, p. 1999-2006 8 p.

    Research output: Contribution to journalArticle

  88. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Oct 2012 In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

    Research output: Contribution to journalArticle

  89. Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

    Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J. 21 Sep 2012 In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

    Research output: Contribution to journalArticle

  90. Disruptions on the highways of cellular signalling

    Alessi, D. Sep 2012 In : FEBS Journal. 279, p. 23-23 1 p.

    Research output: Contribution to journalMeeting abstract

  91. Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

    Trost, M., Sauvageau, M., Hérault, O., Deleris, P., Pomiès, C., Chagraoui, J., Mayotte, N., Meloche, S., Sauvageau, G. & Thibault, P. 23 Aug 2012 In : Blood. 120, 8, p. e17-27 11 p.

    Research output: Contribution to journalArticle

  92. Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

    Kulathu, Y. & Komander, D. Aug 2012 In : Nature Reviews Molecular Cell Biology. 13, 8, p. 508-523 16 p.

    Research output: Contribution to journalArticle

  93. Brain penetrant LRRK2 inhibitor

    Choi, H. G., Zhang, J., Deng, X., Hatcher, J. M., Patricelli, M. P., Zhao, Z., Alessi, D. R. & Gray, N. S. Aug 2012 In : ACS Medicinal Chemistry Letters. 3, 8, p. 658-662 5 p.

    Research output: Contribution to journalArticle

  94. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels

    Susa, K., Kita, S., Iwamoto, T., Yang, S-S., Lin, S-H., Ohta, A., Sohara, E., Rai, T., Sasaki, S., Alessi, D. R. & Uchida, S. Aug 2012 In : Clinical and Experimental Nephrology. 16, 4, p. 530-538 9 p.

    Research output: Contribution to journalArticle

  95. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205 6 p.

    Research output: Contribution to journalArticle

  96. Phosphatases in SMAD regulation

    Bruce, D. L. & Sapkota, G. P. 4 Jul 2012 In : FEBS Letters. 586, 14, p. 1897-1905 9 p.

    Research output: Contribution to journalArticle

  97. Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

    Jensen, J., Tantiwong, P., Stuenaes, J. T., Molina-Carrion, M., DeFronzo, R. A., Sakamoto, K. & Musi, N. Jul 2012 In : American Journal of Physiology, Endocrinology and Metabolism. 303, 1, p. E82-E89 8 p.

    Research output: Contribution to journalArticle

  98. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  99. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun 2012 In : Diabetes. 61, 6, p. 1423-1433 11 p.

    Research output: Contribution to journalArticle

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