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MRC Protein Phosphorylation Unit

  1. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A. M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W. 1 Jul 2015 In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  2. Structural characterization of LRRK2 inhibitors

    Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. 14 May 2015 In : Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.

    Research output: Contribution to journalArticle

  3. Quantitative proteome analysis of temporally-resolved phagosomes following uptake via key phagocytic receptors

    Dill, B., Gierliński, M., Härtlova, A., González Arandilla, A., Guo, M., Clarke, R. G. & Trost, M. 1 May 2015 In : Molecular & Cellular Proteomics. 14, 5, p. 1334 1349 p., 16

    Research output: Contribution to journalArticle

  4. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

    Rojas-Fernandez, A., Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T. & Sapkota, G. P. 29 Apr 2015 In : Scientific Reports. 5, 6 p., 9811

    Research output: Contribution to journalArticle

  5. K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin

    Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R. & Kulathu, Y. 2 Apr 2015 In : Molecular Cell. 58, 1, p. 83-94 12 p.

    Research output: Contribution to journalArticle

  6. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

    Tiedje, C., Lubas, M., Tehrani, M., Menon, M. B., Ronkina, N., Rousseau, S., Cohen, P., Kotlyarov, A. & Gaestel, M. Feb 2015 In : RNA: a Publication of the RNA Society. 21, 2, p. 262-278 17 p.

    Research output: Contribution to journalArticle

  7. PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

    Kazlauskaite, A. & Muqit, M. M. K. Jan 2015 In : FEBS Journal. 282, 2, p. 215-223 9 p.

    Research output: Contribution to journalArticle

  8. 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

    Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J. 2015 In : Bioinformatics.

    Research output: Contribution to journalArticle

  9. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. 2015 In : Proteomics. 12 p.

    Research output: Contribution to journalArticle

  10. A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens

    Hamilton, J. J., Marlow, V. L., Owen, R. A., Costa, M. D. A. A., Guo, M., Buchanan, G., Chandra, G., Trost, M., Coulthurst, S. J., Palmer, T., Stanley-Wall, N. R. & Sargent, F. 8 Dec 2014 In : Journal of Cell Biology. 207, 5, p. 615-626 12 p.

    Research output: Contribution to journalArticle

  11. Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

    Nair, N., Castor, D., Macartney, T. & Rouse, J. Dec 2014 In : DNA Repair. 24, p. 131-137 7 p.

    Research output: Contribution to journalArticle

  12. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

    Alessi, D. R. & 27 others Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., Klein, S., Lowy, A. M., Banerjee, R., Yang, F., Lee, C-L., Moding, E. J., Kirsch, D. G., Scheideler, A., Varela, I., Bradley, A., Kind, A., Schnieke, A. E., Rodewald, H-R., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. Nov 2014 In : Nature Medicine. 20, 11, p. 1340-1347 8 p.

    Research output: Contribution to journalArticle

  13. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  14. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p., 5359

    Research output: Contribution to journalArticle

  15. Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

    Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A. 21 Oct 2014 In : Science Signaling. 7, 348, 12 p., ra99

    Research output: Contribution to journalArticle

  16. Improved genome editing in human cell lines using the CRISPR method

    Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C. 10 Oct 2014 In : PLoS ONE. 9, 10, 6 p., e109752

    Research output: Contribution to journalArticle

  17. Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway

    Öhman, T., Söderholm, S., Hintsanen, P., Välimäki, E., Lietzén, N., MacKintosh, C., Aittokallio, T., Matikainen, S. & Nyman, T. A. Oct 2014 In : Molecular & Cellular Proteomics. 13, 10, p. 2604-2617 14 p.

    Research output: Contribution to journalArticle

  18. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC

    Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon (Broster), K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. & Jørgensen, C. 18 Sep 2014 In : Analytical Chemistry. ASAP

    Research output: Contribution to journalArticle

  19. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

    Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K. 4 Aug 2014 In : Nature Communications. 5, 4535

    Research output: Contribution to journalArticle

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