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MRC Protein Phosphorylation Unit

  1. P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment

    Wada, M., Canals, D., Adada, M., Coant, N., Salama, M. F., Helke, K. L., Arthur, J. S., Shroyer, K. R., Kitatani, K., Obeid, L. M. & Hannun, Y. A. 7 Aug 2017 In : Oncogene.

    Research output: Contribution to journalArticle

  2. p38α regulates cytokine-induced IFNγ secretion via the Mnk1/eIF4E pathway in Th1 cells

    Salvador-Bernáldez, M., Mateus, S. B., Del Barco Barrantes, I., Arthur, S. C., Martínez-A, C., Nebreda, A. R. & Salvador, J. M. 14 Jun 2017 In : Immunology and Cell Biology.

    Research output: Contribution to journalArticle

  3. Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways

    McGuire, V. A., Rosner, D., Ananieva, O., Ross, E. A., Elcombe, S. E., Naqvi, S., van den Bosch, M. M. W., Monk, C. E., Ruiz-Zorrilla Diez, T., Clark, A. R. & Arthur, J. S. C. Jan 2017 In : Molecular and Cellular Biology. 37, 1, 19 p., e00454-16

    Research output: Contribution to journalArticle

  4. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

    Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 22 Apr 2016 In : eLife. 5, p. 1-18 18 p., e12278

    Research output: Contribution to journalArticle

  5. CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription

    Aregger, M., Kaskar, A., Varshney, D., Fernandez-Sanchez, M. E., Inesta-Vaquera, F. A., Weidlich, S. & Cowling, V. H. 3 Mar 2016 In : Molecular Cell. 61, 5, p. 734-746 13 p.

    Research output: Contribution to journalArticle

  6. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M. 29 Jan 2016 In : eLife. 5, p. 1-28 28 p., e12813

    Research output: Contribution to journalArticle

  7. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. Sep 2015 In : Proteomics. 15, 18, p. 3169-3174 6 p.

    Research output: Contribution to journalArticle

  8. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  9. The promise and peril of chemical probes

    Arrowsmith, C. H. , Audia, J. E. , Austin, C. , Baell, J. , Bennett, J. , Blagg, J. , Bountra, C. , Brennan, P. E. , Brown, P. J. , Bunnage, M. E. , Buser-Doepner, C. , Campbell, R. M. , Carter, A. J. , Cohen, P. , Copeland, R. A. , Cravatt, B. , Dahlin, J. L. , Dhanak, D. , Edwards, A. M. , Frederiksen, M. & 34 others Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J. Aug 2015 In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

    Research output: Contribution to journalComment/debate

  10. A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

    Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. 27 Jul 2015 In : ChemBioChem. 16, 11, p. 1574-1579 6 p.

    Research output: Contribution to journalArticle

  11. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A. M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W. 1 Jul 2015 In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  12. Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

    Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M. K., Fry, A. M., Bayliss, R. & Chin, J. W. Jul 2015 In : Nature Chemical Biology. 11, 7, p. 496-503 8 p.

    Research output: Contribution to journalArticle

  13. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  14. Structural characterization of LRRK2 inhibitors

    Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. 14 May 2015 In : Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.

    Research output: Contribution to journalArticle

  15. Quantitative proteome analysis of temporally-resolved phagosomes following uptake via key phagocytic receptors

    Dill, B., Gierliński, M., Härtlova, A., González Arandilla, A., Guo, M., Clarke, R. G. & Trost, M. 1 May 2015 In : Molecular & Cellular Proteomics. 14, 5, p. 1334 1349 p., 16

    Research output: Contribution to journalArticle

  16. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

    Rojas-Fernandez, A., Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T. & Sapkota, G. P. 29 Apr 2015 In : Scientific Reports. 5, 6 p., 9811

    Research output: Contribution to journalArticle

  17. Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

    Kristariyanto, Y. A., Choi, S-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y. 15 Apr 2015 In : Biochemical Journal. 467, 2, p. 345-352 8 p.

    Research output: Contribution to journalArticle

  18. K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin

    Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R. & Kulathu, Y. 2 Apr 2015 In : Molecular Cell. 58, 1, p. 83-94 12 p.

    Research output: Contribution to journalArticle

  19. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

    Tiedje, C., Lubas, M., Tehrani, M., Menon, M. B., Ronkina, N., Rousseau, S., Cohen, P., Kotlyarov, A. & Gaestel, M. Feb 2015 In : RNA: a Publication of the RNA Society. 21, 2, p. 262-278 17 p.

    Research output: Contribution to journalArticle

  20. SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

    Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, A. M., Foretz, M., Campbell, D. G., Sakamoto, K., Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O. 29 Jan 2015 In : Journal of Cell Science. 128, 3, p. 472-486 15 p.

    Research output: Contribution to journalArticle

  21. PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

    Kazlauskaite, A. & Muqit, M. M. K. Jan 2015 In : FEBS Journal. 282, 2, p. 215-223 9 p.

    Research output: Contribution to journalArticle

  22. 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

    Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J. 2015 In : Bioinformatics.

    Research output: Contribution to journalArticle

  23. Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

    Nair, N., Castor, D., Macartney, T. & Rouse, J. Dec 2014 In : DNA Repair. 24, p. 131-137 7 p.

    Research output: Contribution to journalArticle

  24. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

    Schönhuber, N. , Seidler, B. , Schuck, K. , Veltkamp, C. , Schachtler, C. , Zukowska, M. , Eser, S. , Feyerabend, T. B. , Paul, M. C. , Eser, P. , Klein, S. , Lowy, A. M. , Banerjee, R. , Yang, F. , Lee, C-L. , Moding, E. J. , Kirsch, D. G. , Scheideler, A. , Alessi, D. R. , Varela, I. & 8 others Bradley, A., Kind, A., Schnieke, A. E., Rodewald, H-R., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. Nov 2014 In : Nature Medicine. 20, 11, p. 1340-1347 8 p.

    Research output: Contribution to journalArticle

  25. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  26. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p., 5359

    Research output: Contribution to journalArticle

  27. Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

    Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A. 21 Oct 2014 In : Science Signaling. 7, 348, 12 p., ra99

    Research output: Contribution to journalArticle

  28. Improved genome editing in human cell lines using the CRISPR method

    Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C. 10 Oct 2014 In : PLoS ONE. 9, 10, 6 p., e109752

    Research output: Contribution to journalArticle

  29. Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway

    Öhman, T., Söderholm, S., Hintsanen, P., Välimäki, E., Lietzén, N., MacKintosh, C., Aittokallio, T., Matikainen, S. & Nyman, T. A. Oct 2014 In : Molecular & Cellular Proteomics. 13, 10, p. 2604-2617 14 p.

    Research output: Contribution to journalArticle

  30. The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

    Herhaus, L. & Sapkota, G. P. Oct 2014 In : Cellular Signalling. 26, 10, p. 2186-2192 7 p.

    Research output: Contribution to journalArticle

  31. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC

    Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon (Broster), K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. & Jørgensen, C. 18 Sep 2014 In : Analytical Chemistry. ASAP

    Research output: Contribution to journalArticle

  32. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

    Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K. 4 Aug 2014 In : Nature Communications. 5, 4535

    Research output: Contribution to journalArticle

  33. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. 1 Aug 2014 In : Biochemical Journal. 461, 3, p. 531-537 7 p.

    Research output: Contribution to journalArticle

  34. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 15 Jul 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  35. Structural basis for the recruitment of glycogen synthase by glycogenin

    Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K. & Sicheri, F. 15 Jul 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840 10 p.

    Research output: Contribution to journalArticle

  36. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

    Alessi, D. R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y. & Kahle, K. T. 15 Jul 2014 In : Science Signaling. 7, 334, 10 p., re3

    Research output: Contribution to journalArticle

  37. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

    van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. 1 Jun 2014 In : Biochemical Journal. 460, 2, p. 165-175 11 p.

    Research output: Contribution to journalArticle

  38. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 1 Jun 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  39. Immune diseases caused by mutations in kinases and components of the ubiquitin system

    Cohen, P. Jun 2014 In : Nature Immunology. 15, 6, p. 521-529 9 p.

    Research output: Contribution to journalArticle

  40. The TLR and IL-1 signalling network at a glance

    Cohen, P. Jun 2014 In : Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

    Research output: Contribution to journalArticle

  41. USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

    Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Ewan, R., Bruce, D., Macartney, T., Weidlich, S., Smith, J. C. & Sapkota, G. P. 21 May 2014 In : Open Biology. 4, 13 p., 140065

    Research output: Contribution to journalArticle

  42. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

    Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. 15 May 2014 In : Biochemical Journal. 460, 1, p. 127-139 13 p.

    Research output: Contribution to journalArticle

  43. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 7 May 2014 In : Open Biology. 4, May, 16 p., 140029

    Research output: Contribution to journalArticle

  44. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

    Baron, Y., Pedrioli, P. G., Tyagi, K., Johnson, C., Wood, N. T., Fountaine, D., Wightman, M. & Alexandru, G. May 2014 In : BMC Biology. 12, 20 p., 39

    Research output: Contribution to journalArticle

  45. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

    MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F. 15 Apr 2014 In : Cancer Research. 74, 8, p. 2246-2257 12 p.

    Research output: Contribution to journalArticle

  46. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

    Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K. 19 Mar 2014 In : Open Biology. 4, 14 p., 130213

    Research output: Contribution to journalArticle

  47. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

    Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y-Y., Kolwicz, S. C., Xu, J., Sakamoto, K., Wang, W. & Tian, R. 14 Mar 2014 In : Circulation Research. 114, 6, p. 966-975 10 p.

    Research output: Contribution to journalArticle

  48. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

    Houde, V. P., Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. 15 Feb 2014 In : Biochemical Journal. 458, 1, p. 41-56 16 p.

    Research output: Contribution to journalArticle

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