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  1. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21-May-2013 In : FEBS Letters. 587, 10, p. 1496-1503, 8 p.

    Research output: Contribution to journal › Article

  2. Structural biology: Security measures of a master regulator

    Alessi, D. R. & Kulathu, Y. 1-May-2013 In : Nature.

    Research output: Contribution to journal › Article

  3. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journal › Article

  4. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15-Apr-2013 In : Biochemical Journal. 451, 2, p. 185-194, 10 p., BJ20130026

    Research output: Contribution to journal › Article

  5. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  6. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1-Apr-2013 In : Biochemical Journal. 451, 1, p. 111-122, 12 p.

    Research output: Contribution to journal › Article

  7. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to K channels

    Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Apr-2013 In : Journal of Bioenergetics and Biomembranes. p. 1-13, 13 p.

    Research output: Contribution to journal › Article

  8. The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

    Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K. Apr-2013 In : Human Reproduction. 28, 4, p. 866-876, 11 p.

    Research output: Contribution to journal › Article

  9. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27-Mar-2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journal › Article

  10. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22-Mar-2013 In : PLoS ONE. 8, 3, 15 p., e60086

    Research output: Contribution to journal › Article

  11. Regulation of A20 and other OTU deubiquitinases by reversible oxidation

    Kulathu, Y., Garcia, F. J., Mevissen, T. E. T., Busch, M., Arnaudo, N., Carroll, K. S., Barford, D. & Komander, D. 5-Mar-2013 In : Nature Communications. 4, 1569

    Research output: Contribution to journal › Article

  12. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 479-489, 11 p.

    Research output: Contribution to journal › Article

  13. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

    Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. & Chen, S. G. 15-Jan-2013 In : Human Molecular Genetics. 22, 2, p. 328-344, 17 p.

    Research output: Contribution to journal › Article

  14. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  15. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  16. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan-2013 In : Microvascular Research. 85, p. 86-92, 7 p.

    Research output: Contribution to journal › Article

  17. Ca2+ signalling through CatSper and Ca2+ stores regulate different behaviours in human sperm

    Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  18. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

    Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P-J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P. & Moechars, D. W. 2013 In : Journal of Pharmaceutical and Biomedical Analysis. 76, p. 49-58, 10 p.

    Research output: Contribution to journal › Article

  19. Dual regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt promotes Thrombin-mediated Integrin alpha(IIb)beta(3) activation and granule secretion in platelets

    Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I. 2013 In : Journal of Biological Chemistry. 288, 6, p. 3918-3928, 11 p.

    Research output: Contribution to journal › Article

  20. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, M. S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research.

    Research output: Contribution to journal › Article

  21. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104, 9 p.

    Research output: Contribution to journal › Article

  22. MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

    Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

    Research output: Contribution to journal › Article

  23. Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

    Alessi, D. R. & 21 others Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., Michalski, C. W., Schlitter, A. M., Esposito, I., Kind, A. J., Rad, L., Schnieke, A. E., Baccarini, M., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. 2013 In : Cancer Cell. 23, 3, p. 406-420, 15 p.

    Research output: Contribution to journal › Article

  24. The ULK1 complex Sensing nutrient signals for autophagy activation

    Wong, P-M., Puente, C., Ganley, I. G. & Jiang, X. 2013 In : Autophagy. 9, 2, p. 124-137, 14 p.

    Research output: Contribution to journal › Article

  25. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

    Research output: Contribution to journal › Article

  26. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec-2012 In : Neuropharmacology. 63, 7, p. 1227-1237, 11 p.

    Research output: Contribution to journal › Article

  27. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

    Research output: Contribution to journal › Article

  28. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

    Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zegiraj, E., Turk, B. E. & Sakamoto, K. Nov-2012 In : Cellular Signalling. 24, 11, p. 2085-2094, 10 p.

    Research output: Contribution to journal › Article

  29. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway

    Bruce, D. L., Macartney, T., Yong, W., Shou, W. & Sapkota, G. P. Nov-2012 In : Cellular Signalling. 24, 11, p. 1999-2006, 8 p.

    Research output: Contribution to journal › Article

  30. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Oct-2012 In : Journal of Cell Science. 125, 19, p. 4662-4675

    Research output: Contribution to journal › Article

  31. Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

    Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J. 21-Sep-2012 In : Journal of Biological Chemistry. 287, 39, p. 32346-53, 8 p.

    Research output: Contribution to journal › Article

  32. Disruptions on the highways of cellular signalling

    Alessi, D. Sep-2012 In : FEBS Journal. 279, p. 23-23, 1 p.

    Research output: Contribution to journal › Meeting abstract

  33. Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

    Trost, M., Sauvageau, M., Hérault, O., Deleris, P., Pomiès, C., Chagraoui, J., Mayotte, N., Meloche, S., Sauvageau, G. & Thibault, P. 23-Aug-2012 In : Blood. 120, 8, p. e17-27, 11 p.

    Research output: Contribution to journal › Article

  34. Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages

    Lopez Pelaez, M., Sanz, C., Herrero, C., Fernandez, M., Alemany, S., Fumagalli, S. & Guerra, S. 1-Aug-2012 In : Molecular Biology of the Cell. 23, 15, p. 2982-2992, 11 p.

    Research output: Contribution to journal › Article

  35. Brain penetrant LRRK2 inhibitor

    Choi, H. G., Zhang, J., Deng, X., Hatcher, J. M., Patricelli, M. P., Zhao, Z., Alessi, D. R. & Gray, N. S. Aug-2012 In : ACS Medicinal Chemistry Letters. 3, 8, p. 658-662, 5 p.

    Research output: Contribution to journal › Article

  36. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels

    Susa, K., Kita, S., Iwamoto, T., Yang, S-S., Lin, S-H., Ohta, A., Sohara, E., Rai, T., Sasaki, S., Alessi, D. R. & Uchida, S. Aug-2012 In : Clinical and Experimental Nephrology. 16, 4, p. 530-538, 9 p.

    Research output: Contribution to journal › Article

  37. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10-Jul-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205, 6 p.

    Research output: Contribution to journal › Article

  38. Phosphatases in SMAD regulation

    Bruce, D. L. & Sapkota, G. P. 4-Jul-2012 In : FEBS Letters. 586, 14, p. 1897-1905, 9 p.

    Research output: Contribution to journal › Article

  39. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome

    Campbell-Valois, F-X., Trost, M., Chemali, M., Laplante, A., Duclos, S., Sadeghi, S., Rondeau, C., Desjardins, M., Bell, C., Gagnon, E., Thibault, P., Dill, B. D., Morrow, I. C. & Hatsuzawa, K. 1-Jul-2012 In : Molecular & Cellular Proteomics. 11, 7

    Research output: Contribution to journal › Article

  40. Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

    Jensen, J., Tantiwong, P., Stuenaes, J. T., Molina-Carrion, M., DeFronzo, R. A., Sakamoto, K. & Musi, N. Jul-2012 In : American Journal of Physiology, Endocrinology and Metabolism. 303, 1, p. E82-E89, 8 p.

    Research output: Contribution to journal › Article

  41. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 18-Jun-2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journal › Article

  42. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

    Din, F. V. N., Valanciute, A., Dunlop, M. G., Houde, V. P., Zibrova, D., Sakamoto, K., Alessi, D. R. & Green, K. A. 1-Jun-2012 In : Gastroenterology. 142, 7

    Research output: Contribution to journal › Article

  43. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1-Jun-2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228, 13 p.

    Research output: Contribution to journal › Article

  44. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun-2012 In : Diabetes. 61, 6, p. 1423-1433, 11 p.

    Research output: Contribution to journal › Article

  45. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B cell activation and autoantibody production

    Jayachandran, N., Landego, I., Gibson, I., Miller, A., Wullschleger, S., Alessi, D. & Marshall, A. 1-May-2012 In : Journal of Immunology. 188, Suppl.1, 159.5

    Research output: Contribution to journal › Meeting abstract

  46. Thr(649)Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

    Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C. & Chen, S. May-2012 In : American Journal of Physiology, Endocrinology and Metabolism. 302, 9, p. E1036-E1043, 8 p.

    Research output: Contribution to journal › Article

  47. Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

    Gammoh, N., Lam, D., Puente, C., Marks, P. A., Jiang, X. & Ganley, I. 24-Apr-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6561-6565, 5 p.

    Research output: Contribution to journal › Article

  48. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

    Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H. 1-Apr-2012 In : Biochemical Journal. 443, p. 193-203, 11 p.

    Research output: Contribution to journal › Article

  49. Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J. , Backues, S. K. , Bartholomew, C. R. , Bridges, D. , Gestwicki, J. E. , Han, T. , Jin, M. , Kim, J. K. , Lin, J. D. , Lynch-Day, M. A. , Mao, K. , Nair, U. , Parzych, K. R. , Umekawa, M. , Wang, K. , Yen, W-L. , Zhao, M. , Olsen, L. J. , Abdalla, F. C. , Marcondes, M. & 1,235 others Silva-Zacarin, E. C. M., Silva-Zacarin, E., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Chiarelli, R., Roccheri, M. C., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Saitoh, T., Al-Younes, H. M., Al-Zeer, M. A., Meyer, T. F., Albert, M. L., Albin, R. L., Dowling, J. J., Alegre-Abarrategui, J., Wade-Martins, R., Aleo, M. F., Fanzani, A., Rovetta, F., Alirezaei, M., Chisari, F. V., Whitton, J. L., Almasan, A., Almonte-Becerril, M., Kouri Flores, J. B., Amano, A., Amaravadi, R., Amarnath, S., Fowler, D. H., Amer, A. O., Drew, M. E., Andrieu-Abadie, N., Poirot, M., Vindis, C., Anantharam, V., Kanthasamy, A. G., Kanthasamy, A., Ann, D. K., Anoopkumar-Dukie, S., Grant, G. D., Aoki, H., Apostolova, N., Arancia, G., Condello, M., Meschini, S., Aris, J. P., Asanuma, K., Tomino, Y., Asare, N. Y. O., Ashida, H., Askanas, V., Nogalska, A., Askew, D. S., Auberger, P., Bost, F., Gual, P., Luciano, F., Rocchi, S., Baba, M., Baehrecke, E. H., Bahr, B. A., Bai, X-Y., Chen, X., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Brunetti-Pierri, N., Settembre, C., Bamber, B. A., Bampton, E. T. W., Melino, G., Bánhegyi, G., Bassham, D. C., Bast Jr., R. C., Fan, Z., Lopez-Berestein, G., Lu, Z., Ozpolat, B., Batoko, H., Bay, B-H., Beau, I., Esclatine, A., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Dikic, I., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Sanchez, A. M. J., Bernassola, F., Marfe, G., Palumbo, C., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Espert, L., Blum, J. S., Boise, L. H., Lonial, S., Sun, S-Y., Bonaldo, P., Sandri, M., Boone, D. L., Bornhauser, B. C., Bourquin, J-P., Bortoluci, K. R., Bossis, I., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Nezis, I. P., Rusten, T. E., Stenmark, H., Brenman, J. E., Brennand, A., Michels, P. A. M., Bresnick, E. H., Kang, Y-A., Brest, P., Hofman, P., Mograbi, B., Bristol, M. L., Gewirtz, D. A., Brookes, P. S., Johnson, G. V. W., Brown, E. J., Brumell, J. H., Huang, J., Kim, P. K., Brunk, U. T., Kurz, T., Bulman, D. E., Bultman, S. J., Bultynck, G., Parys, J. B., Burbulla, L. F., Krüger, R., Bursch, W., Butchar, J. P., Buzgariu, W., Galliot, B., Bydlowski, S. P., Cadwell, K., Cahová, M., Papackova, Z., Cai, D., Cai, J., Cai, Q., Calabretta, B., Sotgia, F., Calvo-Garrido, J., Escalante, R., Camougrand, N., Manon, S., Priault, M., Campanella, M., Campos-Salinas, J., Gonzalez-Rey, E., Oliver, F. J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Moreira, P. I., Carew, J. S., Nawrocki, S. T., Carlin, C. R., Carmignac, V., Durbeej, M., Carneiro, L. A. M., Carra, S., Kampinga, H. H., Caruso, R. A., Casari, G., Casas, C., Castino, R., Isidoro, C., Cebollero, E., Reggiori, F., Cecconi, F., Ciriolo, M. R., Piacentini, M., Celli, J., Chaachouay, H., Rodemann, H. P., Chae, H-J., Chai, C-Y., Chan, D. C., Chan, E. Y., Coombs, G. H., Chang, R. C-C., Che, C-M., Lok, C-N., Sy, L-K., Chen, C-C., Lin, W-W., Chen, G-C., Yang, W. Y., Chen, G-Q., Chen, M., Wang, J., Chen, Q., Chen, S. S-L., Ke, P-Y., Lin, Y-L., Chen, W., Chen, Y-G., Liu, Y., Yu, L., Chen, Y., Guan, J-L., Towns, R., Wiley, J. W., Chen, Y-J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Wang, H-G., Yang, J-M., El-Deiry, W. S., Cheong, H., Thompson, C. B., Cheong, J-H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H-L., Chiba, T., Chin, L-S., Li, L., Mao, Z., Chiou, S-H., Cho, C. H., Cho, D-H., Choi, A. M. K., Haspel, J. A., Henske, E. P., Nakahira, K., Ryter, S. W., Choi, D., Choi, K. S., Choi, M. E., Münger, K., Chouaib, S., Choubey, D., Choubey, V., Kaasik, A., Chu, C. T., Rabinowich, H., Chuang, T-H., Chueh, S-H., Chun, T., Park, O. K., Chwae, Y-J., Chye, M-L., Ciarcia, R., Florio, S., Granato, G. E., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Puyal, J., Clarke, R., Saha, T., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condorelli, F., Cookson, M. R., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Helfrich, M. H., Hocking, L. J., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Kaushik, S., Koga, H., Czaja, M. J., Cullen, J. 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  50. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

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  51. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21-Mar-2012 In : EMBO Journal. 31, 6, p. 1394-1404, 11 p.

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  52. A new role of AMP-activated protein kinase in regulating proliferation of mesenchymal stem cells

    Bertrand, L., Balteau, M., Timmermans, A., Viollet, B., Sakamoto, K., Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & De Meester, C. 15-Mar-2012 In : Cardiovascular Research. 93, p. S96-S97, 2 p., P-498

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  53. Potentiation effect of the AMPK activator A-769662 on cardiac myocytes metabolism and survival

    Timmermans, A., Ginion, A., De Meester, C., Sakamoto, K., Vanoverschelde, J-L., Horman, S., Beauloye, C. & Bertrand, L. 15-Mar-2012 In : Cardiovascular Research. 93, p. S72-S73, 2 p., P-362

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  54. Phenformin as prophylaxis and therapy in breast cancer xenografts

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  55. Characterization of TAE684 as a potent LRRK2 kinase inhibitor

    Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. & Gray, N. S. 1-Mar-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1864-1869, 6 p.

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  56. Discovery of potent and selective covalent inhibitors of JNK

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  57. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 12-Jan-2012 In : PLoS Pathogens. 8, 1, e1002373

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  58. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

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  59. Characterization of the cellular action of the MSK inhibitor SB-747651A

    Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. & Arthur, J. S. C. 1-Jan-2012 In : Biochemical Journal. 441, p. 347-357, 11 p.

    Research output: Contribution to journal › Article

  60. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1-Jan-2012 In : Biochemical Journal. 441, p. 339-346, 8 p.

    Research output: Contribution to journal › Article

  61. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1-Jan-2012 In : Biochemical Journal. 441, p. 325-337, 13 p.

    Research output: Contribution to journal › Article

  62. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

    Castaneda-Bueno, M., Graciela Cervantes-Perez, L., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. & Gamba, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7929-7934, 6 p.

    Research output: Contribution to journal › Article

  63. Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

    Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

    Research output: Contribution to journal › Article

  64. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

    Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35973

    Research output: Contribution to journal › Article

  65. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coats, J., Stewart, D., McDougall, G. & Rena, G. 2012

    Research output: Contribution to conference › Poster

  66. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coates, J., Stewart, D., McDougall, G. & Rena, G. 2012 In : Diabetic Medicine. 29, Suppl. 1, p. 41, 1 p., P41

    Research output: Contribution to journal › Meeting abstract

  67. Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

    Lewis, P. A. & Alessi, D. R. 2012 In : Biochemical Society Transactions. 40, 5, p. 1039-1041, 3 p.

    Research output: Contribution to journal › Article

  68. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

    Davis, E. J., Lachaud, C., Appleton, P., MacArtney, T. J., Nathke, I. & Rouse, J. 2012 In : Nature Structural & Molecular Biology. 19, 11, p. 1093-1100, 8 p.

    Research output: Contribution to journal › Article

  69. Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

    Tinti, M., Johnson, C., Toth, R., Ferrier, D. E. K. & MacKintosh, C. 2012 In : Open Biology. 2, 7

    Research output: Contribution to journal › Article

  70. G2019s leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

    Papkovskaia, T. D., Chau, K-Y., Inesta-vaquera, F., Papkovsky, D. B., Healy, D. G., Nishio, K., Staddon, J., Duchen, M. R., Hardy, J., Schapira, A. H. V. & Cooper, J. M. 2012 In : Human Molecular Genetics. 21, 19, p. 4201-4213, 13 p.

    Research output: Contribution to journal › Article

  71. GSK2578215A: a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

    Reith, A. D., Bamborough, P., Jandu, K., Andreotti, D., Mensah, L., Dossang, P., Choi, H. G., Deng, X., Zhang, J., Alessi, D. R. & Gray, N. S. 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 17, p. 5625-5629, 5 p.

    Research output: Contribution to journal › Article

  72. Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

    Neukamm, S. S., Toth, R., Morrice, N., Campbell, D. G., Mackintosh, C., Lehmann, R., Haering, H-U., Schleicher, E. D. & Weigert, C. 2012 In : PLoS ONE. 7, 8, p. e43296

    Research output: Contribution to journal › Article

  73. Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

    Joanne, P., Hourde, C., Ochala, J., Cauderan, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35346

    Research output: Contribution to journal › Article

  74. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

    Pattison, M. J., MacKenzie, K. F. & Arthur, J. S. C. 2012 In : Journal of Immunology. 189, 6, p. 2784-2792, 9 p.

    Research output: Contribution to journal › Article

  75. Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus

    Choi, Y-S., Karelina, K., Alzate-Correa, D., Hoyt, K. R., Impey, S., Arthur, J. S. & Obrietan, K. 2012 In : Journal of Neurochemistry. 123, 5, p. 676-688, 13 p.

    Research output: Contribution to journal › Article

  76. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

    Research output: Contribution to journal › Article

  77. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835, 11 p.

    Research output: Contribution to journal › Article

  78. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91, 6 p.

    Research output: Contribution to journal › Article

  79. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

    Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K. 2012 In : Open Biology. 2, 120080

    Research output: Contribution to journal › Article

  80. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα(12)

    Gan, X., Wang, J., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M. I. & Wu, D. 2012 In : Nature Cell Biology.

    Research output: Contribution to journal › Article

  81. Regulation of the transforming growth factor β pathway by reversible ubiquitylation

    Al-Salihi, M. A., Herhaus, L. & Sapkota, G. P. 2012 In : Open Biology. 2, 120082

    Research output: Contribution to journal › Article

  82. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514, 12 p.

    Research output: Contribution to journal › Article

  83. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

    Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. 2012 In : Science.

    Research output: Contribution to journal › Article

  84. The Dac-tag, an affinity tag based on penicillin-binding protein 5

    Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A. 2012 In : Analytical Biochemistry. 428, 1, p. 64-72, 9 p.

    Research output: Contribution to journal › Article

  85. The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome

    Ang, D. S. C., Kao, M. P. C., Dow, E., Lang, C. & Struthers, A. 2012 In : Heart. 98, 15, p. 1160-5, 6 p.

    Research output: Contribution to journal › Article

  86. USP11 augments TGFβ signaling by deubiquitylating ALK5

    Al-Salihi, M. A., Herhaus, L., Macartney, T. & Sapkota, G. P. 2012 In : Open Biology. 2, 120063

    Research output: Contribution to journal › Article

  87. WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

    Pacheco-Alvarez, D., Vazquez, N., Castaneda-Bueno, M., De-Los-Heros, P., Cortes-Gonzalez, C., Moreno, E., Meade, P., Bobadilla, N. A. & Gamba, G. 2012 In : Cellular Physiology and Biochemistry. 29, 1-2, p. 291-302, 12 p.

    Research output: Contribution to journal › Article

  88. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

    Lopez Pelaez, M., Soria-Castro, I., Bosca, L., Fernandez, M. & Alemany, S. Dec-2011 In : Immunology. 135, p. 105-105, 1 p.

    Research output: Contribution to journal › Meeting abstract

  89. Identification of the human testis protein phosphatase 1 interactome

    Fardilha, M., Esteves, S. L. C., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T. W., da cruz silva, O. A. B. & da cruz silva, E. F. 15-Nov-2011 In : Biochemical Pharmacology. 82, 10, p. 1403-1415, 13 p.

    Research output: Contribution to journal › Article

  90. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

    Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K. 1-Nov-2011 In : Open Biology. 1, NOVEMBER, 110012

    Research output: Contribution to journal › Article

  91. Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy

    Ganley, I. G., Wong, P-M. & Jiang, X. Nov-2011 In : Autophagy. 7, 11, p. 1397-1399, 3 p.

    Research output: Contribution to journal › Editorial

  92. The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

    Chen, S., Synowsky, S., Tinti, M. & MacKintosh, C. Nov-2011 In : Trends in Endocrinology and Metabolism. 22, 11, p. 429-436, 8 p.

    Research output: Contribution to journal › Scientific review

  93. The specificities of small molecule inhibitors of the TGF beta and BMP pathways

    Vogt, J., Traynor, R. & Sapkota, G. P. Nov-2011 In : Cellular Signalling. 23, 11, p. 1831-1842, 12 p.

    Research output: Contribution to journal › Article

  94. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14-Oct-2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674, 12 p.

    Research output: Contribution to journal › Article

  95. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11-Oct-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098, 6 p.

    Research output: Contribution to journal › Article

  96. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

    Sklar, P. , Ripke, S. , Scott, L. J. , Andreassen, O. A. , Cichon, S. , Craddock, N. , Edenberg, H. J. , Nurnberger, J. I. , Rietschel, M. , Blackwood, D. , Corvin, A. , Flickinger, M. , Guan, W. , Mattingsdal, M. , McQuillin, A. , Kwan, P. , Wienker, T. F. , Daly, M. , Dudbridge, F. , Holmans, P. A. & 153 others Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Lohoff, F. W., Potash, J. B., Mahon, P. B., McInnis, M. G., Zoellner, S., Zhang, P., Craig, D. W., Szelinger, S., Barrett, T. B., Breuer, R., Meier, S., Strohmaier, J., Witt, S. H., Tozzi, F., Farmer, A., McGuffin, P., Strauss, J., Xu, W., Kennedy, J. L., Vincent, J. B., Matthews, K., Day, R., Ferreira, M. A., O'Dushlaine, C., Perlis, R., Raychaudhuri, S., Ruderfer, D., Hyoun, P. L., Smoller, J. W., Li, J., Absher, D., Thompson, R. C., Meng, F. G., Schatzberg, A. F., Bunney, W. E., Barchas, J. D., Jones, E. G., Watson, S. J., Myers, R. M., Akil, H., Boehnke, M., Chambert, K., Moran, J., Scolnick, E., Djurovic, S., Melle, I., Morken, G., Gill, M., Morris, D., Quinn, E., Muehleisen, T. W., Degenhardt, F. A., Mattheisen, M., Schumacher, J., Maier, W., Steffens, M., Propping, P., Noethen, M. M., Anjorin, A., Bass, N., Gurling, H., Kandaswamy, R., Lawrence, J., McGhee, K., McIntosh, A., McLean, A. W., Muir, W. J., Pickard, B. S., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, E. K., Grozeva, D., Jones, I. R., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, M. C., Owen, M. J., Collier, D. A., Elkin, A., Matthews, K., Young, A. H., Ferrier, I. N., Williamson, R., Stefansson, K., Stefansson, H., Porgeirsson, P., Steinberg, S., Gustafsson, O., Bergen, S. E., Nimgaonkar, V., Hultman, C., Landen, M., Lichtenstein, P., Sullivan, P., Schalling, M., Osby, U., Backlund, L., Frisen, L., Langstrom, N., Jamain, S., Leboyer, M., Etain, B., Bellivier, F., Petursson, H., Sigurosson, E., Mueller-Mysok, B., Lucae, S., Schwarz, M., Schofield, P. R., Martin, N., Montgomery, G. W., Lathrop, M., Oskarsson, H., Bauer, M., Wright, A., Mitchell, P. B., Hautzinger, M., Reif, A., Kelsoe, J. R., Purcell, S. M. & Psychiat GWAS Consortium Bipolar D Oct-2011 In : Nature Genetics. 43, 10, p. 977-U162, 9 p.

    Research output: Contribution to journal › Article

  97. Visualization and Biochemical Analyses of the Emerging Mammalian 14-3-3-Phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct-2011 In : Molecular & Cellular Proteomics. 10, 10, p. -, 15 p.

    Research output: Contribution to journal › Article

  98. p38 alpha and p38 beta mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons

    Loy, B., Apostolova, G., Dorn, R., McGuire, V. A., Arthur, J. S. C. & Dechant, G. 24-Aug-2011 In : Journal of Neuroscience. 31, 34, p. 12059-12067, 9 p.

    Research output: Contribution to journal › Article

  99. Genetic analysis of specific and redundant roles for p38 alpha and p38 beta MAPKs during mouse development

    del Barco Barrantes, I., Manuel Coya, J., Maina, F., Arthur, J. S. C. & Nebreda, A. R. 2-Aug-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12764-12769, 6 p.

    Research output: Contribution to journal › Article

  100. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 1-Jul-2011 In : Biochemical Journal. 437, p. 157-167, 11 p.

    Research output: Contribution to journal › Article

  101. Evidence of p38 gamma and p38 delta involvement in cell transformation processes

    Isabel Cerezo-Guisado, M., del Reino, P., Remy, G., Kuma, Y., Arthur, J. S. C., Gallego-Ortega, D. & Cuenda, A. Jul-2011 In : Carcinogenesis. 32, 7, p. 1093-1099, 7 p.

    Research output: Contribution to journal › Article

  102. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

    Loeffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R. & Stork, B. Jul-2011 In : Autophagy. 7, 7, p. 696-706, 11 p.

    Research output: Contribution to journal › Article

  103. Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

    Ganley, I. G., Wong, P-M., Gammoh, N. & Jiang, X. 24-Jun-2011 In : Molecular Cell. 42, 6, p. 731-743, 13 p.

    Research output: Contribution to journal › Article

  104. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P. 6-Jun-2011 In : Journal of Experimental Medicine. 208, 6, p. 1215-1228, 14 p.

    Research output: Contribution to journal › Article

  105. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

    Lopez Pelaez, M., Soria-Castro, I., Bosca, L., Fernandez, M. & Alemany, S. Jun-2011 In : European Journal of Immunology. 41, 6, p. 1733-1741, 9 p.

    Research output: Contribution to journal › Article

  106. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

    Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. & Alessi, D. R. 15-May-2011 In : Biochemical Journal. 436, p. 169-179, 11 p.

    Research output: Contribution to journal › Article

  107. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4-May-2011 In : EMBO Journal. 30, 9, p. 1730-1741, 12 p.

    Research output: Contribution to journal › Article

  108. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

    Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S. & Uchida, S. 1-May-2011 In : Journal of Cell Science. 124, 9, p. 1391-1395, 5 p.

    Research output: Contribution to journal › Article

  109. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

    MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. & Houslay, M. D. 1-May-2011 In : Biochemical Journal. 435, p. 755-769, 15 p.

    Research output: Contribution to journal › Article

  110. Erratum to Ppm1E is an in cellulo AMP-activated protein kinase phosphatase (vol 23, pg 114-124, 2011)

    Voss, M., Paterson, J., Kelsall, I. R., Martin-Granados, C., Hastie, C. J., Peggie, M. W. & Cohen, P. T. W. May-2011 In : Cellular Signalling. 23, 5, p. 947-947, 1 p.

    Research output: Contribution to journal › Article

  111. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15-Apr-2011 In : Biochemical Journal. 435, p. 463-474, 12 p.

    Research output: Contribution to journal › Article

  112. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

    Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G. 1-Apr-2011 In : Biochemical Journal. 435, p. 73-83, 11 p.

    Research output: Contribution to journal › Article

  113. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

    Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S. Apr-2011 In : Nature Chemical Biology. 7, 4, p. 203-205, 3 p.

    Research output: Contribution to journal › Article

  114. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

    Ronkina, N., Menon, M. B., Schwermann, J., Arthur, J. S. C., Legault, H., Telliez, J. -B., Kayyali, U. S., Nebreda, A. R., Kotlyarov, A. & Gaestel, M. Apr-2011 In : Nucleic Acids Research. 39, 7, p. 2503-2518, 16 p.

    Research output: Contribution to journal › Article

  115. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29-Mar-2011 In : British Journal of Cancer. 104, 7, p. 1116-1125, 10 p.

    Research output: Contribution to journal › Article

  116. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15-Mar-2011 In : Biochemical Journal. 434, p. 537-548, 12 p.

    Research output: Contribution to journal › Article

  117. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

    Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 1-Mar-2011 In : Journal of Cell Science. 124, 5, p. 789-800, 12 p.

    Research output: Contribution to journal › Article

  118. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1-Mar-2011 In : Biochemical Journal. 434, p. 265-274, 10 p.

    Research output: Contribution to journal › Article

  119. Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

    Chang, S., Iversen, L., Kragballe, K., Arthur, J. S. C. & Johansen, C. Mar-2011 In : Cancer Investigation. 29, 3, p. 240-245, 6 p.

    Research output: Contribution to journal › Article

  120. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

    Deleris, P., Trost, M., Topisirovic, I., Tanguay, P-L., Borden, K. L. B., Thibault, P. & Meloche, S. 25-Feb-2011 In : Journal of Biological Chemistry. 286, 8, p. 6470-6478, 9 p.

    Research output: Contribution to journal › Article

  121. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15-Feb-2011 In : Biochemical Journal. 434, p. 93-104, 12 p.

    Research output: Contribution to journal › Article

  122. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Feb-2011 In : Biochemical Journal. 433, p. 515-525, 11 p.

    Research output: Contribution to journal › Article

  123. A novel transcriptional repressor controlled by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors

    Dissanayake, K., Toth, R., Olsson, O., Campbell, D., Prescott, A. & MacKintosh, C. Feb-2011 In : Clinical & Experimental Metastasis. 28, 2, p. 234-234, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  124. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

    Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P. Feb-2011 In : Nature Genetics. 43, 2, p. 138-U85, 6 p.

    Research output: Contribution to journal › Article

  125. The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice

    Bertelsen, T., Iversen, L., Riis, J. L., Arthur, J. S. C., Bibby, B. M., Kragballe, K. & Johansen, C. Feb-2011 In : Experimental Dermatology. 20, 2, p. 140-145, 6 p.

    Research output: Contribution to journal › Article

  126. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

    Najafov, A., Sommer, E. M., Axten, J. M., DeYoung, M. P. & Alessi, D. R. 15-Jan-2011 In : Biochemical Journal. 433, p. 357-369, 13 p.

    Research output: Contribution to journal › Article

  127. Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

    Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, K. 5-Jan-2011 In : Cell Metabolism. 13, 1, p. 68-79, 12 p.

    Research output: Contribution to journal › Article

  128. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

    Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R. Jan-2011 In : Disease Models & Mechanisms. 4, 1, p. 95-103, 9 p.

    Research output: Contribution to journal › Article

  129. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

    Voss, M., Paterson, J., Kelsall, I. R., Martin-Granados, C., Hastie, C. J., Peggie, M. W. & Cohen, P. T. W. Jan-2011 In : Cellular Signalling. 23, 1, p. 114-124, 11 p.

    Research output: Contribution to journal › Article

  130. Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

    Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. & Arthur, J. S. C. 2011 In : Neuropharmacology. 61, 1-2, p. 148-155, 8 p.

    Research output: Contribution to journal › Article

  131. Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate

    Lilleholt, L. L., Johansen, C., Arthur, J. S. C., Funding, A., Bibby, B. M., Kragballe, K. & Iversen, L. 2011 In : Acta Dermato-Venereologica. 91, 3, p. 271-278, 8 p.

    Research output: Contribution to journal › Article

  132. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A

    Pozuelo-Rubio, M., Leslie, N. R., Murphy, J. & MacKintosh, C. Dec-2010 In : Cell Biochemistry and Biophysics. 58, 3, p. 147-156, 10 p.

    Research output: Contribution to journal › Article

  133. Pseudokinases-remnants of evolution or key allosteric regulators?

    Zeqiraj, E. & van Aalten, D. M. F. Dec-2010 In : Current Opinion in Structural Biology. 20, 6, p. 772-781, 10 p.

    Research output: Contribution to journal › Article

  134. Identification of the MMS22L-TONSL complex that promotes homologous recombination

    Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T. & Rouse, J. 24-Nov-2010 In : Molecular Cell. 40, 4, p. 632-644, 13 p.

    Research output: Contribution to journal › Article

  135. Gpx3 determines competitiveness of normal and leukemic stem cells

    Herault, O., Hope, K. J., Deneault, E., Trost, M., Mayotte, N., Chagraoui, J., Wilhelm, B. T., Cellot, S., Sauvageau, M., Thibault, P. & Sauvageau, G. 19-Nov-2010 In : Blood. 116, 21, p. 670-671, 2 p., Abstract 1587

    Research output: Contribution to journal › Meeting abstract

  136. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant V alpha 14 NKT cells and conventional T cells

    Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R. & Cantrell, D. A. 15-Nov-2010 In : Journal of Immunology. 185, 10, p. 5973-5982, 10 p.

    Research output: Contribution to journal › Article

  137. Uncoupling the Warburg effect from cancer

    Najafov, A. & Alessi, D. R. 9-Nov-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19135-19136, 2 p.

    Research output: Contribution to journal › Comment/debate

  138. Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

    Soutar, M. P. M., Kim, W-Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R. & Sutherland, C. Nov-2010 In : Journal of Neurochemistry. 115, 4, p. 974-983, 10 p.

    Research output: Contribution to journal › Article

  139. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov-2010 In : Glycobiology. 20, 11, p. 1478-1478, 1 p., 92

    Research output: Contribution to journal › Book/Film/Article review

  140. Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation

    Soria-Castro, I., Krzyzanowska, A., Pelaéz, M. L., Regadera, J., Ferrer, G., Montoliu, L., Rodríguez-Ramos, R., Fernández, M. & Alemany, S. 29-Oct-2010 In : Journal of Biological Chemistry. 285, 44, p. 33805-33815, 11 p.

    Research output: Contribution to journal › Article

  141. Regulation of miRNA transcription in macrophages in response to Candida albicans

    Monk, C. E., Hutvagner, G. & Arthur, J. S. C. 27-Oct-2010 In : PLoS ONE. 5, 10, p. -, 12 p., e13669

    Research output: Contribution to journal › Article

  142. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

    Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C. & Alessi, D. R. 15-Oct-2010 In : Biochemical Journal. 431, p. 245-255, 11 p.

    Research output: Contribution to journal › Article

  143. Molecular characterization of the evolution of phagosomes

    Boulais, J., Trost, M., Landry, C. R., Dieckmann, R., Levy, E. D., Soldati, T., Michnick, S. W., Thibault, P. & Desjardins, M. Oct-2010 In : Molecular Systems Biology. 6, p. -, 14 p., 423

    Research output: Contribution to journal › Article

  144. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15-Sep-2010 In : Biochemical Journal. 430, p. 393-404, 12 p.

    Research output: Contribution to journal › Article

  145. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15-Sep-2010 In : Biochemical Journal. 430, p. 405-413, 9 p.

    Research output: Contribution to journal › Article

  146. Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

    Pozo-Guisado, E., Campbell, D. G., Deak, M., Alvarez-Barrientos, A., Morrice, N. A., Alvarez, I. S., Alessi, D. R. & Javier Martin-Romero, F. 15-Sep-2010 In : Journal of Cell Science. 123, 18, p. 3084-3093, 10 p.

    Research output: Contribution to journal › Article

  147. Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry

    Martin, D. M. A., Nett, I. R. E., Vandermoere, F., Barber, J. D., Morrice, N. A. & Ferguson, M. A. J. 1-Sep-2010 In : Bioinformatics. 26, 17, p. 2153-2159, 7 p.

    Research output: Contribution to journal › Article

  148. ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis

    Inesta-Vaquera, F. A., Campbell, D. G., Arthur, J. S. C. & Cuenda, A. 13-Aug-2010 In : Biochemical and Biophysical Research Communications. 399, 1, p. 84-90, 7 p.

    Research output: Contribution to journal › Article

  149. p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

    Sabio, G., Cerezo-Guisado, M. I., del Reino, P., Inesta-Vaquera, F. A., Rousseau, S., Arthur, J. S. C., Campbell, D. G., Centeno, F. & Cuenda, A. 1-Aug-2010 In : Journal of Cell Science. 123, 15, p. 2596-2604, 9 p.

    Research output: Contribution to journal › Article

  150. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. 9-Jul-2010 In : Cell. 142, 1, p. 65-76, 12 p.

    Research output: Contribution to journal › Article

  151. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

    Greenblatt, M. B., Shim, J-H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J. M., Arthur, S., Xie, M., Schneider, M. D., Zhai, B., Gygi, S., Davis, R. & Glimcher, L. H. Jul-2010 In : Journal of Clinical Investigation. 120, 7, p. 2457-2473, 17 p.

    Research output: Contribution to journal › Article

  152. SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2

    Reiche, J., Theilig, F., Rafiqi, F. H., Carlo, A-S., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D. H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E. 15-Jun-2010 In : Molecular and Cellular Biology. 30, 12, p. 3027-3037, 11 p.

    Research output: Contribution to journal › Article

  153. Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

    Toh, G. W. -L., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E. & Rouse, J. 4-Jun-2010 In : DNA Repair. 9, 6, p. 718-726, 9 p.

    Research output: Contribution to journal › Article

  154. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1-Jun-2010 In : Biochemical Journal. 428, p. 281-291, 11 p.

    Research output: Contribution to journal › Article

  155. Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons

    Trunk, K., Benkert, B., Quaeck, N., Muench, R., Scheer, M., Garbe, J., Jaensch, L., Trost, M., Wehland, J., Buer, J., Jahn, M., Schobert, M. & Jahn, D. Jun-2010 In : Environmental Microbiology. 12, 6, p. 1719-1733, 15 p.

    Research output: Contribution to journal › Article

  156. GPR55 ligands promote receptor coupling to multiple signalling pathways

    Henstridge, C. M., Balenga, N. A. B., Schroeder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., Waldhoer, M. & Irving, A. J. Jun-2010 In : British Journal of Pharmacology. 160, 3, p. 604-614, 11 p.

    Research output: Contribution to journal › Article

  157. The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning

    Sicard, P., Clark, J. E., Jacquet, S., Mohammadi, S., Arthur, J. S. C., O'Keefe, S. J. & Marber, M. S. Jun-2010 In : Journal of Molecular and Cellular Cardiology. 48, 6, p. 1324-1328, 5 p.

    Research output: Contribution to journal › Article

  158. Bioinformatic and experimental survey of 14-3-3-binding sites

    Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C. 1-Apr-2010 In : Biochemical Journal. 427, p. 69-78, 10 p.

    Research output: Contribution to journal › Article

  159. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

    Canedo, C. S., Demeulder, B., Ginion, A., Bayascas, J. R., Balligand, J-L., Alessi, D. R., Vanoverschelde, J-L., Beauloye, C., Hue, L. & Bertrand, L. Apr-2010 In : American Journal of Physiology, Endocrinology and Metabolism. 298, 4, p. E761-E769, 9 p.

    Research output: Contribution to journal › Article

  160. Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

    Childs, A. J., Bayne, R. A. L., Murray, A. A., Martins Da Silva, S. J., Collins, C. S., Spears, N. & Anderson, R. A. Apr-2010 In : Developmental Dynamics. 239, 4, p. 1211-1219, 9 p.

    Research output: Contribution to journal › Article

  161. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

    Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R. 30-Mar-2010 In : Science Signaling. 3, 115, p. -, 13 p., ra25

    Research output: Contribution to journal › Article

  162. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1-Feb-2010 In : Biochemical Journal. 425, p. 595-602, 8 p.

    Research output: Contribution to journal › Article

  163. Role of the WNK-activated SPAK kinase in regulating blood pressure

    Rafiqi, F. H., Zuber, A. M., Glover, M., Richardson, C., Fleming, S., Jovanovic, S., Jovanovic, A., O'Shaughnessy, K. M. & Alessi, D. R. Feb-2010 In : Embo Molecular Medicine. 2, 2, p. 63-75, 13 p.

    Research output: Contribution to journal › Article

  164. The nuts and bolts of AGC protein kinases

    Pearce, L. R., Komander, D. & Alessi, D. R. Jan-2010 In : Nature Reviews Molecular Cell Biology. 11, 1, p. 9-22, 14 p.

    Research output: Contribution to journal › Scientific review

  165. Subcellular phosphoproteomics

    Trost, M., Bridon, G., Desjardins, M. & Thibault, P. 2010 In : Mass Spectrometry Reviews. 29, 6, p. 962–990

    Research output: Contribution to journal › Article

  166. The biological function of the proto-oncogene Cot/tpl-2 (MAP kinase kinase kinase 8)

    Fernandez, M., Soria, I., Lopez Pelaez, M., Martin-Duce, A. & Alemany, S. 2010 Emerging Signaling Pathways in Tumor Biology. Lazo, P. A. (ed.). Kerala: Transworld Research Network, p. 25-41 17 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  167. Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes

    Cameron, A. R., Anil, S., Sutherland, E., Harthill, J. & Rena, G. 2010 In : Metallomics: Integrated Biometal Science. 2, 3, p. 195-203, 9 p.

    Research output: Contribution to journal › Article

  168. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

    Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 18-Dec-2009 In : Science. 326, 5960, p. 1707-1711, 5 p.

    Research output: Contribution to journal › Article

  169. Biochemical characterisation of the SWI/SNF family member HLTF

    MacKay, C., Toth, R. & Rouse, J. 11-Dec-2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191, 5 p.

    Research output: Contribution to journal › Article

  170. Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

    Chen, S. & MacKintosh, C. Dec-2009 In : Cellular Signalling. 21, 12, p. 1984-1993, 10 p.

    Research output: Contribution to journal › Article

  171. Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

    Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K. & Komander, D. Dec-2009 In : Nature Structural & Molecular Biology. 16, 12, p. 1328-30, 3 p.

    Research output: Contribution to journal › Article

  172. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15-Nov-2009 In : Biochemical Journal. 424, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  173. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

    Nichols, R. J., Dzamko, N., Hutti, J. E., Cantley, L. C., Deak, M., Moran, J., Bamborough, P., Reith, A. D. & Alessi, D. R. 15-Nov-2009 In : Biochemical Journal. 424, p. 47-60, 14 p.

    Research output: Contribution to journal › Article

  174. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways

    Alarcón, C., Zaromytidou, A-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D. & Massagué, J. 13-Nov-2009 In : Cell. 139, 4, p. 757-769, 13 p.

    Research output: Contribution to journal › Article

  175. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling

    Gao, S., Alarcón, C., Sapkota, G., Rahman, S., Chen, P-Y., Goerner, N., Macias, M. J., Erdjument-Bromage, H., Tempst, P. & Massagué, J. 13-Nov-2009 In : Molecular Cell. 36, 3, p. 457-468, 12 p.

    Research output: Contribution to journal › Article

  176. Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation

    Waugh, C., Sinclair, L., Finlay, D., Bayascas, J. R. & Cantrell, D. 1-Nov-2009 In : Molecular and Cellular Biology. 29, 21, p. 5952-5962, 11 p.

    Research output: Contribution to journal › Article

  177. Differential 14-3-3 affinity capture reveals new downstream targets of Phosphatidylinositol 3-Kinase signaling

    Dubois, F., Vandermoere, F., Gernez, A., Murphy, J., Toth, R., Chen, S., Geraghty, K. M., Morrice, N. A. & MacKintosh, C. Nov-2009 In : Molecular & Cellular Proteomics. 8, 11, p. 2487-2499, 13 p.

    Research output: Contribution to journal › Article

  178. Generation of a conditional CREB Ser133Ala knockin mouse

    Wingate, A. D., Martin, K. J., Hunter, C., Carr, J. M., Clacher, C. & Arthur, J. S. C. Oct-2009 In : Genesis. 47, 10, p. 688-696, 9 p.

    Research output: Contribution to journal › Article

  179. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmoller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A. & Wojtaszewski, J. F. P. Sep-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E665-E675, 11 p.

    Research output: Contribution to journal › Article

  180. In vivo evidence that SPAK is a new regulator of blood pressure

    Zuber, A. M., Rafiqi, F. H., Glover, M., Alessi, D. R. & O'Shaughnessy, K. M. Sep-2009 In : Journal of Human Hypertension. 23, Supplement 1, p. S3-S3, 1 p., 3.1

    Research output: Contribution to journal › Article

  181. New users of metforminare at low risk of incident cancer a cohort study among people with type 2 diabetes

    Libby, G., Donnelly, L. A., Donnan, P. T., Alessi, D. R., Morris, A. D. & Evans, J. M. M. Sep-2009 In : Diabetes Care. 32, 9, p. 1620-1625, 6 p.

    Research output: Contribution to journal › Article

  182. Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

    Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J. 10-Jul-2009 In : Molecular Cell. 35, 1, p. 116-127, 12 p.

    Research output: Contribution to journal › Article

  183. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1-Jul-2009 In : Biochemical Journal. 421, p. 29-42, 14 p.

    Research output: Contribution to journal › Article

  184. p38 delta mitogen-activated protein kinase Is essential for skin tumor development in mice

    Schindler, E. M., Hindes, A., Gribben, E. L., Burns, C. J., Yin, Y., Lin, M-H., Owen, R. J., Longmore, G. D., Kissling, G. E., Arthur, J. S. C. & Efimova, T. 1-Jun-2009 In : Cancer Research. 69, 11, p. 4648-4655, 8 p.

    Research output: Contribution to journal › Article

  185. A meeting of minds: overcoming roadblocks in the development of therapies for neurodegenerative disorders

    Muqit, M. M. K. & Alessi, D. R. Jun-2009 In : Embo Molecular Medicine. 1, 3, p. 139-141, 3 p.

    Research output: Contribution to journal › Editorial

  186. ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

    Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Jun-2009 In : PLoS Biology. 7, 6, p. -, 19 p., e1000126

    Research output: Contribution to journal › Article

  187. Control of genome stability by Slx protein complexes

    Rouse, J. Jun-2009 In : Biochemical Society Transactions. 37, p. 495-510, 16 p.

    Research output: Contribution to journal › Article

  188. FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C

    Fuller, W., Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. & Shattock, M. J. Jun-2009 In : American Journal of Physiology: Cell Physiology. 296, 6, p. C1346-C1355, 10 p.

    Research output: Contribution to journal › Article

  189. Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and I kappa B Kinase epsilon A DISTINCT UPSTREAM KINASE MEDIATES SER-172 PHOSPHORYLATION AND ACTIVATION

    Clark, K., Plater, L., Peggie, M. & Cohen, P. 22-May-2009 In : Journal of Biological Chemistry. 284, 21, p. 14136-14146, 11 p.

    Research output: Contribution to journal › Article

  190. ULK1 center dot ATG13 center dot FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

    Ganley, I. G., Lam, D. H., Wang, J., Ding, X., Chen, S. & Jiang, X. 1-May-2009 In : Journal of Biological Chemistry. 284, 18, p. 12297-12305, 9 p.

    Research output: Contribution to journal › Article

  191. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

    Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J. May-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048, 7 p.

    Research output: Contribution to journal › Article

  192. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frosig, C., Pehmoller, C., Chen, S., Maarbjerg, S. J., Brandt, N., MacKintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E. A., Pilegaard, H. & Wojtaszewski, J. F. P. May-2009 In : Diabetologia. 52, 5, p. 891-900, 10 p.

    Research output: Contribution to journal › Article

  193. Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

    Topisirovic, I., Siddiqui, N., Lapointe, V. L., Trost, M., Thibault, P., Bangeranye, C., Pinol-Roma, S. & Borden, K. L. B. 22-Apr-2009 In : EMBO Journal. 28, 8, p. 1087-1098, 12 p.

    Research output: Contribution to journal › Article

  194. New insights into mTOR Signaling: mTORC2 and beyond

    Alessi, D. R., Pearce, L. R. & Garcia-Martinez, J. M. 21-Apr-2009 In : Science Signaling. 2, 67, p. -, 4 p., pe27

    Research output: Contribution to journal › Article

  195. RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1

    Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S. & Paludan, S. R. 17-Apr-2009 In : Journal of Biological Chemistry. 284, 16, p. 10774-10782, 9 p.

    Research output: Contribution to journal › Article

  196. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24-Mar-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590, 7 p.

    Research output: Contribution to journal › Article

  197. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

    San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P. & Gamba, G. 17-Mar-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4384-4389, 6 p.

    Research output: Contribution to journal › Article

  198. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15-Mar-2009 In : Biochemical Journal. 418, p. 625-634, 10 p.

    Research output: Contribution to journal › Article

  199. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

    Yang, H-T., Peggie, M., Cohen, P. & Rousseau, S. 13-Mar-2009 In : Biochemical and Biophysical Research Communications. 380, 3, p. 705-709, 5 p.

    Research output: Contribution to journal › Article

  200. Control of histone methylation and genome stability by PTIP

    Munoz, I. M. & Rouse, J. Mar-2009 In : EMBO Reports. 10, 3, p. 239-245, 7 p.

    Research output: Contribution to journal › Scientific review

  201. 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)

    Wood, N. T., Meek, D. W. & MacKintosh, C. 18-Feb-2009 In : FEBS Letters. 583, 4, p. 615-620, 6 p.

    Research output: Contribution to journal › Article

  202. Regulation of the activity and expression of ERK8 by DNA damage

    Klevernic, I. V., Martin, N. M. B. & Cohen, P. 18-Feb-2009 In : FEBS Letters. 583, 4, p. 680-684, 5 p.

    Research output: Contribution to journal › Article

  203. The phagosomal proteome in interferon-gamma-activated macrophages

    Trost, M., English, L., Lemieux, S., Courcelles, M., Desjardins, M. & Thibault, P. 16-Jan-2009 In : Immunity. 30, 1, p. 143-154, 12 p.

    Research output: Contribution to journal › Article

  204. Proteinuria in mice expressing PKB/SGK-resistant GSK3

    Boini, K. M., Amann, K., Kempe, D., Alessi, D. R. & Lang, F. Jan-2009 In : American Journal of Physiology: Renal Physiology. 296, 1, p. F153-F159, 7 p.

    Research output: Contribution to journal › Article

  205. Dopamine dysregulation syndrome in a patient with early onset Parkinsonism and Parkin gene mutations

    Sammler, E. M., Swingler, R. J., Stuart, A. & Muqit, M. 2009 In : Movement Disorders. 24, 16, p. 2442-2443, 2 p.

    Research output: Contribution to journal › Letter

  206. Estrogen regulation of p53 isoforms in the human breast cancer cell line MCF7

    Vendrell, J. A., Bourdon, J., Cohen, P. A. & Thompson, A. M. 2009 In : Cancer Research. 69, 2 Suppl. 1, 4067

    Research output: Contribution to journal › Meeting abstract

  207. Protein Kinase C-mediated Phosphorylation and activation of PDE3A Regulate cAMP levels in human platelets

    Hunter, R., MacKintosh, C. & Hers, I. 2009 In : Journal of Biological Chemistry. 284, 18, p. 12339-12348, 10 p.

    Research output: Contribution to journal › Article

  208. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2009 In : Diabetologia. 52, Suppl. 1, p. S203-S203, 1 p., PS 29

    Research output: Contribution to journal › Meeting abstract

  209. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

    Garcia-Martinez, J. M. & Alessi, D. R. 15-Dec-2008 In : Biochemical Journal. 416, p. 375-385, 11 p.

    Research output: Contribution to journal › Article

  210. Small-molecule inhibitors of PDK1

    Peifer, C. & Alessi, D. R. 15-Dec-2008 In : ChemMedChem. 3, 12, p. 1810-1838, 29 p.

    Research output: Contribution to journal › Scientific review

  211. Structure of the OSR1 kinase, a hypertension drug target

    Villa, F., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Dec-2008 In : Proteins: Structure, Function, and Bioinformatics. 73, 4, p. 1082-1087, 6 p.

    Research output: Contribution to journal › Article

  212. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15-Nov-2008 In : Biochemical Journal. 416, p. 114, 14 p.

    Research output: Contribution to journal › Article

  213. Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (FEBS Journal (2008) 275, (4211-4221))

    Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W. 1-Nov-2008 In : FEBS Journal. 275, 22, p. 5745, 1 p.

    Research output: Contribution to journal › Article

  214. Glycogen synthase kinase-3 (GSK3): a potential therapeutic target to treat neuroinflammation?

    De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R. & Jope, R. S. 25-Oct-2008 In : Journal of Neuroimmunology. 203, 2, p. 235-235, 1 p., 44

    Research output: Contribution to journal › Article

  215. Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

    Trinkle-Mulcahy, L., Boulon, S., Lam, Y. W., Urcia, R., Boisvert, F-M., Vandermoere, F., Morrice, N. A., Swift, S., Rothbauer, U., Leonhardt, H. & Lamond, A. 20-Oct-2008 In : Journal of Cell Biology. 183, 2, p. 223-239, 17 p.

    Research output: Contribution to journal › Article

  216. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15-Oct-2008 In : Biochemical Journal. 415, p. 297-307, 11 p.

    Research output: Contribution to journal › Article

  217. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

    Richardson, C. & Alessi, D. R. 15-Oct-2008 In : Journal of Cell Science. 121, 20, p. 3293-3304, 12 p.

    Research output: Contribution to journal › Article

  218. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

    Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S. 10-Oct-2008 In : Journal of Biological Chemistry. 283, 41, p. 27653-27667, 15 p.

    Research output: Contribution to journal › Article

  219. Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

    Filippi, B. M. & Alessi, D. R. 6-Oct-2008 In : Journal of Cell Biology. 183, 1, p. 7-9, 3 p.

    Research output: Contribution to journal › Comment/debate

  220. COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration

    Rodriguez, C., Lopez, P., Pozo, M., Duce, A. M., Lopez Pelaez, M., Fernandez, M. & Alemany, S. Sep-2008 In : Cellular Signalling. 20, 9, p. 1625-1631, 7 p.

    Research output: Contribution to journal › Article

  221. ERK5 regulation in naive T-cell activation and survival

    Ananieva, O., Macdonald, A., Wang, X., McCoy, C. E., McIlrath, J., Tournier, C. & Arthur, J. S. C. Sep-2008 In : European Journal of Immunology. 38, 9, p. 2534-2547, 14 p.

    Research output: Contribution to journal › Article

  222. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

    Kim, C., Sano, Y., Todorova, K., Carlson, B. A., Arpa, L., Celada, A., Lawrence, T., Otsu, K., Brissette, J. L., Arthur, J. S. C. & Park, J. M. Sep-2008 In : Nature Immunology. 9, 9, p. 1019-1027, 9 p.

    Research output: Contribution to journal › Article

  223. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

    Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J., Park, J. M., Wingate, A., Monk, C. E., Toth, R., Santos, S. G., Iversen, L. & Arthur, J. S. C. Sep-2008 In : Nature Immunology. 9, 9, p. 1028-1036, 9 p.

    Research output: Contribution to journal › Article

  224. Carrier erythrocyte entrapped thymidine phosphorylas etherapy for MNGIE

    Moran, N. F., Bain, M. D., Muqit, M. M. K. & Bax, B. E. 26-Aug-2008 71, 9, p. 686-688, 3 p.

    Research output: Contribution to journal › Scientific review

  225. Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

    Vazquez-Martin, C., Rouse, J. & Cohen, P. T. W. Aug-2008 In : FEBS Journal. 275, 16, p. 4211-4221, 11 p.

    Research output: Contribution to journal › Article

  226. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

    De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R. & Jope, R. S. 1-Jul-2008 In : Journal of Immunology. 181, 1, p. 338-345, 8 p.

    Research output: Contribution to journal › Article

  227. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation

    Cole, A. R., Soutar, M. P. M., Rembutsu, M., van Aalten, L., Hastie, C. J., Mclauchlan, H., Peggie, M., Balastik, M., Lu, K. P. & Sutherland, C. 27-Jun-2008 In : Journal of Biological Chemistry. 283, 26, p. 18227-18237, 11 p.

    Research output: Contribution to journal › Article

  228. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

    Hines, R. M., Wu, L., Hines, D. J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E., Hormuzdi, S. G., Zhuo, M. & El-Husseini, A. 11-Jun-2008 In : Journal of Neuroscience. 28, 24, p. 6055-6067, 13 p.

    Research output: Contribution to journal › Article

  229. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1-Jun-2008 In : Biochemical Journal. 412, p. 211-221, 11 p.

    Research output: Contribution to journal › Article

  230. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

    Kulathu, Y., Hobeika, E., Turchinovich, G. & Reth, M. 7-May-2008 In : EMBO Journal. 27, 9, p. 1333-44, 12 p.

    Research output: Contribution to journal › Article

  231. Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J. 6-May-2008 In : Cancer Cell. 13, 5, p. 454-463, 10 p.

    Research output: Contribution to journal › Article

  232. Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

    Duro, E., Vaisica, J. A., Brown, G. W. & Rouse, J. 3-May-2008 In : DNA Repair. 7, 5, p. 811-818, 8 p.

    Research output: Contribution to journal › Article

  233. PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

    Goehler, T., Munoz, I. M., Rouse, J. & Blow, J. J. 3-May-2008 In : DNA Repair. 7, 5, p. 775-787, 13 p.

    Research output: Contribution to journal › Article

  234. MSK activation and physiological roles

    Arthur, J. S. C. May-2008 In : Frontiers in Bioscience. 13, p. 5866-5879, 14 p.

    Research output: Contribution to journal › Scientific review

  235. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May-2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272, 15 p.

    Research output: Contribution to journal › Article

  236. The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway

    Chandramohan, Y., Droste, S. K., Arthur, J. S. C. & Reul, J. M. H. M. May-2008 In : European Journal of Neuroscience. 27, 10, p. 2701-2713, 13 p.

    Research output: Contribution to journal › Article

  237. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-inked polyubiquitin chains

    Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. & Alessi, D. R. 15-Apr-2008 In : Biochemical Journal. 411, p. 249-260, 12 p.

    Research output: Contribution to journal › Article

  238. PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

    Belgardt, B. F., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Kloeckener, T., Alessi, D., Kloppenburg, P. & Bruening, J. C. 9-Apr-2008 In : Cell Metabolism. 7, 4, p. 291-301, 11 p.

    Research output: Contribution to journal › Article

  239. Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages

    Marcantonio, M., Trost, M., Courcelles, M., Desjardins, M. & Thibault, P. 1-Apr-2008 In : Molecular & Cellular Proteomics. 7, 4, p. 645-660, 16 p.

    Research output: Contribution to journal › Article

  240. PDK1, but not PKB, is required for the activation of the Mtor/P70s6k pathway by leucine in the heart

    Canedo, C. S., Beauloye, C., Demeulder, B., Ginion, A., Zarrinpashneh, E., Alessi, D. R., Hue, L., Vanoverschelde, J. -L. & Bertrand, L. Apr-2008 In : Cardiovascular Drugs and Therapy. 22, 2, p. 150-150, 1 p.

    Research output: Contribution to journal › Article

  241. Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

    Morton, S., Hesson, L., Peggie, M. & Cohen, P. 19-Mar-2008 In : FEBS Letters. 582, 6, p. 997-1002, 6 p.

    Research output: Contribution to journal › Article

  242. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

    Richardson, C., Rafiqi, F. H., Karlsson, H. K. R., Moleleki, N., Vandewalle, A., Campbell, D. G., Morrice, N. A. & Alessi, D. R. 1-Mar-2008 In : Journal of Cell Science. 121, 5, p. 675-684, 10 p.

    Research output: Contribution to journal › Article

  243. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

    Windheim, M., Stafford, M., Cohen, P. & Peggie, M. Mar-2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791, 9 p.

    Research output: Contribution to journal › Article

  244. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

    Deutsch, E. W. , Ball, C. A. , Berman, J. J. , Bova, G. S. , Brazma, A. , Bumgarner, R. E. , Campbell, D. , Causton, H. C. , Christiansen, J. H. , Daian, F. , Dauga, D. , Davidson, D. R. , Gimenez, G. , Goo, Y. A. , Grimmond, S. , Henrich, T. , Herrmann, B. G. , Johnson, M. H. , Korb, M. , Mills, J. C. & 20 others Oudes, A. J., Parkinson, H. E., Pascal, L. E., Pollet, N. I., Quackenbush, J., Ramialison, M., Ringwald, M., Salgado, D., Sansone, S-A., Sherlock, G., Stoeckert, C. J., Swedlow, J., Taylor, R. C., Walashek, L., Warford, A., Wilkinson, D. G., Zhou, Y., Zon, L. I., Liu, A. Y. & True, L. D. Mar-2008 In : Nature Biotechnology. 26, 3, p. 305-312, 8 p.

    Research output: Contribution to journal › Article

  245. Systems biology analysis of phagosomes from Interferon-gamma activated mouse macrophages

    Trost, M., Lemieux, S., Thibault, P. & Desjardins, M. Mar-2008 In : European Journal of Cell Biology. 87, Supplement 1, p. 53-53, 1 p., MS4-2

    Research output: Contribution to journal › Meeting abstract

  246. Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells

    Rembutsu, M., Soutar, M. P. M., Van Aalten, L., Gourlay, R., Hastie, C. J., McLauchlan, H., Morrice, N. A., Cole, A. R. & Sutherland, C. 19-Feb-2008 In : Biochemistry. 47, 7, p. 2153-2161, 9 p.

    Research output: Contribution to journal › Article

  247. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 711-722, 12 p.

    Research output: Contribution to journal › Article

  248. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

    Windheim, M., Peggie, M. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 723-729, 7 p.

    Research output: Contribution to journal › Article

  249. IL-1 beta-stimulated activation of ERK1/2 and p38 alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells

    Yang, H-T., Cohen, P. & Rousseau, S. Feb-2008 In : Cellular Signalling. 20, 2, p. 375-380, 6 p.

    Research output: Contribution to journal › Article

  250. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

    Chen, S., Murphy, J., Toth, R., Campbell, D. G., Morrice, N. A. & Mackintosh, C. 15-Jan-2008 In : Biochemical Journal. 409, p. 449-459, 11 p.

    Research output: Contribution to journal › Article

  251. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., Garra, A. O., Ley, S. C. & Cohen, P. 15-Jan-2008 In : Journal of Cell Science. 121, 2, p. 149-154, 6 p.

    Research output: Contribution to journal › Article

  252. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

    Ganley, I. G., Espinosa, E. & Pfeffer, S. R. 14-Jan-2008 In : Journal of Cell Biology. 180, 1, p. 159-172, 14 p.

    Research output: Contribution to journal › Article

  253. Displacement affinity chromatography of protein phosphatase one (PP1) complexes

    Moorhead, G. B. G., Trinkle-Mulcahy, L., Nimick, M., De Wever, V., Campbell, D. G., Gourlay, R., Lam, Y. W. & Lamond, A. I. 1-Jan-2008 In : BMC Biochemistry. 9, 1

    Research output: Contribution to journal › Article

  254. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

    Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W. 2008 In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332, 18 p.

    Research output: Contribution to journal › Article

  255. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2008

    Research output: Contribution to conference › Poster

  256. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, p. 43-52, 10 p.

    Research output: Contribution to journal › Article

  257. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15-Dec-2007 In : Biochemical Journal. 408, p. 297-315, 19 p.

    Research output: Contribution to journal › Article

  258. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K., Thompson, A., Mathers, J., Holland, S., Stark, M. J. R., Lane, D. & Westwood, N. J. Dec-2007 In : Molecular Cancer Therapeutics. 6, 12, p. 3476S-3477S, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  259. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Zaru, R., Ronkina, N., Gaestel, M., Arthur, S. & Watts, C. Nov-2007 In : Nature Immunology. 8, 11, p. 1227-1235, 9 p.

    Research output: Contribution to journal › Article

  260. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16-Oct-2007 In : Biochemical Journal. 401, 1, p. 29-38, 10 p.

    Research output: Contribution to journal › Article

  261. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15-Oct-2007 In : Biochemical Journal. 407, p. 231-241, 11 p.

    Research output: Contribution to journal › Article

  262. Structural insights into the recognition of substrates and activators by the OSR1 kinase

    Villa, F., Goebel, J., Rafiqi, F. H., Deak, M., Thastrup, J., Alessi, D. R. & van Aalten, D. M. F. 1-Sep-2007 In : EMBO Reports. 8, 9, p. 839-845, 7 p.

    Research output: Contribution to journal › Article

  263. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep-2007 In : Diabetes. 56, 9, p. 2218-2227, 10 p.

    Research output: Contribution to journal › Article

  264. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

    Fonseca, B. D., Smith, E. M., Lee, V. H. -Y., MacKintosh, C. & Proud, C. G. 24-Aug-2007 In : Journal of Biological Chemistry. 282, 34, p. 24514-24524, 11 p.

    Research output: Contribution to journal › Article

  265. Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

    Munoz, I. M., Jowsey, P. A., Toth, R. & Rouse, J. Aug-2007 In : Nucleic Acids Research. 35, 16, p. 5312-5322, 11 p.

    Research output: Contribution to journal › Article

  266. Balancing BMP signaling through integrated inputs into the Smad1 linker

    Sapkota, G., Alarcón, C., Spagnoli, F. M., Brivanlou, A. H. & Massagué, J. 9-Feb-2007 In : Molecular Cell. 25, 3, p. 441-454, 14 p.

    Research output: Contribution to journal › Article

  267. E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

    Cowling, V. H. & Cole, M. D. 2007 In : Oncogene. 26, 24, p. 3582-6, 5 p.

    Research output: Contribution to journal › Article

  268. HATs off to capping: a new mechanism for Myc

    Cowling, V. H. & Cole, M. D. 2007 In : Cell Cycle. 6, 8, p. 907-9, 3 p.

    Research output: Contribution to journal › Scientific review

  269. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K. 2007 In : Journal of Biological Chemistry. 282, 45, p. 32549-32560, 12 p.

    Research output: Contribution to journal › Article

  270. Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors

    Li, H., Cherukuri, P., Li, N., Cowling, V., Spinella, M., Cole, M., Godwin, A. K., Wells, W. & DiRenzo, J. 2007 In : Cancer Research. 67, 2, p. 501-10, 10 p.

    Research output: Contribution to journal › Article

  271. Turning the tables: Myc activates Wnt in breast cancer

    Cowling, V. H. & Cole, M. D. 2007 In : Cell Cycle. 6, 21, p. 2625-7, 3 p.

    Research output: Contribution to journal › Scientific review

  272. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-β pathways

    Sapkota, G., Knockaert, M., Alarcón, C., Montalvo, E., Brivanlou, A. H. & Massagué, J. 29-Dec-2006 In : Journal of Biological Chemistry. 281, 52, p. 40412-40419, 8 p.

    Research output: Contribution to journal › Article

  273. 3'phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium

    Budas, G. R., Sukhodub, A., Alessi, D. R. & Jovanovic, A. Dec-2006 In : FASEB Journal. 20, 14, p. 2556-2558, 3 p.

    Research output: Contribution to journal › Article

  274. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1-Nov-2006 In : Biochemical Journal. 399, 3, p. 427-434, 8 p.

    Research output: Contribution to journal › Article

  275. Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose

    Harthill, J. E., Meek, S. E. M., Morrice, N., Peggie, M., Borch, J., Wong, B. H. C. & MacKintosh, C. Jul-2006 In : Plant Journal. 47, 2, p. 211-223, 13 p.

    Research output: Contribution to journal › Article

  276. The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin

    Hastie, C. J., Vázquez-Martin, C., Philp, A., Stark, M. J. R. & Cohen, P. T. W. Jul-2006 In : FEBS Journal. 273, 14, p. 3322-34, 13 p.

    Research output: Contribution to journal › Article

  277. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

    Cole, A. R., Causeret, F., Yadirgi, G., Hastie, C. J., Mclauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M., Sutherland, C. & Sutherland, C. 16-Jun-2006 In : Journal of Biological Chemistry. 281, 24, p. 16591-16598, 8 p.

    Research output: Contribution to journal › Article

  278. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

    Liu, H. K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C. J., Hundal, H. S., Sutherland, C. & Sutherland, C. 6-Apr-2006 In : BMC Molecular Biology. 7, p. -, 12 p., 14

    Research output: Contribution to journal › Article

  279. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15-Mar-2006 In : Biochemical Journal. 394, 3, p. 545-555, 11 p.

    Research output: Contribution to journal › Article

  280. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

    Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L. 2006 In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

    Research output: Contribution to journal › Article

  281. Mechanism of transcriptional activation by the Myc oncoproteins

    Cowling, V. H. & Cole, M. D. 2006 In : Seminars in Cancer Biology. 16, 4, p. 242-52, 11 p.

    Research output: Contribution to journal › Scientific review

  282. The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN

    Layer, G., Pierik, A. J., Trost, M., Rigby, S. E., Leech, H. K., Grage, K., Breckau, D., Astner, I., Jänsch, L., Heathcote, P., Warren, M. J., Heinz, D. W. & Jahn, D. 2006 In : Journal of Biological Chemistry. 281, 23, p. 15727-15734, 8 p.

    Research output: Contribution to journal › Article

  283. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

    Knockaert, M., Sapkota, G., Alarcón, C., Massagué, J. & Brivanlou, A. H. 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 11940-11945, 6 p.

    Research output: Contribution to journal › Article

  284. Generation and characterization of p38beta (MAPK11) gene-targeted mice

    Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., Malone, L., Kollias, G. & Arthur, S. C. Dec-2005 In : Molecular and Cellular Biology. 25, 23, p. 10454-10464, 11 p.

    Research output: Contribution to journal › Article

  285. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov-2005 In : Diabetes. 54, 11, p. 3161-3168, 8 p.

    Research output: Contribution to journal › Article

  286. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

    Bayascas, J. R., Leslie, N., Parsons, R., Fleming, S. & Alessi, D. Oct-2005 In : Current Biology. 15, 20, p. 1839-1846, 8 p.

    Research output: Contribution to journal › Article

  287. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

    Alessi, D., Deak, M., Morrice, N. & Vitari, A. Oct-2005 In : Biochemical Journal. 391, 1, p. 17-24, 8 p.

    Research output: Contribution to journal › Article

  288. 14-3-3 Phosphoproteomics for linking signalling pathways to cellular processes

    MacKintosh, C., Harthill, J. & Kulma, A. Jul-2005 In : Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 141, 3, p. S250-S250, 1 p.

    Research output: Contribution to journal › Meeting abstract

  289. Metformin and reduced risk of cancer in diabetic patients

    Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R. & Morris, A. D. Jun-2005 In : BMJ. 330, 7503, p. 1304-1305, 2 p.

    Research output: Contribution to journal › Article

  290. Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding

    Komander, D., Kular, G., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 13-May-2005 In : Journal of Biological Chemistry. 280, 19, p. 18797-18802, 6 p.

    Research output: Contribution to journal › Article

  291. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May-2005 In : The EMBO Journal. 24, 10, p. 1810-1820, 11 p.

    Research output: Contribution to journal › Article

  292. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May-2005 In : The EMBO Journal. 24, 9, p. 1696-1705, 10 p.

    Research output: Contribution to journal › Article

  293. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R. Apr-2005 In : The EMBO Journal. 24, 8, p. 1571-1583, 13 p.

    Research output: Contribution to journal › Article

  294. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

    Villa, F., Deak, M., Bloomberg, G. B., Alessi, D. R. & Van Aalten, D. M. F. 4-Mar-2005 In : Journal of Biological Chemistry. 280, 9, p. 8180-8187, 8 p.

    Research output: Contribution to journal › Article

  295. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

    Zeke, T., Morrice, N., Vazquez-Martin, C. & Cohen, T. Jan-2005 In : Biochemical Journal. 385, 1, p. 45-56, 12 p.

    Research output: Contribution to journal › Article

  296. 14-3-3s as signalling integrators in plant and human cells

    MacKintosh, C., Pozuelo-Rubio, M., Geraghty, K., Wong, B., Wood, N., Murphy, J., Dubois, F. . & Harthill, J. 2005 In : FEBS Journal. 272, Suppl. 1, p. 460-461, 2 p., J4-004

    Research output: Contribution to journal › Meeting abstract

  297. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639, 7 p.

    Research output: Contribution to journal › Article

  298. Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria species

    Trost, M., Wehmhöner, D., Kärst, U., Dieterich, G., Wehland, J. & Jänsch, L. 2005 In : Proteomics. 5, 6, p. 1544-1557, 14 p.

    Research output: Contribution to journal › Article

  299. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648, 10 p.

    Research output: Contribution to journal › Article

  300. Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence

    Jacobsen, I., Hennig-Pauka, I., Baltes, N., Trost, M. & Gerlach, G-F. 2005 In : Infection and Immunity. 73, 1, p. 226-234, 9 p.

    Research output: Contribution to journal › Article

  301. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

    Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., Mullenders, J., Beijersbergen, R. L., Bernards, R., Ganesan, T. S., Downward, J. & Hancock, D. C. 2005 In : Molecular Cell. 20, 5, p. 673-85, 13 p.

    Research output: Contribution to journal › Article

  302. Isolation of 14-3-3 binding proteins from Hydra

    Pauly, B. S., Stiening, B., MacKintosh, C., Rudd, S., David, C. N. & Bottger, A. 2005 In : European Journal of Cell Biology. 84, Suppl. 1, p. 37-37, 1 p., S2-32

    Research output: Contribution to journal › Meeting abstract

  303. Isolation of 14-3-3 binding proteins from Hydra

    Pauly, B. S., Stiening, B., MacKintosh, C., Rudd, S., David, C. N. & Bottger, A. 2005

    Research output: Contribution to conference › Paper

  304. Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428

    Pozuelo-Rubio, M., Campbell, D. G., Morrice, N. A. & MacKintosh, C. 2005 In : Biochemical Journal. 392, 1, p. 163-172, 10 p.

    Research output: Contribution to journal › Article

  305. Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage

    Flott, S. & Rouse, J. 2005 In : Biochemical Journal. 391, 2, p. 325-333, 9 p.

    Research output: Contribution to journal › Article

  306. A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

    Milne, D., Kampanis, P., Nicol, S., Dias, S., Campbell, D. G., Fuller-Pace, F. & Meek, D. 5-Nov-2004 In : FEBS Letters. 577, 1-2, p. 270-276, 7 p.

    Research output: Contribution to journal › Article

  307. Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

    Morgan, C. P., Skippen, A., Segui, B., Ball, A., Allen-Baume, V., Larijani, B., Murray-Rust, J., McDonald, N., Sapkota, G., Morrice, N. & Cockcroft, S. 5-Nov-2004 In : Journal of Biological Chemistry. 279, 45, p. 47159-47171, 13 p.

    Research output: Contribution to journal › Article

  308. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

    Sakamoto, K., Goransson, O., Hardie, D. G. & Alessi, D. R. Aug-2004 In : American Journal of Physiology, Endocrinology and Metabolism. 287, 2, p. E310-E317

    Research output: Contribution to journal › Article

  309. Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins

    Arthur, S., Fong, A. L., Dwyer, J. M., Davare, M., Reese, E., Obrietan, K. & Impey, S. May-2004 In : Journal of Neuroscience. 24, 18, p. 4324-4332, 9 p.

    Research output: Contribution to journal › Article

  310. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

    Pozuelo-Rubio, M., Geraghty, K. M., Wong, B. H. C., Wood, N. T., Campbell, D. G., Morrice, N. & MacKintosh, C. 15-Apr-2004 In : Biochemical Journal. 379, 2, p. 395-408, 14 p.

    Research output: Contribution to journal › Article

  311. Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

    Kulma, A., Villadsen, D., Campbell, D. G., Meek, S. E. M., Harthill, J. E., Nielsen, T. H. & MacKintosh, C. Mar-2004 In : Plant Journal. 37, 5, p. 654-667, 14 p.

    Research output: Contribution to journal › Article

  312. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb-2004 In : The EMBO Journal. 23, 4, p. 833-843, 11 p.

    Research output: Contribution to journal › Article

  313. Crystal structure of MO25 in complex with the C terminus of the pseudo kinase STE20-related adaptor

    Milburn, C. C., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 2004 In : Nature Structural & Molecular Biology. 11, 2, p. 193-200, 8 p.

    Research output: Contribution to journal › Article

  314. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a

    Rena, G., Bain, J., Elliott, M. & Cohen, P. 2004 In : EMBO Reports. 5, 1, p. 60-65, 6 p.

    Research output: Contribution to journal › Article

  315. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

    Rouse, J. 2004 In : The EMBO Journal. 23, 5, p. 1188-1197, 10 p.

    Research output: Contribution to journal › Article

  316. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

    Jowsey, P. A., Doherty, A. J. & Rouse, J. 2004 In : Journal of Biological Chemistry. 279, 53, p. 55562-55569, 8 p.

    Research output: Contribution to journal › Article

  317. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

    Hinton, H. J., Alessi, D. R. & Cantrell, D. A. 2004 In : Nature Immunology. 5, 5, p. 539-545, 7 p.

    Research output: Contribution to journal › Article

  318. Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

    Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G. Sep-2003 In : Journal of Biology. 2, 4, p. 28, 1 p.

    Research output: Contribution to journal › Article

  319. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep-2003 In : The EMBO Journal. 22, 18, p. 4666-4676, 11 p.

    Research output: Contribution to journal › Article

  320. 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

    Pozuelo-Rubio, M., Peggie, M., Wong, B. H. C., Morrice, N. & MacKintosh, C. 15-Jul-2003 In : The EMBO Journal. 22, 14, p. 3514-3523, 10 p.

    Research output: Contribution to journal › Article

  321. LKB1, a protein kinase regulating cell proliferation and polarity

    Boudeau, J., Sapkota, G. & Alessi, D. R. 3-Jul-2003 In : FEBS Letters. 546, 1, p. 159-165, 7 p.

    Research output: Contribution to journal › Article

  322. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

    Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C. & Arthur, J. S. C. Jun-2003 In : The EMBO Journal. 22, 11, p. 2788-2797, 10 p.

    Research output: Contribution to journal › Article

  323. Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

    Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Münsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., Mathers, J., Keyse, S. M., Storey, K. & Tickle, C. Jun-2003 In : Current Biology. 13, 12, p. 1009-18, 10 p.

    Research output: Contribution to journal › Article

  324. Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs

    Carnegie, G. K., Sleeman, J. E., Morrice, N., Hastie, C. J., Peggie, M. W., Philp, A., Lamond, A. I. & Cohen, P. T. W. May-2003 In : Journal of Cell Science. 116, 10, p. 1905-1913, 9 p.

    Research output: Contribution to journal › Article

  325. Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance

    Delibegovic, M., Armstrong, C. G., Dobbie, L., Watt, P. W., Smith, A. J. H. & Cohen, T. Mar-2003 In : Diabetes. 52, 3, p. 596-604, 9 p.

    Research output: Contribution to journal › Article

  326. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

    Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R. & Clevers, H. C. 2003 In : EMBO Journal. 22, 12, p. 3062-3072, 11 p.

    Research output: Contribution to journal › Article

  327. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

    Martins, L. M., Turk, B. E., Cowling, V., Borg, A., Jarrell, E. T., Cantley, L. C. & Downward, J. 2003 In : Journal of Biological Chemistry. 278, 49, p. 49417-27, 11 p.

    Research output: Contribution to journal › Article

  328. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism

    Powell, D. J., Hajduch, E., Kular, G. & Hundal, H. S. H. 2003 In : Molecular and Cellular Biology. 23, 21, p. 7794-7808, 15 p.

    Research output: Contribution to journal › Article

  329. Feedback control of the protein kinase TAK1 by SAPK2a/p38

    Cheung, P. C. F., Campbell, D. G., Nebreda, A. R. & Cohen, P. 2003 In : The EMBO Journal. 22, 21, p. 5793-5805, 13 p.

    Research output: Contribution to journal › Article

  330. Stepwise rotation of the γ-subunit of EFoF1-ATP synthase during ATP synthesis: a single-molecule FRET approach

    Borsch, M., Diez, M., Zimmermann, B., Trost, M., Steigmiller, S. & Graber, P. 2003 Manipulation and analysis of biomolecules, cells, and tissues. Nicolau, D. V., Enderlein, J., Leif, R. C. & Farkas, D. L. (eds.). Bellingham: SPIE-International Society for Optical Engineering, Vol. 4962, p. 11-21 11 p. (Progress in biomedical optics; 14).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  331. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells

    Harthill, J. E., Pozuelo-Rubio, M., Milne, F. C. & MacKintosh, C. 1-Dec-2002 In : Biochemical Journal. 368, p. 565-572, 8 p.

    Research output: Contribution to journal › Article

  332. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

    Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M. & Cohen, P. Dec-2002 In : The EMBO Journal. 21, 23, p. 6505-6514, 10 p.

    Research output: Contribution to journal › Article

  333. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

    Douglas, P., Sapkota, G. P., Morrice, N., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R. & Lees-Miller, S. P. 19-Aug-2002 In : Biochemical Journal. 368, 1, p. 243-251, 9 p.

    Research output: Contribution to journal › Article

  334. Affinity purification of diverse plant and human 14-3-3-binding partners

    Milne, F. C., Moorhead, G., Pozuelo-Rubio, M., Wong, B., Kulma, A., Harthill, J. E., Villadsen, D., Cotelle, V. & MacKintosh, C. Aug-2002 In : Biochemical Society Transactions. 30, 4, p. 379-381, 3 p.

    Research output: Contribution to journal › Article

  335. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

    Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P. & Arthur, J. S. C. Apr-2002 In : Molecular and Cellular Biology. 22, 8, p. 2871-2881, 11 p.

    Research output: Contribution to journal › Article

  336. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1

    Peggie, M., MacKelvie, S., Bloecher, A., Knatko, E., Tatchell, K. & Stark, M. 2002 In : Journal of Cell Science. 115, 1, p. 195-206, 12 p.

    Research output: Contribution to journal › Article

  337. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver

    Munro, S., Cuthbertson, D. J. R., Cunningham, J., Sales, M. & Cohen, P. T. W. 2002 In : Diabetes. 51, 3, p. 591-598, 8 p.

    Research output: Contribution to journal › Article

  338. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

    Sapkota, G. P., Boudeau, J., Deak, M., Kieloch, A., Morrice, N. & Alessi, D. R. 2002 In : Biochemical Journal. 362, Pt 2, p. 481-90, 10 p.

    Research output: Contribution to journal › Article

  339. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence

    Bierne, H., Mazmanian, S. K., Trost, M., Pucciarelli, M. G., Liu, G., Dehoux, P., Jänsch, L., Garcia-del Portillo, F., Schneewind, O., Cossart, P. & European Listeria Genome Consortium 2002 In : Molecular Microbiology. 43, 4, p. 869-81, 13 p.

    Research output: Contribution to journal › Article

  340. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

    Sapkota, G. P., Deak, M., Kieloch, A., Morrice, N., Goodarzi, A. A., Smythe, C., Shiloh, Y., Lees-Miller, S. P. & Alessi, D. R. 2002 In : Biochemical Journal. 368, 2, p. 507-516, 10 p.

    Research output: Contribution to journal › Article

  341. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271, 9 p.

    Research output: Contribution to journal › Article

  342. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

    Lee, M-J., Thangada, S., Paik, J-H., Sapkota, G. P., Ancellin, N., Chae, S-S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R. & Hla, T. Sep-2001 In : Molecular Cell. 8, 3, p. 693-704, 12 p.

    Research output: Contribution to journal › Article

  343. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38

    Knebel, A., Morrice, N. & Cohen, P. Aug-2001 In : The EMBO Journal. 20, 16, p. 4360-4369, 10 p.

    Research output: Contribution to journal › Article

  344. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at Cys433, is essential for LKB1 to suppress cell growth

    Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. . S. C., Williams, M. R., Morrice, N., Deak, M. & Alessi, D. R. 1-Jun-2001 In : Journal of Biological Chemistry. 276, 22, p. 19469-19482, 14 p.

    Research output: Contribution to journal › Article

  345. Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide

    Ropert, C., Almeida, I. C., Closel, M., Travassos, L. R., Ferguson, M. A. J., Cohen, P. & Gazzinelli, R. T. 1-Mar-2001 In : Journal of Immunology. 166, 5, p. 3423-3431, 9 p.

    Research output: Contribution to journal › Article

  346. Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins

    Pozuelo, M., MacKintosh, C., Galvan, A. & Fernandez, E. Jan-2001 In : Planta. 212, 2, p. 264-269, 6 p.

    Research output: Contribution to journal › Article

  347. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

    Holmberg, C. I., Hietakangas, V., Mikhailov, A., Rantanen, J. O., Kallio, M., Meinander, A., Hellman, J., Morrice, N., MacKintosh, C., Morimoto, R. I., Eriksson, J. E. & Sistonen, L. 2001 In : EMBO Journal. 20, 14, p. 3800-3810, 11 p.

    Research output: Contribution to journal › Article

  348. Regulation of plant NR activity by reversible phosphorylation, 14-3-3 proteins and proteolysis

    MacKintosh, C. & Meek, S. E. M. 2001 In : Cellular and Molecular Life Sciences. 58, 2, p. 205-214, 10 p.

    Research output: Contribution to journal › Scientific review

  349. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612, 8 p.

    Research output: Contribution to journal › Article

  350. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G. & Cohen, P. 2001 In : Biochemical Journal. 355, 3, p. 597-607, 11 p.

    Research output: Contribution to journal › Article

  351. Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

    Godber, B. L., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R. & Harrison, R. 17-Mar-2000 In : Journal of Biological Chemistry. 275, 11, p. 7757-7763, 7 p.

    Research output: Contribution to journal › Article

  352. 14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells

    Cotelle, V., Meek, S. E. M., Provan, F., Milne, F. C., Morrice, N. & MacKintosh, C. 2000 In : EMBO Journal. 19, 12, p. 2869-2876, 8 p.

    Research output: Contribution to journal › Article

  353. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and β-catenin

    Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P. & Cohen, P. 1999 In : FEBS Letters. 458, 2, p. 247-251, 5 p.

    Research output: Contribution to journal › Article

  354. Phosphorylation by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on hepatic IGFBP-1 gene expression

    Guo, S., Cichy, S. A., He, X., Wu, J., Rena, G., Cohen, P. & Unterman, T. G. 1999 In : Journal of Investigative Medicine. 47, 7, p. 258A-258A, 1 p.

    Research output: Contribution to journal › Meeting abstract

  355. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

    Guo, S., Rena, G., Cichy, S., He, X., Cohen, P. & Unterman, T. 1999 In : Journal of Biological Chemistry. 274, 24, p. 17184-17192, 9 p.

    Research output: Contribution to journal › Article

  356. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

    Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. 1999 In : Journal of Biological Chemistry. 274, 24, p. 17179-17183, 5 p.

    Research output: Contribution to journal › Article

  357. Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins

    Moorhead, G., Douglas, P., Cotelle, V., Harthill, J., Morrice, N., Meek, S., Deiting, U., Stitt, M., Scarabel, M., Aitken, A. & MacKintosh, C. 1999 In : Plant Journal. 18, 1, p. 1-12, 12 p.

    Research output: Contribution to journal › Article

  358. 14-3-3 proteins: from plant nitrate reductase to wider roles in plant responses to hormones, stresses, and nutrients

    MacKintosh, C. 1998 Photosynthesis: mechanisms and effects - proceedings of the XIth International Congress on Photosynthesis, Budapest, Hungary, August 17–22, 1998. Garab, G. (ed.). Dordrecht: Springer, p. 3511-3516 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  359. Regulation of cytosolic enzymes in primary metabolism by reversible protein phosphorylation

    MacKintosh, C. 1998 In : Current Opinion in Plant Biology. 1, 3, p. 224-229, 6 p.

    Research output: Contribution to journal › Scientific review

  360. First identification of microcystins in Irish lakes aided by a new derivatisation procedure for electrospray mass spectrometric analysis

    Sherlock, I. R., James, K. J., Caudwell, F. . B. & MacKintosh, C. 1997 In : Natural Toxins. 5, 6, p. 247-254, 8 p.

    Research output: Contribution to journal › Article

  361. Three spinach leaf nitrate reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are regulated by reversible phosphorylation and/or Ca2+ ions

    Douglas, P., Pigaglio, E., Ferrer, A., Halford, N. G. & MacKintosh, C. 1997 In : Biochemical Journal. 325, 1, p. 101-109, 9 p.

    Research output: Contribution to journal › Article

  362. New connections in the regulation of PEPCK gene expression by insulin [and discussion]

    Sutherland, C., OBrien, R. M., Granner, D. K., Saklatvala, J., Cohen, P. & White, M. F. 29-Feb-1996 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 351, 1336, p. 191-199, 9 p.

    Research output: Contribution to journal › Article

  363. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

    Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M. 1996 In : EMBO Journal. 15, 14, p. 3621-32, 12 p.

    Research output: Contribution to journal › Article

  364. Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation

    MacKintosh, C., Garton, A. J., McDonnell, A., Barford, D., Cohen, P. T. W., Tonks, N. K. & Cohen, P. 1996 In : FEBS Letters. 397, 2-3, p. 235-238, 4 p.

    Research output: Contribution to journal › Article

  365. Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin

    Moorhead, G., Douglas, P., Morrice, N., Scarabel, M., Aitken, A. & MacKintosh, C. 1996 In : Current Biology. 6, 9, p. 1104-1113, 10 p.

    Research output: Contribution to journal › Article

  366. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1

    Milne, D. M., Campbell, L. E., Campbell, D. G. & Meek, D. W. 10-Mar-1995 In : Journal of Biological Chemistry. 270, 10, p. 5511-5518, 8 p.

    Research output: Contribution to journal › Article

  367. Development of a colorimetric protein phosphorylation assay for detecting cyanobacterial toxins

    Ash, C., MacKintosh, C., MacKintosh, R. & Fricker, C. R. 1995 In : Water Science and Technology. 31, 5-6, p. 47-49, 3 p.

    Research output: Contribution to journal › Article

  368. Identification of a protein that inhibits the phosphorylated form of nitrate reductase from spinach (Spinacia oleracea) leaves

    MacKintosh, C., Douglas, P. & Lillo, C. 1995 In : Plant Physiology. 107, 2, p. 451-457, 7 p.

    Research output: Contribution to journal › Article

  369. Identification of a regulatory phosphorylation site in the hinge 1 region of nitrate reductase from spinach (Spinacea oleracea) leaves

    Douglas, P., Morrice, N. & MacKintosh, C. 1995 In : FEBS Letters. 377, 2, p. 113-117, 5 p.

    Research output: Contribution to journal › Article

  370. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

    Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M. & Cohen, P. 1995 In : Current Biology. 5, 3, p. 283-95, 13 p.

    Research output: Contribution to journal › Article

  371. Protein histidine phosphatase activity in rat liver and spinach leaves

    Matthews, H. R. & MacKintosh, C. 1995 In : FEBS Letters. 364, 1, p. 51-54, 4 p.

    Research output: Contribution to journal › Article

  372. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

    Moorhead, G., MacKintosh, C., Morrice, N. & Cohen, P. 1995 In : FEBS Letters. 362, 2, p. 101-105, 5 p.

    Research output: Contribution to journal › Article

  373. Raised plasma concentrations of brain natriuretic peptide in pulmonary arterial hypertension

    Prasad, N., Lang, C. C., McAlpine, H. M., Choy, A-M. J., MacDonald, T. M. & Struthers, A. D. 1995 In : Respiratory Medicine. 89, 6, p. 445-447, 3 p.

    Research output: Contribution to journal › Article

  374. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1

    MacKintosh, R. W., Dalby, K. N., Campbell, D. G., Cohen, P. T. W., Cohen, P. & MacKintosh, C. 1995 In : FEBS Letters. 371, 3, p. 236-240, 5 p.

    Research output: Contribution to journal › Article

  375. The effect of enalapril on tyramine induced changes in renal function in man

    Rahman, A. R., Lang, C. C. & Struthers, A. D. 1995 In : International Journal of Clinical Pharmacology and Therapeutics. 33, 7, p. 404-9, 6 p.

    Research output: Contribution to journal › Article

  376. Use of a protein phosphatase inhibition test for the detection of cyanobacterial toxins in water

    Ash, C., MacKintosh, C., MacKintosh, R. & Fricker, C. R. 1995 In : Water Science and Technology. 31, 5-6, p. 51-53, 3 p.

    Research output: Contribution to journal › Article

  377. Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography

    Moorhead, G., MacKintosh, R. W., Morrice, N., Gallagher, T. & MacKintosh, C. 1-Dec-1994 In : FEBS Letters. 356, 1, p. 46-50, 5 p.

    Research output: Contribution to journal › Article

  378. Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases

    Milne, D. M., Campbell, D. G., Caudwell, F. B. & Meek, D. W. 25-Mar-1994 In : Journal of Biological Chemistry. 269, 12, p. 9253-9260, 8 p.

    Research output: Contribution to journal › Article

  379. O- and N-Glycosylation of the Leishmania mexicana-secreted acid phosphatase: characterization of a new class of phosphoserine-linked glycans

    Ilg, T., Overath, P., Ferguson, M. A. J., Rutherford, T., Campbell, D. G. & McConville, M. J. 1-Jan-1994 In : Journal of Biological Chemistry. 269, 39, p. 24073-24081, 9 p.

    Research output: Contribution to journal › Article

  380. Inhibitors of protein kinases and phosphatases

    MacKintosh, C. & MacKintosh, R. W. 1994 In : Trends in Biochemical Sciences. 19, 11, p. 444-448, 5 p.

    Research output: Contribution to journal › Scientific review

  381. Protein phosphatase inhibitors activate anti-fungal defence responses of soybean cotyledons and cell cultures

    MacKintosh, C., Lyon, G. D. & MacKintosh, R. W. 1994 In : Plant Journal. 5, 1, p. 137-147, 11 p.

    Research output: Contribution to journal › Article

  382. The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

    Sutherland, C. & Cohen, P. 1994 In : FEBS Letters. 338, 1, p. 37-42, 6 p.

    Research output: Contribution to journal › Article

  383. Inactivation of glycogen-synthase kinase-3-beta by phosphorylation: new kinase connections in insulin and growth-factor signaling

    Sutherland, C., Leighton, I. A. & Cohen, P. 15-Nov-1993 In : Biochemical Journal. 296, 1, p. 15-19, 5 p.

    Research output: Contribution to journal › Comment/debate

  384. Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2: identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

    Sutherland, C., Campbell, D. G. & Cohen, P. 1993 In : European Journal of Biochemistry. 212, 2, p. 581-588, 8 p.

    Research output: Contribution to journal › Article

  385. Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

    Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdellès, B., Mallet, J., Haavik, J. & Cohen, P. 1993 In : European Journal of Biochemistry. 217, 2, p. 715-722, 8 p.

    Research output: Contribution to journal › Article

  386. Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site: inhibitor specificity of cantharidin and ATP analogues

    Li, Y-M., MacKintosh, C. & Casida, J. E. 1993 In : Biochemical Pharmacology. 46, 8, p. 1435-1443, 9 p.

    Research output: Contribution to journal › Article

  387. Renal effects of low dose prazosin in patients with congestive heart failure

    Lang, C. C., Choy, A-M. J., Rahman, A. R. & Struthers, A. D. 1993 In : European Heart Journal. 14, 9, p. 1245-52, 8 p.

    Research output: Contribution to journal › Article

  388. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis

    Xia, M-Q., Hale, G., Lifely, M. R., Ferguson, M. A. J., Campbell, D., Packman, L. & Waldmann, H. 1993 In : Biochemical Journal. 293 ( Pt 3), p. 633-640, 8 p.

    Research output: Contribution to journal › Article

  389. The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts

    Alessi, D. R., Smythe, C. & Keyse, S. M. 1993 In : Oncogene. 8, 7, p. 2015-20, 6 p.

    Research output: Contribution to journal › Article

  390. Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme

    Milne, D. M., Palmer, R. H., Campbell, D. G. & Meek, D. W. Jul-1992 In : Oncogene. 7, 7, p. 1361-1369, 9 p.

    Research output: Contribution to journal › Article

  391. A myofibrillar protein phosphatase from rabbit skeletal muscle contains the β isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin

    Dent, P., MacDougall, L. K., MacKintosh, C., Campbell, D. G. & Cohen, P. 1992 In : European Journal of Biochemistry. 210, 3, p. 1037-1044, 8 p.

    Research output: Contribution to journal › Article

  392. Characterization of the major phosphofructokinase - dephosphorylating protein phosphatases from Ascaris suum muscle

    Daum, G., Schmid, B., MacKintosh, C., Cohen, P. & Hofer, H. W. 1992 In : Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. 1122, 1, p. 23-32, 10 p.

    Research output: Contribution to journal › Article

  393. Dissection of the protein kinase cascades involved in insulin and nerve growth factor action

    Cohen, P., Campbell, D. G., Dent, P., Gomez, N., Lavoinne, A., Nakielny, S., Stokoe, D., Sutherland, C. & Traverse, S. 1992 In : Biochemical Society Transactions. 20, 3, p. 671-674, 4 p.

    Research output: Contribution to journal › Article

  394. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

    Liu, J., Albers, M. W., Wandless, T. J., Luan, S., Alberg, D. G., Belshaw, P. J., Cohen, P. ., MacKintosh, C., Klee, C. B. & Schreiber, S. L. 1992 In : Biochemistry. 31, 16, p. 3896-3901, 6 p.

    Research output: Contribution to journal › Article

  395. Regulation of spinach-leaf nitrate reductase by reversible phosphorylation

    MacKintosh, C. 1992 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1137, 1, p. 121-126, 6 p.

    Research output: Contribution to journal › Comment/debate

  396. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

    Silva, E. F. D. C. ., Hughes, V., McDonald, P., Stark, M. J. R. & Cohen, P. T. W. 13-Jun-1991 In : Biochimica et Biophysica Acta: General Subjects. 1089, 2, p. 269-272, 4 p.

    Research output: Contribution to journal › Comment/debate

  397. A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11

    Doonan, J. H., MacKintosh, C., Osmani, S., Cohen, P., Bai, G., Lee, E. Y. & Morris, N. R. 1991 In : Journal of Biological Chemistry. 266, 28, p. 18889-18894, 6 p.

    Research output: Contribution to journal › Article

  398. Illumination increases the phosphorylation state of maize leaf phospho enolpyruvate car☐ylase by causing an increase in the activity of a protein kinase

    McNaughton, G. A. L., MacKintosh, C., Fewson, C. A., Wilkins, M. B. & Nimmo, H. G. 1991 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1093, 2-3, p. 189-195, 7 p.

    Research output: Contribution to journal › Article

  399. Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase

    MacKintosh, C., Coggins, J. & Cohen, P. 1991 In : Biochemical Journal. 273, 3, p. 733-738, 6 p.

    Research output: Contribution to journal › Article

  400. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes

    Sneddon, A. A., Cohen, P. T. W. & Stark, M. J. R. Dec-1990 In : EMBO Journal. 9, 13, p. 4339-4346, 8 p.

    Research output: Contribution to journal › Article

  401. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

    MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. & Codd, G. A. 1990 In : FEBS Letters. 264, 2, p. 187-192, 6 p.

    Research output: Contribution to journal › Article

  402. Sucrose-phosphate synthase is dephosphorylated by protein phosphatase 2A in spinach leaves: evidence from the effects of okadaic acid and microcystin

    Siegl, G., MacKintosh, C. & Stitt, M. 1990 In : FEBS Letters. 270, 1-2, p. 198-202, 5 p.

    Research output: Contribution to journal › Article

  403. Tautomycin from the bacterium Streptomyces verticillatus: another potent and specific inhibitor of protein phosphatases 1 and 2A

    MacKintosh, C. & Klumpp, S. 1990 In : FEBS Letters. 277, 1-2, p. 137-140, 4 p.

    Research output: Contribution to journal › Article

  404. Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase

    Nimmo, H. G., Douglas, F., Kleanthous, C., Campbell, D. G. & MacKintosh, C. 1989 In : Biochemical Journal. 261, 2, p. 431-435, 5 p.

    Research output: Contribution to journal › Article

  405. Identification of high levels of type 1 and type 2A protein phosphatases in higher plants

    MacKintosh, C. & Cohen, P. 1989 In : Biochemical Journal. 262, 1, p. 335-339, 5 p.

    Research output: Contribution to journal › Article

  406. Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

    MacKintosh, C., Campbell, D. G., Hiraga, A. & Cohen, P. 1988 In : FEBS Letters. 234, 1, p. 189-194, 6 p.

    Research output: Contribution to journal › Article

  407. Purification and properties of Escherichia coli isocitrate lyase

    MacKintosh, C. & Nimmo, H. G. Apr-1986 In : Biochemical Society Transactions. 14, 2, p. 320-321, 2 p.

    Research output: Contribution to journal › Meeting abstract

  408. Release of oxytocin and prolactin in response to suckling.

    McNeilly, A. S., Robinson, I. C., Houston, M. J. & Howie, P. W. Jan-1983 In : British Medical Journal. 286, 6361, p. 257-259, 3 p.

    Research output: Contribution to journal › Article

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