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MRC Protein Phosphorylation Unit

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  1. The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

    Herhaus, L. & Sapkota, G. P. Oct 2014 In : Cellular Signalling. 26, 10, p. 2186-2192 7 p.

    Research output: Contribution to journalArticle

  2. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. 1 Aug 2014 In : Biochemical Journal. 461, 3, p. 531-537 7 p.

    Research output: Contribution to journalArticle

  3. Structural basis for the recruitment of glycogen synthase by glycogenin

    Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K. & Sicheri, F. 15 Jul 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840 10 p.

    Research output: Contribution to journalArticle

  4. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

    Alessi, D. R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y. & Kahle, K. T. 15 Jul 2014 In : Science Signaling. 7, 334, 10 p.re3

    Research output: Contribution to journalArticle

  5. Immune diseases caused by mutations in kinases and components of the ubiquitin system

    Cohen, P. Jun 2014 In : Nature Immunology. 15, 6, p. 521-529 9 p.

    Research output: Contribution to journalArticle

  6. The TLR and IL-1 signalling network at a glance

    Cohen, P. Jun 2014 In : Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

    Research output: Contribution to journalArticle

  7. USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

    Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Ewan, R., Bruce, D., Macartney, T., Weidlich, S., Smith, J. C. & Sapkota, G. P. 21 May 2014 In : Open Biology. 4, 140065

    Research output: Contribution to journalArticle

  8. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

    MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F. 15 Apr 2014 In : Cancer Research. 74, 8, p. 2246-2257 12 p.

    Research output: Contribution to journalArticle

  9. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

    Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K. 19 Mar 2014 In : Open Biology. 4, 14 p.130213

    Research output: Contribution to journalArticle

  10. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

    Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y-Y., Kolwicz, S. C., Xu, J., Sakamoto, K., Wang, W. & Tian, R. 14 Mar 2014 In : Circulation Research. 114, 6, p. 966-975 10 p.

    Research output: Contribution to journalArticle

  11. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

    Houde, V. P., Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. 15 Feb 2014 In : Biochemical Journal. 458, 1, p. 41-56 16 p.

    Research output: Contribution to journalArticle

  12. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  13. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

    Iovino, M., Pfisterer, U., Holton, J. L., Lashley, T., Swingler, R. J., Calo, L., Treacy, R., Revesz, T., Parmar, M., Goedert, M., Muqit, M. M. K. & Spillantini, M. G. Feb 2014 In : Acta Neuropathologica. 127, 2, p. 283-295

    Research output: Contribution to journalArticle

  14. AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions

    Meyer, A., Hilgen, G., Dorgau, B., Sammler, E. M., Weiler, R., Monyer, H., Dedek, K. & Hormuzdi, S. G. 2014 In : Journal of Cell Science. 127, 6, p. 1190-1202 13 p.

    Research output: Contribution to journalArticle

  15. ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

    Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & MacKintosh, C. 2014 In : Database: the Journal of Biological Databases and Curation. 2014, bat085

    Research output: Contribution to journalArticle

  16. GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

    Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S. 2014 In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

    Research output: Contribution to journalArticle

  17. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 2014 In : Open Biology. 4, May, 16 p.140029

    Research output: Contribution to journalArticle

  18. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  19. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

    van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. 2014 In : Biochemical Journal. 460, 2, p. 165-175 11 p.

    Research output: Contribution to journalArticle

  20. Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  21. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

    Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. 2014 In : Biochemical Journal. 460, 1, p. 127-139 13 p.

    Research output: Contribution to journalArticle

  22. Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

    Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C. & Sapkota, G. P. 2014 In : Open Biology. 4, FEB

    Research output: Contribution to journalArticle

  23. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  24. Transcriptional regulation of IL-10 and its cell-specific role in vivo

    MacKenzie, K. F., Pattison, M. & Arthur, J. S. C. 2014 In : Critical Reviews in Immunology. 34, 4, p. 315-345 31 p.

    Research output: Contribution to journalArticle

  25. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

    Baron, Y., Pedrioli, P. G., Tyagi, K., Johnson, C., Wood, N. T., Fountaine, D., Wightman, M. & Alexandru, G. 2014 In : BMC Biology. 12, 39

    Research output: Contribution to journalArticle

  26. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  27. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

    Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J-D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S. & Gray, N. S. Dec 2013 In : European Journal of Medicinal Chemistry. 70, p. 758-767 10 p.

    Research output: Contribution to journalArticle

  28. TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P transactivation upstream of Rho-kinase-2 activation

    Cencetti, F., Bernacchioni, C., Tonelli, F., Roberts, E., Donati, C. & Bruni, P. Nov 2013 In : FASEB Journal. 27, 11, p. 4532-4546 15 p.

    Research output: Contribution to journalArticle

  29. Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

    Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J. 24 Oct 2013 In : Molecular Cell. 52, 2, p. 221-233 13 p.

    Research output: Contribution to journalArticle

  30. Proteomic identification of novel secreted anti-bacterial toxins of the Serratia marcescens Type VI secretion system

    Fritsch, M. J., Trunk, K., Alcoforado Diniz, J., Guo, M., Trost, M. & Coulthurst, S. J. Oct 2013 In : Molecular & Cellular Proteomics. 12, 10, p. 2735-2749

    Research output: Contribution to journalArticle

  31. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  32. Localization-dependent and -independent roles of SLX4 in regulating telomeres

    Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J. 12 Sep 2013 In : Cell Reports. 4, 5, p. 853-860 8 p.

    Research output: Contribution to journalArticle

  33. Effect of IRS4 levels on PI 3-kinase signalling.

    Hoxhaj, G., Dissanayake, K. & MacKintosh, C. 10 Sep 2013 In : PLoS ONE. 8, 9, p. e73327 9 p.

    Research output: Contribution to journalArticle

  34. Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

    Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W. 1 Sep 2013 In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

    Research output: Contribution to journalArticle

  35. Hydrophilic strong anion exchange chromatography for proteomics: what's the future outlook?

    Ritorto, M. S., Trost, M. & Cook, K. Sep 2013 In : Bioanalysis. 5, 18, p. 2219-2221 3 p.

    Research output: Contribution to journalArticle

  36. Molecular mechanism of action of metformin: old or new insights?

    Rena, G., Pearson, E. R. & Sakamoto, K. Sep 2013 In : Diabetologia. 56, 9, p. 1898-1906 9 p.

    Research output: Contribution to journalArticle

  37. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

    Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P. 23 Aug 2013 In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

    Research output: Contribution to journalArticle

  38. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

    Mevissen, T. E. T., Hospenthal, M. K., Geurink, P. P., Elliott, P. R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S. M. V., Ovaa, H. & Komander, D. 3 Jul 2013 In : Cell. 154, 1, p. 169-184 16 p.

    Research output: Contribution to journalArticle

  39. X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor

    Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S. C., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. & Knapp, S. 13 Jun 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4413-4421 9 p.

    Research output: Contribution to journalArticle

  40. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

    Keusekotten, K., Elliott, P. R., Glockner, L., Fiil, B. K., Damgaard, R. B., Kulathu, Y., Wauer, T., Hospenthal, M. K., Gyrd-Hansen, M., Krappmann, D., Hofmann, K. & Komander, D. 6 Jun 2013 In : Cell. 153, 6, p. 1312-1326 15 p.

    Research output: Contribution to journalArticle

  41. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

    Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Jun 2013 In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

    Research output: Contribution to journalArticle

  42. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21 May 2013 In : FEBS Letters. 587, 10, p. 1496-1503 8 p.

    Research output: Contribution to journalArticle

  43. Structural biology: Security measures of a master regulator

    Alessi, D. R. & Kulathu, Y. 1 May 2013 In : Nature.

    Research output: Contribution to journalArticle

  44. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  45. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

    Remenyi, J., van den Bosch, M. W. M., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S. C., Frenguelli, B. G. & Pankratov, Y. 26 Apr 2013 In : PLoS ONE. 8, 4, 14 p.e62509

    Research output: Contribution to journalArticle

  46. LKB1 and AMPK and the cancer-metabolism link - ten years after

    Hardie, D. G. & Alessi, D. R. 15 Apr 2013 In : BMC Biology. 11, 11 p.36

    Research output: Contribution to journalArticle

  47. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15 Apr 2013 In : Biochemical Journal. 451, 2, p. 185-194 10 p.BJ20130026

    Research output: Contribution to journalArticle

  48. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  49. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1 Apr 2013 In : Biochemical Journal. 451, 1, p. 111-122 12 p.

    Research output: Contribution to journalArticle

  50. MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop

    MacKenzie, K. F., Van den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. E. & Arthur, J. S. C. Apr 2013 In : Molecular and Cellular Biology. 33, 7, p. 1456-1467 12 p.

    Research output: Contribution to journalArticle

  51. The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

    Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K. Apr 2013 In : Human Reproduction. 28, 4, p. 866-876 11 p.

    Research output: Contribution to journalArticle

  52. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27 Mar 2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journalArticle

  53. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22 Mar 2013 In : PLoS ONE. 8, 3, 15 p.e60086

    Research output: Contribution to journalArticle

  54. Regulation of A20 and other OTU deubiquitinases by reversible oxidation

    Kulathu, Y., Garcia, F. J., Mevissen, T. E. T., Busch, M., Arnaudo, N., Carroll, K. S., Barford, D. & Komander, D. 5 Mar 2013 In : Nature Communications. 4, 1569

    Research output: Contribution to journalArticle

  55. Ca2+ signalling through CatSper and Ca2+ stores regulate different behaviours in human sperm

    Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R. 1 Mar 2013 In : Journal of Biological Chemistry. 288, 9, p. 6248-6258 11 p.

    Research output: Contribution to journalArticle

  56. Structural insights into the activation of MST3 by MO25

    Mehellou, Y., Alessi, D. R., Macartney, T. J., Szklarz, M., Knapp, S. & Elkins, J. M. 15 Feb 2013 In : Biochemical and Biophysical Research Communications. 431, 3, p. 604-609 6 p.

    Research output: Contribution to journalArticle

  57. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

    Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J. Feb 2013 In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

    Research output: Contribution to journalArticle

  58. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 479-489 11 p.

    Research output: Contribution to journalArticle

  59. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

    Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. & Chen, S. G. 15 Jan 2013 In : Human Molecular Genetics. 22, 2, p. 328-344 17 p.

    Research output: Contribution to journalArticle

  60. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  61. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan 2013 In : Microvascular Research. 85, p. 86-92 7 p.

    Research output: Contribution to journalArticle

  62. Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

    Hau, A. M., Greenwood, J. A., Loehr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., McPhail, K. L. & Ishmael, J. E. 2013 In : PLoS ONE. 8, 6, 16 p. e65250

    Research output: Contribution to journalArticle

  63. Cross talk between the Akt and p38α pathways in macrophages downstream of toll-like receptor signaling

    McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L. E., O'Keefe, S. J., Boothby, M., Gaestel, M. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology. 33, 21, p. 4152-4165 14 p.

    Research output: Contribution to journalArticle

  64. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

    Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P-J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P. & Moechars, D. W. 2013 In : Journal of Pharmaceutical and Biomedical Analysis. 76, p. 49-58 10 p.

    Research output: Contribution to journalArticle

  65. Dual regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt promotes Thrombin-mediated Integrin alpha(IIb)beta(3) activation and granule secretion in platelets

    Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I. 2013 In : Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

    Research output: Contribution to journalArticle

  66. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journalArticle

  67. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research. 12, 6, p. 2449-2457 9 p.

    Research output: Contribution to journalArticle

  68. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

  69. Loss of iron triggers PINK1/Parkin-independent mitophagy

    Allen, G. F. G., Toth, R., James, J. & Ganley, I. G. 2013 In : EMBO Reports. 14, p. 1127-1135 9 p.

    Research output: Contribution to journalArticle

  70. Molecular control of the NEMO family of ubiquitin-binding proteins

    Clark, K., Nanda, S. & Cohen, P. 2013 In : Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

    Research output: Contribution to journalArticle

  71. N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

    Melo, Z., De Los Heros, P., Cruz-Rangel, S., Vázquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A. & Gamba, G. 2013 In : Journal of Biological Chemistry. 288, 44, p. 31468-31476 9 p.

    Research output: Contribution to journalArticle

  72. p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

    Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. & Tauro, S. 2013 In : British Journal of Cancer. 109, October, p. 2432=2444 13 p.

    Research output: Contribution to journalArticle

  73. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

    Arthur, J. S. C. & 21 others Park, J., Al-Ramahi, I., Tan, Q., Mollema, N., Diaz-Garcia, J. R., Gallego-Flores, T., Lu, H-C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L. S., Richman, R., Liu, X., Gao, Y., Shaw, C. A., Orr, H. T., Westbrook, T. F., Botas, J. & Zoghbi, H. Y. 2013 In : Nature. 498, 7454, p. 325-331 7 p.

    Research output: Contribution to journalArticle

  74. Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

    Alessi, D. R. & 21 others Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., Michalski, C. W., Schlitter, A. M., Esposito, I., Kind, A. J., Rad, L., Schnieke, A. E., Baccarini, M., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. 2013 In : Cancer Cell. 23, 3, p. 406-420 15 p.

    Research output: Contribution to journalArticle

  75. The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

    Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K. 2013 In : FEBS Journal. 280, 12, p. 2830-2841 12 p.

    Research output: Contribution to journalArticle

  76. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p.e77537

    Research output: Contribution to journalArticle

  77. The ULK1 complex Sensing nutrient signals for autophagy activation

    Wong, P-M., Puente, C., Ganley, I. G. & Jiang, X. 2013 In : Autophagy. 9, 2, p. 124-137 14 p.

    Research output: Contribution to journalArticle

  78. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  79. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec 2012 In : Neuropharmacology. 63, 7, p. 1227-1237 11 p.

    Research output: Contribution to journalArticle

  80. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

    Research output: Contribution to journalArticle

  81. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

    Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zegiraj, E., Turk, B. E. & Sakamoto, K. Nov 2012 In : Cellular Signalling. 24, 11, p. 2085-2094 10 p.

    Research output: Contribution to journalArticle

  82. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway

    Bruce, D. L., Macartney, T., Yong, W., Shou, W. & Sapkota, G. P. Nov 2012 In : Cellular Signalling. 24, 11, p. 1999-2006 8 p.

    Research output: Contribution to journalArticle

  83. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Oct 2012 In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

    Research output: Contribution to journalArticle

  84. Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

    Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J. 21 Sep 2012 In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

    Research output: Contribution to journalArticle

  85. Disruptions on the highways of cellular signalling

    Alessi, D. Sep 2012 In : FEBS Journal. 279, p. 23-23 1 p.

    Research output: Contribution to journalMeeting abstract

  86. Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

    Trost, M., Sauvageau, M., Hérault, O., Deleris, P., Pomiès, C., Chagraoui, J., Mayotte, N., Meloche, S., Sauvageau, G. & Thibault, P. 23 Aug 2012 In : Blood. 120, 8, p. e17-27 11 p.

    Research output: Contribution to journalArticle

  87. Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

    Kulathu, Y. & Komander, D. Aug 2012 In : Nature Reviews Molecular Cell Biology. 13, 8, p. 508-523 16 p.

    Research output: Contribution to journalArticle

  88. Brain penetrant LRRK2 inhibitor

    Choi, H. G., Zhang, J., Deng, X., Hatcher, J. M., Patricelli, M. P., Zhao, Z., Alessi, D. R. & Gray, N. S. Aug 2012 In : ACS Medicinal Chemistry Letters. 3, 8, p. 658-662 5 p.

    Research output: Contribution to journalArticle

  89. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels

    Susa, K., Kita, S., Iwamoto, T., Yang, S-S., Lin, S-H., Ohta, A., Sohara, E., Rai, T., Sasaki, S., Alessi, D. R. & Uchida, S. Aug 2012 In : Clinical and Experimental Nephrology. 16, 4, p. 530-538 9 p.

    Research output: Contribution to journalArticle

  90. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205 6 p.

    Research output: Contribution to journalArticle

  91. Phosphatases in SMAD regulation

    Bruce, D. L. & Sapkota, G. P. 4 Jul 2012 In : FEBS Letters. 586, 14, p. 1897-1905 9 p.

    Research output: Contribution to journalArticle

  92. Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

    Jensen, J., Tantiwong, P., Stuenaes, J. T., Molina-Carrion, M., DeFronzo, R. A., Sakamoto, K. & Musi, N. Jul 2012 In : American Journal of Physiology, Endocrinology and Metabolism. 303, 1, p. E82-E89 8 p.

    Research output: Contribution to journalArticle

  93. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  94. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun 2012 In : Diabetes. 61, 6, p. 1423-1433 11 p.

    Research output: Contribution to journalArticle

  95. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

    Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. 18 May 2012 In : Science. 336, 6083, p. 918-922 5 p.

    Research output: Contribution to journalArticle

  96. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B cell activation and autoantibody production

    Jayachandran, N., Landego, I., Gibson, I., Miller, A., Wullschleger, S., Alessi, D. & Marshall, A. 1 May 2012 In : Journal of Immunology. 188, Suppl.1, 159.5

    Research output: Contribution to journalMeeting abstract

  97. Thr(649)Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

    Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C. & Chen, S. May 2012 In : American Journal of Physiology, Endocrinology and Metabolism. 302, 9, p. E1036-E1043 8 p.

    Research output: Contribution to journalArticle

  98. Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

    Gammoh, N., Lam, D., Puente, C., Marks, P. A., Jiang, X. & Ganley, I. 24 Apr 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6561-6565 5 p.

    Research output: Contribution to journalArticle

  99. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

    Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H. 1 Apr 2012 In : Biochemical Journal. 443, p. 193-203 11 p.

    Research output: Contribution to journalArticle

  100. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1 Apr 2012 In : Biochemical Journal. 443, 1, p. 57-64 8 p.

    Research output: Contribution to journalArticle

  101. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21 Mar 2012 In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

    Research output: Contribution to journalArticle

  102. Phenformin as prophylaxis and therapy in breast cancer xenografts

    Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. & Thompson, A. M. 13 Mar 2012 In : British Journal of Cancer. 106, 6, p. 1117-1122 6 p.

    Research output: Contribution to journalArticle

  103. Characterization of TAE684 as a potent LRRK2 kinase inhibitor

    Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. & Gray, N. S. 1 Mar 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1864-1869 6 p.

    Research output: Contribution to journalArticle

  104. Potentiation effect of the AMPK activator A-769662 on cardiac myocytes metabolism and survival

    Timmermans, A., Ginion, A., De Meester, C., Sakamoto, K., Vanoverschelde, J-L., Horman, S., Beauloye, C. & Bertrand, L. Mar 2012 In : Cardiovascular Research. 93, S1, p. S72-S73 2 p.P-362

    Research output: Contribution to journalArticle

  105. Discovery of potent and selective covalent inhibitors of JNK

    Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S. 27 Jan 2012 In : Chemistry & Biology. 19, 1, p. 140-154 15 p.

    Research output: Contribution to journalArticle

  106. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

    Ho, K-K., McGuire, V. A., Koo, C-Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. C. & Lam, E. W. -F. 6 Jan 2012 In : Journal of Biological Chemistry. 287, 2, p. 1545-1555 11 p.

    Research output: Contribution to journalArticle

  107. Characterization of the cellular action of the MSK inhibitor SB-747651A

    Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. & Arthur, J. S. C. 1 Jan 2012 In : Biochemical Journal. 441, p. 347-357 11 p.

    Research output: Contribution to journalArticle

  108. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1 Jan 2012 In : Biochemical Journal. 441, p. 339-346 8 p.

    Research output: Contribution to journalArticle

  109. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1 Jan 2012 In : Biochemical Journal. 441, p. 325-337 13 p.

    Research output: Contribution to journalArticle

  110. A new role of AMP-activated protein kinase in regulating proliferation of mesenchymal stem cells

    Bertrand, L., Balteau, M., Timmermans, A., Viollet, B., Sakamoto, K., Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & De Meester, C. 2012 In : Cardiovascular Research. 93, 1, p. S96-S97 2 p.P-498

    Research output: Contribution to journalArticle

  111. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

    Castaneda-Bueno, M., Graciela Cervantes-Perez, L., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. & Gamba, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7929-7934 6 p.

    Research output: Contribution to journalArticle

  112. Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from  seudomonas aeruginosa

    Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

    Research output: Contribution to journalArticle

  113. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

    Din, F. V. N., Valanciute, A., Dunlop, M. G., Houde, V. P., Zibrova, D., Sakamoto, K., Alessi, D. R. & Green, K. A. 2012 In : Gastroenterology. 142, 7

    Research output: Contribution to journalArticle

  114. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

    Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. - 11 p.e35973

    Research output: Contribution to journalArticle

  115. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coats, J., Stewart, D., McDougall, G. & Rena, G. 2012

    Research output: Contribution to conferencePoster

  116. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coates, J., Stewart, D., McDougall, G. & Rena, G. 2012 In : Diabetic Medicine. 29, Suppl. 1, p. 41 1 p.P41

    Research output: Contribution to journalMeeting abstract

  117. Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages

    Lopez-Pelaez, M., Fumagalli, S., Sanz, C., Herrero, C., Guerra, S., Fernandez, M. & Alemany, S. 2012 In : Molecular Biology of the Cell. 23, 15, p. 2982-2992 11 p.

    Research output: Contribution to journalArticle

  118. Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

    Lewis, P. A. & Alessi, D. R. 2012 In : Biochemical Society Transactions. 40, 5, p. 1039-1041 3 p.

    Research output: Contribution to journalArticle

  119. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

    Davis, E. J., Lachaud, C., Appleton, P., MacArtney, T. J., Nathke, I. & Rouse, J. 2012 In : Nature Structural & Molecular Biology. 19, 11, p. 1093-1100 8 p.

    Research output: Contribution to journalArticle

  120. Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

    Tinti, M., Johnson, C., Toth, R., Ferrier, D. E. K. & MacKintosh, C. 2012 In : Open Biology. 2, 7, 120103

    Research output: Contribution to journalArticle

  121. G2019s leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

    Papkovskaia, T. D., Chau, K-Y., Inesta-vaquera, F., Papkovsky, D. B., Healy, D. G., Nishio, K., Staddon, J., Duchen, M. R., Hardy, J., Schapira, A. H. V. & Cooper, J. M. 2012 In : Human Molecular Genetics. 21, 19, p. 4201-4213 13 p.

    Research output: Contribution to journalArticle

  122. GSK2578215A: a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

    Reith, A. D., Bamborough, P., Jandu, K., Andreotti, D., Mensah, L., Dossang, P., Choi, H. G., Deng, X., Zhang, J., Alessi, D. R. & Gray, N. S. 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 17, p. 5625-5629 5 p.

    Research output: Contribution to journalArticle

  123. Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J. , Backues, S. K. , Bartholomew, C. R. , Bridges, D. , Gestwicki, J. E. , Han, T. , Jin, M. , Kim, J. K. , Lin, J. D. , Lynch-Day, M. A. , Mao, K. , Nair, U. , Parzych, K. R. , Umekawa, M. , Wang, K. , Yen, W-L. , Zhao, M. , Olsen, L. J. , Abdalla, F. C. , Marcondes, M. & 1,234 others Silva-Zacarin, E. C. M., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Chiarelli, R., Roccheri, M. C., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Saitoh, T., Al-Younes, H. M., Al-Zeer, M. A., Meyer, T. F., Albert, M. L., Albin, R. L., Dowling, J. J., Alegre-Abarrategui, J., Wade-Martins, R., Aleo, M. F., Fanzani, A., Rovetta, F., Alirezaei, M., Chisari, F. V., Whitton, J. L., Almasan, A., Almonte-Becerril, M., Kouri Flores, J. B., Amano, A., Amaravadi, R., Amarnath, S., Fowler, D. H., Amer, A. O., Drew, M. E., Andrieu-Abadie, N., Poirot, M., Vindis, C., Anantharam, V., Kanthasamy, A. G., Kanthasamy, A., Ann, D. K., Anoopkumar-Dukie, S., Grant, G. D., Aoki, H., Apostolova, N., Arancia, G., Condello, M., Meschini, S., Aris, J. P., Asanuma, K., Tomino, Y., Asare, N. Y. O., Ashida, H., Askanas, V., Nogalska, A., Askew, D. S., Auberger, P., Bost, F., Gual, P., Luciano, F., Rocchi, S., Baba, M., Baehrecke, E. H., Bahr, B. A., Bai, X-Y., Chen, X., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Brunetti-Pierri, N., Settembre, C., Bamber, B. A., Bampton, E. T. W., Melino, G., Bánhegyi, G., Bassham, D. C., Bast Jr., R. C., Fan, Z., Lopez-Berestein, G., Lu, Z., Ozpolat, B., Batoko, H., Bay, B-H., Beau, I., Esclatine, A., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Dikic, I., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Sanchez, A. M. J., Bernassola, F., Marfe, G., Palumbo, C., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Espert, L., Blum, J. S., Boise, L. H., Lonial, S., Sun, S-Y., Bonaldo, P., Sandri, M., Boone, D. L., Bornhauser, B. C., Bourquin, J-P., Bortoluci, K. R., Bossis, I., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Nezis, I. P., Rusten, T. E., Stenmark, H., Brenman, J. E., Brennand, A., Michels, P. A. M., Bresnick, E. H., Kang, Y-A., Brest, P., Hofman, P., Mograbi, B., Bristol, M. L., Gewirtz, D. A., Brookes, P. S., Johnson, G. V. W., Brown, E. J., Brumell, J. H., Huang, J., Kim, P. K., Brunk, U. T., Kurz, T., Bulman, D. E., Bultman, S. J., Bultynck, G., Parys, J. B., Burbulla, L. F., Krüger, R., Bursch, W., Butchar, J. P., Buzgariu, W., Galliot, B., Bydlowski, S. P., Cadwell, K., Cahová, M., Papackova, Z., Cai, D., Cai, J., Cai, Q., Calabretta, B., Sotgia, F., Calvo-Garrido, J., Escalante, R., Camougrand, N., Manon, S., Priault, M., Campanella, M., Campos-Salinas, J., Gonzalez-Rey, E., Oliver, F. J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Moreira, P. I., Carew, J. S., Nawrocki, S. T., Carlin, C. R., Carmignac, V., Durbeej, M., Carneiro, L. A. M., Carra, S., Kampinga, H. H., Caruso, R. A., Casari, G., Casas, C., Castino, R., Isidoro, C., Cebollero, E., Reggiori, F., Cecconi, F., Ciriolo, M. R., Piacentini, M., Celli, J., Chaachouay, H., Rodemann, H. P., Chae, H-J., Chai, C-Y., Chan, D. C., Chan, E. Y., Coombs, G. H., Chang, R. C-C., Che, C-M., Lok, C-N., Sy, L-K., Chen, C-C., Lin, W-W., Chen, G-C., Yang, W. Y., Chen, G-Q., Chen, M., Wang, J., Chen, Q., Chen, S. S-L., Ke, P-Y., Lin, Y-L., Chen, W., Chen, Y-G., Liu, Y., Yu, L., Chen, Y., Guan, J-L., Towns, R., Wiley, J. W., Chen, Y-J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Wang, H-G., Yang, J-M., El-Deiry, W. S., Cheong, H., Thompson, C. B., Cheong, J-H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H-L., Chiba, T., Chin, L-S., Li, L., Mao, Z., Chiou, S-H., Cho, C. H., Cho, D-H., Choi, A. M. K., Haspel, J. A., Henske, E. P., Nakahira, K., Ryter, S. W., Choi, D., Choi, K. S., Choi, M. E., Münger, K., Chouaib, S., Choubey, D., Choubey, V., Kaasik, A., Chu, C. T., Rabinowich, H., Chuang, T-H., Chueh, S-H., Chun, T., Park, O. K., Chwae, Y-J., Chye, M-L., Ciarcia, R., Florio, S., Granato, G. E., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Puyal, J., Clarke, R., Saha, T., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condorelli, F., Cookson, M. R., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Helfrich, M. H., Hocking, L. J., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Kaushik, S., Koga, H., Czaja, M. J., Cullen, J. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., Fueyo, J., Gomez-Manzano, C., Jiang, H., De Haan, C. A. M., Monastyrska, I., De Martino, L., Fiorito, F., Iovane, V., Pagnini, U., De Milito, A., Joseph, B., Panaretakis, T., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Schneider, C., Deng, Y. Z., Naqvi, N. I., Dengjel, J., Dent, P., Denton, D., Kumar, S., Deretic, V., Desai, S. D., Devenish, R. J., Mijaljica, D., Prescott, M., Ramm, G., Di Gioacchino, M., Di Paolo, G., Duff, K., Yu, W. H., Przedborski, S., Yamamoto, A., Di Pietro, C., Marazziti, D., Matteoni, R., Tocchini-Valentini, G., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Fotedar, R., Hansen, M., Moscat, J., Reed, J. C., Salvesen, G., Yang, Z., Diaz-Nido, J., Izquierdo, M., Dinesh-Kumar, S. P., Ding, W-X., Distelhorst, C. W., Subauste, C. S., Wang, X., Zhu, X., Oleinick, N. L., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Willbold, D., Dorsey, F. C., Dosenko, V., Doxsey, S., Dreux, M., Duan, Q., Duchosal, M. A., Dugail, I., Kroemer, G., Maiuri, M. C., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Noegel, A. A., Eissa, N. T., Lin, W-C., Ekmekcioglu, S., Elazar, Z., Elgendy, M., Minucci, S., Ellerby, L. M., Er Eng, K., McInerney, G. M., Engelbrecht, A-M., Loos, B., Engelender, S., Erenpreisa, J., Eskelinen, E-L., Espina, V., Fan, H., Fan, J., Fan, Q-W., Ilkhanizadeh, S., Weiss, W. A., Fang, S., Monteiro, M. J., Fang, Y., Fanto, M., Farkas, T., Jäättelä, M., Farré, J-C., Nazarko, T. Y., Faure, M., Fechheimer, M., Furukawa, R. H., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Gottlieb, R. A., Fisher, E. A., Fisher, P. B., Flajolet, M., Tian, Y., Florez-McClure, M. L., Fon, E. A., Fornai, F., Fortunato, F., Fox, H. S., Franco, R., Frankel, L. B., Lund, A. H., Fransen, M., Fuentes, J. M., González-Polo, R. A., Fujii, J., Fujisaki, K., Umemiya-Shirafuji, R., Fujita, E., Fukuda, M., Gaestel, M., Menon, M. B., Gailly, P., Gajewska, M., Motyl, T., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F-B., Gao, G. F., Gao, J., Garcia, L., Lavandero, S., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Golstein, P., Pierre, P., Gautel, M., Gawriluk, T. R., Hale, A. N., Ledbetter, D. J., Rucker III, E. B., Gegg, M. E., Schapira, A. H. V., Geng, J., Harper, J. W., Germain, M., Slack, R. S., Lieberman, A., Lukacs, N. W., Ghavami, S., Halayko, A. J., Kirshenbaum, L. A., Yeganeh, B., Ghosh, P., Lee, J., Giammarioli, A. M., Malorni, W., Giatromanolaki, A. N., Sivridis, E., Gibson, S. B., Gilkerson, R. W., Sulzer, D., Ginger, M. L., Ginsberg, H. N., Tabas, I., Golab, J., Goligorsky, M. S., Goncu, E., Gongora, C., Le Cam, L., Pattingre, S., Gonzalez, C. D., Vaccaro, M. I., Gonzalez, R., González-Estévez, C., Gorbunov, N. V., Gorski, S., Goruppi, S., Gozuacik, D., Green, K. N., Gregorc, A., Gros, F., Muller, S., Grose, C., Grunt, T. W., Guan, K-L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Van Den Berghe, G., Vanhorebeek, I., Gustafsson, A. B., Halonen, S. K., Hamasaki, M., Noda, T., Yoshimori, T., Han, F., Hancock, M. K., Harada, H., Harada, M., Hardt, S. E., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Hayashi, S-I., Hazelhurst, L. A., He, C., Levine, B., Terada, A. S., He, Y-W., Rathmell, J. C., Taylor, G. A., Hébert, M-J., Heidenreich, K. A., Helgason, G. V., Holyoake, T. L., Herman, B., Reiter, R. J., Herman, P. K., Hetz, C., Hilfiker, S., Navarro, M., Hill, J. A., Nemchenko, A., Yoshimoto, K., Hofmann, T. G., Höhfeld, J., Hong, M-H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C-A. A., Hu, H-M., Hua, Y., Huang, C., Liu, B., Huang, S., Sinicrope, F. A., Huang, W-P., Huber, T. B., Huh, W-K., Hung, T-H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Inoki, K., Into, T., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isobe, K-I., Iwasaki, A., Izumi, Y., Jaakkola, P. M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J-H., Jeung, E-B., Ma, Y., Wang, D., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Overholtzer, M., Jiménez, A., Revuelta, J. L., Jin, S., Joe, C. O., Lee, G. M., Johansen, T., Lamark, T., Johnson, D. E., Jones, N. L., Joseph, S. K., Joubert, A. M., Juhász, G., Kovács, A. L., László, L., Lõw, P., Sass, M., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y-K., Kaarniranta, K., Kabuta, T., Wada, K., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Zhivotovsky, B., Kanamori, H., Takemura, G., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Lotze, M. T., Tang, D., Kanki, T., Kanneganti, T-D., Kanno, H., Karantza, V., Kaushal, G. P., Kawazoe, Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Van Der Klei, I. J., Kiger, A. A., Kihara, A., Obara, K., Kim, D. R., Kim, D-H., Yoon, S-Y., Kim, E-K., Yu, S-W., Kim, H-R., Kim, J-S., Kim, J. H., Kim, J. C., Meisler, M. H., McQuibban, G. A., Kim, S. W., Kim, Y-S., Koh, Y. H., Kim, Y., Marten, M. R., Kimchi, A., Kimmelman, A. C., King, J. S., Ryan, K. M., Kinsella, T. J., Kirkin, V., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Lingor, P., Tönges, L., Koh, J-Y., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Kominami, E., Ueno, T., Kong, H. J., Kong, W-J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kraft, C., Krainc, D., McLean, P. J., Tannous, B. A., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Krut, O., Ktistakis, N. T., Kuan, C-Y., Kucharczyk, R., Sirko, A., Zoladek, T., Kumar, A., Kumar, R., Kundu, M., Kung, H-J., Kwon, H. J., La Spada, A. R., Spector, S. A., Lafont, F., Landry, J., Lavoie, J. N., Lane, J. D., Lapaquette, P., Laporte, J. F., Layfield, R., Lazo, P. A., Mollinedo, F., Le, W., Li, S., Lee, A. J. X., Swanton, C., Lee, B-W., Lee, J-H., Levy, E., Nixon, R. A., Yang, D-S., Lee, M., Lee, M-S., Lee, S. H., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H-Y., Lei, Q-Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., McConkey, D. J., Levenson, V. V., Li, F., Vierstra, R. D., Li, J-L., Li, W., Li, X-J., Li, Y-B., Yin, J-J., Li, Y-P., Liang, C., Ou, J-H. J., Liang, Q., Liao, Y-F., Liberski, P. P., Sikorska, B., Lim, H. J., Lim, K-L., Pervaiz, S., Soong, T. W., Lim, K., Lin, C-F., Lin, F-C., Lin, J., Lin, K., Linden, R., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, C-F., Liu, K., Liu, L., Wang, F., Liu, Q. A., Liu, W., Phang, J. M., Zabirnyk, O., Liu, Y-C., Lockshin, R. A., Meléndez, A., Zakeri, Z., López-Otín, C., Lossi, L., Merighi, A., Lu, B., Macian, F., Santambrogio, L., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Malagoli, D., Malicdan, M. C. V., Man, N., Zhou, C-Z., Mandelkow, E-M., Manov, I., Mao, X., Marambaud, P., Marcel, Y. L., Ouimet, M., Marchbank, K., Waters, S. L., Whitehouse, C. A., Marchetti, P., Marciniak, S. J., Mardi, M., Mariño, G., Markaki, M., Tavernarakis, N., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Vila, M., Masini, M., Matarrese, P., Matsuo, S., Mayer, A., Mazure, N. M., McConnell, M. J., McDermott, C., McDonald, C., McKenna, S. L., McLaughlin, B., McMaster, C. R., Rosen, K., Meijer, A. J., Melia, T. J., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menzies, F. M., Moreau, K., Rubinsztein, D. C., Mercer, C. A., Merry, D. E., Meyer, C. G., Miao, C-Y., Miao, J-Y., Michiels, C., Milojkovic, A., Miracco, C., Miranti, C. K., Mitroulis, I., Ritis, K., Miyazawa, K., Mizushima, N., Mohseni, S., Strålfors, P., Molero, X., Mollereau, B., Momoi, T., Monick, M. M., Moore, M. N., Mora, R., Moriyasu, Y., Mostowy, S., Mottram, J. C., Moussa, C. E-H., Simone, C., Münz, C., Murphy, L. O., Nyfeler, B., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nakagawa, T., Nakano, H., Nakatogawa, H., Nanjundan, M., Narendra, D. P., Youle, R. J., Narita, M., Netea, M. G., Neufeld, T. P., Ney, P. A., Nguyen, H. P., Nie, D., Nishino, I., Noguchi, S., Nislow, C., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Oberley, T. D., Oddo, S., Ogawa, M., Sasakawa, C., Ohashi, T., Shimada, Y., Okamoto, K., Welford, S. M., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Paganetti, P., Pallet, N., Palmer, G. E., Pan, T., Pandey, U. B., Papassideri, I., Paris, I., Segura-Aguilar, J., Patschan, S., Patterson, C., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Wang, M., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Shanmugam, M., Pöggeler, S., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Produit-Zengaffinen, N., Schorderet, D. F., Progulske-Fox, A., Proikas-Cezanne, T., Przyklenk, K., Puertollano, R., Qian, S-B., Qin, L., Qin, Z-H., Wang, G., Zhang, H-L., Quaggin, S. E., Raben, N., Rabkin, S. W., Rahman, I., Rami, A., Randall, G., Randow, F., Williams, R. L., Yao, T-P., Ravikumar, B., Ray, S. K., Reed, B. H., Régnier-Vigouroux, A., Reichert, A. S., Reiners Jr., J. J., Ren, J., Rhodes, C. J., Rizzo, E., Robbins, J., Roberge, M., Roca, H., De Córdoba, S. R., Rohrer, B., Roninson, I. B., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rubin, B. P., Ruckdeschel, K., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Sabatini, D. M., Sarkar, S., Sadoshima, J., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvioli, R., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Scorrano, L., Schiaffino, S., Sankar, U., Sansanwal, P., Sarwal, M., Saran, S., Sasnauskiene, A., Sato, K., Sato, M., Scharl, M., Schätzl, H. M., Scheper, W., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schüller, C., Schwartz, G. K., Sealy, L., Seglen, P. O., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Shacka, J. J., Zhang, J., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H-M., Shen, W-C., Sheng, Z-H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J-J., Shih, C-M., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Simmons, A., Simon, A. K., Simon, H-U., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Siu, P. M., Skop, V., Skulachev, V. P., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Spies, C. D., Von Haefen, C., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Sui, X., Sun, J., Sun, Z-J., Zhao, Y-F., Sung, J. J. Y., Wu, W. K. K., Suzuki, K., Suzuki, T., Swanson, M. S., Sweeney, S. T., Szabadkai, G., Vicencio, J. M., Taegtmeyer, H., Tafani, M., Takács-Vellai, K., Vellai, T., Takano, Y., Takegawa, K., Takeshita, F., Talbot, N. J., Tan, K. S. W., Zhu, Y., Tanida, I., Taylor, G. S., Taylor, J. P., Terman, A., Tettamanti, G., Thevissen, K., Thorburn, A., Thumm, M., Tian, F., Tolkovsky, A. M., Tooze, S. A., Wang, Y., Tournier, C., Tower, J., Trajkovic, V., Travassos, L. H., Tsai, T-F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Unni, V. K., Valente, E. M., Van Doorn, W. G., Van Dyk, L. F., Van Egmond, M., Van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vaquero, E. C., Velasco, G., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., Votruba, M., Walker, C. L., Walsh, C. M., Walter, J., Wan, X-B., Wang, A., Wang, C., Wang, H., Wang, H-D., Wang, R. C., Wang, Y-J., Wang, Z., Zhang, J-P., Wang, Z. C., Wansink, D. G., Ward, D. M., Watada, H., Webster, P., Wei, L., Weihl, C. C., Wen, L-P., Whitworth, A. J., Wileman, T., Wilkinson, S., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D-C., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xu, D-Z., Xu, J., Xu, L., Xu, X., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, E., Yang, S. Y., Yang, W., Yao, M-C., Yin, X-M., Yoo, O-J., Yoon, G., Yorimitsu, T., Yoshikawa, Y., You, H. J., Younes, A., Yuan, Z-M., Yue, Z., Yun, C-H., Yuzaki, M., David Zacks, E., Zacksenhaus, L., Zaffaroni, N., Zeh III, H. J., Zeitlin, S. O., Zhang, H., Zhang, L., Zhang, L., Zhang, M-Y., Zhang, X. D., Zhao, Y., Zhu, W-G., Zhao, Z. J., Park, J., Zheng, X., Zhong, Q., Zhu, C., Zhu, X-F., Zong, W-X., Zorzano, A., Zschocke, J., Zuckerbraun, B., Xie, Z., Yamamoto, A. & Rao, V. A. 2012 In : Autophagy. 8, 4, p. 445-544 100 p.

    Research output: Contribution to journalArticle

  124. Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

    Neukamm, S. S., Toth, R., Morrice, N., Campbell, D. G., Mackintosh, C., Lehmann, R., Haering, H-U., Schleicher, E. D. & Weigert, C. 2012 In : PLoS ONE. 7, 8, p. e43296

    Research output: Contribution to journalArticle

  125. Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

    Joanne, P., Hourde, C., Ochala, J., Cauderan, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A. 2012 In : PLoS ONE. 7, 4, p. - 11 p.e35346

    Research output: Contribution to journalArticle

  126. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

    Pattison, M. J., MacKenzie, K. F. & Arthur, J. S. C. 2012 In : Journal of Immunology. 189, 6, p. 2784-2792 9 p.

    Research output: Contribution to journalArticle

  127. Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus

    Choi, Y-S., Karelina, K., Alzate-Correa, D., Hoyt, K. R., Impey, S., Arthur, J. S. & Obrietan, K. 2012 In : Journal of Neurochemistry. 123, 5, p. 676-688 13 p.

    Research output: Contribution to journalArticle

  128. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051 13 p.

    Research output: Contribution to journalArticle

  129. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

    Research output: Contribution to journalArticle

  130. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

    Research output: Contribution to journalArticle

  131. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

    Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K. 2012 In : Open Biology. 2, 120080

    Research output: Contribution to journalArticle

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    Gan, X., Wang, J., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M. I. & Wu, D. 2012 In : Nature Cell Biology.

    Research output: Contribution to journalArticle

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    Campbell-Valois, F-X., Trost, M., Chemali, M., Dill, B. D., Laplante, A., Duclos, S., Sadeghi, S., Rondeau, C., Morrow, I. C., Bell, C., Gagnon, E., Hatsuzawa, K., Thibault, P. & Desjardins, M. 2012 In : Molecular & Cellular Proteomics. 11, 7, M111.016378

    Research output: Contribution to journalArticle

  134. Regulation of the transforming growth factor β pathway by reversible ubiquitylation

    Al-Salihi, M. A., Herhaus, L. & Sapkota, G. P. 2012 In : Open Biology. 2, 120082

    Research output: Contribution to journalArticle

  135. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514 12 p.

    Research output: Contribution to journalArticle

  136. The Dac-tag, an affinity tag based on penicillin-binding protein 5

    Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A. 2012 In : Analytical Biochemistry. 428, 1, p. 64-72 9 p.

    Research output: Contribution to journalArticle

  137. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journalArticle

  138. The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome

    Ang, D. S. C., Kao, M. P. C., Dow, E., Lang, C. & Struthers, A. 2012 In : Heart. 98, 15, p. 1160-5 6 p.

    Research output: Contribution to journalArticle

  139. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journalArticle

  140. USP11 augments TGFβ signaling by deubiquitylating ALK5

    Al-Salihi, M. A., Herhaus, L., Macartney, T. & Sapkota, G. P. 2012 In : Open Biology. 2, 120063

    Research output: Contribution to journalArticle

  141. WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

    Pacheco-Alvarez, D., Vazquez, N., Castaneda-Bueno, M., De-Los-Heros, P., Cortes-Gonzalez, C., Moreno, E., Meade, P., Bobadilla, N. A. & Gamba, G. 2012 In : Cellular Physiology and Biochemistry. 29, 1-2, p. 291-302 12 p.

    Research output: Contribution to journalArticle

  142. Quantitative proteomic analysis of the adipocyte plasma membrane

    Prior, M. J., Larance, M., Lawrence, R. T., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J. R., La-Borde, P. J., Buckley, M., Kanazawa, H., Parton, R. G., Guilhaus, M. & James, D. E. 4 Nov 2011 In : Journal of Proteome Research. 10, 11, p. 4970-4982 13 p.

    Research output: Contribution to journalArticle

  143. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

    Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K. 1 Nov 2011 In : Open Biology. 1, NOVEMBER, 110012

    Research output: Contribution to journalArticle

  144. Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy

    Ganley, I. G., Wong, P-M. & Jiang, X. Nov 2011 In : Autophagy. 7, 11, p. 1397-1399 3 p.

    Research output: Contribution to journalEditorial

  145. The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

    Chen, S., Synowsky, S., Tinti, M. & MacKintosh, C. Nov 2011 In : Trends in Endocrinology and Metabolism. 22, 11, p. 429-436 8 p.

    Research output: Contribution to journalScientific review

  146. The specificities of small molecule inhibitors of the TGF beta and BMP pathways

    Vogt, J., Traynor, R. & Sapkota, G. P. Nov 2011 In : Cellular Signalling. 23, 11, p. 1831-1842 12 p.

    Research output: Contribution to journalArticle

  147. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14 Oct 2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674 12 p.

    Research output: Contribution to journalArticle

  148. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11 Oct 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098 6 p.

    Research output: Contribution to journalArticle

  149. Absolute SILAC-compatible expression strain allows SUMO-2 copy number determination in clinical samples

    Matic, I., Jaffray, E. G., Oxenham, S. K., Groves, M. J., Barratt, C. L. R., Tauro, S., Stanley-Wall, N. R. & Hay, R. T. Oct 2011 In : Journal of Proteome Research. 10, 10, p. 4869-4875 7 p.

    Research output: Contribution to journalArticle

  150. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

    Sklar, P. , Ripke, S. , Scott, L. J. , Andreassen, O. A. , Cichon, S. , Craddock, N. , Edenberg, H. J. , Nurnberger, J. I. , Rietschel, M. , Blackwood, D. , Corvin, A. , Flickinger, M. , Guan, W. , Mattingsdal, M. , McQuillin, A. , Kwan, P. , Wienker, T. F. , Daly, M. , Dudbridge, F. , Holmans, P. A. & 153 others Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Lohoff, F. W., Potash, J. B., Mahon, P. B., McInnis, M. G., Zoellner, S., Zhang, P., Craig, D. W., Szelinger, S., Barrett, T. B., Breuer, R., Meier, S., Strohmaier, J., Witt, S. H., Tozzi, F., Farmer, A., McGuffin, P., Strauss, J., Xu, W., Kennedy, J. L., Vincent, J. B., Matthews, K., Day, R., Ferreira, M. A., O'Dushlaine, C., Perlis, R., Raychaudhuri, S., Ruderfer, D., Lee, P. H., Smoller, J. W., Li, J., Absher, D., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Jones, E. G., Meng, F. G., Thompson, R. C., Watson, S. J., Myers, R. M., Akil, H., Boehnke, M., Chambert, K., Moran, J., Scolnick, E., Djurovic, S., Melle, I., Morken, G., Gill, M., Morris, D., Quinn, E., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Schumacher, J., Maier, W., Steffens, M., Propping, P., Noethen, M. M., Anjorin, A., Bass, N., Gurling, H., Kandaswamy, R., Lawrence, J., McGhee, K., McIntosh, A., McLean, A. W., Muir, W. J., Pickard, B. S., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, E. K., Grozeva, D., Jones, I. R., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, M. C., Owen, M. J., Collier, D. A., Elkin, A., Matthews, K., Young, A. H., Ferrier, I. N., Williamson, R., Stefansson, K., Stefansson, H., Porgeirsson, P., Steinberg, S., Gustafsson, O., Bergen, S. E., Nimgaonkar, V., Hultman, C., Landen, M., Lichtenstein, P., Sullivan, P., Schalling, M., Osby, U., Backlund, L., Frisen, L., Langstrom, N., Jamain, S., Leboyer, M., Etain, B., Bellivier, F., Petursson, H., Sigurosson, E., Mueller-Mysok, B., Lucae, S., Schwarz, M., Schofield, P. R., Martin, N., Montgomery, G. W., Lathrop, M., Oskarsson, H., Bauer, M., Wright, A., Mitchell, P. B., Hautzinger, M., Reif, A., Kelsoe, J. R., Purcell, S. M. & Psychiat GWAS Consortium Bipolar D Oct 2011 In : Nature Genetics. 43, 10, p. 977-983 7 p.

    Research output: Contribution to journalArticle

  151. Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct 2011 In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

    Research output: Contribution to journalArticle

  152. p38 alpha and p38 beta mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons

    Loy, B., Apostolova, G., Dorn, R., McGuire, V. A., Arthur, J. S. C. & Dechant, G. 24 Aug 2011 In : Journal of Neuroscience. 31, 34, p. 12059-12067 9 p.

    Research output: Contribution to journalArticle

  153. Genetic analysis of specific and redundant roles for p38 alpha and p38 beta MAPKs during mouse development

    del Barco Barrantes, I., Manuel Coya, J., Maina, F., Arthur, J. S. C. & Nebreda, A. R. 2 Aug 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12764-12769 6 p.

    Research output: Contribution to journalArticle

  154. Evidence of p38 gamma and p38 delta involvement in cell transformation processes

    Cerezo-Guisado, M. I., del Reino, P., Remy, G., Kuma, Y., Arthur, J. S. C., Gallego-Ortega, D. & Cuenda, A. Jul 2011 In : Carcinogenesis. 32, 7, p. 1093-1099 7 p.

    Research output: Contribution to journalArticle

  155. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

    Loeffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R. & Stork, B. Jul 2011 In : Autophagy. 7, 7, p. 696-706 11 p.

    Research output: Contribution to journalArticle

  156. Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

    Ganley, I. G., Wong, P-M., Gammoh, N. & Jiang, X. 24 Jun 2011 In : Molecular Cell. 42, 6, p. 731-743 13 p.

    Research output: Contribution to journalArticle

  157. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P. 6 Jun 2011 In : Journal of Experimental Medicine. 208, 6, p. 1215-1228 14 p.

    Research output: Contribution to journalArticle

  158. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

    Lopez Pelaez, M., Soria-Castro, I., Bosca, L., Fernandez, M. & Alemany, S. Jun 2011 In : European Journal of Immunology. 41, 6, p. 1733-1741 9 p.

    Research output: Contribution to journalArticle

  159. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

    Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. & Alessi, D. R. 15 May 2011 In : Biochemical Journal. 436, p. 169-179 11 p.

    Research output: Contribution to journalArticle

  160. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4 May 2011 In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

    Research output: Contribution to journalArticle

  161. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

    Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S. & Uchida, S. 1 May 2011 In : Journal of Cell Science. 124, 9, p. 1391-1395 5 p.

    Research output: Contribution to journalArticle

  162. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

    MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. & Houslay, M. D. 1 May 2011 In : Biochemical Journal. 435, p. 755-769 15 p.

    Research output: Contribution to journalArticle

  163. Erratum to Ppm1E is an in cellulo AMP-activated protein kinase phosphatase (vol 23, pg 114-124, 2011)

    Voss, M., Paterson, J., Kelsall, I. R., Martin-Granados, C., Hastie, C. J., Peggie, M. W. & Cohen, P. T. W. May 2011 In : Cellular Signalling. 23, 5, p. 947-947 1 p.

    Research output: Contribution to journalArticle

  164. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15 Apr 2011 In : Biochemical Journal. 435, 2, p. 463-474 12 p.

    Research output: Contribution to journalArticle

  165. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

    Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G. 1 Apr 2011 In : Biochemical Journal. 435, p. 73-83 11 p.

    Research output: Contribution to journalArticle

  166. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

    Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S. Apr 2011 In : Nature Chemical Biology. 7, 4, p. 203-205 3 p.

    Research output: Contribution to journalArticle

  167. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

    Ronkina, N., Menon, M. B., Schwermann, J., Arthur, J. S. C., Legault, H., Telliez, J. -B., Kayyali, U. S., Nebreda, A. R., Kotlyarov, A. & Gaestel, M. Apr 2011 In : Nucleic Acids Research. 39, 7, p. 2503-2518 16 p.

    Research output: Contribution to journalArticle

  168. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29 Mar 2011 In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

    Research output: Contribution to journalArticle

  169. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15 Mar 2011 In : Biochemical Journal. 434, p. 537-548 12 p.

    Research output: Contribution to journalArticle

  170. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

    Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 1 Mar 2011 In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

    Research output: Contribution to journalArticle

  171. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1 Mar 2011 In : Biochemical Journal. 434, p. 265-274 10 p.

    Research output: Contribution to journalArticle

  172. Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model

    Chang, S., Iversen, L., Kragballe, K., Arthur, J. S. C. & Johansen, C. Mar 2011 In : Cancer Investigation. 29, 3, p. 240-245 6 p.

    Research output: Contribution to journalArticle

  173. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

    Deleris, P., Trost, M., Topisirovic, I., Tanguay, P-L., Borden, K. L. B., Thibault, P. & Meloche, S. 25 Feb 2011 In : Journal of Biological Chemistry. 286, 8, p. 6470-6478 9 p.

    Research output: Contribution to journalArticle

  174. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15 Feb 2011 In : Biochemical Journal. 434, p. 93-104 12 p.

    Research output: Contribution to journalArticle

  175. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Feb 2011 In : Biochemical Journal. 433, p. 515-525 11 p.

    Research output: Contribution to journalArticle

  176. A novel transcriptional repressor controlled by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors

    Dissanayake, K., Toth, R., Olsson, O., Campbell, D., Prescott, A. & MacKintosh, C. Feb 2011 In : Clinical & Experimental Metastasis. 28, 2, p. 234-234 1 p.

    Research output: Contribution to journalBook/Film/Article review

  177. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

    Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P. Feb 2011 In : Nature Genetics. 43, 2, p. 138-U85 6 p.

    Research output: Contribution to journalArticle

  178. The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice

    Bertelsen, T., Iversen, L., Riis, J. L., Arthur, J. S. C., Bibby, B. M., Kragballe, K. & Johansen, C. Feb 2011 In : Experimental Dermatology. 20, 2, p. 140-145 6 p.

    Research output: Contribution to journalArticle

  179. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

    Najafov, A., Sommer, E. M., Axten, J. M., DeYoung, M. P. & Alessi, D. R. 15 Jan 2011 In : Biochemical Journal. 433, p. 357-369 13 p.

    Research output: Contribution to journalArticle

  180. Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

    Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, K. 5 Jan 2011 In : Cell Metabolism. 13, 1, p. 68-79 12 p.

    Research output: Contribution to journalArticle

  181. Diagnostic tools in male infertility-the question of sperm dysfunction

    Barratt, C. L. R., Mansell, S., Beaton, C., Tardif, S. & Oxenham, S. K. Jan 2011 In : Asian Journal of Andrology. 13, 1, p. 53-58 6 p.

    Research output: Contribution to journalScientific review

  182. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

    Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R. Jan 2011 In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

    Research output: Contribution to journalArticle

  183. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

    Voss, M., Paterson, J., Kelsall, I. R., Martin-Granados, C., Hastie, C. J., Peggie, M. W. & Cohen, P. T. W. Jan 2011 In : Cellular Signalling. 23, 1, p. 114-124 11 p.

    Research output: Contribution to journalArticle

  184. Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

    Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. & Arthur, J. S. C. 2011 In : Neuropharmacology. 61, 1-2, p. 148-155 8 p.

    Research output: Contribution to journalArticle

  185. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: implications for NO synthase 2 expression

    Lopez Pelaez, M., Soria-Castro, I., Bosca, L., Fernandez, M. & Alemany, S. 2011 In : Immunology. 135, S1, p. 105 1 p.613

    Research output: Contribution to journalMeeting abstract

  186. Identification of the human testis protein phosphatase 1 interactome

    Fardilha, M., Esteves, S. L. C., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T. W., da cruz e silva, O. A. B. & da cruz e silva, E. F. 2011 In : Biochemical Pharmacology. 82, 10, p. 1403-1415 13 p.

    Research output: Contribution to journalArticle

  187. Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate

    Lilleholt, L. L., Johansen, C., Arthur, J. S. C., Funding, A., Bibby, B. M., Kragballe, K. & Iversen, L. 2011 In : Acta Dermato-Venereologica. 91, 3, p. 271-278 8 p.

    Research output: Contribution to journalArticle

  188. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 2011 In : Biochemical Journal. 437, p. 157-167 11 p.

    Research output: Contribution to journalArticle

  189. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A

    Pozuelo-Rubio, M., Leslie, N. R., Murphy, J. & MacKintosh, C. Dec 2010 In : Cell Biochemistry and Biophysics. 58, 3, p. 147-156 10 p.

    Research output: Contribution to journalArticle

  190. Pseudokinases-remnants of evolution or key allosteric regulators?

    Zeqiraj, E. & van Aalten, D. M. F. Dec 2010 In : Current Opinion in Structural Biology. 20, 6, p. 772-781 10 p.

    Research output: Contribution to journalArticle

  191. Identification of the MMS22L-TONSL complex that promotes homologous recombination

    Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T. & Rouse, J. 24 Nov 2010 In : Molecular Cell. 40, 4, p. 632-644 13 p.

    Research output: Contribution to journalArticle

  192. Gpx3 determines competitiveness of normal and leukemic stem cells

    Herault, O., Hope, K. J., Deneault, E., Trost, M., Mayotte, N., Chagraoui, J., Wilhelm, B. T., Cellot, S., Sauvageau, M., Thibault, P. & Sauvageau, G. 19 Nov 2010 In : Blood. 116, 21, p. 670-671 2 p.Abstract 1587

    Research output: Contribution to journalMeeting abstract

  193. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant V alpha 14 NKT cells and conventional T cells

    Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R. & Cantrell, D. A. 15 Nov 2010 In : Journal of Immunology. 185, 10, p. 5973-5982 10 p.

    Research output: Contribution to journalArticle

  194. Uncoupling the Warburg effect from cancer

    Najafov, A. & Alessi, D. R. 9 Nov 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19135-19136 2 p.

    Research output: Contribution to journalComment/debate

  195. Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

    Soutar, M. P. M., Kim, W-Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R. & Sutherland, C. Nov 2010 In : Journal of Neurochemistry. 115, 4, p. 974-983 10 p.

    Research output: Contribution to journalArticle

  196. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1478-1478 1 p.92

    Research output: Contribution to journalBook/Film/Article review

  197. Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation

    Soria-Castro, I., Krzyzanowska, A., Pelaéz, M. L., Regadera, J., Ferrer, G., Montoliu, L., Rodríguez-Ramos, R., Fernández, M. & Alemany, S. 29 Oct 2010 In : Journal of Biological Chemistry. 285, 44, p. 33805-33815 11 p.

    Research output: Contribution to journalArticle

  198. Regulation of miRNA transcription in macrophages in response to Candida albicans

    Monk, C. E., Hutvagner, G. & Arthur, J. S. C. 27 Oct 2010 In : PLoS ONE. 5, 10, p. - 12 p.e13669

    Research output: Contribution to journalArticle

  199. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

    Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C. & Alessi, D. R. 15 Oct 2010 In : Biochemical Journal. 431, p. 245-255 11 p.

    Research output: Contribution to journalArticle

  200. Molecular characterization of the evolution of phagosomes

    Boulais, J., Trost, M., Landry, C. R., Dieckmann, R., Levy, E. D., Soldati, T., Michnick, S. W., Thibault, P. & Desjardins, M. Oct 2010 In : Molecular Systems Biology. 6, p. - 14 p.423

    Research output: Contribution to journalArticle

  201. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15 Sep 2010 In : Biochemical Journal. 430, p. 393-404 12 p.

    Research output: Contribution to journalArticle

  202. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15 Sep 2010 In : Biochemical Journal. 430, p. 405-413 9 p.

    Research output: Contribution to journalArticle

  203. Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

    Pozo-Guisado, E., Campbell, D. G., Deak, M., Alvarez-Barrientos, A., Morrice, N. A., Alvarez, I. S., Alessi, D. R. & Martin-Romero, F. J. 15 Sep 2010 In : Journal of Cell Science. 123, 18, p. 3084-3093 10 p.

    Research output: Contribution to journalArticle

  204. Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry

    Martin, D. M. A., Nett, I. R. E., Vandermoere, F., Barber, J. D., Morrice, N. A. & Ferguson, M. A. J. 1 Sep 2010 In : Bioinformatics. 26, 17, p. 2153-2159 7 p.

    Research output: Contribution to journalArticle

  205. ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis

    Inesta-Vaquera, F. A., Campbell, D. G., Arthur, J. S. C. & Cuenda, A. 13 Aug 2010 In : Biochemical and Biophysical Research Communications. 399, 1, p. 84-90 7 p.

    Research output: Contribution to journalArticle

  206. p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

    Sabio, G., Cerezo-Guisado, M. I., del Reino, P., Inesta-Vaquera, F. A., Rousseau, S., Arthur, J. S. C., Campbell, D. G., Centeno, F. & Cuenda, A. 1 Aug 2010 In : Journal of Cell Science. 123, 15, p. 2596-2604 9 p.

    Research output: Contribution to journalArticle

  207. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. 9 Jul 2010 In : Cell. 142, 1, p. 65-76 12 p.

    Research output: Contribution to journalArticle

  208. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

    Greenblatt, M. B., Shim, J-H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J. M., Arthur, S., Xie, M., Schneider, M. D., Zhai, B., Gygi, S., Davis, R. & Glimcher, L. H. Jul 2010 In : Journal of Clinical Investigation. 120, 7, p. 2457-2473 17 p.

    Research output: Contribution to journalArticle

  209. SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2

    Reiche, J., Theilig, F., Rafiqi, F. H., Carlo, A-S., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D. H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E. 15 Jun 2010 In : Molecular and Cellular Biology. 30, 12, p. 3027-3037 11 p.

    Research output: Contribution to journalArticle

  210. Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

    Toh, G. W. -L., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E. & Rouse, J. 4 Jun 2010 In : DNA Repair. 9, 6, p. 718-726 9 p.

    Research output: Contribution to journalArticle

  211. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1 Jun 2010 In : Biochemical Journal. 428, 2, p. 281-291 11 p.

    Research output: Contribution to journalArticle

  212. Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons

    Trunk, K., Benkert, B., Quaeck, N., Muench, R., Scheer, M., Garbe, J., Jaensch, L., Trost, M., Wehland, J., Buer, J., Jahn, M., Schobert, M. & Jahn, D. Jun 2010 In : Environmental Microbiology. 12, 6, p. 1719-1733 15 p.

    Research output: Contribution to journalArticle

  213. GPR55 ligands promote receptor coupling to multiple signalling pathways

    Henstridge, C. M., Balenga, N. A. B., Schroeder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., Waldhoer, M. & Irving, A. J. Jun 2010 In : British Journal of Pharmacology. 160, 3, p. 604-614 11 p.

    Research output: Contribution to journalArticle

  214. The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning

    Sicard, P., Clark, J. E., Jacquet, S., Mohammadi, S., Arthur, J. S. C., O'Keefe, S. J. & Marber, M. S. Jun 2010 In : Journal of Molecular and Cellular Cardiology. 48, 6, p. 1324-1328 5 p.

    Research output: Contribution to journalArticle

  215. Bioinformatic and experimental survey of 14-3-3-binding sites

    Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C. 1 Apr 2010 In : Biochemical Journal. 427, 1, p. 69-78 10 p.

    Research output: Contribution to journalArticle

  216. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

    Canedo, C. S., Demeulder, B., Ginion, A., Bayascas, J. R., Balligand, J-L., Alessi, D. R., Vanoverschelde, J-L., Beauloye, C., Hue, L. & Bertrand, L. Apr 2010 In : American Journal of Physiology, Endocrinology and Metabolism. 298, 4, p. E761-E769 9 p.

    Research output: Contribution to journalArticle

  217. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

    Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R. 30 Mar 2010 In : Science Signaling. 3, 115, p. - 13 p.ra25

    Research output: Contribution to journalArticle

  218. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1 Feb 2010 In : Biochemical Journal. 425, p. 595-602 8 p.

    Research output: Contribution to journalArticle

  219. Role of the WNK-activated SPAK kinase in regulating blood pressure

    Rafiqi, F. H., Zuber, A. M., Glover, M., Richardson, C., Fleming, S., Jovanovic, S., Jovanovic, A., O'Shaughnessy, K. M. & Alessi, D. R. Feb 2010 In : Embo Molecular Medicine. 2, 2, p. 63-75 13 p.

    Research output: Contribution to journalArticle

  220. The nuts and bolts of AGC protein kinases

    Pearce, L. R., Komander, D. & Alessi, D. R. Jan 2010 In : Nature Reviews Molecular Cell Biology. 11, 1, p. 9-22 14 p.

    Research output: Contribution to journalScientific review

  221. Glycogen synthase kinase 3

    Cohen, P. & Frame, S. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 569-573 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  222. Naturally occurring inhibitors of protein serine/threonine phosphatases

    MacKintosh, C. & Diplexcito, J. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 683-687 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  223. Phosphatase families dephosphorylating serine and threonine residues in proteins

    Cohen, P. T. W. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 659-675 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  224. Subcellular phosphoproteomics

    Trost, M., Bridon, G., Desjardins, M. & Thibault, P. 2010 In : Mass Spectrometry Reviews. 29, 6, p. 962–990

    Research output: Contribution to journalArticle

  225. The biological function of the proto-oncogene Cot/tpl-2 (MAP kinase kinase kinase 8)

    Fernandez, M., Soria, I., Lopez Pelaez, M., Martin-Duce, A. & Alemany, S. 2010 Emerging Signaling Pathways in Tumor Biology. Lazo, P. A. (ed.). Kerala: Transworld Research Network, p. 25-41 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  226. Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes

    Cameron, A. R., Anil, S., Sutherland, E., Harthill, J. & Rena, G. 2010 In : Metallomics: Integrated Biometal Science. 2, 3, p. 195-203 9 p.

    Research output: Contribution to journalArticle

  227. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

    Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 18 Dec 2009 In : Science. 326, 5960, p. 1707-1711 5 p.

    Research output: Contribution to journalArticle

  228. Biochemical characterisation of the SWI/SNF family member HLTF

    MacKay, C., Toth, R. & Rouse, J. 11 Dec 2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

    Research output: Contribution to journalArticle

  229. Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

    Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K. & Komander, D. Dec 2009 In : Nature Structural & Molecular Biology. 16, 12, p. 1328-30 3 p.

    Research output: Contribution to journalArticle

  230. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15 Nov 2009 In : Biochemical Journal. 424, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  231. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

    Nichols, R. J., Dzamko, N., Hutti, J. E., Cantley, L. C., Deak, M., Moran, J., Bamborough, P., Reith, A. D. & Alessi, D. R. 15 Nov 2009 In : Biochemical Journal. 424, p. 47-60 14 p.

    Research output: Contribution to journalArticle

  232. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways

    Alarcón, C., Zaromytidou, A-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D. & Massagué, J. 13 Nov 2009 In : Cell. 139, 4, p. 757-769 13 p.

    Research output: Contribution to journalArticle

  233. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling

    Gao, S., Alarcón, C., Sapkota, G., Rahman, S., Chen, P-Y., Goerner, N., Macias, M. J., Erdjument-Bromage, H., Tempst, P. & Massagué, J. 13 Nov 2009 In : Molecular Cell. 36, 3, p. 457-468 12 p.

    Research output: Contribution to journalArticle

  234. Differential 14-3-3 affinity capture reveals new downstream targets of Phosphatidylinositol 3-Kinase signaling

    Dubois, F., Vandermoere, F., Gernez, A., Murphy, J., Toth, R., Chen, S., Geraghty, K. M., Morrice, N. A. & MacKintosh, C. Nov 2009 In : Molecular & Cellular Proteomics. 8, 11, p. 2487-2499 13 p.

    Research output: Contribution to journalArticle

  235. Generation of a conditional CREB Ser133Ala knockin mouse

    Wingate, A. D., Martin, K. J., Hunter, C., Carr, J. M., Clacher, C. & Arthur, J. S. C. Oct 2009 In : Genesis. 47, 10, p. 688-696 9 p.

    Research output: Contribution to journalArticle

  236. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmoller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A. & Wojtaszewski, J. F. P. Sep 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E665-E675 11 p.

    Research output: Contribution to journalArticle

  237. In vivo evidence that SPAK is a new regulator of blood pressure

    Zuber, A. M., Rafiqi, F. H., Glover, M., Alessi, D. R. & O'Shaughnessy, K. M. Sep 2009 In : Journal of Human Hypertension. 23, Supplement 1, p. S3-S3 1 p.3.1

    Research output: Contribution to journalArticle

  238. New users of metformin are at low risk of incident cancer a cohort study among people with type 2 diabetes

    Libby, G., Donnelly, L. A., Donnan, P. T., Alessi, D. R., Morris, A. D. & Evans, J. M. M. Sep 2009 In : Diabetes Care. 32, 9, p. 1620-1625 6 p.

    Research output: Contribution to journalArticle

  239. Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

    Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J. 10 Jul 2009 In : Molecular Cell. 35, 1, p. 116-127 12 p.

    Research output: Contribution to journalArticle

  240. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1 Jul 2009 In : Biochemical Journal. 421, p. 29-42 14 p.

    Research output: Contribution to journalArticle

  241. p38 delta mitogen-activated protein kinase Is essential for skin tumor development in mice

    Schindler, E. M., Hindes, A., Gribben, E. L., Burns, C. J., Yin, Y., Lin, M-H., Owen, R. J., Longmore, G. D., Kissling, G. E., Arthur, J. S. C. & Efimova, T. 1 Jun 2009 In : Cancer Research. 69, 11, p. 4648-4655 8 p.

    Research output: Contribution to journalArticle

  242. ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

    Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Jun 2009 In : PLoS Biology. 7, 6, p. - 19 p.e1000126

    Research output: Contribution to journalArticle

  243. Control of genome stability by Slx protein complexes

    Rouse, J. Jun 2009 In : Biochemical Society Transactions. 37, p. 495-510 16 p.

    Research output: Contribution to journalArticle

  244. FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C

    Fuller, W., Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. & Shattock, M. J. Jun 2009 In : American Journal of Physiology: Cell Physiology. 296, 6, p. C1346-C1355 10 p.

    Research output: Contribution to journalArticle

  245. ULK1 center dot ATG13 center dot FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

    Ganley, I. G., Lam, D. H., Wang, J., Ding, X., Chen, S. & Jiang, X. 1 May 2009 In : Journal of Biological Chemistry. 284, 18, p. 12297-12305 9 p.

    Research output: Contribution to journalArticle

  246. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

    Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J. May 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048 7 p.

    Research output: Contribution to journalArticle

  247. Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

    Topisirovic, I., Siddiqui, N., Lapointe, V. L., Trost, M., Thibault, P., Bangeranye, C., Pinol-Roma, S. & Borden, K. L. B. 22 Apr 2009 In : EMBO Journal. 28, 8, p. 1087-1098 12 p.

    Research output: Contribution to journalArticle

  248. New insights into mTOR Signaling: mTORC2 and beyond

    Alessi, D. R., Pearce, L. R. & Garcia-Martinez, J. M. 21 Apr 2009 In : Science Signaling. 2, 67, p. - 4 p.pe27

    Research output: Contribution to journalArticle

  249. RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1

    Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S. & Paludan, S. R. 17 Apr 2009 In : Journal of Biological Chemistry. 284, 16, p. 10774-10782 9 p.

    Research output: Contribution to journalArticle

  250. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590 7 p.

    Research output: Contribution to journalArticle

  251. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

    San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P. & Gamba, G. 17 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4384-4389 6 p.

    Research output: Contribution to journalArticle

  252. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15 Mar 2009 In : Biochemical Journal. 418, p. 625-634 10 p.

    Research output: Contribution to journalArticle

  253. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

    Yang, H-T., Peggie, M., Cohen, P. & Rousseau, S. 13 Mar 2009 In : Biochemical and Biophysical Research Communications. 380, 3, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  254. Control of histone methylation and genome stability by PTIP

    Munoz, I. M. & Rouse, J. Mar 2009 In : EMBO Reports. 10, 3, p. 239-245 7 p.

    Research output: Contribution to journalScientific review

  255. 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)

    Wood, N. T., Meek, D. W. & MacKintosh, C. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 615-620 6 p.

    Research output: Contribution to journalArticle

  256. Regulation of the activity and expression of ERK8 by DNA damage

    Klevernic, I. V., Martin, N. M. B. & Cohen, P. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 680-684 5 p.

    Research output: Contribution to journalArticle

  257. The phagosomal proteome in interferon-gamma-activated macrophages

    Trost, M., English, L., Lemieux, S., Courcelles, M., Desjardins, M. & Thibault, P. 16 Jan 2009 In : Immunity. 30, 1, p. 143-154 12 p.

    Research output: Contribution to journalArticle

  258. Proteinuria in mice expressing PKB/SGK-resistant GSK3

    Boini, K. M., Amann, K., Kempe, D., Alessi, D. R. & Lang, F. Jan 2009 In : American Journal of Physiology: Renal Physiology. 296, 1, p. F153-F159 7 p.

    Research output: Contribution to journalArticle

  259. Dopamine dysregulation syndrome in a patient with early onset Parkinsonism and Parkin gene mutations

    Sammler, E. M., Swingler, R. J., Stuart, A. & Muqit, M. 2009 In : Movement Disorders. 24, 16, p. 2442-2443 2 p.

    Research output: Contribution to journalLetter

  260. Estrogen regulation of p53 isoforms in the human breast cancer cell line MCF7

    Vendrell, J. A., Bourdon, J., Cohen, P. A. & Thompson, A. M. 2009 In : Cancer Research. 69, 2 Suppl. 1, 4067

    Research output: Contribution to journalMeeting abstract

  261. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frosig, C., Pehmoller, C., Chen, S., Maarbjerg, S. J., Brandt, N., MacKintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E. A., Pilegaard, H. & Wojtaszewski, J. F. P. 2009 In : Diabetologia. 52, 5, p. 891-900 10 p.

    Research output: Contribution to journalArticle

  262. Protein Kinase C-mediated Phosphorylation and activation of PDE3A Regulate cAMP levels in human platelets

    Hunter, R., MacKintosh, C. & Hers, I. 2009 In : Journal of Biological Chemistry. 284, 18, p. 12339-12348 10 p.

    Research output: Contribution to journalArticle

  263. The human spermatozoon: a stripped down but refined machine

    Barratt, C. L. R., Kay, V. & Oxenham, S. K. 2009 In : Journal of Biology. 8, 7, p. 63

    Research output: Contribution to journalArticle

  264. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2009 In : Diabetologia. 52, Suppl. 1, p. S203-S203 1 p.PS 29

    Research output: Contribution to journalMeeting abstract

  265. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

    Garcia-Martinez, J. M. & Alessi, D. R. 15 Dec 2008 In : Biochemical Journal. 416, 3, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  266. Small-molecule inhibitors of PDK1

    Peifer, C. & Alessi, D. R. 15 Dec 2008 In : ChemMedChem. 3, 12, p. 1810-1838 29 p.

    Research output: Contribution to journalScientific review

  267. Structure of the OSR1 kinase, a hypertension drug target

    Villa, F., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Dec 2008 In : Proteins: Structure, Function, and Bioinformatics. 73, 4, p. 1082-1087 6 p.

    Research output: Contribution to journalArticle

  268. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15 Nov 2008 In : Biochemical Journal. 416, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

  269. Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (FEBS Journal (2008) 275, (4211-4221))

    Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W. 1 Nov 2008 In : FEBS Journal. 275, 22, p. 5745 1 p.

    Research output: Contribution to journalArticle

  270. Glycogen synthase kinase-3 (GSK3): a potential therapeutic target to treat neuroinflammation?

    De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R. & Jope, R. S. 25 Oct 2008 In : Journal of Neuroimmunology. 203, 2, p. 235-235 1 p.44

    Research output: Contribution to journalArticle

  271. Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

    Trinkle-Mulcahy, L., Boulon, S., Lam, Y. W., Urcia, R., Boisvert, F-M., Vandermoere, F., Morrice, N. A., Swift, S., Rothbauer, U., Leonhardt, H. & Lamond, A. 20 Oct 2008 In : Journal of Cell Biology. 183, 2, p. 223-239 17 p.

    Research output: Contribution to journalArticle

  272. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15 Oct 2008 In : Biochemical Journal. 415, p. 297-307 11 p.

    Research output: Contribution to journalArticle

  273. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

    Richardson, C. & Alessi, D. R. 15 Oct 2008 In : Journal of Cell Science. 121, 20, p. 3293-3304 12 p.

    Research output: Contribution to journalArticle

  274. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

    Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S. 10 Oct 2008 In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

    Research output: Contribution to journalArticle

  275. Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

    Filippi, B. M. & Alessi, D. R. 6 Oct 2008 In : Journal of Cell Biology. 183, 1, p. 7-9 3 p.

    Research output: Contribution to journalComment/debate

  276. COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration

    Rodriguez, C., Lopez, P., Pozo, M., Duce, A. M., Lopez Pelaez, M., Fernandez, M. & Alemany, S. Sep 2008 In : Cellular Signalling. 20, 9, p. 1625-1631 7 p.

    Research output: Contribution to journalArticle

  277. ERK5 regulation in naive T-cell activation and survival

    Ananieva, O., Macdonald, A., Wang, X., McCoy, C. E., McIlrath, J., Tournier, C. & Arthur, J. S. C. Sep 2008 In : European Journal of Immunology. 38, 9, p. 2534-2547 14 p.

    Research output: Contribution to journalArticle

  278. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

    Kim, C., Sano, Y., Todorova, K., Carlson, B. A., Arpa, L., Celada, A., Lawrence, T., Otsu, K., Brissette, J. L., Arthur, J. S. C. & Park, J. M. Sep 2008 In : Nature Immunology. 9, 9, p. 1019-1027 9 p.

    Research output: Contribution to journalArticle

  279. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

    Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J., Park, J. M., Wingate, A., Monk, C. E., Toth, R., Santos, S. G., Iversen, L. & Arthur, J. S. C. Sep 2008 In : Nature Immunology. 9, 9, p. 1028-1036 9 p.

    Research output: Contribution to journalArticle

  280. Carrier erythrocyte entrapped thymidine phosphorylas etherapy for MNGIE

    Moran, N. F., Bain, M. D., Muqit, M. M. K. & Bax, B. E. 26 Aug 2008 In : Neurology. 71, 9, p. 686-688 3 p.

    Research output: Contribution to journalScientific review

  281. Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage

    Vazquez-Martin, C., Rouse, J. & Cohen, P. T. W. Aug 2008 In : FEBS Journal. 275, 16, p. 4211-4221 11 p.

    Research output: Contribution to journalArticle

  282. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

    De Sarno, P., Axtell, R. C., Raman, C., Roth, K. A., Alessi, D. R. & Jope, R. S. 1 Jul 2008 In : Journal of Immunology. 181, 1, p. 338-345 8 p.

    Research output: Contribution to journalArticle

  283. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation

    Cole, A. R., Soutar, M. P. M., Rembutsu, M., van Aalten, L., Hastie, C. J., Mclauchlan, H., Peggie, M., Balastik, M., Lu, K. P. & Sutherland, C. 27 Jun 2008 In : Journal of Biological Chemistry. 283, 26, p. 18227-18237 11 p.

    Research output: Contribution to journalArticle

  284. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

    Hines, R. M., Wu, L., Hines, D. J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E., Hormuzdi, S. G., Zhuo, M. & El-Husseini, A. 11 Jun 2008 In : Journal of Neuroscience. 28, 24, p. 6055-6067 13 p.

    Research output: Contribution to journalArticle

  285. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1 Jun 2008 In : Biochemical Journal. 412, p. 211-221 11 p.

    Research output: Contribution to journalArticle

  286. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

    Kulathu, Y., Hobeika, E., Turchinovich, G. & Reth, M. 7 May 2008 In : EMBO Journal. 27, 9, p. 1333-44 12 p.

    Research output: Contribution to journalArticle

  287. Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J. 6 May 2008 In : Cancer Cell. 13, 5, p. 454-463 10 p.

    Research output: Contribution to journalArticle

  288. Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

    Duro, E., Vaisica, J. A., Brown, G. W. & Rouse, J. 3 May 2008 In : DNA Repair. 7, 5, p. 811-818 8 p.

    Research output: Contribution to journalArticle

  289. MSK activation and physiological roles

    Arthur, J. S. C. May 2008 In : Frontiers in Bioscience. 13, p. 5866-5879 14 p.

    Research output: Contribution to journalScientific review

  290. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May 2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

    Research output: Contribution to journalArticle

  291. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-inked polyubiquitin chains

    Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. & Alessi, D. R. 15 Apr 2008 In : Biochemical Journal. 411, p. 249-260 12 p.

    Research output: Contribution to journalArticle

  292. Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages

    Marcantonio, M., Trost, M., Courcelles, M., Desjardins, M. & Thibault, P. 1 Apr 2008 In : Molecular & Cellular Proteomics. 7, 4, p. 645-660 16 p.

    Research output: Contribution to journalArticle

  293. PDK1, but not PKB, is required for the activation of the Mtor/P70s6k pathway by leucine in the heart

    Canedo, C. S., Beauloye, C., Demeulder, B., Ginion, A., Zarrinpashneh, E., Alessi, D. R., Hue, L., Vanoverschelde, J. -L. & Bertrand, L. Apr 2008 In : Cardiovascular Drugs and Therapy. 22, 2, p. 150-150 1 p.

    Research output: Contribution to journalArticle

  294. Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

    Morton, S., Hesson, L., Peggie, M. & Cohen, P. 19 Mar 2008 In : FEBS Letters. 582, 6, p. 997-1002 6 p.

    Research output: Contribution to journalArticle

  295. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

    Richardson, C., Rafiqi, F. H., Karlsson, H. K. R., Moleleki, N., Vandewalle, A., Campbell, D. G., Morrice, N. A. & Alessi, D. R. 1 Mar 2008 In : Journal of Cell Science. 121, 5, p. 675-684 10 p.

    Research output: Contribution to journalArticle

  296. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

    Windheim, M., Stafford, M., Peggie, M. & Cohen, P. Mar 2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791 9 p.

    Research output: Contribution to journalArticle

  297. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

    Deutsch, E. W. , Ball, C. A. , Berman, J. J. , Bova, G. S. , Brazma, A. , Bumgarner, R. E. , Campbell, D. , Causton, H. C. , Christiansen, J. H. , Daian, F. , Dauga, D. , Davidson, D. R. , Gimenez, G. , Goo, Y. A. , Grimmond, S. , Henrich, T. , Herrmann, B. G. , Johnson, M. H. , Korb, M. , Mills, J. C. & 20 others Oudes, A. J., Parkinson, H. E., Pascal, L. E., Pollet, N., Quackenbush, J., Ramialison, M., Ringwald, M., Salgado, D., Sansone, S-A., Sherlock, G., Stoeckert, C. J., Swedlow, J., Taylor, R. C., Walashek, L., Warford, A., Wilkinson, D. G., Zhou, Y., Zon, L. I., Liu, A. Y. & True, L. D. Mar 2008 In : Nature Biotechnology. 26, 3, p. 305-312 8 p.

    Research output: Contribution to journalArticle

  298. Systems biology analysis of phagosomes from Interferon-gamma activated mouse macrophages

    Trost, M., Lemieux, S., Thibault, P. & Desjardins, M. Mar 2008 In : European Journal of Cell Biology. 87, Supplement 1, p. 53-53 1 p.MS4-2

    Research output: Contribution to journalMeeting abstract

  299. Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells

    Rembutsu, M., Soutar, M. P. M., Van Aalten, L., Gourlay, R., Hastie, C. J., McLauchlan, H., Morrice, N. A., Cole, A. R. & Sutherland, C. 19 Feb 2008 In : Biochemistry. 47, 7, p. 2153-2161 9 p.

    Research output: Contribution to journalArticle

  300. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1 Feb 2008 In : Biochemical Journal. 409, p. 711-722 12 p.

    Research output: Contribution to journalArticle

  301. IL-1β-stimulated activation of ERK1/2 and p38α MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-α in HeLa cells

    Yang, H-T., Cohen, P. & Rousseau, S. Feb 2008 In : Cellular Signalling. 20, 2, p. 375-380 6 p.

    Research output: Contribution to journalArticle

  302. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

    Chen, S., Murphy, J., Toth, R., Campbell, D. G., Morrice, N. A. & Mackintosh, C. 15 Jan 2008 In : Biochemical Journal. 409, 2, p. 449-459 11 p.

    Research output: Contribution to journalArticle

  303. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C. & Cohen, P. 15 Jan 2008 In : Journal of Cell Science. 121, 2, p. 149-154 6 p.

    Research output: Contribution to journalArticle

  304. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

    Ganley, I. G., Espinosa, E. & Pfeffer, S. R. 14 Jan 2008 In : Journal of Cell Biology. 180, 1, p. 159-172 14 p.

    Research output: Contribution to journalArticle

  305. Displacement affinity chromatography of protein phosphatase one (PP1) complexes

    Moorhead, G. B. G., Trinkle-Mulcahy, L., Nimick, M., De Wever, V., Campbell, D. G., Gourlay, R., Lam, Y. W. & Lamond, A. I. 1 Jan 2008 In : BMC Biochemistry. 9, 1

    Research output: Contribution to journalArticle

  306. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

    Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W. 2008 In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332 18 p.

    Research output: Contribution to journalArticle

  307. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

    Sakamoto, K. & Holman, G. D. 2008 In : American Journal of Physiology, Endocrinology and Metabolism. 295, 1, p. E29-E37

    Research output: Contribution to journalArticle

  308. PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

    Belgardt, B. F., Husch, A., Rother, E., Ernst, M. B., Wunderlich, F. T., Hampel, B., Kloeckener, T., Alessi, D., Kloppenburg, P. & Bruening, J. C. 2008 In : Cell Metabolism. 7, 4, p. 291-301 11 p.

    Research output: Contribution to journalArticle

  309. PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

    Goehler, T., Munoz, I. M., Rouse, J. & Blow, J. J. 2008 In : DNA Repair. 7, 5, p. 775-787 13 p.

    Research output: Contribution to journalArticle

  310. Silencing metabolic disorders by novel SIRT1 activators

    Sakamoto, K. 2008 In : Cell Metabolism. 7, 1, p. 3-4 2 p.

    Research output: Contribution to journalArticle

  311. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2008

    Research output: Contribution to conferencePoster

  312. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, 1, p. 43-52 10 p.

    Research output: Contribution to journalArticle

  313. The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2

    Paytubi, S., Morrice, N. A., Boudeau, J. & Proud, C. G. 2008 In : Biochemical Journal. 409, 1, p. 223-231 9 p.

    Research output: Contribution to journalArticle

  314. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15 Dec 2007 In : Biochemical Journal. 408, p. 297-315 19 p.

    Research output: Contribution to journalArticle

  315. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K., Thompson, A., Mathers, J., Holland, S., Stark, M. J. R., Lane, D. & Westwood, N. J. Dec 2007 In : Molecular Cancer Therapeutics. 6, 12, p. 3476S-3477S 2 p.

    Research output: Contribution to journalBook/Film/Article review

  316. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Zaru, R., Ronkina, N., Gaestel, M., Arthur, S. & Watts, C. Nov 2007 In : Nature Immunology. 8, 11, p. 1227-1235 9 p.

    Research output: Contribution to journalArticle

  317. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16 Oct 2007 In : Biochemical Journal. 401, 1, p. 29-38 10 p.

    Research output: Contribution to journalArticle

  318. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15 Oct 2007 In : Biochemical Journal. 407, p. 231-241 11 p.

    Research output: Contribution to journalArticle

  319. Structural insights into the recognition of substrates and activators by the OSR1 kinase

    Villa, F., Goebel, J., Rafiqi, F. H., Deak, M., Thastrup, J., Alessi, D. R. & van Aalten, D. M. F. 1 Sep 2007 In : EMBO Reports. 8, 9, p. 839-845 7 p.

    Research output: Contribution to journalArticle

  320. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep 2007 In : Diabetes. 56, 9, p. 2218-2227 10 p.

    Research output: Contribution to journalArticle

  321. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

    Fonseca, B. D., Smith, E. M., Lee, V. H. -Y., MacKintosh, C. & Proud, C. G. 24 Aug 2007 In : Journal of Biological Chemistry. 282, 34, p. 24514-24524 11 p.

    Research output: Contribution to journalArticle

  322. Identification of protor as a novel rictor-binding component of mTOR complex-2

    Pearce, L. R., Huang, X., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F. M., Gourlay, R., Magnuson, M. A. & Alessi, D. R. 1 Aug 2007 In : Biochemical Journal. 405, 3, p. 513-522 10 p.

    Research output: Contribution to journalArticle

  323. p38 MAP-kinases pathway regulation, function and role in human diseases

    Cuenda, A. & Rousseau, S. Aug 2007 In : Biochimica et Biophysica Acta: General Subjects. 1773, 8, p. 1358-75 18 p.

    Research output: Contribution to journalArticle

  324. Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

    Munoz, I. M., Jowsey, P. A., Toth, R. & Rouse, J. Aug 2007 In : Nucleic Acids Research. 35, 16, p. 5312-5322 11 p.

    Research output: Contribution to journalArticle

  325. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

    McCoy, C. E., Macdonald, A., Morrice, N. A., Campbell, D. G., Deak, M., Toth, R., McIlrath, J. & Arthur, J. S. C. 15 Mar 2007 In : Biochemical Journal. 402, 3, p. 491-501 11 p.

    Research output: Contribution to journalArticle

  326. Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

    Windheim, M., Lang, C., Peggie, M., Plater, L. A. & Cohen, P. 9 Mar 2007 In : Biochemical Journal. 404, 2, p. 179-90 12 p.

    Research output: Contribution to journalArticle

  327. SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein

    Browne, G. J., Fardilha, M., Oxenham, S. K., Wu, W., Helps, N. R., da Cruz E. Silva, O. A. B., Cohen, P. T. W. & da Cruz E. Silva, E. F. 15 Feb 2007 In : Biochemical Journal. 402, 1, p. 187-196 10 p.

    Research output: Contribution to journalArticle

  328. Balancing BMP signaling through integrated inputs into the Smad1 linker

    Sapkota, G., Alarcón, C., Spagnoli, F. M., Brivanlou, A. H. & Massagué, J. 9 Feb 2007 In : Molecular Cell. 25, 3, p. 441-454 14 p.

    Research output: Contribution to journalArticle

  329. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

    Zagórska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., Deak, M., Campbell, D. G., Morrice, N. A., Prescott, A. R. & Alessi, D. R. 1 Jan 2007 In : Journal of Cell Biology. 176, 1, p. 89-100 12 p.

    Research output: Contribution to journalArticle

  330. AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels

    Sukhodub, A., Jovanović, S., Du, Q., Budas, G., Clelland, A. K., Shen, M., Sakamoto, K., Tian, R. & Jovanović, A. Jan 2007 In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 210, 1, p. 224-36 13 p.

    Research output: Contribution to journalArticle

  331. Targeting of TMV movement protein to plasmodesmata requires the actin/ER network: evidence from FRAP

    Wright, K. M., Wood, N. T., Roberts, A. G., Chapman, S., Boevink, P., MacKenzie, K. M. & Oparka, K. J. Jan 2007 In : Traffic. 8, 1, p. 21-31 11 p.

    Research output: Contribution to journalArticle

  332. Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR

    Jowsey, P., Morrice, N. A., Hastie, C. J., McLauchlan, H., Toth, R. & Rouse, J. 2007 In : DNA Repair. 6, 10, p. 1536-1544 9 p.

    Research output: Contribution to journalArticle

  333. E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

    Cowling, V. H. & Cole, M. D. 2007 In : Oncogene. 26, 24, p. 3582-6 5 p.

    Research output: Contribution to journalArticle

  334. HATs off to capping: a new mechanism for Myc

    Cowling, V. H. & Cole, M. D. 2007 In : Cell Cycle. 6, 8, p. 907-9 3 p.

    Research output: Contribution to journalScientific review

  335. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

    Jaleel, M., Nichols, R. J., Deak, M., Campbell, D. G., Gillardon, F., Knebel, A. & Alessi, D. R. 2007 In : Biochemical Journal. 405, 2, p. 307-317 11 p.

    Research output: Contribution to journalArticle

  336. MAPK activation by radio waves

    Arthur, J. S. C. 2007 In : Biochemical Journal. 405, 3, p. e5-e6 2 p.

    Research output: Contribution to journalArticle

  337. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K. 2007 In : Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

    Research output: Contribution to journalArticle

  338. Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors

    Li, H., Cherukuri, P., Li, N., Cowling, V., Spinella, M., Cole, M., Godwin, A. K., Wells, W. & DiRenzo, J. 2007 In : Cancer Research. 67, 2, p. 501-10 10 p.

    Research output: Contribution to journalArticle

  339. The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug

    Kelsall, I. R., Munro, S., Hallyburton, I., Treadway, J. L. & Cohen, P. T. W. 2007 In : FEBS Letters. 581, 24, p. 4749-4753 5 p.

    Research output: Contribution to journalArticle

  340. The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo

    Toole, B. J. & Cohen, P. T. W. 2007 In : Cellular Signalling. 19, 5, p. 1044-1055 12 p.

    Research output: Contribution to journalArticle

  341. Turning the tables: Myc activates Wnt in breast cancer

    Cowling, V. H. & Cole, M. D. 2007 In : Cell Cycle. 6, 21, p. 2625-7 3 p.

    Research output: Contribution to journalScientific review

  342. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-β pathways

    Sapkota, G., Knockaert, M., Alarcón, C., Montalvo, E., Brivanlou, A. H. & Massagué, J. 29 Dec 2006 In : Journal of Biological Chemistry. 281, 52, p. 40412-40419 8 p.

    Research output: Contribution to journalArticle

  343. 3'phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium

    Budas, G. R., Sukhodub, A., Alessi, D. R. & Jovanovic, A. Dec 2006 In : FASEB Journal. 20, 14, p. 2556-2558 3 p.

    Research output: Contribution to journalArticle

  344. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1 Nov 2006 In : Biochemical Journal. 399, 3, p. 427-434 8 p.

    Research output: Contribution to journalArticle

  345. Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose

    Harthill, J. E., Meek, S. E. M., Morrice, N., Peggie, M., Borch, J., Wong, B. H. C. & MacKintosh, C. Jul 2006 In : Plant Journal. 47, 2, p. 211-223 13 p.

    Research output: Contribution to journalArticle

  346. The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin

    Hastie, C. J., Vázquez-Martin, C., Philp, A., Stark, M. J. R. & Cohen, P. T. W. Jul 2006 In : FEBS Journal. 273, 14, p. 3322-34 13 p.

    Research output: Contribution to journalArticle

  347. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

    Cole, A. R., Causeret, F., Yadirgi, G., Hastie, C. J., Mclauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M., Sutherland, C. & Sutherland, C. 16 Jun 2006 In : Journal of Biological Chemistry. 281, 24, p. 16591-16598 8 p.

    Research output: Contribution to journalArticle

  348. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

    Liu, H. K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C. J., Hundal, H. S., Sutherland, C. & Sutherland, C. 6 Apr 2006 In : BMC Molecular Biology. 7, p. - 12 p.14

    Research output: Contribution to journalArticle

  349. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15 Mar 2006 In : Biochemical Journal. 394, 3, p. 545-555 11 p.

    Research output: Contribution to journalArticle

  350. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

    Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L. 2006 In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

    Research output: Contribution to journalArticle

  351. Mechanism of transcriptional activation by the Myc oncoproteins

    Cowling, V. H. & Cole, M. D. 2006 In : Seminars in Cancer Biology. 16, 4, p. 242-52 11 p.

    Research output: Contribution to journalScientific review

  352. The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN

    Layer, G., Pierik, A. J., Trost, M., Rigby, S. E., Leech, H. K., Grage, K., Breckau, D., Astner, I., Jänsch, L., Heathcote, P., Warren, M. J., Heinz, D. W. & Jahn, D. 2006 In : Journal of Biological Chemistry. 281, 23, p. 15727-15734 8 p.

    Research output: Contribution to journalArticle

  353. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

    Knockaert, M., Sapkota, G., Alarcón, C., Massagué, J. & Brivanlou, A. H. 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 11940-11945 6 p.

    Research output: Contribution to journalArticle

  354. Generation and characterization of p38beta (MAPK11) gene-targeted mice

    Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., Malone, L., Kollias, G. & Arthur, S. C. Dec 2005 In : Molecular and Cellular Biology. 25, 23, p. 10454-10464 11 p.

    Research output: Contribution to journalArticle

  355. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov 2005 In : Diabetes. 54, 11, p. 3161-3168 8 p.

    Research output: Contribution to journalArticle

  356. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

    Bayascas, J. R., Leslie, N., Parsons, R., Fleming, S. & Alessi, D. Oct 2005 In : Current Biology. 15, 20, p. 1839-1846 8 p.

    Research output: Contribution to journalArticle

  357. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

    Alessi, D., Deak, M., Morrice, N. & Vitari, A. Oct 2005 In : Biochemical Journal. 391, 1, p. 17-24 8 p.

    Research output: Contribution to journalArticle

  358. 14-3-3 Phosphoproteomics for linking signalling pathways to cellular processes

    MacKintosh, C., Harthill, J. & Kulma, A. Jul 2005 In : Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 141, 3, p. S250-S250 1 p.

    Research output: Contribution to journalMeeting abstract

  359. Metformin and reduced risk of cancer in diabetic patients

    Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R. & Morris, A. D. Jun 2005 In : BMJ. 330, 7503, p. 1304-1305 2 p.

    Research output: Contribution to journalArticle

  360. Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding

    Komander, D., Kular, G., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 13 May 2005 In : Journal of Biological Chemistry. 280, 19, p. 18797-18802 6 p.

    Research output: Contribution to journalArticle

  361. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May 2005 In : The EMBO Journal. 24, 10, p. 1810-1820 11 p.

    Research output: Contribution to journalArticle

  362. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May 2005 In : The EMBO Journal. 24, 9, p. 1696-1705 10 p.

    Research output: Contribution to journalArticle

  363. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R. Apr 2005 In : The EMBO Journal. 24, 8, p. 1571-1583 13 p.

    Research output: Contribution to journalArticle

  364. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

    Zeke, T., Morrice, N., Vazquez-Martin, C. & Cohen, T. Jan 2005 In : Biochemical Journal. 385, 1, p. 45-56 12 p.

    Research output: Contribution to journalArticle

  365. 14-3-3s as signalling integrators in plant and human cells

    MacKintosh, C., Pozuelo-Rubio, M., Geraghty, K., Wong, B., Wood, N., Murphy, J., Dubois, F. . & Harthill, J. 2005 In : FEBS Journal. 272, Suppl. 1, p. 460-461 2 p.J4-004

    Research output: Contribution to journalMeeting abstract

  366. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639 7 p.

    Research output: Contribution to journalArticle

  367. Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria species

    Trost, M., Wehmhöner, D., Kärst, U., Dieterich, G., Wehland, J. & Jänsch, L. 2005 In : Proteomics. 5, 6, p. 1544-1557 14 p.

    Research output: Contribution to journalArticle

  368. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648 10 p.

    Research output: Contribution to journalArticle

  369. Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence

    Jacobsen, I., Hennig-Pauka, I., Baltes, N., Trost, M. & Gerlach, G-F. 2005 In : Infection and Immunity. 73, 1, p. 226-234 9 p.

    Research output: Contribution to journalArticle

  370. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

    Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., Mullenders, J., Beijersbergen, R. L., Bernards, R., Ganesan, T. S., Downward, J. & Hancock, D. C. 2005 In : Molecular Cell. 20, 5, p. 673-85 13 p.

    Research output: Contribution to journalArticle

  371. Isolation of 14-3-3 binding proteins from Hydra

    Pauly, B. S., Stiening, B., MacKintosh, C., Rudd, S., David, C. N. & Bottger, A. 2005 In : European Journal of Cell Biology. 84, Suppl. 1, p. 37-37 1 p.S2-32

    Research output: Contribution to journalMeeting abstract

  372. Isolation of 14-3-3 binding proteins from Hydra

    Pauly, B. S., Stiening, B., MacKintosh, C., Rudd, S., David, C. N. & Bottger, A. 2005

    Research output: Contribution to conferencePaper

  373. Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428

    Pozuelo-Rubio, M., Campbell, D. G., Morrice, N. A. & MacKintosh, C. 2005 In : Biochemical Journal. 392, 1, p. 163-172 10 p.

    Research output: Contribution to journalArticle

  374. Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage

    Flott, S. & Rouse, J. 2005 In : Biochemical Journal. 391, 2, p. 325-333 9 p.

    Research output: Contribution to journalArticle

  375. A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

    Milne, D., Kampanis, P., Nicol, S., Dias, S., Campbell, D. G., Fuller-Pace, F. & Meek, D. 5 Nov 2004 In : FEBS Letters. 577, 1-2, p. 270-276 7 p.

    Research output: Contribution to journalArticle

  376. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

    Sakamoto, K., Goransson, O., Hardie, D. G. & Alessi, D. R. Aug 2004 In : American Journal of Physiology, Endocrinology and Metabolism. 287, 2, p. E310-E317

    Research output: Contribution to journalArticle

  377. Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins

    Arthur, S., Fong, A. L., Dwyer, J. M., Davare, M., Reese, E., Obrietan, K. & Impey, S. 5 May 2004 In : Journal of Neuroscience. 24, 18, p. 4324-4332 9 p.

    Research output: Contribution to journalArticle

  378. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

    Pozuelo-Rubio, M., Geraghty, K. M., Wong, B. H. C., Wood, N. T., Campbell, D. G., Morrice, N. & MacKintosh, C. 15 Apr 2004 In : Biochemical Journal. 379, 2, p. 395-408 14 p.

    Research output: Contribution to journalArticle

  379. Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

    Kulma, A., Villadsen, D., Campbell, D. G., Meek, S. E. M., Harthill, J. E., Nielsen, T. H. & MacKintosh, C. Mar 2004 In : Plant Journal. 37, 5, p. 654-667 14 p.

    Research output: Contribution to journalArticle

  380. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb 2004 In : The EMBO Journal. 23, 4, p. 833-843 11 p.

    Research output: Contribution to journalArticle

  381. Crystal structure of MO25 in complex with the C terminus of the pseudo kinase STE20-related adaptor

    Milburn, C. C., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 2004 In : Nature Structural & Molecular Biology. 11, 2, p. 193-200 8 p.

    Research output: Contribution to journalArticle

  382. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a

    Rena, G., Bain, J., Elliott, M. & Cohen, P. 2004 In : EMBO Reports. 5, 1, p. 60-65 6 p.

    Research output: Contribution to journalArticle

  383. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

    Rouse, J. 2004 In : The EMBO Journal. 23, 5, p. 1188-1197 10 p.

    Research output: Contribution to journalArticle

  384. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

    Jowsey, P. A., Doherty, A. J. & Rouse, J. 2004 In : Journal of Biological Chemistry. 279, 53, p. 55562-55569 8 p.

    Research output: Contribution to journalArticle

  385. Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

    Morgan, C. P., Skippen, A., Segui, B., Ball, A., Allen-Baume, V., Larijani, B., Murray-Rust, J., McDonald, N., Sapkota, G., Morrice, N. & Cockcroft, S. 2004 In : Journal of Biological Chemistry. 279, 45, p. 47159-47171 13 p.

    Research output: Contribution to journalArticle

  386. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

    Hinton, H. J., Alessi, D. R. & Cantrell, D. A. 2004 In : Nature Immunology. 5, 5, p. 539-545 7 p.

    Research output: Contribution to journalArticle

  387. Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

    Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G. Sep 2003 In : Journal of Biology. 2, 4, p. 28 1 p.

    Research output: Contribution to journalArticle

  388. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep 2003 In : The EMBO Journal. 22, 18, p. 4666-4676 11 p.

    Research output: Contribution to journalArticle

  389. 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

    Pozuelo-Rubio, M., Peggie, M., Wong, B. H. C., Morrice, N. & MacKintosh, C. 15 Jul 2003 In : The EMBO Journal. 22, 14, p. 3514-3523 10 p.

    Research output: Contribution to journalArticle

  390. LKB1, a protein kinase regulating cell proliferation and polarity

    Boudeau, J., Sapkota, G. & Alessi, D. R. 3 Jul 2003 In : FEBS Letters. 546, 1, p. 159-165 7 p.

    Research output: Contribution to journalArticle

  391. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

    Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C. & Arthur, J. S. C. Jun 2003 In : The EMBO Journal. 22, 11, p. 2788-2797 10 p.

    Research output: Contribution to journalArticle

  392. Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

    Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Münsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., Mathers, J., Keyse, S. M., Storey, K. & Tickle, C. Jun 2003 In : Current Biology. 13, 12, p. 1009-18 10 p.

    Research output: Contribution to journalArticle

  393. Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs

    Carnegie, G. K., Sleeman, J. E., Morrice, N., Hastie, C. J., Peggie, M. W., Philp, A., Lamond, A. I. & Cohen, P. T. W. May 2003 In : Journal of Cell Science. 116, 10, p. 1905-1913 9 p.

    Research output: Contribution to journalArticle

  394. The specificities of protein kinase inhibitors: an update

    Bain, J., McLauchlan, H., Elliott, M. & Cohen, P. 1 Apr 2003 In : Biochemical Journal. 371, 1, p. 199-204 6 p.

    Research output: Contribution to journalArticle

  395. Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance

    Delibegovic, M., Armstrong, C. G., Dobbie, L., Watt, P. W., Smith, A. J. H. & Cohen, T. Mar 2003 In : Diabetes. 52, 3, p. 596-604 9 p.

    Research output: Contribution to journalArticle

  396. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

    Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R. & Clevers, H. C. 2003 In : EMBO Journal. 22, 12, p. 3062-3072 11 p.

    Research output: Contribution to journalArticle

  397. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

    Martins, L. M., Turk, B. E., Cowling, V., Borg, A., Jarrell, E. T., Cantley, L. C. & Downward, J. 2003 In : Journal of Biological Chemistry. 278, 49, p. 49417-27 11 p.

    Research output: Contribution to journalArticle

  398. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism

    Powell, D. J., Hajduch, E., Kular, G. & Hundal, H. S. H. 2003 In : Molecular and Cellular Biology. 23, 21, p. 7794-7808 15 p.

    Research output: Contribution to journalArticle

  399. Feedback control of the protein kinase TAK1 by SAPK2a/p38

    Cheung, P. C. F., Campbell, D. G., Nebreda, A. R. & Cohen, P. 2003 In : The EMBO Journal. 22, 21, p. 5793-5805 13 p.

    Research output: Contribution to journalArticle

  400. Stepwise rotation of the γ-subunit of EFoF1-ATP synthase during ATP synthesis: a single-molecule FRET approach

    Borsch, M., Diez, M., Zimmermann, B., Trost, M., Steigmiller, S. & Graber, P. 2003 Manipulation and analysis of biomolecules, cells, and tissues. Nicolau, D. V., Enderlein, J., Leif, R. C. & Farkas, D. L. (eds.). Bellingham: SPIE-International Society for Optical Engineering, Vol. 4962, p. 11-21 11 p. (Progress in biomedical optics; 14).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  401. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells

    Harthill, J. E., Pozuelo-Rubio, M., Milne, F. C. & MacKintosh, C. 1 Dec 2002 In : Biochemical Journal. 368, p. 565-572 8 p.

    Research output: Contribution to journalArticle

  402. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

    Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M. & Cohen, P. Dec 2002 In : The EMBO Journal. 21, 23, p. 6505-6514 10 p.

    Research output: Contribution to journalArticle

  403. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

    Douglas, P., Sapkota, G. P., Morrice, N., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R. & Lees-Miller, S. P. 19 Aug 2002 In : Biochemical Journal. 368, 1, p. 243-251 9 p.

    Research output: Contribution to journalArticle

  404. Affinity purification of diverse plant and human 14-3-3-binding partners

    Milne, F. C., Moorhead, G., Pozuelo-Rubio, M., Wong, B., Kulma, A., Harthill, J. E., Villadsen, D., Cotelle, V. & MacKintosh, C. Aug 2002 In : Biochemical Society Transactions. 30, 4, p. 379-381 3 p.

    Research output: Contribution to journalArticle

  405. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

    Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P. & Arthur, J. S. C. Apr 2002 In : Molecular and Cellular Biology. 22, 8, p. 2871-2881 11 p.

    Research output: Contribution to journalArticle

  406. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1

    Peggie, M., MacKelvie, S., Bloecher, A., Knatko, E., Tatchell, K. & Stark, M. 2002 In : Journal of Cell Science. 115, 1, p. 195-206 12 p.

    Research output: Contribution to journalArticle

  407. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver

    Munro, S., Cuthbertson, D. J. R., Cunningham, J., Sales, M. & Cohen, P. T. W. 2002 In : Diabetes. 51, 3, p. 591-598 8 p.

    Research output: Contribution to journalArticle

  408. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

    Sapkota, G. P., Boudeau, J., Deak, M., Kieloch, A., Morrice, N. & Alessi, D. R. 2002 In : Biochemical Journal. 362, Pt 2, p. 481-90 10 p.

    Research output: Contribution to journalArticle

  409. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence

    Bierne, H., Mazmanian, S. K., Trost, M., Pucciarelli, M. G., Liu, G., Dehoux, P., Jänsch, L., Garcia-del Portillo, F., Schneewind, O., Cossart, P. & European Listeria Genome Consortium 2002 In : Molecular Microbiology. 43, 4, p. 869-81 13 p.

    Research output: Contribution to journalArticle

  410. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

    Sapkota, G. P., Deak, M., Kieloch, A., Morrice, N., Goodarzi, A. A., Smythe, C., Shiloh, Y., Lees-Miller, S. P. & Alessi, D. R. 2002 In : Biochemical Journal. 368, 2, p. 507-516 10 p.

    Research output: Contribution to journalArticle

  411. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

    Research output: Contribution to journalArticle

  412. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

    Lee, M-J., Thangada, S., Paik, J-H., Sapkota, G. P., Ancellin, N., Chae, S-S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R. & Hla, T. Sep 2001 In : Molecular Cell. 8, 3, p. 693-704 12 p.

    Research output: Contribution to journalArticle

  413. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38

    Knebel, A., Morrice, N. & Cohen, P. Aug 2001 In : The EMBO Journal. 20, 16, p. 4360-4369 10 p.

    Research output: Contribution to journalArticle

  414. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at Cys433, is essential for LKB1 to suppress cell growth

    Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. . S. C., Williams, M. R., Morrice, N., Deak, M. & Alessi, D. R. 1 Jun 2001 In : Journal of Biological Chemistry. 276, 22, p. 19469-19482 14 p.

    Research output: Contribution to journalArticle

  415. Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins

    Pozuelo, M., MacKintosh, C., Galvan, A. & Fernandez, E. Jan 2001 In : Planta. 212, 2, p. 264-269 6 p.

    Research output: Contribution to journalArticle

  416. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

    Holmberg, C. I., Hietakangas, V., Mikhailov, A., Rantanen, J. O., Kallio, M., Meinander, A., Hellman, J., Morrice, N., MacKintosh, C., Morimoto, R. I., Eriksson, J. E. & Sistonen, L. 2001 In : EMBO Journal. 20, 14, p. 3800-3810 11 p.

    Research output: Contribution to journalArticle

  417. Regulation of plant NR activity by reversible phosphorylation, 14-3-3 proteins and proteolysis

    MacKintosh, C. & Meek, S. E. M. 2001 In : Cellular and Molecular Life Sciences. 58, 2, p. 205-214 10 p.

    Research output: Contribution to journalScientific review

  418. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612 8 p.

    Research output: Contribution to journalArticle

  419. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G. & Cohen, P. 2001 In : Biochemical Journal. 355, 3, p. 597-607 11 p.

    Research output: Contribution to journalArticle

  420. Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies, S. P., Reddy, H., Caivano, M. & Cohen, P. 1 Oct 2000 In : Biochemical Journal. 351, 1, p. 95-105 11 p.

    Research output: Contribution to journalArticle

  421. Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

    Godber, B. L., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R. & Harrison, R. 17 Mar 2000 In : Journal of Biological Chemistry. 275, 11, p. 7757-7763 7 p.

    Research output: Contribution to journalArticle

  422. 14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells

    Cotelle, V., Meek, S. E. M., Provan, F., Milne, F. C., Morrice, N. & MacKintosh, C. 2000 In : EMBO Journal. 19, 12, p. 2869-2876 8 p.

    Research output: Contribution to journalArticle

  423. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and β-catenin

    Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P. & Cohen, P. 1999 In : FEBS Letters. 458, 2, p. 247-251 5 p.

    Research output: Contribution to journalArticle

  424. Phosphorylation by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on hepatic IGFBP-1 gene expression

    Guo, S., Cichy, S. A., He, X., Wu, J., Rena, G., Cohen, P. & Unterman, T. G. 1999 In : Journal of Investigative Medicine. 47, 7, p. 258A-258A 1 p.

    Research output: Contribution to journalMeeting abstract

  425. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

    Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. 1999 In : Journal of Biological Chemistry. 274, 24, p. 17179-17183 5 p.

    Research output: Contribution to journalArticle

  426. Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins

    Moorhead, G., Douglas, P., Cotelle, V., Harthill, J., Morrice, N., Meek, S., Deiting, U., Stitt, M., Scarabel, M., Aitken, A. & MacKintosh, C. 1999 In : Plant Journal. 18, 1, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  427. 14-3-3 proteins: from plant nitrate reductase to wider roles in plant responses to hormones, stresses, and nutrients

    MacKintosh, C. 1998 Photosynthesis: mechanisms and effects - proceedings of the XIth International Congress on Photosynthesis, Budapest, Hungary, August 17–22, 1998. Garab, G. (ed.). Dordrecht: Springer, Vol. 1, p. 3511-3516 6 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  428. Regulation of cytosolic enzymes in primary metabolism by reversible protein phosphorylation

    MacKintosh, C. 1998 In : Current Opinion in Plant Biology. 1, 3, p. 224-229 6 p.

    Research output: Contribution to journalScientific review

  429. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

    Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B. & Cohen, P. Apr 1997 In : Current Biology. 7, 4, p. 261-269 9 p.

    Research output: Contribution to journalArticle

  430. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

    Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A. & Bownes, M. 1997 In : Current Biology. 7, 10, p. 776-789 14 p.

    Research output: Contribution to journalArticle

  431. First identification of microcystins in Irish lakes aided by a new derivatisation procedure for electrospray mass spectrometric analysis

    Sherlock, I. R., James, K. J., Caudwell, F. . B. & MacKintosh, C. 1997 In : Natural Toxins. 5, 6, p. 247-254 8 p.

    Research output: Contribution to journalArticle

  432. Three spinach leaf nitrate reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are regulated by reversible phosphorylation and/or Ca2+ ions

    Douglas, P., Pigaglio, E., Ferrer, A., Halford, N. G. & MacKintosh, C. 1997 In : Biochemical Journal. 325, 1, p. 101-109 9 p.

    Research output: Contribution to journalArticle

  433. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

    Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M. 15 Jul 1996 In : EMBO Journal. 15, 14, p. 3621-32 12 p.

    Research output: Contribution to journalArticle

  434. New connections in the regulation of PEPCK gene expression by insulin [and discussion]

    Sutherland, C., O'Brien, R. M., Granner, D. K., Saklatvala, J., Cohen, P. & White, M. F. 29 Feb 1996 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 351, 1336, p. 191-199 9 p.

    Research output: Contribution to journalArticle

  435. Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation

    MacKintosh, C., Garton, A. J., McDonnell, A., Barford, D., Cohen, P. T. W., Tonks, N. K. & Cohen, P. 1996 In : FEBS Letters. 397, 2-3, p. 235-238 4 p.

    Research output: Contribution to journalArticle

  436. Mechanism of activation of protein kinase B by insulin and IGF-1

    Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. & Hemmings, B. A. 1996 In : EMBO Journal. 15, 23, p. 6541-6551 11 p.

    Research output: Contribution to journalArticle

  437. Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin

    Moorhead, G., Douglas, P., Morrice, N., Scarabel, M., Aitken, A. & MacKintosh, C. 1996 In : Current Biology. 6, 9, p. 1104-1113 10 p.

    Research output: Contribution to journalArticle

  438. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

    Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M. & Hemmings, B. A. 28 Dec 1995 In : Nature. 378, p. 785-789 5 p.

    Research output: Contribution to journalLetter

  439. PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

    Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. & Saltiel, A. R. 17 Nov 1995 In : Journal of Biological Chemistry. 270, 46, p. 27489-27494 6 p.

    Research output: Contribution to journalArticle

  440. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

    Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R. & Lee, J. C. 8 May 1995 In : FEBS Letters. 364, 2, p. 229-233 5 p.

    Research output: Contribution to journalArticle

  441. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1

    Milne, D. M., Campbell, L. E., Campbell, D. G. & Meek, D. W. 10 Mar 1995 In : Journal of Biological Chemistry. 270, 10, p. 5511-5518 8 p.

    Research output: Contribution to journalArticle

  442. Development of a colorimetric protein phosphorylation assay for detecting cyanobacterial toxins

    Ash, C., MacKintosh, C., MacKintosh, R. & Fricker, C. R. 1995 In : Water Science and Technology. 31, 5-6, p. 47-49 3 p.

    Research output: Contribution to journalArticle

  443. Identification of a protein that inhibits the phosphorylated form of nitrate reductase from spinach (Spinacia oleracea) leaves

    MacKintosh, C., Douglas, P. & Lillo, C. 1995 In : Plant Physiology. 107, 2, p. 451-457 7 p.

    Research output: Contribution to journalArticle

  444. Identification of a regulatory phosphorylation site in the hinge 1 region of nitrate reductase from spinach (Spinacea oleracea) leaves

    Douglas, P., Morrice, N. & MacKintosh, C. 1995 In : FEBS Letters. 377, 2, p. 113-117 5 p.

    Research output: Contribution to journalArticle

  445. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

    Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M. & Cohen, P. 1995 In : Current Biology. 5, 3, p. 283-95 13 p.

    Research output: Contribution to journalArticle

  446. Protein histidine phosphatase activity in rat liver and spinach leaves

    Matthews, H. R. & MacKintosh, C. 1995 In : FEBS Letters. 364, 1, p. 51-54 4 p.

    Research output: Contribution to journalArticle

  447. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

    Moorhead, G., MacKintosh, C., Morrice, N. & Cohen, P. 1995 In : FEBS Letters. 362, 2, p. 101-105 5 p.

    Research output: Contribution to journalArticle

  448. Raised plasma concentrations of brain natriuretic peptide in pulmonary arterial hypertension

    Prasad, N., Lang, C. C., McAlpine, H. M., Choy, A-M. J., MacDonald, T. M. & Struthers, A. D. 1995 In : Respiratory Medicine. 89, 6, p. 445-447 3 p.

    Research output: Contribution to journalArticle

  449. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1

    MacKintosh, R. W., Dalby, K. N., Campbell, D. G., Cohen, P. T. W., Cohen, P. & MacKintosh, C. 1995 In : FEBS Letters. 371, 3, p. 236-240 5 p.

    Research output: Contribution to journalArticle

  450. The effect of enalapril on tyramine induced changes in renal function in man

    Rahman, A. R., Lang, C. C. & Struthers, A. D. 1995 In : International Journal of Clinical Pharmacology and Therapeutics. 33, 7, p. 404-9 6 p.

    Research output: Contribution to journalArticle

  451. Use of a protein phosphatase inhibition test for the detection of cyanobacterial toxins in water

    Ash, C., MacKintosh, C., MacKintosh, R. & Fricker, C. R. 1995 In : Water Science and Technology. 31, 5-6, p. 51-53 3 p.

    Research output: Contribution to journalArticle

  452. Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography

    Moorhead, G., MacKintosh, R. W., Morrice, N., Gallagher, T. & MacKintosh, C. 1 Dec 1994 In : FEBS Letters. 356, 1, p. 46-50 5 p.

    Research output: Contribution to journalArticle

  453. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

    Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. & Nebreda, A. R. 23 Sep 1994 In : Cell. 78, 6, p. 1027-1037 11 p.

    Research output: Contribution to journalArticle

  454. Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases

    Milne, D. M., Campbell, D. G., Caudwell, F. B. & Meek, D. W. 25 Mar 1994 In : Journal of Biological Chemistry. 269, 12, p. 9253-9260 8 p.

    Research output: Contribution to journalArticle

  455. O- and N-Glycosylation of the Leishmania mexicana-secreted acid phosphatase: characterization of a new class of phosphoserine-linked glycans

    Ilg, T., Overath, P., Ferguson, M. A. J., Rutherford, T., Campbell, D. G. & McConville, M. J. 1 Jan 1994 In : Journal of Biological Chemistry. 269, 39, p. 24073-24081 9 p.

    Research output: Contribution to journalArticle

  456. Inhibitors of protein kinases and phosphatases

    MacKintosh, C. & MacKintosh, R. W. 1994 In : Trends in Biochemical Sciences. 19, 11, p. 444-448 5 p.

    Research output: Contribution to journalScientific review

  457. Protein phosphatase inhibitors activate anti-fungal defence responses of soybean cotyledons and cell cultures

    MacKintosh, C., Lyon, G. D. & MacKintosh, R. W. 1994 In : Plant Journal. 5, 1, p. 137-147 11 p.

    Research output: Contribution to journalArticle

  458. Inactivation of glycogen-synthase kinase-3-beta by phosphorylation: new kinase connections in insulin and growth-factor signaling

    Sutherland, C., Leighton, I. A. & Cohen, P. 15 Nov 1993 In : Biochemical Journal. 296, 1, p. 15-19 5 p.

    Research output: Contribution to journalComment/debate

  459. Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress

    Hughes, V., Müller, A., Stark, M. J. R. & Cohen, P. T. W. Aug 1993 In : European Journal of Biochemistry. 216, 1, p. 269-279 11 p.

    Research output: Contribution to journalArticle

  460. Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

    Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdellès, B., Mallet, J., Haavik, J. & Cohen, P. 1993 In : European Journal of Biochemistry. 217, 2, p. 715-722 8 p.

    Research output: Contribution to journalArticle

  461. Renal effects of low dose prazosin in patients with congestive heart failure

    Lang, C. C., Choy, A-M. J., Rahman, A. R. & Struthers, A. D. 1993 In : European Heart Journal. 14, 9, p. 1245-52 8 p.

    Research output: Contribution to journalArticle

  462. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis

    Xia, M-Q., Hale, G., Lifely, M. R., Ferguson, M. A. J., Campbell, D., Packman, L. & Waldmann, H. 1993 In : Biochemical Journal. 293 ( Pt 3), p. 633-640 8 p.

    Research output: Contribution to journalArticle

  463. Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme

    Milne, D. M., Palmer, R. H., Campbell, D. G. & Meek, D. W. Jul 1992 In : Oncogene. 7, 7, p. 1361-1369 9 p.

    Research output: Contribution to journalArticle

  464. Characterization of the major phosphofructokinase - dephosphorylating protein phosphatases from Ascaris suum muscle

    Daum, G., Schmid, B., MacKintosh, C., Cohen, P. & Hofer, H. W. 1992 In : Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. 1122, 1, p. 23-32 10 p.

    Research output: Contribution to journalArticle

  465. Dissection of the protein kinase cascades involved in insulin and nerve growth factor action

    Cohen, P., Campbell, D. G., Dent, P., Gomez, N., Lavoinne, A., Nakielny, S., Stokoe, D., Sutherland, C. & Traverse, S. 1992 In : Biochemical Society Transactions. 20, 3, p. 671-674 4 p.

    Research output: Contribution to journalArticle

  466. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

    Liu, J., Albers, M. W., Wandless, T. J., Luan, S., Alberg, D. G., Belshaw, P. J., Cohen, P. ., MacKintosh, C., Klee, C. B. & Schreiber, S. L. 1992 In : Biochemistry. 31, 16, p. 3896-3901 6 p.

    Research output: Contribution to journalArticle

  467. Regulation of spinach-leaf nitrate reductase by reversible phosphorylation

    MacKintosh, C. 1992 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1137, 1, p. 121-126 6 p.

    Research output: Contribution to journalComment/debate

  468. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

    Silva, E. F. D. C. E., Hughes, V., McDonald, P., Stark, M. J. R. & Cohen, P. T. W. 13 Jun 1991 In : Biochimica et Biophysica Acta: General Subjects. 1089, 2, p. 269-272 4 p.

    Research output: Contribution to journalComment/debate

  469. A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11

    Doonan, J. H., MacKintosh, C., Osmani, S., Cohen, P., Bai, G., Lee, E. Y. & Morris, N. R. 1991 In : Journal of Biological Chemistry. 266, 28, p. 18889-18894 6 p.

    Research output: Contribution to journalArticle

  470. Illumination increases the phosphorylation state of maize leaf phospho enolpyruvate car☐ylase by causing an increase in the activity of a protein kinase

    McNaughton, G. A. L., MacKintosh, C., Fewson, C. A., Wilkins, M. B. & Nimmo, H. G. 1991 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1093, 2-3, p. 189-195 7 p.

    Research output: Contribution to journalArticle

  471. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes

    Sneddon, A. A., Cohen, P. T. W. & Stark, M. J. R. Dec 1990 In : EMBO Journal. 9, 13, p. 4339-4346 8 p.

    Research output: Contribution to journalArticle

  472. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

    MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. & Codd, G. A. 1990 In : FEBS Letters. 264, 2, p. 187-192 6 p.

    Research output: Contribution to journalArticle

  473. Tautomycin from the bacterium Streptomyces verticillatus: another potent and specific inhibitor of protein phosphatases 1 and 2A

    MacKintosh, C. & Klumpp, S. 1990 In : FEBS Letters. 277, 1-2, p. 137-140 4 p.

    Research output: Contribution to journalArticle

  474. Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase

    Nimmo, H. G., Douglas, F., Kleanthous, C., Campbell, D. G. & MacKintosh, C. 1989 In : Biochemical Journal. 261, 2, p. 431-435 5 p.

    Research output: Contribution to journalArticle

  475. Identification of high levels of type 1 and type 2A protein phosphatases in higher plants

    MacKintosh, C. & Cohen, P. 1989 In : Biochemical Journal. 262, 1, p. 335-339 5 p.

    Research output: Contribution to journalArticle

  476. Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

    MacKintosh, C., Campbell, D. G., Hiraga, A. & Cohen, P. 1988 In : FEBS Letters. 234, 1, p. 189-194 6 p.

    Research output: Contribution to journalArticle

  477. Purification and properties of Escherichia coli isocitrate lyase

    MacKintosh, C. & Nimmo, H. G. Apr 1986 In : Biochemical Society Transactions. 14, 2, p. 320-321 2 p.

    Research output: Contribution to journalMeeting abstract

  478. Release of oxytocin and prolactin in response to suckling.

    McNeilly, A. S., Robinson, I. C., Houston, M. J. & Howie, P. W. Jan 1983 In : British Medical Journal. 286, 6361, p. 257-259 3 p.

    Research output: Contribution to journalArticle

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