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Oncology & Molecular Medicine

  1. MEK is a therapeutic and chemopreventative target in squamous cell carcinoma

    Adelmann, C. H., Truong, K. A., Liang, R. J., Bansal, V., Gandee, L., Saporito, R., Lee, W., Du, L., Nicholas, C., Napoli, M., Mino, B., South, A. P., Proby, C. M., Leigh, I. M., Coarfa, C., Flores, E. R. & Tsai, K. Y. Sep 2016 In : Journal of Investigative Dermatology. 136, 9, p. 1920-1924 5 p.

    Research output: Contribution to journalLetter

  2. Phase II randomized preoperative window-of-opportunity study of the PI3K inhibitor pictilisib plus anastrozole compared with anastrozole alone in patients with estrogen receptor-positive breast cancer

    Schmid, P. , Pinder, S. E. , Wheatley, D. , Macaskill, J. , Zammit, C. , Hu, J. , Price, R. , Bundred, N. , Hadad, S. , Shia, A. , Sarker, S. J. , Lim, L. , Gazinska, P. , Woodman, N. , Korbie, D. , Trau, M. , Mainwaring, P. , Gendreau, S. , Lackner, M. R. & 7 others Derynck, M., Wilson, T. R., Butler, H., Earl, G., Parker, P., Purushotham, A. & Thompson, A. 10 Jun 2016 In : Journal of Clinical Oncology. 34, 17, p. 1987-1994 8 p.

    Research output: Contribution to journalArticle

  3. Bubble wrap for optical trapping and cell culturing

    McDonald, C. & McGloin, D. 1 Oct 2015 In : Biomedical Optics Express. 6, 10, p. 3757-3764 8 p.

    Research output: Contribution to journalArticle

  4. Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

    Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P. Sep 2015 In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

    Research output: Contribution to journalArticle

  5. Value of shear-wave elastography in the diagnosis of symptomatic invasive lobular breast cancer

    Sim, Y. T., Vinnicombe, S., Whelehan, P., Thomson, K. & Evans, A. Jun 2015 In : Clinical Radiology. 70, 6, p. 604-609 6 p.

    Research output: Contribution to journalArticle

  6. Effect of probiotics on the expression of Barrett's oesophagus biomarkers

    Namin, B. M., Daryani, N. E., Mirshafiey, A., Yazdi, M. K. S. & Dallal, M. M. S. Apr 2015 In : Journal of Medical Microbiology. 64, 4, p. 348-354 7 p.

    Research output: Contribution to journalArticle

  7. Allergic contact dermatitis in children; has there been a change in allergens?

    Vongyer, G. A. & Green, C. Jan 2015 In : Clinical and Experimental Dermatology. 40, 1, p. 31-34 4 p.

    Research output: Contribution to journalArticle

  8. Photodynamic diagnostic ureterorenoscopy with orally administered 5-aminolaevulinic acid as photosensitiser: how I do it

    Kata, S. G., Nabi, G., Eljamel, S., Chlosta, P., Moseley, H. & Aboumarzouk, O. M. Dec 2014 In : Urologia Internationalis. 93, 4, p. 384-388 5 p.

    Research output: Contribution to journalArticle

  9. Shear-wave elastography contributes to accurate tumour size estimation when assessing small breast cancers

    Mullen, R., Thompson, J. M., Moussa, O., Vinnicombe, S. & Evans, A. Dec 2014 In : Clinical Radiology. 69, 12, p. 1259-1263 5 p.

    Research output: Contribution to journalArticle

  10. Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients

    Fleming, S. & 37 others Gill, A. J., Hes, O., Papathomas, T., Sedivcová, M., Tan, P. H., Agaimy, A., Andresen, P. A., Kedziora, A., Clarkson, A., Toon, C. W., Sioson, L., Watson, N., Chou, A., Paik, J., Clifton-Bligh, R. J., Robinson, B. G., Benn, D. E., Hills, K., Maclean, F., Niemeijer, N. D., Vlatkovic, L., Hartmann, A., Corssmit, E. P. M., van Leenders, G. J. L. H., Przybycin, C., McKenney, J. K., Magi-Galluzzi, C., Yilmaz, A., Yu, D., Nicoll, K. D., Yong, J. L., Sibony, M., Yakirevich, E., Chow, C. W., Miettinen, M., Michal, M. & Trpkov, K. Dec 2014 In : American Journal of Surgical Pathology. 38, 12, p. 1588-1602 15 p.

    Research output: Contribution to journalArticle

  11. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p., 5359

    Research output: Contribution to journalArticle

  12. Fertility preservation in men with cancer

    Tournaye, H., Dohle, G. R. & Barratt, C. L. R. 4 Oct 2014 In : Lancet. 384, 9950, p. 1295-1301 7 p.

    Research output: Contribution to journalArticle

  13. NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

    South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M. Oct 2014 In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638

    Research output: Contribution to journalArticle

  14. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

    Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P. Oct 2014 In : Stem Cells. 32, 10, p. 2605-2615

    Research output: Contribution to journalArticle

  15. Laser energy: think of a number

    Moseley, H. Oct 2014 In : British Journal of Dermatology. 171, 4, p. 691-692 2 p.

    Research output: Contribution to journalComment/debate

  16. Topical photodynamic therapy for non-malignant skin conditions: experience from a university teaching hospital

    Lau, Y. N., Moseley, H. & Ibbotson, S. H. Oct 2014 In : Photodermatology, Photoimmunology & Photomedicine. 30, 5, p. 280-282 3 p.

    Research output: Contribution to journalArticle

  17. Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

    El-Mokadem, I., Fitzpatrick, J., Bondad, J., Rauchhaus, P., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G. 23 Sep 2014 In : British Journal of Cancer. 111, 7, p. 1381-1390 10 p.

    Research output: Contribution to journalArticle

  18. Digital mammographic density and breast cancer risk: a case-control study of six alternative density assessment methods

    Eng, A., Gallant, Z., Shepherd, J., McCormack, V., Li, J., Dowsett, M., Vinnicombe, S., Allen, S. & dos-Santos-Silva, I. 20 Sep 2014 In : Breast Cancer Research. 16, 5, 12 p., 439

    Research output: Contribution to journalArticle

  19. Genes involved in epithelial differentiation and development are differentially expressed in oral and genital lichen planus epithelium compared to normal epithelium

    Danielsson, K., Coates, P. J., Ebrahimi, M., Nylander, E., Wahlin, Y-B. & Nylander, K. Sep 2014 In : Acta Dermato-Venereologica. 94, 5, p. 526-530 5 p.

    Research output: Contribution to journalArticle

  20. Importance of β-defensins in sperm function

    Dorin, J. R. & Barratt, C. L. R. Sep 2014 In : Molecular Human Reproduction. 20, 9, p. 821-826 6 p.

    Research output: Contribution to journalArticle

  21. Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains

    Pinheiro, A., Woof, J. M., Almeida, T., Abrantes, J., Alves, P. C., Gortázar, C. & Esteves, P. J. Sep 2014 In : Open Biology. 4, 9, 9 p., 140088

    Research output: Contribution to journalArticle

  22. The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

    Salmond, R. J., Brownlie, R. J., Morrison, V. L. & Zamoyska, R. Sep 2014 In : Nature Immunology. 15, 9, p. 875-883 8 p.

    Research output: Contribution to journalArticle

  23. Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

    Hamilton, D. L., Philp, A., MacKenzie, M. G., Patton, A., Towler, M. C., Gallagher, I. J., Bodine, S. C. & Baar, K. 15 Aug 2014 In : American Journal of Physiology, Endocrinology and Metabolism. 307, 4, p. E365-E373 9 p.

    Research output: Contribution to journalArticle

  24. The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: the MORGAM Project Cohort Component

    Ferrario, M. M. , Veronesi, G. , Chambless, L. E. , Tunstall-Pedoe, H. , Kuulasmaa, K. , Salomaa, V. , Borglykke, A. , Hart, N. , Söderberg, S. , Cesana, G. , Jørgensen, T. , Agger, C. , Juolevi, A. , Vartiainen, E. , Jousilahti, P. , Cepaitis, Z. , Haukijärvi, A. , Joseph, B. , Kulathinal, S. & 75 others Niemelä, M., Saarela, O., Ducimetière, P., Bingham, A., Arveiler, D., Haas, B., Wagner, A., Ferrières, J., Ruidavets, J-B., Bongard, V., Amouyel, P., Montaye, M., Dallongeville, J., Döring, A., Wichmann, E., Fornari, C., Sega, R., Mancia, G., Facchetti, R., Vanuzzo, D., Pilotto, L., Picco, F., Mattiussi, F., Gigante, S., Tamosiunas, A., Domarkiene, S., Rastenyte, D., Bernotiene, G., Radisauskas, R., Baceviciene, M., Luksiene, D., Malinauskiene, V., Bernotaite, L., Pajak, A., Kawalec, E., Broda, G., Kurjata, P., Rywik, S. L., Polakowska, M., Pytlak, A., Nikitin, Y., Malyutina, S., Gafarov, V., Feigin, V., Siminova, G., Voevoda, M., Vinogradova, T., Nasonova, N., Veriovkin, E., Eliasson, M., Stegmayr, B., Eriksson, M., Asplund, K., Kee, F., Evans, A., Yarnell, J., Gardner, E., Woodward, M., Evans, A., Cashman, S., Evans, A., Blankenberg, S., Kee, F., Palotie, A., Perola, M., Peters, A., Salomaa, V., Tregouet, D., Asplund, K., Cambien, F., Tiret, L., Peltonen, L., Shields, D., Stegmayr, B. & Wiklund, P-G. Aug 2014 In : Heart. 100, 15, p. 1179-1187 9 p.

    Research output: Contribution to journalArticle

  25. Therapeutic targeting of integrin αvβ6 in breast cancer

    Moore, K. M. , Thomas, G. J. , Duffy, S. W. , Warwick, J. , Gabe, R. , Chou, P. , Ellis, I. O. , Green, A. R. , Haider, S. , Brouilette, K. , Saha, A. , Vallath, S. , Bowen, R. , Chelala, C. , Eccles, D. , Tapper, W. J. , Thompson, A. M. , Quinlan, P. , Jordan, L. & 9 others Gillett, C., Brentnall, A., Violette, S., Weinreb, P. H., Kendrew, J., Barry, S. T., Hart, I. R., Jones, J. L. & Marshall, J. F. Aug 2014 In : Journal of the National Cancer Institute. 106, 8, 14 p., dju169

    Research output: Contribution to journalArticle

  26. Use of skin adhesive in dermatological surgery

    Lau, Y. N., Green, C. M., Hussain, W. & Affleck, A. G. Aug 2014 In : Clinical and Experimental Dermatology. 39, 6, p. 773-774 2 p.

    Research output: Contribution to journalArticle

  27. Adverse surgical outcomes in screen-detected ductal carcinoma in situ of the breast

    Thomas, J., Hanby, A., Pinder, S. E., Ball, G., Lawrence, G., Maxwell, A., Wallis, M., Evans, A., Dobson, H., Clements, K., Thompson, A. & Sloane Project Steering Group Jul 2014 In : European Journal of Cancer. 50, 11, p. 1880-1890 11 p.

    Research output: Contribution to journalArticle

  28. Drug-induced photosensitivity

    Dawe, R. S. & Ibbotson, S. H. Jul 2014 In : Dermatologic Clinics. 32, 3, p. 363-368 6 p.

    Research output: Contribution to journalArticle

  29. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

    Navarini, A. A. , Simpson, M. A. , Weale, M. , Knight, J. , Carlavan, I. , Reiniche, P. , Burden, D. A. , Layton, A. , Bataille, V. , Allen, M. , Pleass, R. , Pink, A. , Creamer, D. , English, J. , Munn, S. , Walton, S. , The Acne Genetic Study Group, Willis, C. , Déret, S. & 6 others Voegel, J. J., Smith, C. H., Trembath, R. C., Barker, J. N., Ferguson, A. & Green, N. 13 Jun 2014 In : Nature Communications. 5, 6 p., 4020

    Research output: Contribution to journalArticle

  30. A data standard for sourcing fit-for-purpose biological samples in an integrated virtual network of biobanks

    Confederation of Cancer Biobanks (CCB) Working Group 3 Jun 2014 In : Biopreservation and Biobanking. 12, 3, p. 184-191 8 p.

    Research output: Contribution to journalArticle

  31. Comparative cancer survival in European countries

    Munro, A. J. Jun 2014 In : British Medical Bulletin. 110, 1, p. 5-22 18 p.

    Research output: Contribution to journalArticle

  32. The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers

    Iyer, R. S., Nicol, S. M., Quinlan, P. R., Thompson, A. M., Meek, D. W. & Fuller-Pace, F. V. 1 May 2014 In : Cell cycle (Georgetown, Tex.). 13, 9, p. 1413-1423 11 p.

    Research output: Contribution to journalArticle

  33. Decreasing cost of flexible ureterorenoscopy: single-use laser fiber cost analysis

    Chapman, R. A., Somani, B. K., Robertson, A., Healy, S. & Kata, S. G. May 2014 In : Urology. 83, 5, p. 1003-1005 3 p.

    Research output: Contribution to journalArticle

  34. Antibiotic treatments and microbes in the gut

    Macfarlane, S. Apr 2014 In : Environmental Microbiology. 16, 4, p. 919-924 6 p.

    Research output: Contribution to journalArticle

  35. Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

    Tatton-Brown, K. , Seal, S. , Ruark, E. , Harmer, J. , Ramsay, E. , del Vecchio Duarte, S. , Zachariou, A. , Hanks, S. , O'Brien, E. , Aksglaede, L. , Baralle, D. , Dabir, T. , Gener, B. , Goudie, D. , Homfray, T. , Kumar, A. , Pilz, D. T. , Selicorni, A. , Temple, I. K. & 5 others Van Maldergem, L., Yachelevich, N., Childhood Overgrowth Consortium, van Montfort, R. & Rahman, N. Apr 2014 In : Nature Genetics. 46, 4, p. 385-388 4 p.

    Research output: Contribution to journalArticle

  36. Pirfenidone in idiopathic pulmonary fibrosis: expert panel discussion on the management of drug-related adverse events

    Costabel, U., Bendstrup, E., Cottin, V., Dewint, P., Egan, J. J. J., Ferguson, J., Groves, R., Hellström, P. M., Kreuter, M., Maher, T. M., Molina-Molina, M., Nordlind, K., Sarafidis, A. & Vancheri, C. Apr 2014 In : Advances in Therapy. 31, 4, p. 375-391 17 p.

    Research output: Contribution to journalArticle

  37. Review of an established UK home phototherapy service 1998-2011: improving access to a cost-effective treatment for chronic skin disease

    Cameron, H., Yule, S., Dawe, R. S., Ibbotson, S. H., Moseley, H. & Ferguson, J. Apr 2014 In : Public Health. 128, 4, p. 317-324 8 p.

    Research output: Contribution to journalArticle

  38. What are the characteristics of breast cancers misclassified as benign by quantitative ultrasound shear wave elastography?

    Vinnicombe, S. J., Whelehan, P., Thomson, K., McLean, D., Purdie, C. A., Jordan, L. B., Hubbard, S. & Evans, A. J. Apr 2014 In : European Radiology. 24, 4, p. 921-926 6 p.

    Research output: Contribution to journalArticle

  39. Biopsy confirmation of metastatic sites in breast cancer patients: clinical impact and future perspectives

    Criscitiello, C., André, F., Thompson, A. M., De Laurentiis, M., Esposito, A., Gelao, L., Fumagalli, L., Locatelli, M., Minchella, I., Orsi, F., Goldhirsch, A. & Curigliano, G. 21 Mar 2014 In : Breast Cancer Research. 16, 2, 10 p., 205

    Research output: Contribution to journalArticle

  40. BPAG1-e restricts keratinocyte migration through control of adhesion stability

    Michael, M., Begum, R., Fong, K., Pourreyrone, C., South, A. P., McGrath, J. A. & Parsons, M. Mar 2014 In : Journal of Investigative Dermatology. 134, 3, p. 773-782 10 p.

    Research output: Contribution to journalArticle

  41. Impact assessment of energy-efficient lighting in patients with lupus erythematosus: a pilot study

    Fenton, L., Dawe, R., Ibbotson, S., Ferguson, J., Silburn, S. & Moseley, H. Mar 2014 In : The British journal of dermatology. 170, 3, p. 694-698 5 p.

    Research output: Contribution to journalArticle

  42. Signalling pathways in succinate dehydrogenase B-associated renal carcinoma

    Fleming, S., Mayer, N. J., Vlatkovic, L. J., McLean, J., McConachie, M. & Baty, D. Mar 2014 In : Histopathology. 64, 4, p. 477-483 7 p.

    Research output: Contribution to journalArticle

  43. Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes

    Dayal, J. H. S., Cole, C. L., Pourreyron, C., Watt, S. A., Lim, Y. Z., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Stieger, B., Jahoda, C., Leigh, I. M. & South, A. P. 15 Feb 2014 In : Journal of Cell Science. 127, 4, p. 740-751 12 p.

    Research output: Contribution to journalArticle

  44. How to improve safe delivery of intense pulsed light treatment

    Moseley, H. Feb 2014 In : Photodermatology, Photoimmunology & Photomedicine. 30, 1, p. 52 1 p.

    Research output: Contribution to journalLetter

  45. Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study

    Bruce, J., Thornton, A. J., Powell, R., Johnston, M., Wells, M., Heys, S. D., Thompson, A. M., Cairns Smith, W., Chambers, A. W. & Scott, N. W. Feb 2014 In : PAIN. 155, 2, p. 232-243 12 p.

    Research output: Contribution to journalArticle

  46. Responses to ionising radiation mediated by inflammatory mechanisms

    Mukherjee, D., Coates, P. J., Lorimore, S. A. & Wright, E. G. Feb 2014 In : Journal of Pathology. 232, 3, p. 289-299 11 p.

    Research output: Contribution to journalLiterature review

  47. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-a randomised trial

    Vaidya, J. S. , Wenz, F. , Bulsara, M. , Tobias, J. S. , Joseph, D. J. , Keshtgar, M. , Flyger, H. L. , Massarut, S. , Alvarado, M. , Saunders, C. , Eiermann, W. , Metaxas, M. , Sperk, E. , Sütterlin, M. , Brown, D. , Esserman, L. , Roncadin, M. , Thompson, A. , Dewar, J. A. & 10 others Holtveg, H. M. R., Pigorsch, S., Falzon, M., Harris, E., Matthews, A., Brew-Graves, C., Potyka, I., Corica, T., Williams, N. R. & Baum, M. Feb 2014 In : Lancet. 383, 9917, p. 603-613 11 p.

    Research output: Contribution to journalArticle

  48. The composite moberg flap for reconstruction of complex thumb tip injuries

    Kandamany, N. & Naasan, A. Feb 2014 In : Plastic and Reconstructive Surgery. 133, 2, p. 235e-236e 1 p.

    Research output: Contribution to journalLetter

  49. Accuracy of non-operative identification of the sentinel lymph node using combined gamma and ultrasound scanning

    Whelehan, P., Vinnicombe, S. J., Brown, D. C., McLean, D. & Evans, A. 2014 In : Clinical Radiology. 69, 8, p. 849-852 4 p.

    Research output: Contribution to journalArticle

  50. Aicardi syndrome in a 47 XXY male - A variable developmental phenotype?

    Shetty, J., Fraser, J., Goudie, D. & Kirkpatrick, M. 2014 In : European Journal of Paediatric Neurology. 18, 4, p. 529-531 3 p.

    Research output: Contribution to journalArticle

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