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Pharmacology & Neuroscience

  1. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

    Lambert, J. J. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Thompson, A. M. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886 12 p.

    Research output: Contribution to journalArticle

  2. The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

    Kinsella, J. M., Laidlaw, H. A., Tang, T., Harvey, J., Sutherland, C. & Ashford, M. L. J. 2004 In : BMC Clinical Pharmacology. 4, 17, 13 p.

    Research output: Contribution to journalArticle

  3. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function

    Connolly, C. N. & Wafford, K. A. 2004 In : Biochemical Society Transactions. 32, p. 529-534 6 p.

    Research output: Contribution to journalArticle

  4. Tumour necrosis factor a decreases glucose-6-phosphatase gene expression by activation of nuclear factor kB

    Grempler, R., Kienitz, A., Werner, T., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R. & Schmoll, D. 2004 In : Biochemical Journal. 382, p. 471-479 9 p.

    Research output: Contribution to journalArticle

  5. Sedation and anesthesia mediated by distinct GABAA receptor isoforms

    Reynolds, D. S., Rosahl, T. W., Cirone, J., O'Meara, G. F., Haythornthwaite, A., Newman, R. J., Myers, J., Sur, C., Howell, O., Rutter, A. R., Atack, J., Macaulay, A. J., Hadingham, K. L., Hutson, P. H., Belelli, D., Lambert, J., Dawson, G. R., McKernan, R., Whiting, P. J. & Wafford, K. A. Sep 2003 In : Journal of Neuroscience. 23, 24, p. 8608-8617 10 p.

    Research output: Contribution to journalArticle

  6. Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal

    Boyd, G. W., Doward, A. I., Kirkness, E. F., Millar, N. S. & Connolly, C. N. 25 Jul 2003 In : Journal of Biological Chemistry. 278, 30, p. 27681-27687 7 p.

    Research output: Contribution to journalArticle

  7. A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

    Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J. & Peters, J. A. Jul 2003 In : Nature. 424, 6946, p. 321-324 4 p.

    Research output: Contribution to journalArticle

  8. The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

    Belelli, D., Muntoni, A-L., Merrywest, S. D., Gentet, L. J., Casula, A., Callachan, H., Madau, P., Gemmell, D. K., Hamilton, N. M., Lambert, J. J., Sillar, K. T. & Peters, J. A. Jul 2003 In : Neuropharmacology. 45, 1, p. 57-71 15 p.

    Research output: Contribution to journalArticle

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