Pharmacology & Neuroscience

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to K channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Apr-2013 In : Journal of Bioenergetics and Biomembranes. p. 1-13, 13 p.

Research output: Contribution to journal › Article

Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Palmer, M. J., Moffat, C., Saranzewa, N., Harvey, J., Wright, G. A. & Connolly, C. N. 27-Mar-2013 In : Nature Communications. 4, 1634

Research output: Contribution to journal › Article

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41, 1 p., P43

Research output: Contribution to journal › Meeting abstract

Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

Research output: Contribution to journal › Meeting abstract

How does glucophage (metformin) work? Investigation of the cellular action of chemical analogues

Logie, L., Bacon, S., Middleton, P., Harthill, J., Coats, J., Stewart, D., Sakamoto, K., McDougall, G. & Rena, G. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41, 1 p., P44

Research output: Contribution to journal › Meeting abstract

Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49, 1 p., P70

Research output: Contribution to journal › Meeting abstract

Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

Research output: Contribution to journal › Article

The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland

Bollan, K. A., Hothersall, J. D., Moffat, C., Durkacz, J., Saranzewa, N., Wright, G. A., Raine, N. E., Highet, F. & Connolly, C. N. Feb-2013 In : Parasitology Research. 112, 2, p. 751-759, 9 p.

Research output: Contribution to journal › Article

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.

Doherty, G. H., Beccano-Kelly, D., Yan, S-D., Gunn-Moore, F. & Harvey, J. Jan-2013 In : Neurobiology of Aging. 34, 1, p. 226-37

Research output: Contribution to journal › Article

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

Jensen, M. L., Wafford, K. A., Brown, A. R., Belelli, D., Lambert, J. J. & Mirza, N. R. 2013 In : British Journal of Pharmacology. 168, 5, p. 1118-1132, 15 p.

Research output: Contribution to journal › Article

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17-Dec-2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453, 13 p.

Research output: Contribution to journal › Article

Identifying key knowledge needs for evidence-based conservation of wild insect pollinators: A collaborative cross-sectoral exercise

Dicks, L. V. , Abrahams, A. , Atkinson, J. , Biesmeijer, J. , Bourn, N. , Brown, C. , Brown, M. J. F. , Carvell, C. , Connolly, C. , Cresswell, J. E. , Croft, P. , Darvill, B. , De Zylva, P. , Effingham, P. , Fountain, M. , Goggin, A. , Harding, D. , Harding, T. , Hartfield, C. , Heard, M. S. & 30 others Heathcote, R., Heaver, D., Holland, J., Howe, M., Hughes, B., Huxley, T., Kunin, W. E., Little, J., Mason, C., Memmott, J., Osborne, J., Pankhurst, T., Paxton, R. J., Pocock, M. J. O., Potts, S. G., Power, E. F., Raine, N. E., Ranelagh, E., Roberts, S., Saunders, R., Smith, K., Smith, R. M., Sutton, P., Tilley, L. A. N., Tinsley, A., Tonhasca, A., Vanbergen, A. J., Webster, S., Wilson, A. & Sutherland, W. J. 12-Oct-2012 In : Insect Conservation and Diversity.

Research output: Contribution to journal › Article

Hypoglycaemia: exercise for the brain?

Ashford, M., Beall, C. & McCrimmon, R. Oct-2012 In : Journal of Neuroendocrinology. 24, 10, p. 1365-1366, 2 p.

Research output: Contribution to journal › Article

Insulin resistance in the brain: An old-age or new-age problem?

Williamson, R., McNeilly, A. & Sutherland, C. 15-Sep-2012 In : Biochemical Pharmacology. 84, 6, p. 737-45, 9 p.

Research output: Contribution to journal › Article

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour

Beall, C., Hamilton, D. L., Gallagher, J., Logie, L., Wright, K., Soutar, M. P., Dadak, S., Ashford, F. B., Haythorne, E., Du, Q., Jovanovic, A., McCrimmon, R. J. & Ashford, M. L. J. Sep-2012 In : Diabetologia. 55, 9, p. 2432-2444, 13 p.

Research output: Contribution to journal › Article

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule

Zhang, H., Etherington, L-A., Hafner, A-S., Belelli, D., Coussen, F., Delagrange, P., Chaouloff, F., Spedding, M., Lambert, J. J., Choquet, D. & Groc, L. 26-Jun-2012 In : Molecular Psychiatry. 18, p. 471-484, 14 p.

Research output: Contribution to journal › Article

Cannabinoid receptors in submandibular acinar cells: functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling

Kopach, O., Vats, J., Netsyk, O., Voitenko, N., Irving, A. & Fedirko, N. 15-Apr-2012 In : Journal of Cell Science. 125, 8, p. 1884-1895, 12 p.

Research output: Contribution to journal › Article

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

Research output: Contribution to journal › Article

Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

Bacon, S., Harthill, J., Coates, J., Stewart, D., McDougall, G. & Rena, G. 2012 In : Diabetic Medicine. 29, Suppl. 1, p. 41, 1 p., P41

Research output: Contribution to journal › Meeting abstract

Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

Schofield, C. J. & Sutherland, C. 2012 In : Diabetic Medicine. 29, 8, p. 972-979, 8 p.

Research output: Contribution to journal › Book/Film/Article review

From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits

Youssef, F. F. & Irving, A. J. 2012 In : West Indian Medical Journal. 61, 3

Research output: Contribution to journal › Article

MSK1 regulates homeostatic and experience-dependent synaptic plasticity

Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

Research output: Contribution to journal › Article

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D. 2012 In : Oncogene.

Research output: Contribution to journal › Article

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J. 2012 In : Cell Metabolism. 16, 2, p. 139-141, 3 p.

Research output: Contribution to journal › Article

Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors

Nuritova, F. & Frenguelli, B. G. 2012 In : Neuroscience. 222, p. 159-172, 14 p.

Research output: Contribution to journal › Article

Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

Godfrey, V., Martin, A. L., Struthers, A. D. & Lyles, G. A. Dec-2011 In : British Journal of Pharmacology. 164, 8, p. 2003-2014, 12 p.

Research output: Contribution to journal › Article

Guide to Receptors and Channels (GRAC), 5th edition

Alexander, S. P. H., Mathie, A. & Peters, J. Nov-2011 In : British Journal of Pharmacology. 164, p. 12, 2 p.

Research output: Contribution to journal › Editorial

Distinct mechanisms regulate GABA(A) receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

Panzanelli, P., Gunn, B. G., Schlatter, M. C., Benke, D., Tyagarajan, S. K., Scheiffele, P., Belelli, D., Lambert, J. J., Rudolph, U. & Fritschy, J-M. 15-Oct-2011 In : Journal of Physiology. 589, 20, p. 4959-4980, 22 p.

Research output: Contribution to journal › Article

Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3

Farghaian, H., Turnley, A. M., Sutherland, C. & Cole, A. R. 15-Jul-2011 In : Journal of Biological Chemistry. 286, 28, p. 25274-25283, 10 p.

Research output: Contribution to journal › Article

Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)center dot Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

Astle, M. V., Ooms, L. M., Cole, A. R., Binge, L. C., Dyson, J. M., Layton, M. J., Petratos, S., Sutherland, C. & Mitchell, C. A. 1-Jul-2011 In : Journal of Biological Chemistry. 286, 26, p. 23407-23418, 12 p.

Research output: Contribution to journal › Article

Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A(1) Receptors

zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. & Frenguelli, B. 20-Apr-2011 In : Journal of Neuroscience. 31, 16, p. 6221-6234, 14 p.

Research output: Contribution to journal › Article

Neuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains

Williamson, R. & Sutherland, C. 1-Mar-2011 In : Current Alzheimer Research. 8, 2, p. 213-221, 9 p.

Research output: Contribution to journal › Article

Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

Claret, M. , Smith, M. A. , Knauf, C. , Al-Qassab, H. , Woods, A. , Heslegrave, A. , Piipari, K. , Emmanuel, J. J. , Colom, A. , Valet, P. , Cani, P. D. , Begum, G. , White, A. , Mucket, P. , Peters, M. , Mizuno, K. , Batterham, R. L. , Giese, K. P. , Ashworth, A. , Burcelin, R. & 3 others Ashford, M. L., Carling, D. & Withers, D. J. Mar-2011 In : Diabetes. 60, 3, p. 735-745, 11 p.

Research output: Contribution to journal › Article

CRMP2 Hyperphosphorylation is Characteristic of Alzheimer's Disease and not a Feature Common to Other Neurodegenerative Diseases

Williamson, R., van Aalten, L., Mann, D. M. A., Platt, B., Plattner, F., Bedford, L., Mayer, J., Howlett, D., Usardi, A., Sutherland, C. & Cole, A. R. 2011 In : Journal of Alzheimer's Disease. 27, 3, p. 615-625, 11 p.

Research output: Contribution to journal › Article

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

Moult, P. R. & Harvey, J. 2011 In : Neuropharmacology. 61, 5-6, p. 924-936, 13 p.

Research output: Contribution to journal › Article

What are the bona fide GSK3 substrates?

Sutherland, C. 2011 In : International Journal of Alzheimer's Disease. 2011, p. 1-23

Research output: Contribution to journal › Article

Regulation of Tau-Dependent Toxicity by Brain Selective/SAD Kinases

Lyn-Adams, C., Frenguelli, B., Moffat, K. & Sutherland, C. Dec-2010 In : Journal of Neurogenetics. 24, p. 12-12, 1 p.

Research output: Contribution to journal › Meeting abstract

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

Soutar, M. P. M., Kim, W-Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R. & Sutherland, C. Nov-2010 In : Journal of Neurochemistry. 115, 4, p. 974-983, 10 p.

Research output: Contribution to journal › Article

Generation, validation and humanisation of a novel insulin resistant cell model

Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C. 1-Oct-2010 In : Biochemical Pharmacology. 80, 7, p. 1042-1049, 8 p.

Research output: Contribution to journal › Article

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J. & Ashford, M. L. J. 15-Jul-2010 In : Biochemical Journal. 429, p. 323-333, 11 p.

Research output: Contribution to journal › Article

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

Clayton, E. L., Sue, N., Smillie, K. J., O'Leary, T., Bache, N., Cheung, G., Cole, A. R., Wyllie, D. J., Sutherland, C., Robinson, P. J. & Cousin, M. A. Jul-2010 In : Nature Neuroscience. 13, 7, p. 845-U85, 9 p.

Research output: Contribution to journal › Article

Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis

Piipari, K., Beall, C., Al-Qassab, H., Smith, M. A., Carling, D., Viollet, B., Ashford, M. L. J. & Withers, D. J. Jun-2010 In : Endocrine Reviews. 31, 3, p. S810-S810, 1 p.

Research output: Contribution to journal › Book/Film/Article review

Leptin: The Missing Link in Alzheimer Disease?

Harvey, J. May-2010 In : Clinical Chemistry. 56, 5, p. 696-697, 2 p.

Research output: Contribution to journal › Editorial

GSK3 beta Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

Alabed, Y. Z., Pool, M., Tone, S. O., Sutherland, C. & Fournier, A. E. 21-Apr-2010 In : Journal of Neuroscience. 30, 16, p. 5635-5643, 9 p.

Research output: Contribution to journal › Article

All tangled up: tau-dependent neurodegeneration

Lyn-Adams, C., Moffat, K., Sutherland, C. & Frenguelli, B. G. 1-Apr-2010 In : Biochemist. 32, 2, p. 10-13, 4 p.

Research output: Contribution to journal › Article