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  1. AMPK: regulating energy balance at the cellular and whole body levels

    Hardie, D. G. & Ashford, M. L. J. Mar 2014 In : Physiology. 29, 2, p. 99-107 9 p.

    Research output: Contribution to journalArticle

  2. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A

    Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H. S. Mar 2014 In : PLoS ONE. 9, 3, 10 p.e92255

    Research output: Contribution to journalArticle

  3. Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

    Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferré, P., Foufelle, F., Hundal, H. S. & Hajduch, E. 2014 In : PLoS ONE. 9, 7, 9 p.e101865

    Research output: Contribution to journalArticle

  4. Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance

    Palmer, M. J. & Harvey, J. 2014 In : Journal of Neurophysiology.

    Research output: Contribution to journalArticle

  5. International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

    Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R. R., Pin, J-P., Sexton, P. M., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J. 2014 In : Pharmacological Reviews. 66, 4, p. 918-947 30 p.

    Research output: Contribution to journalArticle

  6. Localisation and stress-induced plasticity of GABA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

    Corteen, N. L., Carter, J. A., Rudolph, U., Belelli, D., Lambert, J. J. & Swinny, J. D. 2014 In : Brain Structure and Function. June

    Research output: Contribution to journalArticle

  7. Phosphoinositide 3-kinases upregulate system xc- via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy

    Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M-A., Halatsch, M-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., Aronica, E., Smolders, I., Ludolph, A. C., Methner, A., Conrad, M., Massie, A., Hardingham, G. E. & Maher, P. 2014 In : Antioxidants & Redox Signaling. 20, 18, p. 2907-2922 16 p.

    Research output: Contribution to journalArticle

  8. Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

    Moreno, E., Andradas, C., Medrano, M., Caffarel, M. M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M. R., Irving, A. J., Lluís, C., Canela, E. I., Fernández-Ruiz, J., Guzmán, M., McCormick, P. J. & Sánchez, C. 2014 In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

  9. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress-response.

    Gunn, B., Cunningham, L., Cooper, M. A., Corteen, N., Seifi, M., Swinny, J. D., Lambert, J. J. & Belelli, D. 11 Dec 2013 In : Journal of Neuroscience. 33, 50, p. 19534-19554 21 p.

    Research output: Contribution to journalArticle

  10. Prolonged inhibition of 5-HT3 receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

    Hothersall, J. D., Moffat, C. & Connolly, C. N. Jul 2013 In : British Journal of Pharmacology. 169, 6, p. 1252-1262 11 p.

    Research output: Contribution to journalArticle

  11. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

    Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Jun 2013 In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

    Research output: Contribution to journalArticle

  12. Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

    Palmer, M. J., Moffat, C., Saranzewa, N., Harvey, J., Wright, G. A. & Connolly, C. N. 27 Mar 2013 In : Nature Communications. 4, 1634

    Research output: Contribution to journalArticle

  13. Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

    Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41 1 p.P43

    Research output: Contribution to journalMeeting abstract

  14. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2 1 p.P577

    Research output: Contribution to journalMeeting abstract

  15. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013

    Research output: Contribution to conferencePoster

  16. How does glucophage (metformin) work? Investigation of the cellular action of chemical analogues

    Logie, L., Bacon, S., Middleton, P., Harthill, J., Coats, J., Stewart, D., Sakamoto, K., McDougall, G. & Rena, G. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41 1 p.P44

    Research output: Contribution to journalMeeting abstract

  17. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49 1 p.P70

    Research output: Contribution to journalMeeting abstract

  18. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28 Feb 2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journalArticle

  19. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

    Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J. Feb 2013 In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

    Research output: Contribution to journalArticle

  20. The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland

    Bollan, K. A., Hothersall, J. D., Moffat, C., Durkacz, J., Saranzewa, N., Wright, G. A., Raine, N. E., Highet, F. & Connolly, C. N. Feb 2013 In : Parasitology Research. 112, 2, p. 751-759 9 p.

    Research output: Contribution to journalArticle

  21. Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.

    Doherty, G. H., Beccano-Kelly, D., Yan, S-D., Gunn-Moore, F. & Harvey, J. Jan 2013 In : Neurobiology of Aging. 34, 1, p. 226-37

    Research output: Contribution to journalArticle

  22. 5-chloroindole: a potent allosteric modulator of the 5-HT3 receptor

    Newman, A. . S., Batis, N., Grafton, G., Caputo, F., Brady, C. A., Lambert, J. J., Peters, J. A., Gordon, J., Barnes, N. M., Brain, K. L., Powell, A. D. & Barnes, N. M. 2013 In : British Journal of Pharmacology. 169, 6, p. 1228-1238 11 p.

    Research output: Contribution to journalArticle

  23. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

    Jensen, M. L., Wafford, K. A., Brown, A. R., Belelli, D., Lambert, J. J. & Mirza, N. R. 2013 In : British Journal of Pharmacology. 168, 5, p. 1118-1132 15 p.

    Research output: Contribution to journalArticle

  24. Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

    Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J. 2013

    Research output: Contribution to conferencePoster

  25. How does glucophage (metformin) work? Investigation of the cellular action of chemical analogues

    Logie, L., Bacon, S., Middleton, P., Harthill, J., Coats, J., Stewart, D., Sakamoto, K., McDougall, G. & Rena, G. 2013

    Research output: Contribution to conferencePoster

  26. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. 2013

    Research output: Contribution to conferencePoster

  27. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

    Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17 Dec 2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

    Research output: Contribution to journalArticle

  28. Hypoglycaemia: exercise for the brain?

    Ashford, M., Beall, C. & McCrimmon, R. Oct 2012 In : Journal of Neuroendocrinology. 24, 10, p. 1365-1366 2 p.

    Research output: Contribution to journalArticle

  29. Insulin resistance in the brain: An old-age or new-age problem?

    Williamson, R., McNeilly, A. & Sutherland, C. 15 Sep 2012 In : Biochemical Pharmacology. 84, 6, p. 737-45 9 p.

    Research output: Contribution to journalArticle

  30. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour

    Beall, C., Hamilton, D. L., Gallagher, J., Logie, L., Wright, K., Soutar, M. P., Dadak, S., Ashford, F. B., Haythorne, E., Du, Q., Jovanovic, A., McCrimmon, R. J. & Ashford, M. L. J. Sep 2012 In : Diabetologia. 55, 9, p. 2432-2444 13 p.

    Research output: Contribution to journalArticle

  31. Cannabinoid receptors in submandibular acinar cells: functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling

    Kopach, O., Vats, J., Netsyk, O., Voitenko, N., Irving, A. & Fedirko, N. 15 Apr 2012 In : Journal of Cell Science. 125, 8, p. 1884-1895 12 p.

    Research output: Contribution to journalArticle

  32. Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

    Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

    Research output: Contribution to journalArticle

  33. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coats, J., Stewart, D., McDougall, G. & Rena, G. 2012

    Research output: Contribution to conferencePoster

  34. Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses

    Bacon, S., Harthill, J., Coates, J., Stewart, D., McDougall, G. & Rena, G. 2012 In : Diabetic Medicine. 29, Suppl. 1, p. 41 1 p.P41

    Research output: Contribution to journalMeeting abstract

  35. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

    Schofield, C. J. & Sutherland, C. 2012 In : Diabetic Medicine. 29, 8, p. 972-979 8 p.

    Research output: Contribution to journalBook/Film/Article review

  36. From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits

    Youssef, F. F. & Irving, A. J. 2012 In : West Indian Medical Journal. 61, 3

    Research output: Contribution to journalArticle

  37. Identifying key knowledge needs for evidence-based conservation of wild insect pollinators: a collaborative cross-sectoral exercise

    Dicks, L. V. , Abrahams, A. , Atkinson, J. , Biesmeijer, J. , Bourn, N. , Brown, C. , Brown, M. J. F. , Carvell, C. , Connolly, C. , Cresswell, J. E. , Croft, P. , Darvill, B. , De Zylva, P. , Effingham, P. , Fountain, M. , Goggin, A. , Harding, D. , Harding, T. , Hartfield, C. , Heard, M. S. & 30 others Heathcote, R., Heaver, D., Holland, J., Howe, M., Hughes, B., Huxley, T., Kunin, W. E., Little, J., Mason, C., Memmott, J., Osborne, J., Pankhurst, T., Paxton, R. J., Pocock, M. J. O., Potts, S. G., Power, E. F., Raine, N. E., Ranelagh, E., Roberts, S., Saunders, R., Smith, K., Smith, R. M., Sutton, P., Tilley, L. A. N., Tinsley, A., Tonhasca, A., Vanbergen, A. J., Webster, S., Wilson, A. & Sutherland, W. J. 2012 In : Insect Conservation and Diversity. 6, 3, p. 435-446 12 p.

    Research output: Contribution to journalArticle

  38. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051 13 p.

    Research output: Contribution to journalArticle

  39. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

    Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D. 2012 In : Oncogene. 32, p. 3765-3781 17 p.

    Research output: Contribution to journalArticle

  40. Nrf2 orchestrates fuel partitioning for cell proliferation

    Hayes, J. D. & Ashford, M. L. J. 2012 In : Cell Metabolism. 16, 2, p. 139-141 3 p.

    Research output: Contribution to journalArticle

  41. Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule

    Zhang, H., Etherington, L-A., Hafner, A-S., Belelli, D., Coussen, F., Delagrange, P., Chaouloff, F., Spedding, M., Lambert, J. J., Choquet, D. & Groc, L. 2012 In : Molecular Psychiatry. 18, p. 471-484 14 p.

    Research output: Contribution to journalArticle

  42. Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

    Godfrey, V., Martin, A. L., Struthers, A. D. & Lyles, G. A. Dec 2011 In : British Journal of Pharmacology. 164, 8, p. 2003-2014 12 p.

    Research output: Contribution to journalArticle

  43. Guide to Receptors and Channels (GRAC), 5th edition

    Alexander, S. P. H., Mathie, A. & Peters, J. Nov 2011 In : British Journal of Pharmacology. 164, p. 12 2 p.

    Research output: Contribution to journalEditorial

  44. Distinct mechanisms regulate GABA(A) receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

    Panzanelli, P., Gunn, B. G., Schlatter, M. C., Benke, D., Tyagarajan, S. K., Scheiffele, P., Belelli, D., Lambert, J. J., Rudolph, U. & Fritschy, J-M. 15 Oct 2011 In : Journal of Physiology. 589, 20, p. 4959-4980 22 p.

    Research output: Contribution to journalArticle

  45. Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3

    Farghaian, H., Turnley, A. M., Sutherland, C. & Cole, A. R. 15 Jul 2011 In : Journal of Biological Chemistry. 286, 28, p. 25274-25283 10 p.

    Research output: Contribution to journalArticle

  46. Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)center dot Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

    Astle, M. V., Ooms, L. M., Cole, A. R., Binge, L. C., Dyson, J. M., Layton, M. J., Petratos, S., Sutherland, C. & Mitchell, C. A. 1 Jul 2011 In : Journal of Biological Chemistry. 286, 26, p. 23407-23418 12 p.

    Research output: Contribution to journalArticle

  47. Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A(1) Receptors

    zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. & Frenguelli, B. 20 Apr 2011 In : Journal of Neuroscience. 31, 16, p. 6221-6234 14 p.

    Research output: Contribution to journalArticle

  48. Neuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains

    Williamson, R. & Sutherland, C. 1 Mar 2011 In : Current Alzheimer Research. 8, 2, p. 213-221 9 p.

    Research output: Contribution to journalArticle

  49. Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

    Ashford, M. L. & 22 others Claret, M., Smith, M. A., Knauf, C., Al-Qassab, H., Woods, A., Heslegrave, A., Piipari, K., Emmanuel, J. J., Colom, A., Valet, P., Cani, P. D., Begum, G., White, A., Mucket, P., Peters, M., Mizuno, K., Batterham, R. L., Giese, K. P., Ashworth, A., Burcelin, R., Carling, D. & Withers, D. J. Mar 2011 In : Diabetes. 60, 3, p. 735-745 11 p.

    Research output: Contribution to journalArticle

  50. CRMP2 Hyperphosphorylation is Characteristic of Alzheimer's Disease and not a Feature Common to Other Neurodegenerative Diseases

    Williamson, R., van Aalten, L., Mann, D. M. A., Platt, B., Plattner, F., Bedford, L., Mayer, J., Howlett, D., Usardi, A., Sutherland, C. & Cole, A. R. 2011 In : Journal of Alzheimer's Disease. 27, 3, p. 615-625 11 p.

    Research output: Contribution to journalArticle

  51. NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

    Moult, P. R. & Harvey, J. 2011 In : Neuropharmacology. 61, 5-6, p. 924-936 13 p.

    Research output: Contribution to journalArticle

  52. What are the bona fide GSK3 substrates?

    Sutherland, C. 2011 In : International Journal of Alzheimer's Disease. 2011, p. 1-23

    Research output: Contribution to journalArticle

  53. Regulation of Tau-Dependent Toxicity by Brain Selective/SAD Kinases

    Lyn-Adams, C., Frenguelli, B., Moffat, K. & Sutherland, C. Dec 2010 In : Journal of Neurogenetics. 24, p. 12-12 1 p.

    Research output: Contribution to journalMeeting abstract

  54. Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

    Soutar, M. P. M., Kim, W-Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R. & Sutherland, C. Nov 2010 In : Journal of Neurochemistry. 115, 4, p. 974-983 10 p.

    Research output: Contribution to journalArticle

  55. Generation, validation and humanisation of a novel insulin resistant cell model

    Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C. 1 Oct 2010 In : Biochemical Pharmacology. 80, 7, p. 1042-1049 8 p.

    Research output: Contribution to journalArticle

  56. Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

    Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J. & Ashford, M. L. J. 15 Jul 2010 In : Biochemical Journal. 429, 2, p. 323-333 11 p.

    Research output: Contribution to journalArticle

  57. Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

    Clayton, E. L., Sue, N., Smillie, K. J., O'Leary, T., Bache, N., Cheung, G., Cole, A. R., Wyllie, D. J., Sutherland, C., Robinson, P. J. & Cousin, M. A. Jul 2010 In : Nature Neuroscience. 13, 7, p. 845-U85 9 p.

    Research output: Contribution to journalArticle

  58. Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis

    Piipari, K., Beall, C., Al-Qassab, H., Smith, M. A., Carling, D., Viollet, B., Ashford, M. L. J. & Withers, D. J. Jun 2010 In : Endocrine Reviews. 31, 3, p. S810-S810 1 p.

    Research output: Contribution to journalBook/Film/Article review

  59. Leptin: The Missing Link in Alzheimer Disease?

    Harvey, J. May 2010 In : Clinical Chemistry. 56, 5, p. 696-697 2 p.

    Research output: Contribution to journalEditorial

  60. GSK3 beta Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

    Alabed, Y. Z., Pool, M., Tone, S. O., Sutherland, C. & Fournier, A. E. 21 Apr 2010 In : Journal of Neuroscience. 30, 16, p. 5635-5643 9 p.

    Research output: Contribution to journalArticle

  61. All tangled up: tau-dependent neurodegeneration

    Lyn-Adams, C., Moffat, K., Sutherland, C. & Frenguelli, B. G. 1 Apr 2010 In : Biochemist. 32, 2, p. 10-13 4 p.

    Research output: Contribution to journalArticle

  62. Impact of the chaperone RIC-3 on the expression of human 5-HT3 receptors: role of 5-HT3 B, C, D and E subunits

    Walstab, J., Hammer, C., Lasitschka, F., Connolly, C., Rappold, G., Boenisch, H. & Niesler, B. Mar 2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 16-16 1 p.

    Research output: Contribution to journalBook/Film/Article review

  63. Cocaine effects on mouse incentive-learning and human addiction are linked to alpha 2 subunit-containing GABA(A) receptors

    Dixon, C. I., Morris, H. V., Breen, G., Desrivieres, S., Jugurnauth, S., Steiner, R. C., Vallada, H., Guindalini, C., Laranjeira, R., Messas, G., Rosahl, T. W., Atack, J. R., Peden, D. R., Belelli, D., Lambert, J. J., King, S. L., Schumann, G. & Stephens, D. N. 2 Feb 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2289-2294 6 p.

    Research output: Contribution to journalArticle

  64. Neurosteroids: Endogenous allosteric modulators of GABA receptors

    Lambert, J. J., Cooper, M. A., Simmons, R. D. J., Weir, C. J. & Belelli, D. 1 Dec 2009 In : Psychoneuroendocrinology. 34, SUPPL. 1

    Research output: Contribution to journalArticle

  65. Rapid dendritic and axonal responses to neuronal insults

    Mizielinska, S. M., Greenwood, S. M., Tummala, H. & Connolly, C. N. Dec 2009 In : Biochemical Society Transactions. 37, p. 1389-1393 5 p.

    Research output: Contribution to journalArticle

  66. Regulation of glutamate receptor trafficking by leptin

    Moult, P. R. & Harvey, J. Dec 2009 In : Biochemical Society Transactions. 37, p. 1364-1368 5 p.

    Research output: Contribution to journalArticle

  67. Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons

    Al-Qassab, H., Smith, M. A., Irvine, E. E., Guillermet-Guibert, J., Claret, M., Choudhury, A. I., Selman, C., Piipari, K., Clements, M., Lingard, S., Chandarana, K., Bell, J. D., Barsh, G. S., Smith, A. J. H., Batterham, R. L., Ashford, M. L. J., Vanhaesebroeck, B. & Withers, D. J. 4 Nov 2009 In : Cell Metabolism. 10, 5, p. 343-354 12 p.

    Research output: Contribution to journalArticle

  68. An in vitro model for the prediction of chemical metabolism and toxicity

    Ding, S-H., Vardy, A., Elcombe, C. R. & Wolf, C. R. 28 Jul 2009 In : Toxicology. 262, 1, p. 23-23 1 p.

    Research output: Contribution to journalBook/Film/Article review

  69. Increased CRMP2 Phosphorylation is Observed in Alzheimer's Disease: Does this Tell us Anything About Disease Development?

    Soutar, M. P. M., Thornhill, P., Cole, A. R. & Sutherland, C. Jun 2009 In : Current Alzheimer Research. 6, 3, p. 269-278 10 p.

    Research output: Contribution to journalArticle

  70. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

    Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J. May 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048 7 p.

    Research output: Contribution to journalArticle

  71. Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels

    Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. & Ashford, M. L. J. 3 Apr 2009 In : Journal of Biological Chemistry. 284, 14, p. 9331-9340 10 p.

    Research output: Contribution to journalArticle

  72. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15 Mar 2009 In : Biochemical Journal. 418, p. 665-671 7 p.

    Research output: Contribution to journalArticle

  73. 5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus

    Hisadome, K., Smith, M. A., Choudhury, A. I., Claret, M., Withers, D. J. & Ashford, M. L. J. 3 Mar 2009 In : Neuroscience. 159, 1, p. 83-93 11 p.

    Research output: Contribution to journalArticle

  74. Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors

    Herd, M. B., Foister, N., Chandra, D., Peden, D. R., Homanics, G. E., Brown, V. J., Balfour, D. J. K., Lambert, J. J. & Belelli, D. Mar 2009 In : European Journal of Neuroscience. 29, 6, p. 1177-1187 11 p.

    Research output: Contribution to journalArticle

  75. Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus

    Etherington, L-A. V., Patterson, G. E., Meechan, L., Boison, D., Irving, A. J., Dale, N. & Frenguelli, B. G. Feb 2009 In : Neuropharmacology. 56, 2, p. 429-437 9 p.

    Research output: Contribution to journalArticle

  76. Leptin reverses long-term potentiation at hippocampal CA1 synapses

    Moult, P. R., Milojkovic, B. & Harvey, J. Feb 2009 In : Journal of Neurochemistry. 108, 3, p. 685-696 12 p.

    Research output: Contribution to journalArticle

  77. Bi-directional modulation of fast inhibitory synaptic transmission by leptin

    Solovyova, N., Moult, P. R., Milojkovic, B., Lambert, J. J. & Harvey, J. Jan 2009 In : Journal of Neurochemistry. 108, 1, p. 190-201 12 p.

    Research output: Contribution to journalArticle

  78. Novel compounds selectively enhance delta subunit containing GABA(A) receptors and increase tonic currents in thalamus

    Wafford, K. A., van Niel, M. B., Ma, Q. P., Horridge, E., Herd, M. B., Peden, D. R., Belelli, D. & Lambert, J. Jan 2009 In : Neuropharmacology. 56, 1, p. 182-189 8 p.

    Research output: Contribution to journalArticle

  79. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

    Henstridge, C. M., Balenga, N. A. B., Ford, L. A., Ross, R. A., Waldhoer, M. & Irving, A. J. 2009 In : FASEB Journal. 23, 1, p. 183-193 11 p.

    Research output: Contribution to journalArticle

  80. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2009 In : Diabetologia. 52, Suppl. 1, p. S203-S203 1 p.PS 29

    Research output: Contribution to journalMeeting abstract

  81. Anaesthesia generates neuronal insulin resistance by inducing hypothermia

    Holscher, C., van Aalten, L. & Sutherland, C. 9 Oct 2008 In : BMC Neuroscience. 9, p. - 7 p.100

    Research output: Contribution to journalArticle

  82. Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

    Moult, P. R. & Harvey, J. 1 Oct 2008 In : Cell Adhesion and Migration. 2, 4, p. 269-275 7 p.

    Research output: Contribution to journalArticle

  83. The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development

    Reis, B., Finkenstaedt, D., Finlay, D. K., Cantrell, D. A., Pfeffer, K. & Beer, S. Aug 2008 In : Wiener Klinische Wochenschrift. 120, Supplement 1, p. 20-20 1 p.057

    Research output: Contribution to journalBook/Film/Article review

  84. Neuroprotective actions of leptin on central and peripheral neurons in vitro

    Doherty, G. H., Oldreive, C. & Harvey, J. 17 Jul 2008 In : Neuroscience. 154, 4, p. 1297-1307 11 p.

    Research output: Contribution to journalArticle

  85. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation

    Cole, A. R., Soutar, M. P. M., Rembutsu, M., van Aalten, L., Hastie, C. J., Mclauchlan, H., Peggie, M., Balastik, M., Lu, K. P. & Sutherland, C. 27 Jun 2008 In : Journal of Biological Chemistry. 283, 26, p. 18227-18237 11 p.

    Research output: Contribution to journalArticle

  86. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May 2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

    Research output: Contribution to journalArticle

  87. Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells

    Rembutsu, M., Soutar, M. P. M., Van Aalten, L., Gourlay, R., Hastie, C. J., McLauchlan, H., Morrice, N. A., Cole, A. R. & Sutherland, C. 19 Feb 2008 In : Biochemistry. 47, 7, p. 2153-2161 9 p.

    Research output: Contribution to journalArticle

  88. Developmental maturation of synaptic and extrasynaptic GABA(A) receptors in mouse thalamic ventrobasal neurones

    Peden, D. R., Petitjean, C. M., Herd, M. B., Durakoglugil, M. S., Rosahl, T. W., Wafford, K., Homanics, G. E., Belelli, D., Fritschy, J-M. & Lambert, J. J. 15 Feb 2008 In : Journal of Physiology. 586, 4, p. 965-987 23 p.

    Research output: Contribution to journalArticle

  89. Identification of small compounds that mimic insulin action on the transcription factor FOXO1a

    Cameron, A., Anton, S., Reetoo, N., Melville, L., Houston, N., Dayal, S., McDougall, G., Stewart, D. & Rena, G. 2008 In : Diabetes. 57, Suppl., p. A699-A700 2 p.

    Research output: Contribution to journalMeeting abstract

  90. Measuring GSK3 expression and activity in cells

    Cole, A. R. & Sutherland, C. 2008 Wnt signaling: pathway methods and mammalian models. Vincan , E. (ed.). Humana Press, p. 45-65 21 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  91. Neurosteroid modulation of GABA(A) receptors: Molecular determinants and significance in health and disease

    Mitchell, E. A., Herd, M. B., Gunn, B. G., Lambert, J. J. & Belelli, D. 2008 In : Neurochemistry International. 52, 4-5, p. 588-595 8 p.

    Research output: Contribution to journalArticle

  92. Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

    Oldreive, C. E., Harvey, J. & Doherty, G. H. 2008 In : Neuroscience Letters. 438, 1, p. 17-21 5 p.

    Research output: Contribution to journalArticle

  93. The identification and characterisation of compounds with insulin-like properties

    Cameron, A. R., Harthill, J. & Rena, G. 2008

    Research output: Contribution to conferencePoster

  94. Trafficking of 5-HT3 and GABA(A) receptors (Review)

    Connolly, C. 2008 In : Molecular Membrane Biology. 25, 4, p. 293-301 9 p.

    Research output: Contribution to journalScientific review

  95. Dendritic and mitochondrial changes during glutamate excitotoxicity

    Greenwood, S. M. & Connolly, C. N. Dec 2007 In : Neuropharmacology. 53, 8, p. 891-898 8 p.

    Research output: Contribution to journalScientific review

  96. Leptin regulation of neuronal excitability and cognitive function

    Harvey, J. Dec 2007 In : Current Opinion in Pharmacology. 7, 6, p. 643-647 5 p.

    Research output: Contribution to journalScientific review

  97. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

    Cole, A. R., Noble, W., van Aalten, L., Plattner, F., Meimaridou, R., Hogan, D., Taylor, M., LaFrancois, J., Gunn-Moore, F., Verkhratsky, A., Oddo, S., LaFerla, F., Giese, K. P., Dineley, K. T., Duff, K., Richardson, J. C., Du Yan, S., Hanger, D. P., Allan, S. M. & Sutherland, C. Nov 2007 In : Journal of Neurochemistry. 103, 3, p. 1132-1144 13 p.

    Research output: Contribution to journalArticle

  98. Differential subcellular localization of RIC-3 Isoforms and their role in determining 5-HT3 receptor composition

    Cheng, A., Bollan, K. A., Greenwood, S. M., Irving, A. J. & Connolly, C. N. 7 Sep 2007 In : Journal of Biological Chemistry. 282, 36, p. 26158-26166 9 p.

    Research output: Contribution to journalArticle

  99. Mitochondrial dysfunction and dendritic beading during neuronal toxicity

    Greenwood, S. M., Mizielinska, S. M., Frenguelli, B. G., Harvey, J. & Connolly, C. N. 7 Sep 2007 In : Journal of Biological Chemistry. 282, 36, p. 26235-26244 10 p.

    Research output: Contribution to journalArticle

  100. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep 2007 In : Diabetes. 56, 9, p. 2218-2227 10 p.

    Research output: Contribution to journalArticle

  101. GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids

    Mitchell, E. A., Gentet, L. J., Dempster, J. & Belelli, D. Sep 2007 In : Journal of Physiology. 583, 3, p. 1021-1040 20 p.

    Research output: Contribution to journalArticle

  102. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

    Claret, M., Smith, M. A., Batterham, R. L., Selman, C., Choudhury, A. I., Fryer, L. G. D., Clements, M., Al-Qassab, H., Heffron, H., Xu, A. W., Speakman, J. R., Barsh, G. S., Viollet, B., Vaulont, S., Ashford, M. L. J., Carling, D. & Withers, D. J. Aug 2007 In : Journal of Clinical Investigation. 117, 8, p. 2325-2336 12 p.

    Research output: Contribution to journalArticle

  103. Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

    O'Malley, D., MacDonald, N., Mizielinska, S., Connolly, C. N., Irving, A. J. & Harvey, J. Aug 2007 In : Molecular and Cellular Neuroscience. 35, 4, p. 559-572 14 p.

    Research output: Contribution to journalArticle

  104. BVT.3531 reduces body weight and activates KATP channels in isolated arcuate neurons in rats

    Mirshamsi, S., Olsson, M., Arnelo, U., Kinsella, J. M., Permert, J. & Ashford, M. L. J. Jun 2007 In : Regulatory Peptides. 141, 1-3, p. 19-24 6 p.

    Research output: Contribution to journalArticle

  105. Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging

    McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J. Jun 2007 In : Molecular and Cellular Neuroscience. 35, 2, p. 237-248 12 p.

    Research output: Contribution to journalArticle

  106. Cannabinoid modulation of neuronal function after oxygen/glucose deprivation in area CA1 of the rat hippocampus

    Youssef, F. F., Hormuzdi, S. G., Irving, A. J. & Frenguelli, B. G. May 2007 In : Neuropharmacology. 52, 6, p. 1327-1335 9 p.

    Research output: Contribution to journalArticle

  107. Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

    Krzywkowski, K., Jensen, A. A., Connolly, C. N. & Brauner-Osborne, H. Apr 2007 In : Pharmacogenetics and Genomics. 17, 4, p. 255-266 12 p.

    Research output: Contribution to journalArticle

  108. Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor

    Deeb, T. Z., Carland, J. E., Cooper, M. A., Livesey, M. R., Lambert, J. J., Peters, J. A. & Hales, T. G. Mar 2007 In : Journal of Biological Chemistry. 282, 9, p. 6172-6182 11 p.

    Research output: Contribution to journalArticle

  109. A neural protection racket: AMPK and the GABAB receptor

    Hardie, D. G. & Frenguelli, B. G. 18 Jan 2007 In : Neuron. 53, 2, p. 159-162 4 p.

    Research output: Contribution to journalArticle

  110. Leptin: a diverse regulator of neuronal function

    Harvey, J. Jan 2007 In : Journal of Neurochemistry. 100, 2, p. 307-313 7 p.

    Research output: Contribution to journalArticle

  111. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances

    Smith, M. A., Hisadome, K., Al-Qassab, H., Heffron, H., Withers, D. J. & Ashford, M. L. J. Jan 2007 In : Journal of Physiology. 578, 2, p. 425-438 14 p.

    Research output: Contribution to journalArticle

  112. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084 7 p.

    Research output: Contribution to journalArticle

  113. An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor

    McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J. 2007 In : Molecular Pharmacology. 71, 4, p. 976-984 9 p.

    Research output: Contribution to journalArticle

  114. Hardwiring the brain: endocannabinoids shape neuronal connectivity

    Berghuis, P., Rajnicek, A. M., Morozov, Y. M., Ross, R. A., Mulder, J., Urban, G. M., Monory, K., Marsicano, G., Matteoli, M., Canty, A., Irving, A. J., Katona, I., Yanagawa, Y., Rakic, P., Lutz, B., Mackie, K. & Harkany, T. 2007 In : Science. 316, 5828, p. 1212-1216 5 p.

    Research output: Contribution to journalArticle

  115. MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin

    O'Malley, D. & Harvey, J. 2007 In : European Journal of Neuroscience. 25, 3, p. 673-682 10 p.

    Research output: Contribution to journalArticle

  116. Molecular connexions between dementia and diabetes

    Cole, A. R., Astell, A., Green, C. & Sutherland, C. 2007 In : Neuroscience and Biobehavioral Reviews. 31, 7, p. 1046-1063 18 p.

    Research output: Contribution to journalScientific review

  117. A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

    Finlay, D., Ruiz-Alcaraz, A. J., Lipina, C., Perrier, S. & Sutherland, C. Oct 2006 In : Journal of Molecular Endocrinology. 37, 2, p. 227-237 11 p.

    Research output: Contribution to journalArticle

  118. An asymmetric contribution to gamma-aminobutyric type a receptor function of a conserved lysine within TM2-3 of alpha 1, beta 2, and gamma 2 subunits

    Hales, T. G., Deeb, T. Z., Tang, H., Bollan, K. A., King, D. P., Johnson, S. J. & Connolly, C. N. 23 Jun 2006 In : Journal of Biological Chemistry. 281, 25, p. 17034-17043 10 p.

    Research output: Contribution to journalArticle

  119. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

    Cole, A. R., Causeret, F., Yadirgi, G., Hastie, C. J., Mclauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M., Sutherland, C. & Sutherland, C. 16 Jun 2006 In : Journal of Biological Chemistry. 281, 24, p. 16591-16598 8 p.

    Research output: Contribution to journalArticle

  120. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

    Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J. Jun 2006 In : The EMBO Journal. 25, 11, p. 2377-2387 11 p.

    Research output: Contribution to journalArticle

  121. Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and α4β2 nicotinic acetylcholine receptors

    Hales, T. G., Dunlop, J. I., Deeb, T. Z., Carland, J. E., Kelley, S. P., Lambert, J. J. & Peters, J. A. Mar 2006 In : Journal of Biological Chemistry. 281, 12, p. 8062-8071 10 p.

    Research output: Contribution to journalArticle

  122. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol

    Borghese, C. M., Storustovu, S. I., Ebert, B., Herd, M. B., Belelli, D., Lambert, J. J., Marshall, G., Wafford, K. A. & Harris, R. A. Mar 2006 In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1360-1368 9 p.

    Research output: Contribution to journalArticle

  123. The role of GABAA receptor biogenesis, structure and function in epilepsy

    Mizielinska, S., Greenwood, S. & Connolly, C. N. 2006 In : Biochemical Society Transactions. 34, 5, p. 863-867 5 p.

    Research output: Contribution to journalArticle

  124. The role of GABAA receptor biogenesis, structure and function in epilepsy

    Mizielinska, S., Greenwood, S. & Connolly, C. N. 2006

    Research output: Contribution to conferencePaper

  125. A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

    Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C. 1 Dec 2005 In : Biochemical Journal. 392, p. 345-352 8 p.

    Research output: Contribution to journalArticle

  126. Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels

    O'Malley, D., Irving, A. J. & Harvey, J. Nov 2005 In : FASEB Journal. 19, 11, p. 1917-1919 3 p.

    Research output: Contribution to journalArticle

  127. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

    Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. & Hardie, D. G. Jul 2005 In : Cell Metabolism. 2, 1, p. 9-19 11 p.

    Research output: Contribution to journalArticle

  128. Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3

    Cheng, A., McDonald, N. A. & Connolly, C. N. 10 Jun 2005 In : Journal of Biological Chemistry. 280, 23, p. 22502-22507 6 p.

    Research output: Contribution to journalArticle

  129. Activation of hypothalamic ATP-sensitive K+ channels by the aminoguanidine carboxylate BVT.12777

    Mirshamsi, S., Laidlaw, H. A., Spanswick, D. & Ashford, M. L. J. Apr 2005 In : Journal of Neuroendocrinology. 17, 4, p. 246-254 9 p.

    Research output: Contribution to journalArticle

  130. The role of insulin receptor substrate 2 in hypothalamic and β cell function

    Choudhury, A. I., Heffron, H., Smith, M. A., Al-Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., Bedford, D. C., Hisadome, K., Diakonov, I., Moosajee, V., Bell, J. D., Speakman, J. R., Batterham, R. L., Barsh, G. S., Ashford, M. L. J. & Withers, D. J. Apr 2005 In : Journal of Clinical Investigation. 115, 4, p. 940-950 11 p.

    Research output: Contribution to journalArticle

  131. Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells

    MacAulay, K., Blair, A. S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C. & Hundal, H. S. 11 Mar 2005 In : Journal of Biological Chemistry. 280, 10, p. 9509-9518 10 p.

    Research output: Contribution to journalArticle

  132. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

    Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. & Wolf, C. R. 2005 In : Journal of Biological Chemistry. 280, 6, p. 4367-4373 7 p.

    Research output: Contribution to journalArticle

  133. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639 7 p.

    Research output: Contribution to journalArticle

  134. Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons

    Ward, M. W., Kushnareva, Y., Greenwood, S. & Connolly, C. N. 2005 In : Journal of Neurochemistry. 92, 5, p. 1081-1090 10 p.

    Research output: Contribution to journalArticle

  135. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648 10 p.

    Research output: Contribution to journalArticle

  136. Extrasynaptic GABA(A) receptors of thalamocortical neurons: a molecular target for hypnotics

    Belelli, D., Peden, D. R., Rosahl, T. W., Wafford, K. A. & Lambert, J. J. 2005 In : Journal of Neuroscience. 25, 50, p. 11513-11520 8 p.

    Research output: Contribution to journalArticle

  137. The epilepsy mutation, γ2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors

    Hales, T. G., Tang, H., Bollan, K. A., Johnson, S. J., King, D. P., McDonald, N. A., Cheng, A. & Connolly, C. N. 2005 In : Molecular and Cellular Neuroscience. 29, 1, p. 120-127 8 p.

    Research output: Contribution to journalArticle

  138. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and K-ATP channel activation

    Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C. & Ashford, M. L. J. 6 Dec 2004 In : BMC Neuroscience. 5, p. - 18 p.54

    Research output: Contribution to journalArticle

  139. GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons

    Cole, A. R., Knebel, A., Morrice, N. A., Robertson, L. A., Irving, A. J., Connolly, C. N. & Sutherland, C. 26 Nov 2004 In : Journal of Biological Chemistry. 279, 48, p. 50176-50180 5 p.

    Research output: Contribution to journalArticle

  140. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

    Caraiscos, V. B., Elliott, E. M., You-Ten, K. E., Cheng, V. Y., Belelli, D., Newell, J. G., Jackson, M. F., Lambert, J. J., Rosahl, T. W., Wafford, K. A., MacDonald, J. F., Orser, B. A. & Iversen, L. L. (ed.) Mar 2004 In : Proceedings of the National Academy of Sciences of the United States of America. 101, 10, p. 3662-3667 6 p.

    Research output: Contribution to journalArticle

  141. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a

    Rena, G., Bain, J., Elliott, M. & Cohen, P. 2004 In : EMBO Reports. 5, 1, p. 60-65 6 p.

    Research output: Contribution to journalArticle

  142. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

    Finlay, D., Patel, S., Dickson, L. M., Shpiro, N., Marquez, R., Rhodes, C. J. & Sutherland, C. 2004 In : BMC Molecular Biology. 5, p. - 13 p.15

    Research output: Contribution to journalArticle

  143. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

    Lambert, J. J. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Thompson, A. M. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886 12 p.

    Research output: Contribution to journalArticle

  144. The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

    Kinsella, J. M., Laidlaw, H. A., Tang, T., Harvey, J., Sutherland, C. & Ashford, M. L. J. 2004 In : BMC Clinical Pharmacology. 4, 17, 13 p.

    Research output: Contribution to journalArticle

  145. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function

    Connolly, C. N. & Wafford, K. A. 2004 In : Biochemical Society Transactions. 32, p. 529-534 6 p.

    Research output: Contribution to journalArticle

  146. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function

    Connolly, C. N. & Wafford, K. A. 2004

    Research output: Contribution to conferencePaper

  147. Tumour necrosis factor a decreases glucose-6-phosphatase gene expression by activation of nuclear factor kB

    Grempler, R., Kienitz, A., Werner, T., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R. & Schmoll, D. 2004 In : Biochemical Journal. 382, p. 471-479 9 p.

    Research output: Contribution to journalArticle

  148. Sedation and anesthesia mediated by distinct GABAA receptor isoforms

    Reynolds, D. S., Rosahl, T. W., Cirone, J., O'Meara, G. F., Haythornthwaite, A., Newman, R. J., Myers, J., Sur, C., Howell, O., Rutter, A. R., Atack, J., Macaulay, A. J., Hadingham, K. L., Hutson, P. H., Belelli, D., Lambert, J., Dawson, G. R., McKernan, R., Whiting, P. J. & Wafford, K. A. Sep 2003 In : Journal of Neuroscience. 23, 24, p. 8608-8617 10 p.

    Research output: Contribution to journalArticle

  149. Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal

    Boyd, G. W., Doward, A. I., Kirkness, E. F., Millar, N. S. & Connolly, C. N. 25 Jul 2003 In : Journal of Biological Chemistry. 278, 30, p. 27681-27687 7 p.

    Research output: Contribution to journalArticle

  150. A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

    Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J. & Peters, J. A. Jul 2003 In : Nature. 424, 6946, p. 321-324 4 p.

    Research output: Contribution to journalArticle

  151. The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

    Belelli, D., Muntoni, A-L., Merrywest, S. D., Gentet, L. J., Casula, A., Callachan, H., Madau, P., Gemmell, D. K., Hamilton, N. M., Lambert, J. J., Sillar, K. T. & Peters, J. A. Jul 2003 In : Neuropharmacology. 45, 1, p. 57-71 15 p.

    Research output: Contribution to journalArticle

  152. Leptin in the CNS: much more than a satiety signal

    Harvey, J. & Ashford, M. L. J. Jun 2003 In : Neuropharmacology. 44, 7, p. 845-54 10 p.

    Research output: Contribution to journalArticle

  153. Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel

    Smith, M. A., Herson, P. S., Lee, K., Pinnock, R. D. & Ashford, M. L. J. 1 Mar 2003 In : Journal of Physiology. 547, 2, p. 417-425 9 p.

    Research output: Contribution to journalArticle

  154. Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

    Patel, S., Lipina, C. & Sutherland, C. 2003 In : FEBS Letters. 549, 1-3, p. 72-76 5 p.

    Research output: Contribution to journalArticle

  155. GABAA receptor composition is determined by distinct assembly signals within α and β subunits

    Bollan, K., King, D., Robertson, L. A., Brown, K., Taylor, P. M., Moss, S. J. & Connolly, C. N. 2003 In : Journal of Biological Chemistry. 278, 7, p. 4747-4755 9 p.

    Research output: Contribution to journalArticle

  156. Multiple assembly signals in g-aminobutyric acid (type A) receptor subunits combine to drive receptor construction and composition

    Bollan, K., Robertson, L. A., Tang, H. & Connolly, C. N. 2003 In : Biochemical Society Transactions. 31, 4, p. 875-879 5 p.

    Research output: Contribution to journalArticle

  157. Multiple assembly signals in g-aminobutyric acid (type A) receptor subunits combine to drive receptor construction and composition

    Bollan, K., Robertson, L. A., Tang, H. & Connolly, C. N. 2003

    Research output: Contribution to conferencePaper

  158. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels

    Shanley, L. J., O'Malley, D., Irving, A. J., Ashford, M. L. & Harvey, J. Dec 2002 In : Journal of Physiology. 545, 3, p. 933-944 12 p.

    Research output: Contribution to journalArticle

  159. Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels

    Ainscow, E. K., Mirshamsi, S., Tang, T., Ashford, M. L. J. & Rutter, G. A. 15 Oct 2002 In : Journal of Physiology. 544, 2, p. 429-445 17 p.

    Research output: Contribution to journalArticle

  160. The influence of subunit composition on the interaction of neurosteroids with GABAA receptors

    Belelli, D., Casula, A., Ling, A. & Lambert, J. J. Sep 2002 In : Neuropharmacology. 43, 4, p. 651-661 11 p.

    Research output: Contribution to journalArticle

  161. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

    Shanley, L. J., Irving, A. J., Rae, M. G., Ashford, M. L. J. & Harvey, J. Apr 2002 In : Nature Neuroscience. 5, 4, p. 299-300 2 p.

    Research output: Contribution to journalArticle

  162. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity

    Patel, S., Lochhead, P. A., Rena, G., Fumagalli, S., Pende, M., Kozma, S. C., Thomas, G. & Sutherland, C. 22 Mar 2002 In : Journal of Biological Chemistry. 277, 12, p. 9889-9895 7 p.

    Research output: Contribution to journalArticle

  163. Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins

    Boyd, G. W., Low, P., Dunlop, J. I., Robertson, L. A., Vardy, A., Lambert, J. J., Peters, J. A. & Connolly, C. N. 2002 In : Molecular and Cellular Neuroscience. 21, 1, p. 38-50 13 p.

    Research output: Contribution to journalArticle

  164. Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

    Woods, Y. L. & Rena, G. 2002 In : Biochemical Society Transactions. 30, 4, p. 391-397 7 p.

    Research output: Contribution to journalArticle

  165. Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

    Woods, Y. L. & Rena, G. 2002

    Research output: Contribution to conferencePaper

  166. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

    Research output: Contribution to journalArticle

  167. Vanilloid receptor type 1-immunoreactivity is expressed by intrinsic afferent neurones in the guinea-pig myenteric plexus

    Anavi-Goffer, S., McKay, N. G., Ashford, M. L. J. & Coutts, A. A. 2002 In : Neuroscience Letters. 319, 1, p. 53-57 5 p.

    Research output: Contribution to journalArticle

  168. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity

    Shanley, L. J., Irving, A. J. & Harvey, J. Dec 2001 In : Journal of Neuroscience. 21, 24, p. RC186-1-RC186-6

    Research output: Contribution to journalArticle

  169. Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons

    Coutts, A. A., Anavi-Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G. & Irving, A. J. Apr 2001 In : Journal of Neuroscience. 21, 7, p. 2425-2433 9 p.

    Research output: Contribution to journalArticle

  170. Does passive smoking increase the frequency of health service contacts in children with asthma?

    Crombie, I. K., Wright, A., Irvine, L., Clark, R. A. & Slane, P. W. Jan 2001 In : Thorax. 56, 1, p. 9-12 4 p.

    Research output: Contribution to journalArticle

  171. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression

    Lochhead, P. A., Coghlan, M., Rice, S. Q. J. & Sutherland, C. 2001 In : Diabetes. 50, 5, p. 937-946 10 p.

    Research output: Contribution to journalArticle

  172. Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10

    Rena, G., Begg, F., Ross, A., Mackenzie, C., Mcphee, I., Campbell, L., Huston, E., Sullivan, M. & Houslay, M. D. 2001 In : Molecular Pharmacology. 59, 5, p. 996-1011 16 p.

    Research output: Contribution to journalArticle

  173. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612 8 p.

    Research output: Contribution to journalArticle

  174. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G. & Cohen, P. 2001 In : Biochemical Journal. 355, 3, p. 597-607 11 p.

    Research output: Contribution to journalArticle

  175. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

    Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G. & Sutherland, C. 2000 In : Diabetes. 49, 6, p. 896-903 8 p.

    Research output: Contribution to journalArticle

  176. Analysis of GABAA receptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras

    Kittler, J. T., Wang, J., Connolly, C. N., Vicini, S., Smart, T. G. & Moss, S. J. 2000 In : Molecular and Cellular Neuroscience. 16, 4, p. 440-452 13 p.

    Research output: Contribution to journalArticle

  177. Identification of residues within GABAA receptor subunits that mediate specific assembly with receptor β subunits

    Taylor, P. M., Connolly, C. N., Kittler, J. T., Gorrie, G. H., Hosie, A., Smart, T. G. & Moss, S. J. 2000 In : Journal of Neuroscience. 20, 4, p. 1297-1306 10 p.

    Research output: Contribution to journalArticle

  178. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

    Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H. & Ashford, M. L. J. 2000 In : Nature Neuroscience. 3, 8, p. 757-758 2 p.

    Research output: Contribution to journalArticle

  179. Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDES): two N-terminal, domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum

    Shakur, Y., Takeda, K., Kenan, Y., Yu, Z-X., Rena, G., Brandt, D., Houslay, M. D., Degerman, E., Ferrans, V. J. & Manganiello, V. C. 2000 In : Journal of Biological Chemistry. 275, 49, p. 38749-38761 13 p.

    Research output: Contribution to journalArticle

  180. NF-kappa B inhibits glucocorticoid and cAMP-mediated expression of the phosphoenolpyruvate carboxykinase gene

    Waltner-Law, M., Daniels, M. C., Sutherland, C. & Granner, D. K. 2000 In : Journal of Biological Chemistry. 275, 41, p. 31847-31856 10 p.

    Research output: Contribution to journalArticle

  181. Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the KATP channel inhibitors, ciclazindol and englitazone

    McKay, N. G., Kinsella, J. M., Campbell, C. M. & Ashford, M. L. J. 2000 In : British Journal of Pharmacology. 130, 4, p. 857-866 10 p.

    Research output: Contribution to journalArticle

  182. The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

    Wang, J-C., Stafford, J. M., Scott, D. K., Sutherland, C. & Granner, D. K. 2000 In : Journal of Biological Chemistry. 275, 19, p. 14717-14721 5 p.

    Research output: Contribution to journalArticle

  183. Inactivation of large-conductance, calcium-activated potassium channels in rat cortical neurons

    Smith, M. A. & Ashford, M. L. J. Nov 1999 In : Neuroscience. 95, 1, p. 33-50 18 p.

    Research output: Contribution to journalArticle

  184. Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Cλ do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

    Kotani, K., Ogawa, W., Hino, Y., Kitamura, T., Ueno, H., Sano, W., Sutherland, C., Granner, D. K. & Kasuga, M. 1999 In : Journal of Biological Chemistry. 274, 30, p. 21305-21312 8 p.

    Research output: Contribution to journalArticle

  185. Modulation of neuronal and recombinant GABAA receptors by redox reagents

    Amato, A., Connolly, C. N., Moss, S. J. & Smart, T. G. 1999 In : Journal of Physiology. 517, 1, p. 35-50 16 p.

    Research output: Contribution to journalArticle

  186. Phosphorylation by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on hepatic IGFBP-1 gene expression

    Guo, S., Cichy, S. A., He, X., Wu, J., Rena, G., Cohen, P. & Unterman, T. G. 1999 In : Journal of Investigative Medicine. 47, 7, p. 258A-258A 1 p.

    Research output: Contribution to journalMeeting abstract

  187. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

    Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. 1999 In : Journal of Biological Chemistry. 274, 24, p. 17179-17183 5 p.

    Research output: Contribution to journalArticle

  188. Subcellular localization and endocytosis of homomeric γ2 subunit splice variants of γ-aminobutyric acid type A receptors

    Connolly, C. N., Uren, J. M., Thomas, P., Gorrie, G. H., Gibson, A., Smart, T. G. & Moss, S. J. 1999 In : Molecular and Cellular Neuroscience. 13, 4, p. 259-271 13 p.

    Research output: Contribution to journalArticle

  189. Synaptic targeting and regulation of GABAA receptors

    Brandon, N. J., Bedford, F. K., Connolly, C. N., Couve, A., Kittler, J. T., Hanley, J. G., Jovanovic, J. N., Uren, J., Taylor, P., Thomas, P., Smart, T. G. & Moss, S. J. 1999 In : Biochemical Society Transactions. 27, 4, p. 527-530 4 p.

    Research output: Contribution to journalArticle

  190. Synaptic targeting and regulation of GABAA receptors

    Brandon, N. J., Bedford, F. K., Connolly, C. N., Couve, A., Kittler, J. T., Hanley, J. G., Jovanovic, J. N., Uren, J., Taylor, P., Thomas, P., Smart, T. G. & Moss, S. J. 1999

    Research output: Contribution to conferencePaper

  191. A simple method for sequencing small DNAs by introducing precise overlapping ends into restriction digestion fragments

    Rena, G. & Houslay, M. D. 1998 In : Nucleic Acids Research. 26, 16, p. 3867-3868 2 p.

    Research output: Contribution to journalArticle

  192. Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

    Sullivan, M., Rena, G., Begg, F., Gordon, L., Olsen, A. S. & Houslay, M. D. 1998 In : Biochemical Journal. 333, 3, p. 693-703 11 p.

    Research output: Contribution to journalArticle

  193. Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart

    Kostic, M. M., Erdogan, S., Rena, G., Borchert, G., Hoch, B., Bartel, S., Scotland, G., Huston, E., Houslay, M. D. & Krause, E. G. 1997 In : Journal of Molecular and Cellular Cardiology. 29, 11, p. 3135-3146 12 p.

    Research output: Contribution to journalArticle

  194. Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines

    Pooley, L., Shakur, Y., Rena, G. & Houslay, M. D. 1997 In : Biochemical Journal. 321, 1, p. 177-185 9 p.

    Research output: Contribution to journalArticle

  195. Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase

    Rena, G. & 20 others Houslay, M. D., Scotland, G., Erdogan, S., Huston, E., Mackenzie, S., McCallum, J. F., McPhee, I., Pooley, L., Ross, A., Beard, M., Peden, A., Begg, F., Wilkinson, I., Yarwood, S., Ackerman, C., Houslay, E. S., Hoffman, R., Engels, P., Sullivan, M. & Bolger, G. 1997 In : Biochemical Society Transactions. 25, 2, p. 374-381 8 p.

    Research output: Contribution to journalArticle

  196. Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells

    Sutherland, C., Tebbey, P. W. & Granner, D. K. 1997 In : Diabetes. 46, 1, p. 17-22 6 p.

    Research output: Contribution to journalArticle

  197. Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase

    Spence, S., Rena, G., Sullivan, M., Erdogan, S. & Houslay, M. D. 1997 In : Biochemical Journal. 321, 1, p. 157-163 7 p.

    Research output: Contribution to journalArticle

  198. The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides

    McDowell, G., Coutie, W., Shaw, C., Buchanan, K. D., Struthers, A. D. & Nicholls, D. P. 1997 In : British Journal of Clinical Pharmacology. 43, 3, p. 329-332 4 p.

    Research output: Contribution to journalArticle

  199. The high-affinity sulphonylurea receptor regulates KATP channels in nerve terminals of the rat motor cortex

    Lee, K., Dixon, A. K., Rowe, I. C., Ashford, M. L. & Richardson, P. J. Jun 1996 In : Journal of Neurochemistry. 66, 6, p. 2562-2571 10 p.

    Research output: Contribution to journalArticle

  200. Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

    Osawa, H., Sutherland, C., Robey, R. B., Printz, R. L. & Granner, D. K. 1996 In : Journal of Biological Chemistry. 271, 28, p. 16690-16694 5 p.

    Research output: Contribution to journalArticle

  201. Subcellular localization of γ-aminobutyric acid type A receptors is determined by receptor β subunits

    Connolly, C. N., Wooltorton, J. R. A., Smart, T. G. & Moss, S. J. 1996 In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9899-9904 6 p.

    Research output: Contribution to journalArticle

  202. Cloning and functional expression of the cDNA.-encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain

    Bond, C. T., Ammala, C., Ashfield, R., Blair, T. A., Gribble, F., Khan, R. N., Lee, K., Proks, P., Rowe, I. C. M., Sakura, H., Ashford, M. J., Adelman, J. P. & Ashcroft, F. M. 1995 In : FEBS Letters. 367, 1, p. 61-66 6 p.

    Research output: Contribution to journalArticle

  203. Cloning and functional expression of a rat heart KATP channel

    Ashford, M. L. J., Bond, C. T., Blair, T. A. & Adelman, J. P. 1994 In : Nature. 370, 6489, p. 456-459 4 p.

    Research output: Contribution to journalArticle

  204. Nucleotide Regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1

    Reale, V., Hales, C. N. & Ashford, M. L. 1994 In : Journal of Membrane Biology. 141, 2, p. 101-112 12 p.

    Research output: Contribution to journalArticle

  205. Inactivation of glycogen-synthase kinase-3-beta by phosphorylation: new kinase connections in insulin and growth-factor signaling

    Sutherland, C., Leighton, I. A. & Cohen, P. 15 Nov 1993 In : Biochemical Journal. 296, 1, p. 15-19 5 p.

    Research output: Contribution to journalComment/debate

  206. Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11

    Khan, R. N., Hales, C. N., Ozanne, S. E., Adogu, A. A. & Ashford, M. L. J. 1993 In : Proceedings of the Royal Society B. 253, 1338, p. 225-231 7 p.

    Research output: Contribution to journalArticle

  207. Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

    Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdellès, B., Mallet, J., Haavik, J. & Cohen, P. 1993 In : European Journal of Biochemistry. 217, 2, p. 715-722 8 p.

    Research output: Contribution to journalArticle

  208. Dissection of the protein kinase cascades involved in insulin and nerve growth factor action

    Cohen, P., Campbell, D. G., Dent, P., Gomez, N., Lavoinne, A., Nakielny, S., Stokoe, D., Sutherland, C. & Traverse, S. 1992 In : Biochemical Society Transactions. 20, 3, p. 671-674 4 p.

    Research output: Contribution to journalArticle

  209. Voltage-dependent block of locust muscle glutamate channels by chlorisondamine

    Ashford, M. L. J., Boden, P., Ramsey, R. L., Sansom, M. S. P., Shinozaki, H. & Usherwood, P. N. R. 1988 In : Journal of Experimental Biology. 134, 1, p. 131-154 24 p.

    Research output: Contribution to journalArticle

  210. Effects of trimetaphan on locust muscle glutamate receptors

    Ashford, M. L. J., Boden, P., Ramsey, R. L., Shinozaki, H. & Usherwood, P. N. R. 1987 In : Journal of Experimental Biology. 130, 1, p. 405-424 20 p.

    Research output: Contribution to journalArticle

  211. Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane

    Reale, V., Ashford, M. L. J. & Barnard, E. A. 1987 In : Neuroscience Letters. 83, 1-2, p. 89-94 6 p.

    Research output: Contribution to journalArticle

  212. K-channels in an insulin-secreting cell line: Effects of ATP and sulphonylureas

    Ashford, M. L. J., Sturgess, N. C., Cook, D. L. & Hales, C. N. 1986 Biophysics of the pancreatic ß-cell. Atwater, I., Rojas, E. & Soria, B. (eds.). Plenum Press, p. 69-76 8 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  213. Platelet activation in allergic asthma

    Greer, I. A., Winter, J. H., Gaffney, D., McLoughlin, K., Belch, J. J., Boyd, G. & Forbes, C. D. 1985 In : Thrombosis and Haemostasis. 53, 3, p. 438

    Research output: Contribution to journalArticle

  214. Kinetic analysis of channels gated by glutamate receptors in locust muscle membrane

    Ashford, M. L. J., Kerry, C., Kitz, K. S., Ramsey, R. L., Sansom, M. S. P. & Usherwood, P. N. R. 1984 Electropharmacology of the in vitro synapse: The Proceedings of a Satellite Symposium of the 9th International Congress of Pharmacology, St. Andrews, U.K. 6-8 August 1984. Cottrell, G. A. (ed.). Fife: St. Andrews University Press, p. 14-15 2 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  215. Kinetic analysis of channels gated by L-glutamate receptors in locust muscle membrane

    Ashford, M. L. J., Kerry, C. J., Kitz, K. S., Ramsey, R. L., Sansom, M. S. P. & Usherwood, P. N. R. 1984 Biophysics of Membrane Transport. Tomicki, B., Kuczera, J. J. & Prezstalski, S. (eds.). University of Wroclaw Press, p. 157-166 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  216. Platelets in asthma

    Greer, I. A., Winter, J. H., Gaffney, D., McLoughlin, K., Belch, J. J. F., Boyd, G. & Forbes, C. D. 1984 In : Lancet. 2, 8417-8418, p. 1479 1 p.

    Research output: Contribution to journalLetter

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