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  1. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journal › Article

  2. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15-Apr-2013 In : Biochemical Journal. 451, 2, p. 185-194, 10 p., BJ20130026

    Research output: Contribution to journal › Article

  3. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1-Apr-2013 In : Biochemical Journal. 451, 1, p. 111-122, 12 p.

    Research output: Contribution to journal › Article

  4. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27-Mar-2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journal › Article

  5. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  6. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, M. S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research.

    Research output: Contribution to journal › Article

  7. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104, 9 p.

    Research output: Contribution to journal › Article

  8. Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

    Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V. 20-Dec-2012 In : PLoS ONE. 7, 12, e51672

    Research output: Contribution to journal › Article

  9. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

    Research output: Contribution to journal › Article

  10. NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway

    Hjerpe, R., Thomas, Y. & Kurz, T. Aug-2012 In : Journal of Molecular Biology. 421, 1, p. 27-9, 3 p.

    Research output: Contribution to journal › Article

  11. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 18-Jun-2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journal › Article

  12. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1-Jun-2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228, 13 p.

    Research output: Contribution to journal › Article

  13. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1 alpha accumulation

    Bandau, S., Knebel, A., Gage, Z. O., Wood, N. T. & Alexandru, G. 26-Apr-2012 In : BMC Biology. 10, p. -, 15 p., 36

    Research output: Contribution to journal › Article

  14. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21-Mar-2012 In : EMBO Journal. 31, 6, p. 1394-1404, 11 p.

    Research output: Contribution to journal › Article

  15. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1-Feb-2012 In : Biochemical Journal. 441, p. 927-936, 10 p.

    Research output: Contribution to journal › Article

  16. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 12-Jan-2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journal › Article

  17. Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins

    Alexandru, G. 1-Jan-2012 Methods in Molecular Biology: Ubiquitin Family Modifiers and the Proteasome. Springer, Vol. 832, p. 305-312 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

  18. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1-Jan-2012 In : Biochemical Journal. 441, p. 339-346, 8 p.

    Research output: Contribution to journal › Article

  19. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

    Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D. Jan-2012 In : Nature Structural & Molecular Biology. 19, 1, p. 62-U83, 11 p.

    Research output: Contribution to journal › Article

  20. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835, 11 p.

    Research output: Contribution to journal › Article

  21. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91, 6 p.

    Research output: Contribution to journal › Article

  22. RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

    Oestergaard, V. H., Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, S., Mailand, N. & Lisby, M. 2012 In : DNA Repair. 11, 11, p. 892-905, 14 p.

    Research output: Contribution to journal › Article

  23. The Dac-tag, an affinity tag based on penicillin-binding protein 5

    Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A. 2012 In : Analytical Biochemistry. 428, 1, p. 64-72, 9 p.

    Research output: Contribution to journal › Article

  24. The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair

    Kelsall, I. R., Langenick, J., MacKay, C., Patel, K. J. & Alpi, A. F. 2012 In : PLoS ONE. 7, 5, p. -, 10 p., e36970

    Research output: Contribution to journal › Article

  25. Identification of the human testis protein phosphatase 1 interactome

    Fardilha, M., Esteves, S. L. C., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T. W., da cruz silva, O. A. B. & da cruz silva, E. F. 15-Nov-2011 In : Biochemical Pharmacology. 82, 10, p. 1403-1415, 13 p.

    Research output: Contribution to journal › Article

  26. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14-Oct-2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674, 12 p.

    Research output: Contribution to journal › Article

  27. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11-Oct-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098, 6 p.

    Research output: Contribution to journal › Article

  28. Visualization and Biochemical Analyses of the Emerging Mammalian 14-3-3-Phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct-2011 In : Molecular & Cellular Proteomics. 10, 10, p. -, 15 p.

    Research output: Contribution to journal › Article

  29. In the family with ubiquitin

    Alexandru, G., Pariente, N. & Xirodimas, D. Sep-2011 In : EMBO Reports. 12, 9, p. 880-882, 3 p.

    Research output: Contribution to journal › Editorial

  30. The TFIIH subunit Tfb3 regulates cullin neddylation

    Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T., Boone, C., Deshaies, R. J. & Peter, M. 5-Aug-2011 In : Molecular Cell. 43, 3, p. 488-495, 8 p.

    Research output: Contribution to journal › Article

  31. Traceless and site-specific ubiquitination of recombinant proteins

    Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W. 20-Jul-2011 In : Journal of the American Chemical Society. 133, 28, p. 10708-10711, 4 p.

    Research output: Contribution to journal › Article

  32. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P. 6-Jun-2011 In : Journal of Experimental Medicine. 208, 6, p. 1215-1228, 14 p.

    Research output: Contribution to journal › Article

  33. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15-Mar-2011 In : Biochemical Journal. 434, p. 537-548, 12 p.

    Research output: Contribution to journal › Article

  34. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15-Feb-2011 In : Biochemical Journal. 434, p. 93-104, 12 p.

    Research output: Contribution to journal › Article

  35. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

    Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. 8-Feb-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233, 6 p.

    Research output: Contribution to journal › Article

  36. Purification and identification of endogenous polySUMO conjugates

    Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T. Feb-2011 In : EMBO Reports. 12, 2, p. 142-148, 7 p.

    Research output: Contribution to journal › Article

  37. Compositions and method of treating hypoxia-associated diseases

    Alexandru, G., Deshaies, R. & Graumann, J. 11-Jan-2011 US 07867724

    Research output: Patent

  38. Natural product-guided discovery of a fungal chitinase inhibitor

    Rush, C. L., Schuettelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F. 22-Dec-2010 In : Chemistry & Biology. 17, 12, p. 1275-1281, 7 p.

    Research output: Contribution to journal › Article

  39. Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

    Bodenmiller, B. , Wanka, S. , Kraft, C. , Urban, J. , Campbell, D. , Pedrioli, P. G. , Gerrits, B. , Picotti, P. , Lam, H. , Vitek, O. , Brusniak, M-Y. , Roschitzki, B. , Zhang, C. , Shokat, K. M. , Schlapbach, R. , Colman-Lerner, A. , Nolan, G. P. , Nesvizhskii, A. I. , Peter, M. , Loewith, R. & 2 others von Mering, C. & Aebersold, R. 21-Dec-2010 In : Science Signaling. 3, 153, p. -, 8 p., rs4

    Research output: Contribution to journal › Article

  40. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15-Dec-2010 In : EMBO Journal. 29, 24, p. 4210-4222, 13 p.

    Research output: Contribution to journal › Article

  41. Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

    Cohen, P. & Tcherpakov, M. 24-Nov-2010 In : Cell. 143, 5, p. 686-693, 8 p.

    Research output: Contribution to journal › Article

  42. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov-2010 In : Glycobiology. 20, 11, p. 1478-1478, 1 p., 92

    Research output: Contribution to journal › Book/Film/Article review

  43. Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones

    Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W. 29-Oct-2010 In : Chemistry & Biology. 17, 10, p. 1072-1076, 5 p.

    Research output: Contribution to journal › Article

  44. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

    Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W. Oct-2010 In : Nature Chemical Biology. 6, 10, p. 750-757, 8 p.

    Research output: Contribution to journal › Article

  45. Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

    Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F. & Moreau, P. 15-Sep-2010 In : Bioorganic & Medicinal Chemistry. 18, 18, p. 6865-6873, 9 p.

    Research output: Contribution to journal › Article

  46. A dual E3 mechanism for Rub1 Ligation to Cdc53

    Scott, D. C., Monda, J. K., Grace, C. R. R., Duda, D. M., Kriwacki, R. W., Kurz, T. & Schulman, B. A. 10-Sep-2010 In : Molecular Cell. 39, 5, p. 784-796, 13 p.

    Research output: Contribution to journal › Article

  47. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. 9-Jul-2010 In : Cell. 142, 1, p. 65-76, 12 p.

    Research output: Contribution to journal › Article

  48. The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

    Bailly, A. P., Freeman, A., Hall, J., Declais, A-C., Alpi, A., Lilley, D. M. J., Ahmed, S. & Gartner, A. Jul-2010 In : PLoS Genetics. 6, 7, p. -, 16 p., e1001025

    Research output: Contribution to journal › Article

  49. The interplay between phosphorylation and ubiquitination in regulating the innate immune system

    Cohen, P. Jun-2010 In : FEBS Journal. 277, Suppl. 1, p. 9-9, 1 p., I 23

    Research output: Contribution to journal › Book/Film/Article review

  50. Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

    Hjerpe, R., Aillet, F., Lopitz-Otsoa, F., Lang, V., Torres-Ramos, M., Farras, R., Hay, R. T. & Rodriguez, M. S. May-2010 In : International Journal of Biochemistry & Cell Biology. 42, 5, p. 725-735, 11 p.

    Research output: Contribution to journal › Article

  51. Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

    Virdee, S., Macmillan, D. & Waksman, G. 26-Mar-2010 In : Chemistry & Biology. 17, 3, p. 274-284, 11 p.

    Research output: Contribution to journal › Article

  52. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15-Mar-2010 In : Biochemical Journal. 426, p. 281-292, 12 p.

    Research output: Contribution to journal › Article

  53. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1-Jan-2010 In : Biochemical Journal. 425, p. 53-54, 2 p.

    Research output: Contribution to journal › Scientific review

  54. An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages

    Jeram, S. M., Srikumar, T., Zhang, X-D., Eisenhauer, H. A., Rogers, R., Pedrioli, P. G. A., Matunis, M. & Raught, B. 2010 In : Proteomics. 10, 2, p. 254-265, 12 p.

    Research output: Contribution to journal › Article

  55. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16-Dec-2009 In : EMBO Journal. 28, 24, p. 3845-3856, 12 p.

    Research output: Contribution to journal › Article

  56. Biochemical characterisation of the SWI/SNF family member HLTF

    MacKay, C., Toth, R. & Rouse, J. 11-Dec-2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191, 5 p.

    Research output: Contribution to journal › Article

  57. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15-Nov-2009 In : Biochemical Journal. 424, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  58. Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

    Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. & Moreau, P. 22-Oct-2009 In : Journal of Medicinal Chemistry. 52, 20, p. 6369-6381, 13 p.

    Research output: Contribution to journal › Article

  59. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

    Huitema, E. & 95 others Haas, B. J., Kamoun, S., Zody, M. C., Jiang, R. H. Y., Handsaker, R. E., Cano, L. M., Grabherr, M., Kodira, C. D., Raffaele, S., Torto-Alalibo, T., Bozkurt, T. O., Ah-Fong, A. M. V., Alvarado, L., Anderson, V. L., Armstrong, M. R., Avrova, A., Baxter, L., Beynon, J., Boevink, P. C., Bollmann, S. R., Bos, J. I. B., Bulone, V., Cai, G., Cakir, C., Carrington, J. C., Chawner, M., Conti, L., Costanzo, S., Ewan, R., Fahlgren, N., Fischbach, M. A., Fugelstad, J., Gilroy, E. M., Gnerre, S., Green, P. J., Grenville-Briggs, L. J., Griffith, J., Gruenwald, N. J., Horn, K., Horner, N. R., Hu, C-H., Jeong, D-H., Jones, A. M. E., Jones, J. D. G., Jones, R. W., Karlsson, E. K., Kunjeti, S. G., Lamour, K., Liu, Z., Ma, L., MacLean, D., Chibucos, M. C., McDonald, H., McWalters, J., Meijer, H. J. G., Morgan, W., Morris, P. F., Munro, C. A., O'Neill, K., Ospina-Giraldo, M., Pinzon, A., Pritchard, L., Ramsahoye, B., Ren, Q., Restrepo, S., Roy, S., Sadanandom, A., Savidor, A., Schornack, S., Schwartz, D. C., Schumann, U. D., Schwessinger, B., Seyer, L., Sharpe, T., Silvar, C., Song, J., Studholme, D. J., Sykes, S., Thines, M., van de Vondervoort, P. J. I., Phuntumart, V., Wawra, S., Weide, R., Win, J., Young, C., Zhou, S., Fry, W., Meyers, B. C., van West, P., Ristaino, J., Govers, F., Birch, P. R. J., Whisson, S. C., Judelson, H. S. & Nusbaum, C. 17-Sep-2009 In : Nature. 461, 7262, p. 393-398, 6 p.

    Research output: Contribution to journal › Article

  60. Keep Nibbling at the Edges

    Cohen, P. 4-Sep-2009 In : Journal of Biological Chemistry. 284, 36, p. 23891-23901, 11 p.

    Research output: Contribution to journal › Editorial

  61. Protein Kinases of the Innate Immune System as Drug Targets

    Cohen, P. Aug-2009 In : Journal of Biomolecular Screening. 14, 7, p. 894-894, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  62. The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

    Rosado, I. V., Niedzwiedz, W., Alpi, A. F. & Patel, K. J. Jul-2009 In : Nucleic Acids Research. 37, 13, p. 4360-4370, 11 p.

    Research output: Contribution to journal › Article

  63. Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and I kappa B Kinase epsilon A DISTINCT UPSTREAM KINASE MEDIATES SER-172 PHOSPHORYLATION AND ACTIVATION

    Clark, K., Plater, L., Peggie, M. & Cohen, P. 22-May-2009 In : Journal of Biological Chemistry. 284, 21, p. 14136-14146, 11 p.

    Research output: Contribution to journal › Article

  64. Monoubiquitylation in the Fanconi anemia DNA damage response pathway

    Alpi, A. F. & Patel, K. J. 5-Apr-2009 In : DNA Repair. 8, 4, p. 430-435, 6 p.

    Research output: Contribution to journal › Scientific review

  65. Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

    Moser, S. C., von Elsner, S., Buessing, I., Alpi, A., Schnabel, R. & Gartner, A. Apr-2009 In : PLoS Genetics. 5, 4, p. -, 15 p., e1000451

    Research output: Contribution to journal › Article

  66. Targeting protein kinases for the development of anti-inflammatory drugs

    Cohen, P. Apr-2009 In : Current Opinion in Cell Biology. 21, 2, p. 317-324, 8 p.

    Research output: Contribution to journal › Article

  67. Molecular mechanisms of yeast cell wall glucan remodeling

    Hurtado-Guerrero, R., Schuettelkopf, A. W., Mouyna, I., Ibrahim, A. F. M., Shepherd, S., Fontaine, T., Latge, J-P. & van Aalten, D. M. F. 27-Mar-2009 In : Journal of Biological Chemistry. 284, 13, p. 8461-8469, 9 p.

    Research output: Contribution to journal › Article

  68. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24-Mar-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590, 7 p.

    Research output: Contribution to journal › Article

  69. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15-Mar-2009 In : Biochemical Journal. 418, p. 625-634, 10 p.

    Research output: Contribution to journal › Article

  70. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

    Yang, H-T., Peggie, M., Cohen, P. & Rousseau, S. 13-Mar-2009 In : Biochemical and Biophysical Research Communications. 380, 3, p. 705-709, 5 p.

    Research output: Contribution to journal › Article

  71. Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

    Leidel, S., Pedrioli, P. G. A., Bucher, T., Brost, R., Costanzo, M., Schmidt, A., Aebersold, R., Boone, C., Hofmann, K. & Peter, M. 12-Mar-2009 In : Nature. 458, 7235, p. 228-U9, 6 p.

    Research output: Contribution to journal › Article

  72. Towards understanding the virulence functions of RXLR effectors of the oomycete plant pathogen Phytophthora infestans

    Birch, P. R. J., Armstrong, M., Bos, J., Boevink, P., Gilroy, E. M., Taylor, R. M., Wawra, S., Pritchard, L., Conti, L., Ewan, R., Whisson, S. C., van West, P., Sadanandom, A. & Kamoun, S. Mar-2009 In : Journal of Experimental Botany. 60, 4, p. 1133-1140, 8 p.

    Research output: Contribution to journal › Scientific review

  73. 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)

    Wood, N. T., Meek, D. W. & MacKintosh, C. 18-Feb-2009 In : FEBS Letters. 583, 4, p. 615-620, 6 p.

    Research output: Contribution to journal › Article

  74. Regulation of the activity and expression of ERK8 by DNA damage

    Klevernic, I. V., Martin, N. M. B. & Cohen, P. 18-Feb-2009 In : FEBS Letters. 583, 4, p. 680-684, 5 p.

    Research output: Contribution to journal › Article

  75. Estrogen regulation of p53 isoforms in the human breast cancer cell line MCF7

    Vendrell, J. A., Bourdon, J., Cohen, P. A. & Thompson, A. M. 2009 In : Cancer Research. 69, 2 Suppl. 1, 4067

    Research output: Contribution to journal › Meeting abstract

  76. Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

    Alpi, A. F., Pace, P. E., Babu, M. M. & Patel, K. J. 26-Dec-2008 In : Molecular Cell. 32, 6, p. 767-777, 11 p.

    Research output: Contribution to journal › Article

  77. Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

    Mace, P. D., Linke, K., Feltham, R., Schumacher, F-R., Smith, C. A., Vaux, D. L., Silke, J. & Day, C. L. 14-Nov-2008 In : Journal of Biological Chemistry. 283, 46, p. 31633-31640, 8 p.

    Research output: Contribution to journal › Article

  78. Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (FEBS Journal (2008) 275, (4211-4221))

    Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W. 1-Nov-2008 In : FEBS Journal. 275, 22, p. 5745, 1 p.

    Research output: Contribution to journal › Article

  79. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22-Oct-2008 In : EMBO Journal. 27, 20, p. 2780-2788, 9 p.

    Research output: Contribution to journal › Article

  80. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

    Hurtado-Guerrero, R., Raimi, O. G., Min, J., Zeng, H., Vallius, L., Shepherd, S., Ibrahim, A. F. M., Wu, H., Plotnikov, A. N. & van Aalten, D. M. F. 15-Oct-2008 In : Biochemical Journal. 415, p. 217-223, 7 p.

    Research output: Contribution to journal › Article

  81. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1 alpha turnover

    Alexandru, G., Graumann, J., Smith, G. T., Kolawa, N. J., Fang, R. & Deshaies, R. J. 5-Sep-2008 In : Cell. 134, 5, p. 804-816, 13 p.

    Research output: Contribution to journal › Article

  82. p53-driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

    Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P. & Mittnacht, S. Jun-2008 In : Nature Cell Biology. 10, 6, p. 723-730, 8 p.

    Research output: Contribution to journal › Article

  83. The ground state of embryonic stem cell self-renewal

    Ying, Q-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P. & Smith, A. 22-May-2008 In : Nature. 453, 7194, p. 519-523, 5 p.

    Research output: Contribution to journal › Article

  84. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

    McCracken, S. R. C., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P. & Leung, H. Y. 8-May-2008 In : Oncogene. 27, 21, p. 2978-2988, 11 p.

    Research output: Contribution to journal › Article

  85. Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

    Morton, S., Hesson, L., Peggie, M. & Cohen, P. 19-Mar-2008 In : FEBS Letters. 582, 6, p. 997-1002, 6 p.

    Research output: Contribution to journal › Article

  86. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

    Windheim, M., Stafford, M., Cohen, P. & Peggie, M. Mar-2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791, 9 p.

    Research output: Contribution to journal › Article

  87. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 711-722, 12 p.

    Research output: Contribution to journal › Article

  88. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

    Windheim, M., Peggie, M. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 723-729, 7 p.

    Research output: Contribution to journal › Article

  89. IL-1 beta-stimulated activation of ERK1/2 and p38 alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells

    Yang, H-T., Cohen, P. & Rousseau, S. Feb-2008 In : Cellular Signalling. 20, 2, p. 375-380, 6 p.

    Research output: Contribution to journal › Article

  90. Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

    Kurz, T., Chou, Y-C., WillemS, A. R., Meyer-Schaller, N., Hecht, M-L., Tyers, M., Peter', M. & Sicheri, F. 18-Jan-2008 In : Molecular Cell. 29, 1, p. 23-35, 13 p.

    Research output: Contribution to journal › Article

  91. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., Garra, A. O., Ley, S. C. & Cohen, P. 15-Jan-2008 In : Journal of Cell Science. 121, 2, p. 149-154, 6 p.

    Research output: Contribution to journal › Article

  92. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, p. 43-52, 10 p.

    Research output: Contribution to journal › Article

  93. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15-Dec-2007 In : Biochemical Journal. 408, p. 297-315, 19 p.

    Research output: Contribution to journal › Article

  94. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16-Oct-2007 In : Biochemical Journal. 401, 1, p. 29-38, 10 p.

    Research output: Contribution to journal › Article

  95. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15-Oct-2007 In : Biochemical Journal. 407, p. 231-241, 11 p.

    Research output: Contribution to journal › Article

  96. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination

    Alpi, A., Langevin, F., Mosedale, G., Machida, Y. J., Dutta, A. & Patel, K. J. 2007 In : Molecular and Cellular Biology. 27, 24, p. 8421-8430, 10 p.

    Research output: Contribution to journal › Article

  97. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1-Nov-2006 In : Biochemical Journal. 399, 3, p. 427-434, 8 p.

    Research output: Contribution to journal › Article

  98. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May-2005 In : The EMBO Journal. 24, 9, p. 1696-1705, 10 p.

    Research output: Contribution to journal › Article

  99. 14-3-3s as signalling integrators in plant and human cells

    MacKintosh, C., Pozuelo-Rubio, M., Geraghty, K., Wong, B., Wood, N., Murphy, J., Dubois, F. . & Harthill, J. 2005 In : FEBS Journal. 272, Suppl. 1, p. 460-461, 2 p., J4-004

    Research output: Contribution to journal › Meeting abstract

  100. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

    Pozuelo-Rubio, M., Geraghty, K. M., Wong, B. H. C., Wood, N. T., Campbell, D. G., Morrice, N. & MacKintosh, C. 15-Apr-2004 In : Biochemical Journal. 379, 2, p. 395-408, 14 p.

    Research output: Contribution to journal › Article

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