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  1. A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex

    Di Santo, R., Bandau, S. & Stark, M. J. R. Jun 2014 In : Molecular Microbiology. 92, 6, p. 1227-1242 16 p.

    Research output: Contribution to journalArticle

  2. Immune diseases caused by mutations in kinases and components of the ubiquitin system

    Cohen, P. Jun 2014 In : Nature Immunology. 15, 6, p. 521-529 9 p.

    Research output: Contribution to journalArticle

  3. The TLR and IL-1 signalling network at a glance

    Cohen, P. Jun 2014 In : Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

    Research output: Contribution to journalArticle

  4. USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

    Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Ewan, R., Bruce, D., Macartney, T., Weidlich, S., Smith, J. C. & Sapkota, G. P. 21 May 2014 In : Open Biology. 4, 13 p.140065

    Research output: Contribution to journalArticle

  5. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

    Baron, Y., Pedrioli, P. G., Tyagi, K., Johnson, C., Wood, N. T., Fountaine, D., Wightman, M. & Alexandru, G. May 2014 In : BMC Biology. 12, 20 p.39

    Research output: Contribution to journalArticle

  6. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

    MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F. 15 Apr 2014 In : Cancer Research. 74, 8, p. 2246-2257 12 p.

    Research output: Contribution to journalArticle

  7. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

    Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K. 19 Mar 2014 In : Open Biology. 4, 14 p.130213

    Research output: Contribution to journalArticle

  8. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells

    Lennon, J. C., Bright, S. A., Carroll, E., Butini, S., Campiani, G., O'Meara, A., Williams, D. C. & Zisterer, D. M. 15 Feb 2014 In : Biochemical Pharmacology. 87, 4, p. 611-24 14 p.

    Research output: Contribution to journalArticle

  9. Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

    Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 6 p.

    Research output: Contribution to journalArticle

  10. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  11. Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

    Lang, V., Pallara, C., Zabala, A., Lobato-Gil, S., Lopitz-Otsoa, F., Farrás, R., Hjerpe, R., Torres-Ramos, M., Zabaleta, L., Blattner, C., Hay, R. T., Barrio, R., Carracedo, A., Fernandez-Recio, J., Rodríguez, M. S. & Aillet, F. 2014 In : Molecular Oncology. 8, 5, p. 1026-1042 17 p.

    Research output: Contribution to journalArticle

  12. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  13. TRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding

    Rezgui, V. A. N., Tyagi, K., Ranjan, N., Konevega, A. L., Mittelstaet, J., Rodnina, M. V., Peter, M. & Pedrioli, P. G. A. 23 Jul 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12289-12294 6 p.

    Research output: Contribution to journalArticle

  14. Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F. 11 Jul 2013 In : Bioscience Reports. 33, 5, 11 p.e00063

    Research output: Contribution to journalArticle

  15. Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism

    Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F. & Schulman, B. A. 4 Jun 2013 In : Structure. 21, 6, p. 1030-1041 12 p.

    Research output: Contribution to journalArticle

  16. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  17. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15 Apr 2013 In : Biochemical Journal. 451, 2, p. 185-194 10 p.BJ20130026

    Research output: Contribution to journalArticle

  18. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1 Apr 2013 In : Biochemical Journal. 451, 1, p. 111-122 12 p.

    Research output: Contribution to journalArticle

  19. C-elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog

    Lee, H., Alpi, A. F., Park, M. S., Rose, A. & Koo, H-S. 28 Mar 2013 In : PLoS ONE. 8, 3, 10 p.600701

    Research output: Contribution to journalArticle

  20. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27 Mar 2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journalArticle

  21. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  22. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research. 12, 6, p. 2449-2457 9 p.

    Research output: Contribution to journalArticle

  23. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

  24. Molecular control of the NEMO family of ubiquitin-binding proteins

    Clark, K., Nanda, S. & Cohen, P. 2013 In : Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

    Research output: Contribution to journalArticle

  25. The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

    Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K. 2013 In : FEBS Journal. 280, 12, p. 2830-2841 12 p.

    Research output: Contribution to journalArticle

  26. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

    Kelsall, I. R., Duda, D. M., Olszewski, J. L., Hofmann, K., Knebel, A., Langevin, F., Wood, N., Wightman, M., Schulman, B. A. & Alpi, A. F. 2013 In : EMBO Journal. 32, p. 2848-2860 13 p.

    Research output: Contribution to journalArticle

  27. Ubiquitylation-dependent localization of PLK1 in mitosis

    Beck, J., Maerki, S., Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J. R., Peter, M. & Sumara, I. 2013 In : Nature Cell Biology. 15, 4, p. 430-439 10 p.

    Research output: Contribution to journalArticle

  28. Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

    Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V. 20 Dec 2012 In : PLoS ONE. 7, 12, e51672

    Research output: Contribution to journalArticle

  29. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

    Research output: Contribution to journalArticle

  30. NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway

    Hjerpe, R., Thomas, Y. & Kurz, T. Aug 2012 In : Journal of Molecular Biology. 421, 1, p. 27-9 3 p.

    Research output: Contribution to journalArticle

  31. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  32. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1 alpha accumulation

    Bandau, S., Knebel, A., Gage, Z. O., Wood, N. T. & Alexandru, G. 26 Apr 2012 In : BMC Biology. 10, p. - 15 p.36

    Research output: Contribution to journalArticle

  33. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21 Mar 2012 In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

    Research output: Contribution to journalArticle

  34. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1 Feb 2012 In : Biochemical Journal. 441, 3, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  35. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1 Jan 2012 In : Biochemical Journal. 441, p. 339-346 8 p.

    Research output: Contribution to journalArticle

  36. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

    Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D. Jan 2012 In : Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.

    Research output: Contribution to journalArticle

  37. Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins

    Alexandru, G. 2012 Ubiquitin family modifiers and the proteasome: reviews and protocols. Dohmen , R. J. & Scheffner, M. (eds.). Humana Press, p. 305-312 8 p. (Methods in molecular biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  38. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

    Research output: Contribution to journalArticle

  39. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

    Research output: Contribution to journalArticle

  40. RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

    Oestergaard, V. H., Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, S., Mailand, N. & Lisby, M. 2012 In : DNA Repair. 11, 11, p. 892-905 14 p.

    Research output: Contribution to journalArticle

  41. The Dac-tag, an affinity tag based on penicillin-binding protein 5

    Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A. 2012 In : Analytical Biochemistry. 428, 1, p. 64-72 9 p.

    Research output: Contribution to journalArticle

  42. The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair

    Kelsall, I. R., Langenick, J., MacKay, C., Patel, K. J. & Alpi, A. F. 2012 In : PLoS ONE. 7, 5, p. - 10 p.e36970

    Research output: Contribution to journalArticle

  43. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journalArticle

  44. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journalArticle

  45. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14 Oct 2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674 12 p.

    Research output: Contribution to journalArticle

  46. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11 Oct 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098 6 p.

    Research output: Contribution to journalArticle

  47. Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct 2011 In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

    Research output: Contribution to journalArticle

  48. In the family with ubiquitin

    Alexandru, G., Pariente, N. & Xirodimas, D. Sep 2011 In : EMBO Reports. 12, 9, p. 880-882 3 p.

    Research output: Contribution to journalEditorial

  49. The TFIIH subunit Tfb3 regulates cullin neddylation

    Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T., Boone, C., Deshaies, R. J. & Peter, M. 5 Aug 2011 In : Molecular Cell. 43, 3, p. 488-495 8 p.

    Research output: Contribution to journalArticle

  50. Traceless and site-specific ubiquitination of recombinant proteins

    Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W. 20 Jul 2011 In : Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.

    Research output: Contribution to journalArticle

  51. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P. 6 Jun 2011 In : Journal of Experimental Medicine. 208, 6, p. 1215-1228 14 p.

    Research output: Contribution to journalArticle

  52. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15 Mar 2011 In : Biochemical Journal. 434, p. 537-548 12 p.

    Research output: Contribution to journalArticle

  53. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15 Feb 2011 In : Biochemical Journal. 434, p. 93-104 12 p.

    Research output: Contribution to journalArticle

  54. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

    Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. 8 Feb 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.

    Research output: Contribution to journalArticle

  55. Purification and identification of endogenous polySUMO conjugates

    Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T. Feb 2011 In : EMBO Reports. 12, 2, p. 142-148 7 p.

    Research output: Contribution to journalArticle

  56. Compositions and method of treating hypoxia-associated diseases

    Alexandru, G., Deshaies, R. & Graumann, J. 11 Jan 2011 US 07867724

    Research output: Patent

  57. Identification of the human testis protein phosphatase 1 interactome

    Fardilha, M., Esteves, S. L. C., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T. W., da cruz e silva, O. A. B. & da cruz e silva, E. F. 2011 In : Biochemical Pharmacology. 82, 10, p. 1403-1415 13 p.

    Research output: Contribution to journalArticle

  58. Natural product-guided discovery of a fungal chitinase inhibitor

    Rush, C. L., Schuettelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F. 22 Dec 2010 In : Chemistry & Biology. 17, 12, p. 1275-1281 7 p.

    Research output: Contribution to journalArticle

  59. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4210-4222 13 p.

    Research output: Contribution to journalArticle

  60. Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

    Cohen, P. & Tcherpakov, M. 24 Nov 2010 In : Cell. 143, 5, p. 686-693 8 p.

    Research output: Contribution to journalArticle

  61. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1478-1478 1 p.92

    Research output: Contribution to journalBook/Film/Article review

  62. Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones

    Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W. 29 Oct 2010 In : Chemistry & Biology. 17, 10, p. 1072-1076 5 p.

    Research output: Contribution to journalArticle

  63. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

    Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W. Oct 2010 In : Nature Chemical Biology. 6, 10, p. 750-757 8 p.

    Research output: Contribution to journalArticle

  64. Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

    Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F. & Moreau, P. 15 Sep 2010 In : Bioorganic & Medicinal Chemistry. 18, 18, p. 6865-6873 9 p.

    Research output: Contribution to journalArticle

  65. A dual E3 mechanism for Rub1 Ligation to Cdc53

    Scott, D. C., Monda, J. K., Grace, C. R. R., Duda, D. M., Kriwacki, R. W., Kurz, T. & Schulman, B. A. 10 Sep 2010 In : Molecular Cell. 39, 5, p. 784-796 13 p.

    Research output: Contribution to journalArticle

  66. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. 9 Jul 2010 In : Cell. 142, 1, p. 65-76 12 p.

    Research output: Contribution to journalArticle

  67. The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

    Bailly, A. P., Freeman, A., Hall, J., Declais, A-C., Alpi, A., Lilley, D. M. J., Ahmed, S. & Gartner, A. Jul 2010 In : PLoS Genetics. 6, 7, p. - 16 p.e1001025

    Research output: Contribution to journalArticle

  68. The interplay between phosphorylation and ubiquitination in regulating the innate immune system

    Cohen, P. Jun 2010 In : FEBS Journal. 277, Suppl. 1, p. 9-9 1 p.I 23

    Research output: Contribution to journalBook/Film/Article review

  69. Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

    Hjerpe, R., Aillet, F., Lopitz-Otsoa, F., Lang, V., Torres-Ramos, M., Farras, R., Hay, R. T. & Rodriguez, M. S. May 2010 In : International Journal of Biochemistry & Cell Biology. 42, 5, p. 725-735 11 p.

    Research output: Contribution to journalArticle

  70. Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

    Virdee, S., Macmillan, D. & Waksman, G. 26 Mar 2010 In : Chemistry & Biology. 17, 3, p. 274-284 11 p.

    Research output: Contribution to journalArticle

  71. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15 Mar 2010 In : Biochemical Journal. 426, p. 281-292 12 p.

    Research output: Contribution to journalArticle

  72. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1 Jan 2010 In : Biochemical Journal. 425, p. 53-54 2 p.

    Research output: Contribution to journalScientific review

  73. An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages

    Jeram, S. M., Srikumar, T., Zhang, X-D., Eisenhauer, H. A., Rogers, R., Pedrioli, P. G. A., Matunis, M. & Raught, B. 2010 In : Proteomics. 10, 2, p. 254-265 12 p.

    Research output: Contribution to journalArticle

  74. Glycogen synthase kinase 3

    Cohen, P. & Frame, S. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 569-573 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  75. Phosphatase families dephosphorylating serine and threonine residues in proteins

    Cohen, P. T. W. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 659-675 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  76. Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

    Bodenmiller, B. , Wanka, S. , Kraft, C. , Urban, J. , Campbell, D. , Pedrioli, P. G. , Gerrits, B. , Picotti, P. , Lam, H. , Vitek, O. , Brusniak, M-Y. , Roschitzki, B. , Zhang, C. , Shokat, K. M. , Schlapbach, R. , Colman-Lerner, A. , Nolan, G. P. , Nesvizhskii, A. I. , Peter, M. , Loewith, R. & 2 others von Mering, C. & Aebersold, R. 2010 In : Science Signaling. 3, 153, p. - 8 p.rs4

    Research output: Contribution to journalArticle

  77. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3845-3856 12 p.

    Research output: Contribution to journalArticle

  78. Biochemical characterisation of the SWI/SNF family member HLTF

    MacKay, C., Toth, R. & Rouse, J. 11 Dec 2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

    Research output: Contribution to journalArticle

  79. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15 Nov 2009 In : Biochemical Journal. 424, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  80. Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

    Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. & Moreau, P. 22 Oct 2009 In : Journal of Medicinal Chemistry. 52, 20, p. 6369-6381 13 p.

    Research output: Contribution to journalArticle

  81. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

    Huitema, E. & 95 others Haas, B. J., Kamoun, S., Zody, M. C., Jiang, R. H. Y., Handsaker, R. E., Cano, L. M., Grabherr, M., Kodira, C. D., Raffaele, S., Torto-Alalibo, T., Bozkurt, T. O., Ah-Fong, A. M. V., Alvarado, L., Anderson, V. L., Armstrong, M. R., Avrova, A., Baxter, L., Beynon, J., Boevink, P. C., Bollmann, S. R., Bos, J. I. B., Bulone, V., Cai, G., Cakir, C., Carrington, J. C., Chawner, M., Conti, L., Costanzo, S., Ewan, R., Fahlgren, N., Fischbach, M. A., Fugelstad, J., Gilroy, E. M., Gnerre, S., Green, P. J., Grenville-Briggs, L. J., Griffith, J., Gruenwald, N. J., Horn, K., Horner, N. R., Hu, C-H., Jeong, D-H., Jones, A. M. E., Jones, J. D. G., Jones, R. W., Karlsson, E. K., Kunjeti, S. G., Lamour, K., Liu, Z., Ma, L., MacLean, D., Chibucos, M. C., McDonald, H., McWalters, J., Meijer, H. J. G., Morgan, W., Morris, P. F., Munro, C. A., O'Neill, K., Ospina-Giraldo, M., Pinzon, A., Pritchard, L., Ramsahoye, B., Ren, Q., Restrepo, S., Roy, S., Sadanandom, A., Savidor, A., Schornack, S., Schwartz, D. C., Schumann, U. D., Schwessinger, B., Seyer, L., Sharpe, T., Silvar, C., Song, J., Studholme, D. J., Sykes, S., Thines, M., van de Vondervoort, P. J. I., Phuntumart, V., Wawra, S., Weide, R., Win, J., Young, C., Zhou, S., Fry, W., Meyers, B. C., van West, P., Ristaino, J., Govers, F., Birch, P. R. J., Whisson, S. C., Judelson, H. S. & Nusbaum, C. 17 Sep 2009 In : Nature. 461, 7262, p. 393-398 6 p.

    Research output: Contribution to journalArticle

  82. Keep Nibbling at the Edges

    Cohen, P. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 23891-23901 11 p.

    Research output: Contribution to journalEditorial

  83. Protein Kinases of the Innate Immune System as Drug Targets

    Cohen, P. Aug 2009 In : Journal of Biomolecular Screening. 14, 7, p. 894-894 1 p.

    Research output: Contribution to journalBook/Film/Article review

  84. The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

    Rosado, I. V., Niedzwiedz, W., Alpi, A. F. & Patel, K. J. Jul 2009 In : Nucleic Acids Research. 37, 13, p. 4360-4370 11 p.

    Research output: Contribution to journalArticle

  85. Monoubiquitylation in the Fanconi anemia DNA damage response pathway

    Alpi, A. F. & Patel, K. J. 5 Apr 2009 In : DNA Repair. 8, 4, p. 430-435 6 p.

    Research output: Contribution to journalScientific review

  86. Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

    Moser, S. C., von Elsner, S., Buessing, I., Alpi, A., Schnabel, R. & Gartner, A. Apr 2009 In : PLoS Genetics. 5, 4, p. - 15 p.e1000451

    Research output: Contribution to journalArticle

  87. Targeting protein kinases for the development of anti-inflammatory drugs

    Cohen, P. Apr 2009 In : Current Opinion in Cell Biology. 21, 2, p. 317-324 8 p.

    Research output: Contribution to journalArticle

  88. Molecular mechanisms of yeast cell wall glucan remodeling

    Hurtado-Guerrero, R., Schuettelkopf, A. W., Mouyna, I., Ibrahim, A. F. M., Shepherd, S., Fontaine, T., Latge, J-P. & van Aalten, D. M. F. 27 Mar 2009 In : Journal of Biological Chemistry. 284, 13, p. 8461-8469 9 p.

    Research output: Contribution to journalArticle

  89. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590 7 p.

    Research output: Contribution to journalArticle

  90. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15 Mar 2009 In : Biochemical Journal. 418, p. 625-634 10 p.

    Research output: Contribution to journalArticle

  91. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

    Yang, H-T., Peggie, M., Cohen, P. & Rousseau, S. 13 Mar 2009 In : Biochemical and Biophysical Research Communications. 380, 3, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  92. Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

    Leidel, S., Pedrioli, P. G. A., Bucher, T., Brost, R., Costanzo, M., Schmidt, A., Aebersold, R., Boone, C., Hofmann, K. & Peter, M. 12 Mar 2009 In : Nature. 458, 7235, p. 228-U9 6 p.

    Research output: Contribution to journalArticle

  93. Towards understanding the virulence functions of RXLR effectors of the oomycete plant pathogen Phytophthora infestans

    Birch, P. R. J., Armstrong, M., Bos, J., Boevink, P., Gilroy, E. M., Taylor, R. M., Wawra, S., Pritchard, L., Conti, L., Ewan, R., Whisson, S. C., van West, P., Sadanandom, A. & Kamoun, S. Mar 2009 In : Journal of Experimental Botany. 60, 4, p. 1133-1140 8 p.

    Research output: Contribution to journalScientific review

  94. 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)

    Wood, N. T., Meek, D. W. & MacKintosh, C. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 615-620 6 p.

    Research output: Contribution to journalArticle

  95. Regulation of the activity and expression of ERK8 by DNA damage

    Klevernic, I. V., Martin, N. M. B. & Cohen, P. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 680-684 5 p.

    Research output: Contribution to journalArticle

  96. Estrogen regulation of p53 isoforms in the human breast cancer cell line MCF7

    Vendrell, J. A., Bourdon, J., Cohen, P. A. & Thompson, A. M. 2009 In : Cancer Research. 69, 2 Suppl. 1, 4067

    Research output: Contribution to journalMeeting abstract

  97. Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

    Alpi, A. F., Pace, P. E., Babu, M. M. & Patel, K. J. 26 Dec 2008 In : Molecular Cell. 32, 6, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  98. Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (FEBS Journal (2008) 275, (4211-4221))

    Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W. 1 Nov 2008 In : FEBS Journal. 275, 22, p. 5745 1 p.

    Research output: Contribution to journalArticle

  99. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22 Oct 2008 In : EMBO Journal. 27, 20, p. 2780-2788 9 p.

    Research output: Contribution to journalArticle

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