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  1. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

    Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K. 19 Mar 2014 In : Open Biology. 4, 14 p.130213

    Research output: Contribution to journalArticle

  2. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  3. TRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding

    Rezgui, V. A. N., Tyagi, K., Ranjan, N., Konevega, A. L., Mittelstaet, J., Rodnina, M. V., Peter, M. & Pedrioli, P. G. A. 23 Jul 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12289-12294 6 p.

    Research output: Contribution to journalArticle

  4. Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism

    Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F. & Schulman, B. A. 4 Jun 2013 In : Structure. 21, 6, p. 1030-1041 12 p.

    Research output: Contribution to journalArticle

  5. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  6. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15 Apr 2013 In : Biochemical Journal. 451, 2, p. 185-194 10 p.BJ20130026

    Research output: Contribution to journalArticle

  7. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1 Apr 2013 In : Biochemical Journal. 451, 1, p. 111-122 12 p.

    Research output: Contribution to journalArticle

  8. C-elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog

    Lee, H., Alpi, A. F., Park, M. S., Rose, A. & Koo, H-S. 28 Mar 2013 In : PLoS ONE. 8, 3, 10 p.600701

    Research output: Contribution to journalArticle

  9. CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

    Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27 Mar 2013 In : Nature Communications. 4, 1641

    Research output: Contribution to journalArticle

  10. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-77 13 p.

    Research output: Contribution to journalArticle

  11. Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes

    Ritorto, S., Cook, K., Tyagi, K., Pedrioli, P. G. A. & Trost, M. 2013 In : Journal of Proteome Research. 12, 6, p. 2449-2457 9 p.

    Research output: Contribution to journalArticle

  12. Kinase drug discovery: What's next in the field?

    Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

  13. Molecular control of the NEMO family of ubiquitin-binding proteins

    Clark, K., Nanda, S. & Cohen, P. 2013 In : Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

    Research output: Contribution to journalArticle

  14. The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

    Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K. 2013 In : FEBS Journal. 280, 12, p. 2830-2841 12 p.

    Research output: Contribution to journalArticle

  15. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

    Kelsall, I. R., Duda, D. M., Olszewski, J. L., Hofmann, K., Knebel, A., Langevin, F., Wood, N., Wightman, M., Schulman, B. A. & Alpi, A. F. 2013 In : EMBO Journal. 32, p. 2848-2860 13 p.

    Research output: Contribution to journalArticle

  16. Ubiquitylation-dependent localization of PLK1 in mitosis

    Beck, J., Maerki, S., Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J. R., Peter, M. & Sumara, I. 2013 In : Nature Cell Biology. 15, 4, p. 430-439 10 p.

    Research output: Contribution to journalArticle

  17. Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

    Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V. 20 Dec 2012 In : PLoS ONE. 7, 12, e51672

    Research output: Contribution to journalArticle

  18. NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway

    Hjerpe, R., Thomas, Y. & Kurz, T. Aug 2012 In : Journal of Molecular Biology. 421, 1, p. 27-9 3 p.

    Research output: Contribution to journalArticle

  19. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  20. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1 alpha accumulation

    Bandau, S., Knebel, A., Gage, Z. O., Wood, N. T. & Alexandru, G. 26 Apr 2012 In : BMC Biology. 10, p. - 15 p.36

    Research output: Contribution to journalArticle

  21. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21 Mar 2012 In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

    Research output: Contribution to journalArticle

  22. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1 Feb 2012 In : Biochemical Journal. 441, 3, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  23. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1 Jan 2012 In : Biochemical Journal. 441, p. 339-346 8 p.

    Research output: Contribution to journalArticle

  24. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

    Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D. Jan 2012 In : Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.

    Research output: Contribution to journalArticle

  25. Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins

    Alexandru, G. 2012 Ubiquitin family modifiers and the proteasome: reviews and protocols. Dohmen , R. J. & Scheffner, M. (eds.). Humana Press, p. 305-312 8 p. (Methods in molecular biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  26. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

    Research output: Contribution to journalArticle

  27. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

    Research output: Contribution to journalArticle

  28. RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

    Oestergaard, V. H., Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, S., Mailand, N. & Lisby, M. 2012 In : DNA Repair. 11, 11, p. 892-905 14 p.

    Research output: Contribution to journalArticle

  29. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

    Research output: Contribution to journalArticle

  30. The Dac-tag, an affinity tag based on penicillin-binding protein 5

    Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A. 2012 In : Analytical Biochemistry. 428, 1, p. 64-72 9 p.

    Research output: Contribution to journalArticle

  31. The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair

    Kelsall, I. R., Langenick, J., MacKay, C., Patel, K. J. & Alpi, A. F. 2012 In : PLoS ONE. 7, 5, p. - 10 p.e36970

    Research output: Contribution to journalArticle

  32. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journalArticle

  33. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journalArticle

  34. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14 Oct 2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674 12 p.

    Research output: Contribution to journalArticle

  35. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11 Oct 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098 6 p.

    Research output: Contribution to journalArticle

  36. Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct 2011 In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

    Research output: Contribution to journalArticle

  37. In the family with ubiquitin

    Alexandru, G., Pariente, N. & Xirodimas, D. Sep 2011 In : EMBO Reports. 12, 9, p. 880-882 3 p.

    Research output: Contribution to journalEditorial

  38. The TFIIH subunit Tfb3 regulates cullin neddylation

    Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T., Boone, C., Deshaies, R. J. & Peter, M. 5 Aug 2011 In : Molecular Cell. 43, 3, p. 488-495 8 p.

    Research output: Contribution to journalArticle

  39. Traceless and site-specific ubiquitination of recombinant proteins

    Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W. 20 Jul 2011 In : Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.

    Research output: Contribution to journalArticle

  40. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

    Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P. 6 Jun 2011 In : Journal of Experimental Medicine. 208, 6, p. 1215-1228 14 p.

    Research output: Contribution to journalArticle

  41. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15 Mar 2011 In : Biochemical Journal. 434, p. 537-548 12 p.

    Research output: Contribution to journalArticle

  42. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15 Feb 2011 In : Biochemical Journal. 434, p. 93-104 12 p.

    Research output: Contribution to journalArticle

  43. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

    Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. 8 Feb 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.

    Research output: Contribution to journalArticle

  44. Purification and identification of endogenous polySUMO conjugates

    Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T. Feb 2011 In : EMBO Reports. 12, 2, p. 142-148 7 p.

    Research output: Contribution to journalArticle

  45. Compositions and method of treating hypoxia-associated diseases

    Alexandru, G., Deshaies, R. & Graumann, J. 11 Jan 2011 US 07867724

    Research output: Patent

  46. Identification of the human testis protein phosphatase 1 interactome

    Fardilha, M., Esteves, S. L. C., Korrodi-Gregório, L., Vintém, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T. W., da cruz silva, O. A. B. & da cruz silva, E. F. 2011 In : Biochemical Pharmacology. 82, 10, p. 1403-1415 13 p.

    Research output: Contribution to journalArticle

  47. Natural product-guided discovery of a fungal chitinase inhibitor

    Rush, C. L., Schuettelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F. 22 Dec 2010 In : Chemistry & Biology. 17, 12, p. 1275-1281 7 p.

    Research output: Contribution to journalArticle

  48. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4210-4222 13 p.

    Research output: Contribution to journalArticle

  49. Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

    Cohen, P. & Tcherpakov, M. 24 Nov 2010 In : Cell. 143, 5, p. 686-693 8 p.

    Research output: Contribution to journalArticle

  50. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1478-1478 1 p.92

    Research output: Contribution to journalBook/Film/Article review

  51. Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones

    Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W. 29 Oct 2010 In : Chemistry & Biology. 17, 10, p. 1072-1076 5 p.

    Research output: Contribution to journalArticle

  52. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

    Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W. Oct 2010 In : Nature Chemical Biology. 6, 10, p. 750-757 8 p.

    Research output: Contribution to journalArticle

  53. Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

    Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F. & Moreau, P. 15 Sep 2010 In : Bioorganic & Medicinal Chemistry. 18, 18, p. 6865-6873 9 p.

    Research output: Contribution to journalArticle

  54. A dual E3 mechanism for Rub1 Ligation to Cdc53

    Scott, D. C., Monda, J. K., Grace, C. R. R., Duda, D. M., Kriwacki, R. W., Kurz, T. & Schulman, B. A. 10 Sep 2010 In : Molecular Cell. 39, 5, p. 784-796 13 p.

    Research output: Contribution to journalArticle

  55. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. 9 Jul 2010 In : Cell. 142, 1, p. 65-76 12 p.

    Research output: Contribution to journalArticle

  56. The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

    Bailly, A. P., Freeman, A., Hall, J., Declais, A-C., Alpi, A., Lilley, D. M. J., Ahmed, S. & Gartner, A. Jul 2010 In : PLoS Genetics. 6, 7, p. - 16 p.e1001025

    Research output: Contribution to journalArticle

  57. The interplay between phosphorylation and ubiquitination in regulating the innate immune system

    Cohen, P. Jun 2010 In : FEBS Journal. 277, Suppl. 1, p. 9-9 1 p.I 23

    Research output: Contribution to journalBook/Film/Article review

  58. Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

    Hjerpe, R., Aillet, F., Lopitz-Otsoa, F., Lang, V., Torres-Ramos, M., Farras, R., Hay, R. T. & Rodriguez, M. S. May 2010 In : International Journal of Biochemistry & Cell Biology. 42, 5, p. 725-735 11 p.

    Research output: Contribution to journalArticle

  59. Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

    Virdee, S., Macmillan, D. & Waksman, G. 26 Mar 2010 In : Chemistry & Biology. 17, 3, p. 274-284 11 p.

    Research output: Contribution to journalArticle

  60. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15 Mar 2010 In : Biochemical Journal. 426, p. 281-292 12 p.

    Research output: Contribution to journalArticle

  61. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1 Jan 2010 In : Biochemical Journal. 425, p. 53-54 2 p.

    Research output: Contribution to journalScientific review

  62. An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages

    Jeram, S. M., Srikumar, T., Zhang, X-D., Eisenhauer, H. A., Rogers, R., Pedrioli, P. G. A., Matunis, M. & Raught, B. 2010 In : Proteomics. 10, 2, p. 254-265 12 p.

    Research output: Contribution to journalArticle

  63. Glycogen synthase kinase 3

    Cohen, P. & Frame, S. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 569-573 5 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  64. Phosphatase families dephosphorylating serine and threonine residues in proteins

    Cohen, P. T. W. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 659-675 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  65. Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

    Bodenmiller, B. , Wanka, S. , Kraft, C. , Urban, J. , Campbell, D. , Pedrioli, P. G. , Gerrits, B. , Picotti, P. , Lam, H. , Vitek, O. , Brusniak, M-Y. , Roschitzki, B. , Zhang, C. , Shokat, K. M. , Schlapbach, R. , Colman-Lerner, A. , Nolan, G. P. , Nesvizhskii, A. I. , Peter, M. , Loewith, R. & 2 others von Mering, C. & Aebersold, R. 2010 In : Science Signaling. 3, 153, p. - 8 p.rs4

    Research output: Contribution to journalArticle

  66. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3845-3856 12 p.

    Research output: Contribution to journalArticle

  67. Biochemical characterisation of the SWI/SNF family member HLTF

    MacKay, C., Toth, R. & Rouse, J. 11 Dec 2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

    Research output: Contribution to journalArticle

  68. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15 Nov 2009 In : Biochemical Journal. 424, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  69. Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

    Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. & Moreau, P. 22 Oct 2009 In : Journal of Medicinal Chemistry. 52, 20, p. 6369-6381 13 p.

    Research output: Contribution to journalArticle

  70. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

    Huitema, E. & 95 others Haas, B. J., Kamoun, S., Zody, M. C., Jiang, R. H. Y., Handsaker, R. E., Cano, L. M., Grabherr, M., Kodira, C. D., Raffaele, S., Torto-Alalibo, T., Bozkurt, T. O., Ah-Fong, A. M. V., Alvarado, L., Anderson, V. L., Armstrong, M. R., Avrova, A., Baxter, L., Beynon, J., Boevink, P. C., Bollmann, S. R., Bos, J. I. B., Bulone, V., Cai, G., Cakir, C., Carrington, J. C., Chawner, M., Conti, L., Costanzo, S., Ewan, R., Fahlgren, N., Fischbach, M. A., Fugelstad, J., Gilroy, E. M., Gnerre, S., Green, P. J., Grenville-Briggs, L. J., Griffith, J., Gruenwald, N. J., Horn, K., Horner, N. R., Hu, C-H., Jeong, D-H., Jones, A. M. E., Jones, J. D. G., Jones, R. W., Karlsson, E. K., Kunjeti, S. G., Lamour, K., Liu, Z., Ma, L., MacLean, D., Chibucos, M. C., McDonald, H., McWalters, J., Meijer, H. J. G., Morgan, W., Morris, P. F., Munro, C. A., O'Neill, K., Ospina-Giraldo, M., Pinzon, A., Pritchard, L., Ramsahoye, B., Ren, Q., Restrepo, S., Roy, S., Sadanandom, A., Savidor, A., Schornack, S., Schwartz, D. C., Schumann, U. D., Schwessinger, B., Seyer, L., Sharpe, T., Silvar, C., Song, J., Studholme, D. J., Sykes, S., Thines, M., van de Vondervoort, P. J. I., Phuntumart, V., Wawra, S., Weide, R., Win, J., Young, C., Zhou, S., Fry, W., Meyers, B. C., van West, P., Ristaino, J., Govers, F., Birch, P. R. J., Whisson, S. C., Judelson, H. S. & Nusbaum, C. 17 Sep 2009 In : Nature. 461, 7262, p. 393-398 6 p.

    Research output: Contribution to journalArticle

  71. Keep Nibbling at the Edges

    Cohen, P. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 23891-23901 11 p.

    Research output: Contribution to journalEditorial

  72. Protein Kinases of the Innate Immune System as Drug Targets

    Cohen, P. Aug 2009 In : Journal of Biomolecular Screening. 14, 7, p. 894-894 1 p.

    Research output: Contribution to journalBook/Film/Article review

  73. The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

    Rosado, I. V., Niedzwiedz, W., Alpi, A. F. & Patel, K. J. Jul 2009 In : Nucleic Acids Research. 37, 13, p. 4360-4370 11 p.

    Research output: Contribution to journalArticle

  74. Monoubiquitylation in the Fanconi anemia DNA damage response pathway

    Alpi, A. F. & Patel, K. J. 5 Apr 2009 In : DNA Repair. 8, 4, p. 430-435 6 p.

    Research output: Contribution to journalScientific review

  75. Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

    Moser, S. C., von Elsner, S., Buessing, I., Alpi, A., Schnabel, R. & Gartner, A. Apr 2009 In : PLoS Genetics. 5, 4, p. - 15 p.e1000451

    Research output: Contribution to journalArticle

  76. Targeting protein kinases for the development of anti-inflammatory drugs

    Cohen, P. Apr 2009 In : Current Opinion in Cell Biology. 21, 2, p. 317-324 8 p.

    Research output: Contribution to journalArticle

  77. Molecular mechanisms of yeast cell wall glucan remodeling

    Hurtado-Guerrero, R., Schuettelkopf, A. W., Mouyna, I., Ibrahim, A. F. M., Shepherd, S., Fontaine, T., Latge, J-P. & van Aalten, D. M. F. 27 Mar 2009 In : Journal of Biological Chemistry. 284, 13, p. 8461-8469 9 p.

    Research output: Contribution to journalArticle

  78. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590 7 p.

    Research output: Contribution to journalArticle

  79. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15 Mar 2009 In : Biochemical Journal. 418, p. 625-634 10 p.

    Research output: Contribution to journalArticle

  80. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins

    Yang, H-T., Peggie, M., Cohen, P. & Rousseau, S. 13 Mar 2009 In : Biochemical and Biophysical Research Communications. 380, 3, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  81. Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

    Leidel, S., Pedrioli, P. G. A., Bucher, T., Brost, R., Costanzo, M., Schmidt, A., Aebersold, R., Boone, C., Hofmann, K. & Peter, M. 12 Mar 2009 In : Nature. 458, 7235, p. 228-U9 6 p.

    Research output: Contribution to journalArticle

  82. Towards understanding the virulence functions of RXLR effectors of the oomycete plant pathogen Phytophthora infestans

    Birch, P. R. J., Armstrong, M., Bos, J., Boevink, P., Gilroy, E. M., Taylor, R. M., Wawra, S., Pritchard, L., Conti, L., Ewan, R., Whisson, S. C., van West, P., Sadanandom, A. & Kamoun, S. Mar 2009 In : Journal of Experimental Botany. 60, 4, p. 1133-1140 8 p.

    Research output: Contribution to journalScientific review

  83. 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)

    Wood, N. T., Meek, D. W. & MacKintosh, C. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 615-620 6 p.

    Research output: Contribution to journalArticle

  84. Regulation of the activity and expression of ERK8 by DNA damage

    Klevernic, I. V., Martin, N. M. B. & Cohen, P. 18 Feb 2009 In : FEBS Letters. 583, 4, p. 680-684 5 p.

    Research output: Contribution to journalArticle

  85. Estrogen regulation of p53 isoforms in the human breast cancer cell line MCF7

    Vendrell, J. A., Bourdon, J., Cohen, P. A. & Thompson, A. M. 2009 In : Cancer Research. 69, 2 Suppl. 1, 4067

    Research output: Contribution to journalMeeting abstract

  86. Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

    Alpi, A. F., Pace, P. E., Babu, M. M. & Patel, K. J. 26 Dec 2008 In : Molecular Cell. 32, 6, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  87. Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

    Mace, P. D., Linke, K., Feltham, R., Schumacher, F-R., Smith, C. A., Vaux, D. L., Silke, J. & Day, C. L. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31633-31640 8 p.

    Research output: Contribution to journalArticle

  88. Erratum: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (FEBS Journal (2008) 275, (4211-4221))

    Vázquez-Martin, C., Rouse, J. & Cohen, P. T. W. 1 Nov 2008 In : FEBS Journal. 275, 22, p. 5745 1 p.

    Research output: Contribution to journalArticle

  89. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22 Oct 2008 In : EMBO Journal. 27, 20, p. 2780-2788 9 p.

    Research output: Contribution to journalArticle

  90. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

    Hurtado-Guerrero, R., Raimi, O. G., Min, J., Zeng, H., Vallius, L., Shepherd, S., Ibrahim, A. F. M., Wu, H., Plotnikov, A. N. & van Aalten, D. M. F. 15 Oct 2008 In : Biochemical Journal. 415, p. 217-223 7 p.

    Research output: Contribution to journalArticle

  91. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1 alpha turnover

    Alexandru, G., Graumann, J., Smith, G. T., Kolawa, N. J., Fang, R. & Deshaies, R. J. 5 Sep 2008 In : Cell. 134, 5, p. 804-816 13 p.

    Research output: Contribution to journalArticle

  92. p53-driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

    Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P. & Mittnacht, S. Jun 2008 In : Nature Cell Biology. 10, 6, p. 723-730 8 p.

    Research output: Contribution to journalArticle

  93. The ground state of embryonic stem cell self-renewal

    Ying, Q-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P. & Smith, A. 22 May 2008 In : Nature. 453, 7194, p. 519-523 5 p.

    Research output: Contribution to journalArticle

  94. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

    McCracken, S. R. C., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P. & Leung, H. Y. 8 May 2008 In : Oncogene. 27, 21, p. 2978-2988 11 p.

    Research output: Contribution to journalArticle

  95. Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

    Morton, S., Hesson, L., Peggie, M. & Cohen, P. 19 Mar 2008 In : FEBS Letters. 582, 6, p. 997-1002 6 p.

    Research output: Contribution to journalArticle

  96. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

    Windheim, M., Stafford, M., Peggie, M. & Cohen, P. Mar 2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791 9 p.

    Research output: Contribution to journalArticle

  97. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1 Feb 2008 In : Biochemical Journal. 409, p. 711-722 12 p.

    Research output: Contribution to journalArticle

  98. Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

    Kurz, T., Chou, Y-C., WillemS, A. R., Meyer-Schaller, N., Hecht, M-L., Tyers, M., Peter, M. & Sicheri, F. 18 Jan 2008 In : Molecular Cell. 29, 1, p. 23-35 13 p.

    Research output: Contribution to journalArticle

  99. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., Garra, A. O., Ley, S. C. & Cohen, P. 15 Jan 2008 In : Journal of Cell Science. 121, 2, p. 149-154 6 p.

    Research output: Contribution to journalArticle

  100. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, 1, p. 43-52 10 p.

    Research output: Contribution to journalArticle

  101. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15 Dec 2007 In : Biochemical Journal. 408, p. 297-315 19 p.

    Research output: Contribution to journalArticle

  102. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16 Oct 2007 In : Biochemical Journal. 401, 1, p. 29-38 10 p.

    Research output: Contribution to journalArticle

  103. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15 Oct 2007 In : Biochemical Journal. 407, p. 231-241 11 p.

    Research output: Contribution to journalArticle

  104. Identification of protor as a novel rictor-binding component of mTOR complex-2

    Pearce, L. R., Huang, X., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F. M., Gourlay, R., Magnuson, M. A. & Alessi, D. R. 1 Aug 2007 In : Biochemical Journal. 405, 3, p. 513-522 10 p.

    Research output: Contribution to journalArticle

  105. Targeting of TMV movement protein to plasmodesmata requires the actin/ER network: evidence from FRAP

    Wright, K. M., Wood, N. T., Roberts, A. G., Chapman, S., Boevink, P., MacKenzie, K. M. & Oparka, K. J. Jan 2007 In : Traffic. 8, 1, p. 21-31 11 p.

    Research output: Contribution to journalArticle

  106. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination

    Alpi, A., Langevin, F., Mosedale, G., Machida, Y. J., Dutta, A. & Patel, K. J. 2007 In : Molecular and Cellular Biology. 27, 24, p. 8421-8430 10 p.

    Research output: Contribution to journalArticle

  107. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1 Nov 2006 In : Biochemical Journal. 399, 3, p. 427-434 8 p.

    Research output: Contribution to journalArticle

  108. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May 2005 In : The EMBO Journal. 24, 9, p. 1696-1705 10 p.

    Research output: Contribution to journalArticle

  109. 14-3-3s as signalling integrators in plant and human cells

    MacKintosh, C., Pozuelo-Rubio, M., Geraghty, K., Wong, B., Wood, N., Murphy, J., Dubois, F. . & Harthill, J. 2005 In : FEBS Journal. 272, Suppl. 1, p. 460-461 2 p.J4-004

    Research output: Contribution to journalMeeting abstract

  110. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

    Pozuelo-Rubio, M., Geraghty, K. M., Wong, B. H. C., Wood, N. T., Campbell, D. G., Morrice, N. & MacKintosh, C. 15 Apr 2004 In : Biochemical Journal. 379, 2, p. 395-408 14 p.

    Research output: Contribution to journalArticle

  111. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a

    Rena, G., Bain, J., Elliott, M. & Cohen, P. 2004 In : EMBO Reports. 5, 1, p. 60-65 6 p.

    Research output: Contribution to journalArticle

  112. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line

    Wicky, C., Alpi, A., Passannante, M., Rose, A., Gartner, A. & Muller, F. 2004 In : Molecular and Cellular Biology. 24, 11, p. 5016-5027 12 p.

    Research output: Contribution to journalArticle

  113. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus

    Azzam, R., Chen, S. L., Shou, W., Mah, A. S., Alexandru, G., Nasmyth, K., Annan, R. S., Carr, S. A. & Deshaies, R. J. 2004 In : Science. 305, 5683, p. 516-519 4 p.

    Research output: Contribution to journalArticle

  114. Feedback control of the protein kinase TAK1 by SAPK2a/p38

    Cheung, P. C. F., Campbell, D. G., Nebreda, A. R. & Cohen, P. 2003 In : The EMBO Journal. 22, 21, p. 5793-5805 13 p.

    Research output: Contribution to journalArticle

  115. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

    Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M. & Cohen, P. Dec 2002 In : The EMBO Journal. 21, 23, p. 6505-6514 10 p.

    Research output: Contribution to journalArticle

  116. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

    Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P. & Arthur, J. S. C. Apr 2002 In : Molecular and Cellular Biology. 22, 8, p. 2871-2881 11 p.

    Research output: Contribution to journalArticle

  117. Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes

    Fagerholm, S., Morrice, N., Gahmberg, C. G. & Cohen, P. 18 Jan 2002 In : Journal of Biological Chemistry. 277, 3, p. 1728-1738 11 p.

    Research output: Contribution to journalArticle

  118. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

    Research output: Contribution to journalArticle

  119. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

    Ahmed, S., Alpi, A., Hengartner, M. O. & Gartner, A. Dec 2001 In : Current Biology. 11, 24, p. 1934-1944 11 p.

    Research output: Contribution to journalArticle

  120. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38

    Knebel, A., Morrice, N. & Cohen, P. Aug 2001 In : The EMBO Journal. 20, 16, p. 4360-4369 10 p.

    Research output: Contribution to journalArticle

  121. An essential role for calmodulin in regulating human T cell aggregation

    Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.) 28 Feb 2001 In : FEBS Letters. 491, 1-2, p. 131-6 6 p.

    Research output: Contribution to journalArticle

  122. Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

    Alexandru, G., Uhlmann, F., Mechtler, K., Poupart, M-A. & Nasmyth, K. 2001 In : Cell. 105, 4, p. 459-472 14 p.

    Research output: Contribution to journalArticle

  123. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612 8 p.

    Research output: Contribution to journalArticle

  124. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G. & Cohen, P. 2001 In : Biochemical Journal. 355, 3, p. 597-607 11 p.

    Research output: Contribution to journalArticle

  125. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and β-catenin

    Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P. & Cohen, P. 1999 In : FEBS Letters. 458, 2, p. 247-251 5 p.

    Research output: Contribution to journalArticle

  126. Phosphorylation by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on hepatic IGFBP-1 gene expression

    Guo, S., Cichy, S. A., He, X., Wu, J., Rena, G., Cohen, P. & Unterman, T. G. 1999 In : Journal of Investigative Medicine. 47, 7, p. 258A-258A 1 p.

    Research output: Contribution to journalMeeting abstract

  127. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

    Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. 1999 In : Journal of Biological Chemistry. 274, 24, p. 17179-17183 5 p.

    Research output: Contribution to journalArticle

  128. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

    Alexandru, G., Zachariae, W., Schleiffer, A. & Nasmyth, K. 1999 In : EMBO Journal. 18, 10, p. 2707-2721 15 p.

    Research output: Contribution to journalArticle

  129. New connections in the regulation of PEPCK gene expression by insulin [and discussion]

    Sutherland, C., O'Brien, R. M., Granner, D. K., Saklatvala, J., Cohen, P. & White, M. F. 29 Feb 1996 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 351, 1336, p. 191-199 9 p.

    Research output: Contribution to journalArticle

  130. Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation

    MacKintosh, C., Garton, A. J., McDonnell, A., Barford, D., Cohen, P. T. W., Tonks, N. K. & Cohen, P. 1996 In : FEBS Letters. 397, 2-3, p. 235-238 4 p.

    Research output: Contribution to journalArticle

  131. Mechanism of activation of protein kinase B by insulin and IGF-1

    Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. & Hemmings, B. A. 1996 In : EMBO Journal. 15, 23, p. 6541-6551 11 p.

    Research output: Contribution to journalArticle

  132. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

    Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M. & Cohen, P. 1995 In : Current Biology. 5, 3, p. 283-95 13 p.

    Research output: Contribution to journalArticle

  133. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

    Moorhead, G., MacKintosh, C., Morrice, N. & Cohen, P. 1995 In : FEBS Letters. 362, 2, p. 101-105 5 p.

    Research output: Contribution to journalArticle

  134. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1

    MacKintosh, R. W., Dalby, K. N., Campbell, D. G., Cohen, P. T. W., Cohen, P. & MacKintosh, C. 1995 In : FEBS Letters. 371, 3, p. 236-240 5 p.

    Research output: Contribution to journalArticle

  135. The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

    Sutherland, C. & Cohen, P. 1994 In : FEBS Letters. 338, 1, p. 37-42 6 p.

    Research output: Contribution to journalArticle

  136. Inactivation of glycogen-synthase kinase-3-beta by phosphorylation: new kinase connections in insulin and growth-factor signaling

    Sutherland, C., Leighton, I. A. & Cohen, P. 15 Nov 1993 In : Biochemical Journal. 296, 1, p. 15-19 5 p.

    Research output: Contribution to journalComment/debate

  137. Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

    Sutherland, C., Alterio, J., Campbell, D. G., Le Bourdellès, B., Mallet, J., Haavik, J. & Cohen, P. 1993 In : European Journal of Biochemistry. 217, 2, p. 715-722 8 p.

    Research output: Contribution to journalArticle

  138. Characterization of the major phosphofructokinase - dephosphorylating protein phosphatases from Ascaris suum muscle

    Daum, G., Schmid, B., MacKintosh, C., Cohen, P. & Hofer, H. W. 1992 In : Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. 1122, 1, p. 23-32 10 p.

    Research output: Contribution to journalArticle

  139. Dissection of the protein kinase cascades involved in insulin and nerve growth factor action

    Cohen, P., Campbell, D. G., Dent, P., Gomez, N., Lavoinne, A., Nakielny, S., Stokoe, D., Sutherland, C. & Traverse, S. 1992 In : Biochemical Society Transactions. 20, 3, p. 671-674 4 p.

    Research output: Contribution to journalArticle

  140. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

    Liu, J., Albers, M. W., Wandless, T. J., Luan, S., Alberg, D. G., Belshaw, P. J., Cohen, P. ., MacKintosh, C., Klee, C. B. & Schreiber, S. L. 1992 In : Biochemistry. 31, 16, p. 3896-3901 6 p.

    Research output: Contribution to journalArticle

  141. A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11

    Doonan, J. H., MacKintosh, C., Osmani, S., Cohen, P., Bai, G., Lee, E. Y. & Morris, N. R. 1991 In : Journal of Biological Chemistry. 266, 28, p. 18889-18894 6 p.

    Research output: Contribution to journalArticle

  142. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

    MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. & Codd, G. A. 1990 In : FEBS Letters. 264, 2, p. 187-192 6 p.

    Research output: Contribution to journalArticle

  143. Remarkable similarities between yeast and mammalian protein phosphatases

    Cohen, P., Schelling, D. L. & Stark, M. J. R. 3 Jul 1989 In : FEBS Letters. 250, 2, p. 601-606 6 p.

    Research output: Contribution to journalArticle

  144. Identification of high levels of type 1 and type 2A protein phosphatases in higher plants

    MacKintosh, C. & Cohen, P. 1989 In : Biochemical Journal. 262, 1, p. 335-339 5 p.

    Research output: Contribution to journalArticle

  145. Isolation and structural analysis of a peptide containing the novel tyrosyl-glucose linkage in glycogenin.

    Smythe, C., Caudwell, F. B., Ferguson, M. A. J. & Cohen, P. 7 Sep 1988 In : EMBO Journal. 7, 9, p. 2681-2686 6 p.

    Research output: Contribution to journalArticle

  146. Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

    MacKintosh, C., Campbell, D. G., Hiraga, A. & Cohen, P. 1988 In : FEBS Letters. 234, 1, p. 189-194 6 p.

    Research output: Contribution to journalArticle

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