PROteostasis Group of European New InvEstigators (PROGENIE) is an european network formed by new group leaders working on proteostasis. We discuss general topics specific to our career stage and have a forum to discuss our work with an opportunity to gain advice from experts from the different areas of proteostasis. PROGENIE also organises a biannual ‘Autumn School on Proteostasis’ (supported by EMBO/FASEB) with leaders in the proteostasis field offering presentations on proteostasis and career advice.