Biomarker in Abdominal Aortic Aneurysm

Press/Media: Research

Period16 Oct 2019

Media contributions


Media contributions

  • TitleAmino acid blood test illuminates abdominal aneurysms
    Degree of recognitionInternational
    Media name/
    Media typeWeb
    Country/TerritoryUnited Kingdom
    Description The level of the amino acid desmosine in the blood is a good biomarker for potentially deadly abdominal aortic aneurysms and complements measurements of aneurysm size from imaging studies, U.K. researchers reported online October 9 in the Journal of the American Heart Association.

    Abdominal aortic aneurysms are at risk of rupturing, which can be fatal. Desmosine has the potential to be a biomarker of rupture, as the amino acid is released into blood and urine through the breakdown of elastin in the aortic vessel wall.

    Currently, risk is typically assessed by monitoring the diameter of the aneurysm. However, a high level of plasma desmosine (pDES) correlated with aneurysm diameter size and events in an analysis of data from two prospective studies: Magnetic Resonance Imaging for Abdominal Aortic Aneurysms to Predict Rupture or Surgery (MARS) and the United Kingdom Aneurysm Growth Study (UKAGS).

    Desmosine added information beyond what was available from size, Dr. Anna Maria Choy, a senior clinical lecturer and honorary consultant cardiologist at the University of Dundee in Scotland, and colleagues reported in JAHA.

    "Plasma desmosine may have potential as an additional marker for assessing the risk of rupture in patients with abdominal aortic aneurysms," they concluded.
    Producer/AuthorEmily Hayes
    PersonsAnna-Maria Choy