Biomarker of Aortic Aneurysm

Press/Media: Research

Period17 Oct 2019

Media contributions


Media contributions

  • TitleNew blood test could reduce abdominal aortic aneurysm fatalities
    Degree of recognitionInternational
    Media name/outletBioanalysis zone
    Media typeWeb
    Country/TerritoryUnited Kingdom
    DescriptionThe research, published in the Journal of American Heart Association, describes a study carried out by scientists based at the University of Dundee (Scotland). It reports that an assay measuring plasma desmosine concentrations could be able to predict disease severity and clinical outcome in patients with abdominal aortic aneurysm (AAA).

    Abdominal aortic aneurysm disease, described as the ‘silent killer’, is reported to affect 1% of men over the age of 65. At present, men over the age of 65 may be invited for ultrasound screening, if an AAA is detected they will be invited for follow up screenings. The major problem in the clinic is the unpredictability of the disease, aneurysms do not increase in size linearly with time and size does not correlate to rupture risk. Approximately 80% of AAA rupture leads to patient death.

    The researchers believe that an assay detecting plasma levels of desmosine could more accurately predict the risk of AAA rupture. Desmosine is an amino acid derived from elastin, released into the blood stream from diseased aortas.

    In the study, the team measured plasma desmosine and serum biomarker concentrations in 507 retroactive samples from patients with AAA and 162 healthy control subjects. It was demonstrated that plasma desmosine concentrations were significantly raised in patients with AAA and correlated most strongly with aneurysm diameter out of all measured serum biomarkers.

    Co-author Anna-Maria Choy (University of Dundee) explained: “Looking at a retrospective collection of samples from aneurysm patients, we found that not only was this effective in detecting aneurysms, it improved predicting complications and outcomes. This could potentially help to save lives by picking up danger signs missed by the current screening program and identifying which patients should be offered surgery.”
    Producer/AuthorAlex Hyde
    PersonsAnna-Maria Choy