Research Output per year

### Description

This dataset includes the GWAS screening results that were used to the supplementary Figure 1 in the paper “Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin” by Zhou et al. in Nature Genetics.

Brief descriptions of the 12 columns in this file are in the following table.

Column Descriptions

SNP SNP identifier

CHR Chromosome

BP Base pair (NCBI build 36)

EFFECT_ALLELE The effect allele

NMISS Number of subjects in the analyses

OR Odds ratio in the logistic regression, achieving treatment target as cases

STAT_logistic Test statistics from logistic regression

P_logistic P values from logistic regression

BETA Beta from linear regression of HbA1c reduction

STAT_linear Test statistics from linear regression

P_linear P values from linear regression

P_combined Combined p values from linear and logistic regression

The P_combined is derived from a geometric mean of P_logistic and P_linear given that the effect allele’s impact on glycaemic response were consistent between the linear and logistic regression models (STAT_logistic and STAT_linear). Missing values of P_combined are due to the discrepant impact in the two models.

Brief descriptions of the 12 columns in this file are in the following table.

Column Descriptions

SNP SNP identifier

CHR Chromosome

BP Base pair (NCBI build 36)

EFFECT_ALLELE The effect allele

NMISS Number of subjects in the analyses

OR Odds ratio in the logistic regression, achieving treatment target as cases

STAT_logistic Test statistics from logistic regression

P_logistic P values from logistic regression

BETA Beta from linear regression of HbA1c reduction

STAT_linear Test statistics from linear regression

P_linear P values from linear regression

P_combined Combined p values from linear and logistic regression

The P_combined is derived from a geometric mean of P_logistic and P_linear given that the effect allele’s impact on glycaemic response were consistent between the linear and logistic regression models (STAT_logistic and STAT_linear). Missing values of P_combined are due to the discrepant impact in the two models.

Date made available | 7 Oct 2016 |
---|---|

Publisher | University of Dundee |

## Research Output

- 1 Letter

## Variation in the Glucose Transporter gene *SLC2A2 *is associated with glycaemic response to metformin

Zhou, K., Yee, S. W., Seiser, E. L., van Leeuwen, N., Tavendale, R., Bennett, A. J., Groves, C. J., Coleman, R. L., van der Heijden, A. A., Beulens, J. W., de Keyser, C. E., Zaharenko, L., Rotroff, D. M., Out, M., Jablonski, K. A., Chen, L., Javorský, M., Židzik, J., Levin, A. M., Williams, L. K. & 29 others, , Sep 2016, In : Nature Genetics. 48, 9, p. 1055-1059 5 p.Research output: Contribution to journal › Letter

Open Access

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71
Citations
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## Cite this

Zhou, K. (Creator), Pearson, E. (Contributor), Palmer, C. (Contributor) (7 Oct 2016). Combined GWAS of metaformin glycaemic reponse in 1372 GoDARTS patients. University of Dundee. gwas(.zip). 10.15132/10000119