Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease

  • Sara Gomes Moreira (Creator)
  • Alicia Garrido (Creator)
  • Francesca Tonelli (Creator)
  • Donina Obiang (Creator)
  • Eduardo Tolosa (Creator)
  • Maria José Martí (Creator)
  • Javier Ruiz-Martínez (Creator)
  • Ana Vinagre Aragón (Creator)
  • Haizea Hernandez-Eguiazu (Creator)
  • Ioana Croitoru (Creator)
  • Vicky L. Marshall (Creator)
  • Theresa König (Creator)
  • Christoph Hotzy (Creator)
  • Frank Hsieh (Creator)
  • Marianna Sakalosh (Creator)
  • Elizabeth Tengstrand (Creator)
  • Shalini Padmanabhan (Creator)
  • Kalpana M. Merchant (Creator)
  • Christof Bruecke (Creator)
  • Walter Pirker (Creator)
  • Alexander Zimprich (Creator)
  • Esther Sammler (Creator)

Dataset

Description

Participant demographic and clinical characteristics, and urine BMP phospholipid levels.

For each participant, sample collection site is provided as: BCN (Barcelona), VIE (Vienna), DND (Dundee), or SSB (San Sebastian). Also provided are age at study participation, age at PD diagnosis (where applicable), sex (M, for male, and F, for female), experimental group (control, iPD –idiopathic PD –, LRRK2 G2019S, LRRK2 R1441G/C, VPS35 D620N, GBA, or other), and PD status (NMC for non-manifesting mutation carriers, or PD). Values for all measured BMP species presented as ng of BMP per mg of creatinine are provided. Additionally, urine creatinine (mg/ml) and non-normalized BMP levels are provided. BQL designates BMP levels that were below quantification level and NM designates values that were not measured for a particular individual.
Date made available14 Feb 2023
PublisherZenodo

Keywords

  • Urine
  • LRRK2
  • VPS35
  • GBA
  • bis(monoacylglycerol)phosphate
  • lysobisphosphatidic acid
  • Parkinson's disease
  • Movement disorders
  • Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

    Gomes, S., Garrido, A., Tonelli, F., Obiang, D., Tolosa, E., José Martí, M., Ruiz-Martínez, J., Vinagre Aragón, A., Hernandez-Eguiazu, H., Croitoru, I., Marshall, V. L., Koenig, T., Hotzy, C., Hsieh, F., Sakalosh, M., Tengstrand, E., Padmanabhan, S., Merchant, K. M., Bruecke, C. & Pirker, W. & 2 others, Zimprich, A. & Sammler, E. (Lead / Corresponding author), 4 Apr 2023, In: NPJ Parkinson's disease. 9, 4 p., 52.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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