PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations

Description

Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing

Date made available	20 Nov 2024
Publisher	National Center for Biotechnology Information

Keywords

• TET1
• TET2
• TET3
• DNA methylation
• TOPD
• development
• neurodevelopmental disorder

Contact

• [email protected]

Access Dataset

• Data in NCBI GEO

Projects

• 1 Active

• Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)

  Owen-Hughes, T. (Investigator) & Rasmussen, K. (Investigator)

  1/06/19 → 31/05/26

  Project: Research

  • DNA Methylation 100%
  • TET Proteins 91%
  • DNA Demethylation 84%
  • DNA Methylation (DNAm) 77%
  • Developmental Malformation 68%

Research output

• 1 Article
• 1 Preprint

• PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations

  Fleming, A., Knatko, E. V., Li, X., Zoch, A., Heckhausen, Z., Stransky, S., Brenes, A. J., Sidoli, S., Hajkova, P., O'Carroll, D. & Rasmussen, K. (Lead / Corresponding author), Dec 2024, In: Genes & Development. 38, p. 952-964 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Syndromic 100%
  • DNA Methylation (DNAm) 100%
  • Dual Mechanism 100%
  • Neurodevelopmental Disorders 100%
  • TET Proteins 100%

  3   Link opens in a new tab Citations (Scopus)

  89 Downloads (Pure)

• PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations

  Fleming, A., Knatko, E. V., Li, X., Zoch, A., Heckhausen, Z., Stransky, S., Brenes Murillo, A., Sidoli, S., Hajkova, P., O'Carroll, D. & Rasmussen, K. (Lead / Corresponding author), 2 Aug 2024, BioRxiv, 34 p.

  Research output: Working paper/Preprint › Preprint

  File

  • Syndromic 100%
  • Dual Mechanism 100%
  • DNA Demethylation 100%
  • Developmental Malformation 100%
  • DNA Methylation (DNAm) 66%

  37 Downloads (Pure)

Cite this

• DataSetCite

Rasmussen, K. (Creator) (20 Nov 2024). PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations. National Center for Biotechnology Information.