Skip to main navigation Skip to search Skip to main content

QTL summary statistics from the DIRECT consortium

Dataset

Description

These are the complete summary statistics for DIRECT genotype-phenotypes associations (QTLs). The project performed genotype-phenotype associations for gene expression (RNAseq), targeted proteins (Olink), targeted metabolites (Biocrates) and untargeted metabolites (Metabolon) derived from 3,029 blood and plasma samples from the DIRECT cohort. This submission includes supplementary files and nominal pvalues (as uncorrected pvalues) for all associations included in the manuscript. Trans associations included are typically limited to pvalues <1e-04. Network tables are also included, with information to load and use Cytoscape to visualize them. This is version 2, some files were missing on version 1.
Date made available11 Feb 2021
PublisherZenodo
Date of data production11 Feb 2021

Keywords

  • QTLs
  • eQTLs
  • pQTLs
  • metabolites
  • GWAS
  • networks
  • cis
  • trans

Contact

  • Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

    Brown, A. A., Fernandez-Tajes, J. J., Hong, M.-G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T.-D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T. & Hansen, T. H. & 39 others, Hattersley, A. T., Heggie, A. J., Howald, C., Jones, A. G., Kokkola, T., Laakso, M., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Mourby, M., Musholt, P. B., Nilsson, B., Pattou, F., Penet, D., Raverdy, V., Ridderstråle, M., Romano, L., Rutters, F., Sharma, S., Teare, H., Hart, L., Tsirigos, K. D., Vangipurapu, J., Vestergaard, H., Brunak, S., Franks, P. W., Frost, G., Grallert, H., Jablonka, B., McCarthy, M., Pavo, I., Pedersen, O., Ruetten, H., Walker, M., The DIRECT consortium, Pearson, E. R., Dermitzakis, E. T. (Lead / Corresponding author) & Viñuela, A. (Lead / Corresponding author), 21 Aug 2023, In: Nature Communications. 14, 17 p., 5062.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    23   Link opens in a new tab Citations (Scopus)
    227 Downloads (Pure)

Cite this