Research output per year
Research output per year
Description
The spinal cord neural stem cell potential is contained within the ependymal cells lining the central canal. This neural stem cell potential is known to decline with age in the mouse. Here, we microdissected and dissociated into single cells the central canal region from the spinal cord of 4 young adult (3-to-4-month old) and 4 aged (18-to-19-month old) C57BL/6J mice to profile the transcriptomes of cells in and around the central canal using 10x Genomics technology.
| Date made available | 13 Dec 2022 |
|---|---|
| Publisher | EMBL-EBI |
Data Monitor categories
- Mus musculus
- ependymal cell
- spinal cord
- cell maturation
- adult neural stem cell
- mouse
- human
- scRNA-seq
Research output
- 1 Article
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An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury
Rodrigo Albors, A., Singer, G. A., Llorens-Bobadilla, E., Frisén, J., May, A. P., Ponting, C. P. & Storey, K. G. (Lead / Corresponding author), 6 Feb 2023, In: Developmental Cell. 58, 3, p. 239-255.e10 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)99 Downloads (Pure)
Datasets
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Single-cell RNA-sequencing of spinal cord ependymal cells from FOXJ1-EGFP mice
Rodrigo Albors, A. (Creator) & Storey, K. (Creator), EMBL-EBI, 13 Dec 2022
https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-11563
Dataset
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Single-cell transcriptomics of mouse spinal cord ependymal cells
Rodrigo Albors, A. (Creator) & Storey, K. (Creator), posit, 2022
https://ependymalcell.shinyapps.io/ependymal_atlas/ and 2 more links, https://doi.org/10.1101/2022.03.07.483249, https://github.com/aidarodrigo/ependymal_cell (show fewer)
Dataset