Source data Figure 2 from "ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains"

Description

ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
Maike Reinders, Bojana Kravic, Pinki Gahlot, Johannes van den Boom, Nina Schulze, Sophie Levantovsky, Stefan Kleine, Markus Kaiser, Yogesh Kulathu, Christian Behrends, Hemmo Meyer

Source data for Figure 2 presented in Reinders et al. EMBOJ 2025.
For other figures, see respective data sets.

Date made available	31 Jul 2025
Publisher	Mendeley Data

Keywords

• Cell Biology
• Lysosome
• Membrane
• Autophagy
• Ubiquitylation
• Cellular Stress Response

Contact

• [email protected]

• DOI

  10.17632/yk5fs9v2rj

Projects

• 1 Active

• Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains (StressHUb)

  Kulathu, Y. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/22 → 31/12/26

  Project: Research

  • Ubiquitin 100%
  • Branched Ubiquitin Chain 66%
  • Branched-chain 46%
  • Cell Signaling 40%
  • P97 40%

Research output

• 1 Article

• ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains

  Reinders, M., Kravic, B., Gahlot, P., Koska, S., van den Boom, J., Schulze, N., Levantovsky, S., Kleine, S., Kaiser, M., Kulathu, Y., Behrends, C. & Meyer, H. (Lead / Corresponding author), 15 Sept 2025, In: EMBO Journal. 44, 18, p. 5086-5111 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lysosome 100%
  • Ubiquitin 100%
  • Lysosomal Damage 42%
  • Lysophagy 28%
  • Membrane Damage 20%

  5   Link opens in a new tab Citations (Scopus)

  35 Downloads (Pure)

Datasets

• Source data Figures 5-6 from "ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains"

  Reinders, M. (Creator), Kravic, B. (Creator), Gahlot, P. (Creator), van den Boom, J. (Creator), Schulze, N. (Creator), Levantovsky, S. (Creator), Kleine, S. (Creator), Kaiser, M. (Creator), Kulathu, Y. (Creator), Behrends, C. (Creator) & Meyer, H. (Creator), Mendeley Data, 31 Jul 2025

  DOI: 10.17632/m62b7d3n8m

  Dataset

Cite this

• DataSetCite

Reinders, M. (Creator), Kravic, B. (Creator), Gahlot, P. (Creator), van den Boom, J. (Creator), Schulze, N. (Creator), Levantovsky, S. (Creator), Kleine, S. (Creator), Kaiser, M. (Creator), Kulathu, Y. (Creator), Behrends, C. (Creator), Meyer, H. (Creator) (31 Jul 2025). Source data Figure 2 from "ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains". Mendeley Data. 10.17632/yk5fs9v2rj