Biological Chemistry and Drug Discovery

  • United Kingdom

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Trypanosoma brucei brucei Medicine & Life Sciences
Trypanosomiasis Medicine & Life Sciences
Parasites Medicine & Life Sciences
Proteins Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Enzymes Medicine & Life Sciences

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Profiles

No photo of Eleanor Adams

Adams, Eleanor

No photo of Gemma Baillie

Baillie, Gemma

20172017
No photo of Beatriz Baragana
20102018

Research Output 1972 2019

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening
2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journalArticle

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site
1 Citations

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation

Datasets

Whole Genome Sequencing Variant Call Files for Trypanosoma brucei clones resistant to nifurtimox or fexinidazole

Fairlamb, A. (Creator), Foth, B. (Creator), Berriman, M. (Creator), University of Dundee, 2015

Dataset

File

Activities 2012 2019

  • 4 Types of External academic engagement - Membership of peer review panel or committee

Action Medical Research - Scientific Advisory Panel

David Gray (Member)
2019 → …

Activity: Other activity typesTypes of External academic engagement - Membership of peer review panel or committee

Global Antimicrobial Resistance Investment Fund (GAMRIF) panel

David Gray (Member)
20172018

Activity: Other activity typesTypes of External academic engagement - Membership of peer review panel or committee

Member of MRC/AZ Centre for Lead Discovery (CLD)

David Gray (Member)
Jan 2017 → …

Activity: Other activity typesTypes of External academic engagement - Membership of peer review panel or committee

Press / Media

Tuberculosis drug may also target visceral leishmaniasis

Alan Fairlamb & Kevin Read

24/05/16

1 item of media coverage

Press/Media: Research

Student theses

A biophysical approach for the study of G-protein coupled receptor complexes

Author: Aristotelous, T., 2017

Supervisor: Hopkins, A. (Supervisor) & Hopkins Navratilova, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File

Development and optimisation of biosensor analysis for wild-type G protein-coupled receptors

Author: Shepherd, C., 2017

Supervisor: Hopkins, A. (Supervisor), Hopkins Navratilova, I. (Supervisor) & Rawlins, P. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy