Biological Chemistry and Drug Discovery

Projects

Projects per year 2007 2013 2015 2017 2019 2030

• 18 Not started
• 30 Active
• 92 Finished

Projects per year

Search results

• Active

  Harnessing the splicing code for targeted control of gene expression (UNLEASH)

  Gray, D. & Lamond, A.

  1/06/23 → 31/05/29

  Project: Research

• Development of LRRK2 Type II Inhibitors to Understand Utility of these Compounds for the Treatment of Parkinson's Disease

  Alessi, D., Davies, P., Gilbert, I., Gray, D. & Read, K.

  1/03/23 → 30/11/23

  Project: Research

• CRISPR Platform for MalDA Target Validation and Drug Discovery (Transfer)

  Lee, M.

  1/03/23 → 28/02/26

  Project: Research

• Enabling Cryptococcal Meningitis Drug Discovery: Development Of Cryptococcus Screening Cascade And Identification Of High Quality Starting Points For Drug Discovery (Joint with GSK Tres Cantos Open Lab Foundation)

  De Rycker, M. & Gilbert, I.

  16/01/23 → 15/01/25

  Project: Research

• Regulation of Protein Stbility by Lysine Hydroxylation (DP Fellowship) (Transfer)

  Maniaci, C.

  Biotechnology and Biological Sciences Research Council

  5/01/23 → 4/10/23

  Project: Research

• Assisted Transfer Package Letter Agreement between Genome Research Limited (Sanger) the University of Dundee and Dr Marcus Lee

  Lee, M.

  1/01/23 → 31/12/30

  Project: Research

• Development of LRRK2 PROTAC degraders as chemical probes and potential lead compounds for the treatment of Parkinson’s disease (PROCESS)

  Ciulli, A.

  1/09/22 → 29/02/24

  Project: Research

• Application of Biotransformations To Neglected Tropical Disease Research (Joint with Industrial Partner)

  Gilbert, I. & Wyllie, S.

  Wellcome Trust

  8/07/22 → 7/01/24

  Project: Research

• Fully Functional Chemical Probe Library and Proteomic POC Enablement

  Gilbert, I. & Wyllie, S.

  Bill and Melinda Gates Foundation

  1/07/22 → 30/06/25

  Project: Research

• MRC IAA 2021 University of Dundee

  Ferguson, M., Gilbert, I., Gray, D. & Read, K.

  Medical Research Council

  1/04/22 → 31/03/25

  Project: Research

• Organoid High-Throughput Screening Platform For Cryptosporidiosis (Lead: UoD other instns: University of Arizona)

  De Rycker, M., Gilbert, I. & Pawlowic, M.

  Wellcome Trust

  1/04/22 → 31/03/24

  Project: Research

• Refining the Drug Discovery Paradigm for Schistosomiasis (Joint with the Universities of Aberystwyth & Cardiff)

  Gilbert, I., Gray, D., Read, K. & Wyatt, P.

  Wellcome Trust

  1/10/21 → 1/04/24

  Project: Research

  • Schistosomiasis 100%
  • Drug Discovery 87%
  • Praziquantel 84%
  • Education 53%
  • Mass Drug Administration 31%

• Understanding and Preventing Plant Susceptibility to Aphids (APHIDTRAP)

  Bos, J. & Hunter, B.

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/21 → 31/05/26

  Project: Research

• PROTACT Linker Design: towards Functionality (PREDICT)

  Ciulli, A.

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/21 → 30/06/23

  Project: Research

  • Ubiquitin-Protein Ligases 100%
  • Proteolysis 82%
  • Ligands 61%
  • Ubiquitination 37%
  • Proteasome Endopeptidase Complex 36%

• A Platform for Drug Target Deconvolution and Exploitation

  Gilbert, I., Horn, D., Pawlowic, M., Wyatt, P. & Wyllie, S.

  Wellcome Trust

  31/12/20 → 30/12/23

  Project: Research

  • African Trypanosomiasis 100%
  • Chagas Disease 97%
  • Drug Discovery 85%
  • Visceral Leishmaniasis 62%
  • Neglected Diseases 57%

• Elucidating molecular determinants of Trypanosoma cruzi persisters (New Investigator Research Grant) (Joint with the University of Glasgow)

  De Rycker, M.

  Medical Research Council

  1/12/20 → 30/11/24

  Project: Research

• Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectives (MepAntI) (Joint with Helmholtz-Institute for Pharmaceutical Research (Lead), University of Groningen, French Alternative Energies and Atomic Energy Commission, Ghent University, Compound Handling BV, University of Strasbourg, University of Bergen, Research Centre Borstel, Swiss Tropical and Public Health Institute, OmicScouts GmbH)

  Hunter, B.

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/20 → 31/05/24

  Project: Research

• EUbOPEN: Enabling and Unlocking biology in the OPEN (Joint with Goethe University Frankfurt, University of Oxford, Karolinska Institute and 9 others)

  Ciulli, A.

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/20 → 30/04/25

  Project: Research

  • Proteolysis 100%
  • Ubiquitin-Protein Ligases 92%
  • Protein Hydrolysis 59%
  • Protein 54%
  • Kelch Repeat 38%

• Decoding Mechanisms of gene regulation in African Trypanosomes

  Horn, D.

  Wellcome Trust

  1/03/20 → 28/02/25

  Project: Research

  • Trypanosoma brucei brucei 100%
  • Trypanosoma 84%
  • RNA Interference 53%
  • Untranslated Regions 47%
  • F-Box Proteins 41%

• Targeting a New Kingdom The Nature and Importance of Type VI Secretion System Mediated Anti Fungal Activity (joint with University of Newcastle, Heriot-Watt University, Hans Knoll Institute, University of Exeter)

  Coulthurst, S. & Hunter, B.

  Wellcome Trust

  1/11/19 → 31/10/25

  Project: Research

  • Type VI Secretion Systems 100%
  • secretions 87%
  • Acinetobacter baumannii 76%
  • proteins 50%
  • bacteria 33%

• Defining Oocyst Wall Biogenesis and Function in Cryptosporidium Transmission (Reference #UNS68421) (Sir Henry Dale Fellowship)

  Gilbert, I. & Pawlowic, M.

  Wellcome Trust

  1/02/19 → 1/05/24

  Project: Research

• Structure-Guided Drug Discovery for Malaria and Tuberculosis (joint with Structural Genomics Consortium)

  Gilbert, I., Gray, D., Read, K. & Wyatt, P.

  Bill and Melinda Gates Foundation

  1/01/19 → 6/07/24

  Project: Research

  • Plasmodium falciparum 100%
  • Lysine-tRNA Ligase 83%
  • Antimalarials 78%
  • Antimalarial 56%
  • Proteome 49%

• Industrial Collaborative Awards in Science and Engineering (iCASE) Studentships for the University of Dundee

  Hunter, B. & MacKintosh, C.

  Medical Research Council

  3/09/18 → 30/09/25

  Project: Research

  • Pentamidine 100%
  • Anti-Bacterial Agents 84%
  • Trypanosoma brucei brucei 83%
  • Permeability 73%
  • Gram-Negative Bacteria 64%

• KRS Inhibitors: A Dundee Mini Portfolio

  Gilbert, I., Gray, D., Read, K. & Wyatt, P.

  Medicines for Malaria Venture (MMV)

  1/01/18 → 1/07/23

  Project: Research

• A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)

  Field, M.

  Wellcome Trust

  1/10/17 → 31/03/24

  Project: Research

  • Trypanosoma 100%
  • Eukaryota 60%
  • Trypanosoma brucei brucei 59%
  • Euglena gracilis 46%
  • Proteins 42%

• MICA: Delivering Gene Silencing Therapy to the Epidermis and Ocular Surface

  Hickerson, R. & McLean, I.

  Medical Research Council

  1/06/17 → 30/11/23

  Project: Research

  • Epidermolysis Bullosa 100%
  • filaggrin 99%
  • Electromagnetic Phenomena 81%
  • genes 80%
  • Skin 66%

• Wellcome Centre for Anti-Infectives Research

  Cook, S., De Rycker, M., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Pawlowic, M., Read, K., Wyatt, P. & Wyllie, S.

  Wellcome Trust

  1/04/17 → 31/03/24

  Project: Research

  • Drug Discovery 100%
  • Parasites 68%
  • Trypanosoma 68%
  • Pharmaceutical Preparations 63%
  • Trypanosoma brucei brucei 63%

• Architecture of a Biofilm (Joint with University of Edinburgh)

  Campbell, P., Davidson, F., Ferguson, M., Stanley-Wall, N. & Swedlow, J.

  Biotechnology and Biological Sciences Research Council

  1/02/17 → 31/07/23

  Project: Research

  • Bacillus subtilis 100%
  • Biofilms 89%
  • Extracellular Polymeric Substance Matrix 43%
  • Bacteria 22%
  • biofilm 18%

• Training the Next Generation of Scientists in Quantitative and Interdisciplinary Approaches to Biomedical Science (Doctoral Training Partnership)

  Hunter, B. & MacKintosh, C.

  Medical Research Council

  11/11/16 → 30/09/25

  Project: Research

  • deschloroepibatidine 100%
  • glomerulonephritis 63%
  • Binding Sites 49%
  • Nicotinic Receptors 47%
  • pathology 47%

• Protein Glycosylation in Trypanosomes: Defining and Exploiting a Biological System (Senior Investigator Award)

  Ferguson, M.

  Wellcome Trust

  1/10/13 → 30/06/23

  Project: Research

  • Trypanosoma brucei brucei 100%
  • Parasites 37%
  • Trypanosoma 29%
  • Glycosylphosphatidylinositols 28%
  • Glycosylphosphatidylinositol 28%
• Not started

  KinoGlu: A Chemical Strategy to Illuminate CNS Biology

  Farnaby, W.

  Engineering and Physical Sciences Research Council

  1/07/23 → 30/06/26

  Project: Research

• Acclerate China-UK AMR Discovery: Establishing and Exploiting a Joint UK/China Platform to Enable High Throughput Structure and Fragment Based AMR Training and Discovery (Joint with University of Warwick)

  Gilbert, I. & Gray, D.

  Project: Research

• Aref#d: 9354. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund)

  Cohen, P., Downes, P., Fairlamb, A., Ferguson, M., Hunter, B., Lamond, A., Lilley, D., Norman, D., Watts, C. & Williams, J.

  Project: Research

• Target Assessment for Drug Discovery Against the Kinetoplastida

  Dhir, R., Fairlamb, A. & Ferguson, M.

  Project: Research

• Aref#d: 18913. Development of a diagnostic tool for leishmaniasis (Capacity Building Studentship)

  Ferguson, M. & Nikolaev, A.

  Project: Research

• Aref#d: 12419. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund - supplement)

  Cohen, P., Downes, P., Fairlamb, A., Ferguson, M., Hunter, B., Lamond, A., Lilley, D., Norman, D., Watts, C. & Williams, J.

  Project: Research

• Extension to College of Life Sciences Research Complex to Create a Centre for Translational and Interdisciplinary Research (Wolfson Award)

  Barton, G., Chaplain, M., Fairlamb, A., Ferguson, M., Gilbert, I., Hopkins, A., Lamond, A., Swedlow, J. & Wyatt, P.

  Project: Research

• Unlocking Mitophagy Activation With Small Molecule Targeted Protein Stabilisers - Fellowship (Joint with UCL/Francis Crick Institute)

  Farnaby, W.

  Project: Research

• SFC Connecting Capability Fund - Innovative Therapeutics for Ageing

  Ferguson, M.

  Project: Research

• Centre for Translational and Interdisciplinary Research

  Ferguson, M.

  Project: Research

• Aref#d: 21121. Optimised Delivery of Therapeutic siRNA into Human Skin (Milstein Fund)

  Campbell, P., McLean, I. & Smith, F.

  Project: Research

• A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)

  Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

  Project: Research

• Early Career - Target Protein Degradation Network (Joint with University of Glasgow and University of Strathclyde)

  Ciulli, A., Eugui Anta, A., Farnaby, W., Haubrich, K., Mojsa, B. & Spiteri, V.

  Project: Research

• Delivery of Antisense Oligonucleotides to the Basal Layer Using Ultrasound

  Hickerson, R. & McLean, I.

  Project: Research

• ISCEM-DD (Joint with University Of Glasgow)

  Ciulli, A. & Nakasone, M.

  Project: Research

• Scottish Enterprise Offer Letter for CTIR Building

  Ferguson, M.

  Project: Research

• Targeting E3 ubiquitin lifases with sall molecules (iCASE Studentship)

  Ciulli, A. & Virdee, S.

  Project: Research

• Target ID Studies - Gamhepathiopine (Toulouse)

  Wyllie, S.

  Project: Research

• Finished

  Development Of An Anti-Malarial Drug Discovery Pipeline In Ghana (Joint with University Of Ghana and KHUST - Kwame Nkrumah University Of Science And Technology)

  Gilbert, I., Read, K. & Wyllie, S.

  Bill and Melinda Gates Foundation

  18/03/22 → 17/04/23

  Project: Research

• Purchase of Sample Handling Robot And Mass Spec For Structural Spectrometry Drug Screening

  Ferguson, M. & Masson, G.

  Biotechnology and Biological Sciences Research Council

  1/06/21 → 31/05/22

  Project: Research

  • Phosphatidylinositol 3-Kinases 100%
  • Phosphotransferases 28%
  • Rodentia 15%
  • Protein Isoforms 14%
  • Nerve Crush 12%