Biological Chemistry and Drug Discovery

Projects

Projects per year 2007 2013 2015 2017 2019 2030

• 14 Not started
• 15 Active
• 51 Finished

Projects per year

Search results

• Active

  Assisted Transfer Package Letter Agreement between Genome Research Limited (Sanger), The University of Dundee and Dr Marcus Lee

  Lee, M. (Investigator)

  Wellcome Sanger Institute

  1/01/24 → 31/12/30

  Project: Research

• Advancement of Sperm-targeting Contraceptive Agents

  Barratt, C. (Investigator), Gilbert, I. (Investigator), Martins Da Silva, S. (Investigator), Read, K. (Investigator), Swedlow, J. (Investigator) & Wyllie, S. (Investigator)

  Bill and Melinda Gates Foundation

  5/07/23 → 4/07/26

  Project: Research

• Developing a Barcoded Resistance Library for Compound Prioritisation and Target Deconvolution (Transfer)

  Lee, M. (Investigator)

  1/07/23 → 31/12/24

  Project: Research

• CRISPR Platform for MalDA Target Validation and Drug Discovery (Transfer)

  Lee, M. (Investigator)

  Bill and Melinda Gates Foundation

  1/03/23 → 28/02/26

  Project: Research

• Assisted Transfer Package Letter Agreement between Genome Research Limited (Sanger) the University of Dundee and Dr Marcus Lee

  Lee, M. (Investigator)

  Wellcome Sanger Institute

  1/01/23 → 31/12/30

  Project: Research

• Fully Functional Chemical Probe Library and Proteomic POC Enablement

  Gilbert, I. (Investigator) & Wyllie, S. (Investigator)

  Bill and Melinda Gates Foundation

  1/07/22 → 30/06/25

  Project: Research

• Organoid High-Throughput Screening Platform For Cryptosporidiosis (Lead: UoD other instns: University of Arizona)

  De Rycker, M. (Investigator), Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)

  1/04/22 → 31/12/24

  Project: Research

• Understanding and Preventing Plant Susceptibility to Aphids (APHIDTRAP)

  Bos, J. (Investigator) & Hunter, B. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/21 → 31/05/26

  Project: Research

  • Effector Proteins 100%
  • Phloem 62%
  • Phloem-feeding Insects 60%
  • Saliva 50%
  • Unveiling 50%

• A Platform for Drug Target Deconvolution and Exploitation

  Gilbert, I. (Investigator), Horn, D. (Investigator), Pawlowic, M. C. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)

  31/12/20 → 30/03/25

  Project: Research

  • Chagas Disease 100%
  • Visceral Leishmaniasis 72%
  • Drug Discovery 67%
  • Molecular Targets 67%
  • Mode of Action 64%

• Decoding Mechanisms of gene regulation in African Trypanosomes

  Horn, D. (Investigator)

  1/03/20 → 28/02/26

  Project: Research

  • Trypanosoma 100%
  • African Trypanosomes 85%
  • Trypanosoma Brucei 75%
  • Trypanosomatids 61%
  • Trypanosomatid 59%

• Targeting a New Kingdom The Nature and Importance of Type VI Secretion System Mediated Anti Fungal Activity (joint with University of Newcastle, Heriot-Watt University, Hans Knoll Institute, University of Exeter)

  Coulthurst, S. (Investigator) & Hunter, B. (Investigator)

  1/11/19 → 30/04/26

  Project: Research

  • Type VI Secretion System 100%
  • Tautomerase Superfamily 50%
  • NADase 50%
  • Bacterial Competition 50%
  • Immunogenic Proteins 50%

• Defining Oocyst Wall Biogenesis and Function in Cryptosporidium Transmission (Reference #UNS68421) (Sir Henry Dale Fellowship)

  Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)

  1/02/19 → 30/04/25

  Project: Research

  • LysR Family 100%
  • Cryptosporidium 100%
  • Lysine Transfer RNA Ligase 100%
  • Mode of Action 50%
  • Target Engagement 50%

• Industrial Collaborative Awards in Science and Engineering (iCASE) Studentships for the University of Dundee

  Hunter, B. (Investigator) & MacKintosh, C. (Investigator)

  Medical Research Council

  3/09/18 → 30/09/25

  Project: Research

  • Gram-negative Bacteria 100%
  • Gram Negative Bacterium 80%
  • Gram-negative 53%
  • Antibiotics 53%
  • Small Molecule 48%

• Wellcome Centre for Anti-Infectives Research

  Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)

  1/04/17 → 31/03/25

  Project: Research

  • Drug Discovery 100%
  • Trypanosoma Cruzi (T. cruzi) 73%
  • Chagas Disease 66%
  • Visceral Leishmaniasis 61%
  • Trypanosoma Cruzi 61%

• Training the Next Generation of Scientists in Quantitative and Interdisciplinary Approaches to Biomedical Science (Doctoral Training Partnership)

  Hunter, B. (Investigator) & MacKintosh, C. (Investigator)

  Medical Research Council

  11/11/16 → 30/09/25

  Project: Research

  • LysR Family 100%
  • Cryptosporidium 100%
  • Ca2+ 60%
  • Knock-in Mouse Model 60%
  • Ion Channels 54%
• Not started

  An Iron Lens to Identify Environmental Sensing and Responses in Toxoplasma Gondii

  Wyllie, S. (Investigator)

  Project: Research

• Developing a Barcoded Resistance Library for Compound Prioritisation and Target Deconvolution

  Lee, M. (Investigator)

  Project: Research

• Optimisation of hits against persisters

  Bergkessel, M. (Investigator), Gilbert, I. (Investigator), Read, K. (Investigator) & Wyllie, S. (Investigator)

  Project: Research

• Molecule assisted protein-protein interaction mapping via peroxidase activity

  Salerno, A. (Investigator)

  Project: Research

• Breaking the Membrane Permeability Barrier for Antimicrobials in Gram-negative Bacteria (Vacation Scholarship 2017)

  Zachariae, U. (Investigator)

  Project: Research

• Aref#d: 21121. Optimised Delivery of Therapeutic siRNA into Human Skin (Milstein Fund)

  Campbell, P. (Investigator), McLean, I. (Investigator) & Smith, F. (Investigator)

  Project: Research

• Aref#d: 18913. Development of a diagnostic tool for leishmaniasis (Capacity Building Studentship)

  Ferguson, M. (Investigator) & Nikolaev, A. (Investigator)

  Project: Research

• Aref#d: 9354. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund)

  Cohen, P. (Investigator), Downes, P. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Hunter, B. (Investigator), Lamond, A. (Investigator), Lilley, D. (Investigator), Norman, D. (Investigator), Watts, C. (Investigator) & Williams, J. (Investigator)

  Project: Research

• Systems biology of the trypanosome nuclear envelope: Gene expression and mRNA processing

  Field, M. (Investigator)

  Project: Research

• Target ID Studies - Gamhepathiopine (Toulouse)

  Wyllie, S. (Investigator)

  Project: Research

• BBSRC - Exploring the Cryptosporidium kinome

  Pawlowic, M. C. (Investigator) & Wyllie, S. (Investigator)

  Project: Research

• A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)

  Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)

  Project: Research

• Aref#d: 12419. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund - supplement)

  Cohen, P. (Investigator), Downes, P. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Hunter, B. (Investigator), Lamond, A. (Investigator), Lilley, D. (Investigator), Norman, D. (Investigator), Watts, C. (Investigator) & Williams, J. (Investigator)

  Project: Research

• Early Career - Target Protein Degradation Network (Joint with University of Glasgow and University of Strathclyde)

  Ciulli, A. (Investigator), Eugui Anta, A. (Investigator), Farnaby, W. (Investigator), Haubrich, K. (Investigator), Mojsa, B. (Investigator) & Spiteri, V. (Investigator)

  Project: Research

• Finished

  Application of Biotransformations To Neglected Tropical Disease Research (Joint with Industrial Partner)

  Gilbert, I. (Investigator) & Wyllie, S. (Investigator)

  8/07/22 → 7/01/24

  Project: Research

• Development Of An Anti-Malarial Drug Discovery Pipeline In Ghana (Joint with University Of Ghana and KHUST - Kwame Nkrumah University Of Science And Technology)

  Gilbert, I. (Investigator), Read, K. (Investigator) & Wyllie, S. (Investigator)

  Bill and Melinda Gates Foundation

  18/03/22 → 17/04/23

  Project: Research

  • Low-middle Income Countries 100%
  • Drug Discovery 100%
  • Bespoke 100%
  • Practice Placement 50%
  • Training Program 50%

• GPU-Based Machine Learning System For Fundamental Biological Research

  Barton, G. (Investigator), Gilbert, I. (Investigator), Lamond, A. (Investigator), Owen-Hughes, T. (Investigator), Pisliakov, A. (Investigator), Schweikert, G. (Investigator), Sknepnek, R. (Investigator), Swedlow, J. (Investigator), Weijer, K. (Investigator) & Zachariae, U. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/08/21 → 31/07/22

  Project: Research

  • Biological Research 100%
  • Dundee 100%
  • Life Sciences 50%

• High Resolution Structure, Function and Anti-Viral Inhibition of the SARS-CoV2 E Protein Ion Channel (joint with St Andrews University and Trinity College Dublin)

  Zachariae, U. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/02/21 → 7/10/22

  Project: Research

  • Envelope (E) Protein 100%
  • Biological Research 100%
  • Calcium-activated 100%
  • E Protein 100%
  • Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 100%

• Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectives (MepAntI) (Joint with Helmholtz-Institute for Pharmaceutical Research (Lead), University of Groningen, French Alternative Energies and Atomic Energy Commission, Ghent University, Compound Handling BV, University of Strasbourg, University of Bergen, Research Centre Borstel, Swiss Tropical and Public Health Institute, OmicScouts GmbH)

  Hunter, B. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/20 → 31/05/24

  Project: Research

• Genetic Validation of a Promising Drug Target for Cryptosporidiosis

  Baragana, B. (Investigator), Gilbert, I. (Investigator), Pawlowic, M. C. (Investigator) & Wyllie, S. (Investigator)

  Carnegie Trust for the Universities of Scotland

  20/08/19 → 19/02/21

  Project: Research

  • Mode of Action 100%
  • Target Engagement 100%
  • LysR Family 100%
  • Selection Marker 100%
  • Cryptosporidium 100%

• Development of New Agents for the Treatment of Cryptosporidiosis (DPFS) (Joint with University of Vermont)

  Gilbert, I. (Investigator), Gray, D. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)

  Medical Research Council

  1/05/19 → 31/01/23

  Project: Research

  • Anticryptosporidial 100%
  • LysR Family 100%
  • Efficacy in Vivo 100%
  • Cryptosporidium 100%
  • Lysine Transfer RNA Ligase 100%

• Converting Natural Product Leads into Structure and Ligand Based Drug Discovery Campaigns against Leishmaniasis and Chagas' Disease (Joint with Sao Paulo State University)

  Gilbert, I. (Investigator), Read, K. (Investigator) & Wyllie, S. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/22

  Project: Research

• Defining the Function of Cryptosporidium Oocyst Wall Proteins in Parasite Transmission

  Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)

  27/03/19 → 26/03/20

  Project: Research

• Identification and Validation of the Targets of Compounds Demonstrating In Vitro Activity Against Trypanosoma Cruzi (Newton International Fellowship)

  Wyllie, S. (Investigator)

  1/03/19 → 1/09/21

  Project: Research

  • Aryl Aldehydes 100%
  • In Vitro Assessment 100%
  • Benzofuran-3(2H)-one 100%
  • Trypanosoma Cruzi (T. cruzi) 100%
  • Bioactivation 100%

• Industrial Strategy MRC DTP Studentship for the University of Dundee

  Hunter, B. (Investigator) & MacKintosh, C. (Investigator)

  Medical Research Council

  1/09/18 → 28/02/22

  Project: Research

• A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)

  Field, M. (Investigator)

  1/10/17 → 31/03/24

  Project: Research

  • Trypanosome 100%
  • Trypanosoma 95%
  • Eukaryotes 53%
  • Lineages 47%
  • Trypanosoma Brucei 47%

• Development of an Image-Based High Throughput Screening Platform in Full Thickness Skin (Tools and Resources Development Fund: Bioimaging)

  Conneely, M. (Investigator) & Hickerson, R. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/10/17 → 30/09/19

  Project: Research

• University of Dundee NPIF Studentships 2017

  Hunter, B. (Investigator)

  Medical Research Council

  1/09/17 → 28/02/21

  Project: Research

• Mode of Action Studies in Kinetoplastid Parasites (Industrial CASE Studentship)

  Gilbert, I. (Investigator) & Horn, D. (Investigator)

  Medical Research Council

  1/09/17 → 30/09/21

  Project: Research

• Global Mechanisms for Control of the Trypanosome Proteome: Defining the Composition, Origins and Roles of Cullin E3 Ligases

  Field, M. (Investigator)

  Medical Research Council

  1/01/17 → 31/12/19

  Project: Research

  • Nuclear Pore 100%
  • Trypanosoma 95%
  • Proteomics 87%
  • Trypanosome 77%
  • Eukaryotes 77%

• Anchor E3s

  Ciulli, A. (Investigator) & Lucas, X. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/08/16 → 31/07/18

  Project: Research

• Control of Gene Expression in Trypanosoes: Defining the Nuclear Lamina

  Field, M. (Investigator)

  Medical Research Council

  1/07/16 → 29/02/20

  Project: Research

  • Trypanosoma 100%
  • Trypanosome 85%
  • Proteomics 71%
  • Evolution 71%
  • Eukaryotic Cells 68%

• Understanding the Molecular Details as the Basis of Epigenetic Readers Function (Fellowship)

  Bortoluzzi, A. (Investigator) & Ciulli, A. (Investigator)

  1/10/15 → 30/09/16

  Project: Research

• Lipopolysaccharide Translocation Across the Gram-Negative Inner Membrane: Development and Exploitation of Reagents and Knowledge to Guide Early Stage Drug Discovery(EPSRC-DSTL Industrial CASE Studentship)

  Hunter, B. (Investigator)

  Engineering and Physical Sciences Research Council

  1/10/15 → 1/10/19

  Project: Research

• Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)

  Chan, K. H. (Investigator) & Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/10/15 → 30/09/17

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Protein Catabolism 92%
  • Bromodomain 69%
  • Protein Degradation 57%
  • Degrader 57%