Biological Chemistry and Drug Discovery

  • United Kingdom

Research Output

2020

100 years of suramin

Wiedemar, N., Hauser, D. A. & Mäser, P., Mar 2020, In : Antimicrobial Agents and Chemotherapy. 64, 3, p. 1-14 14 p., e01168.

Research output: Contribution to journalReview article

A One Health Approach to Tackle Cryptosporidiosis

Innes, E. A., Chalmers, R. M., Wells, B. & Pawlowic, M. C., Mar 2020, In : Trends in Parasitology. 36, 3, p. 290-303 14 p.

Research output: Contribution to journalReview article

A platform for target prediction of phenotypic screening hit molecules

Homeyer, N., van Deursen, R., Ochoa-Montaño, B., Heikamp, K., Ray, P., Zuccotto, F., Blundell, T. L. & Gilbert, I. H., Mar 2020, In : Journal of Molecular Graphics & Modelling. 95, p. 1-9 9 p., 107485.

Research output: Contribution to journalArticle

Open Access
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42 Downloads (Pure)

A uniquely complex mitochondrial proteome from Euglena gracilis

Hammond, M. J., Nenarokova, A., Butenko, A., Zoltner, M., Lacová Dobáková, E., Field, M. & Lukeš, J., 11 Mar 2020, In : Molecular Biology and Evolution.

Research output: Contribution to journalArticle

Open Access

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Harrison, J. R., Sarkar, S., Hampton, S., Riley, J., Stojanovski, L., Sahlberg, C., Appelqvist, P., Erath, J., Mathan, V., Rodriguez, A., Kaiser, M., Pacanowska, D. G., Read, K. D., Johansson, N. G. & Gilbert, I. H., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 3066-3089 24 p.

Research output: Contribution to journalArticle

Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila

Sparvoli, D., Zoltner, M., Cheng, C-Y., Field, M. C. & Turkewitz, A., 12 Feb 2020, In : Journal of Cell Science. 133, 3, p. 1-18 18 p., jcs238659.

Research output: Contribution to journalArticle

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9

Sateriale, A., Pawlowic, M., Vinayak, S., Brooks, C. & Striepen, B., 2020, Cryptosporidium. Mead, J. R. & Arrowood, M. J. (eds.). New York: Humana Press, p. 219-228 10 p. (Methods in Molecular Biology; vol. 2052).

Research output: Chapter in Book/Report/Conference proceedingChapter

Girlguiding Medicine Maker Badge

Bellany, F., Bell, M., Caldwell, N., Cocco, M., Davis, S., Dowers, K., Wheldon, M. & Floyd, A., Jan 2020, 85 p. Dundee : University of Dundee.

Research output: Other contribution

Open Access
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52 Downloads (Pure)

Identification of small and large genomic candidate variants in bovine pulmonary hypoplasia and anasarca syndrome

Häfliger, I. M., Wiedemar, N., Švara, T., Starič, J., Cociancich, V., Šest, K., Gombač, M., Paller, T., Agerholm, J. S. & Drögemüller, C., 18 Feb 2020, In : Animal Genetics.

Research output: Contribution to journalArticle

New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi

Pedron, J., Boudot, C., Brossas, J., Pinault, E., Bourgeade-Delmas, S., Sournia-Saquet, A., Boutet-Robinet, E., Destere, A., Tronnet, A., Bergé, J., Bonduelle, C., Deraeve, C., Pratviel, G., Stigliani, J-L., Paris, L., Mazier, D., Corvaisier, S., Since, M., Malzert-Freon, A., Wyllie, S. & 5 others, Milne, R., Fairlamb, A. H., Valentin, A., Courtioux, B. & Verhaeghe, P., 6 Feb 2020, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Wang, Q., Boshoff, H. I. M., Harrison, J. R., Ray, P. C., Green, S. R., Wyatt, P. G. & Barry, C. E., 6 Mar 2020, In : Science. 367, 6482, p. 1147-1151 5 p.

Research output: Contribution to journalArticle

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission

Pandey, R., Abel, S., Boucher, M., Wall, R. J., Zeeshan, M., Rea, E., Freville, A., Lu, X. M., Brady, D., Daniel, E., Stanway, R. R., Wheatley, S., Batugedara, G., Hollin, T., Bottrill, A. R., Gupta, D., Holder, A. A., Le Roch, K. G. & Tewari, R., 11 Feb 2020, In : Cell Reports. 30, 6, p. 1883-1897.e6 22 p.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
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41 Downloads (Pure)

Sorting the Muck from the Brass: Analysis of Protein Complexes and Cell Lysates

Zoltner, M., Del Pino, R. C. & Field, M. C., 2020, Trypanosomatids: Methods and Protocols. Michels, P. A. M., Ginger, M. L. & Zilberstein, D. (eds.). New York: Humana Press, Vol. 2116. p. 645-653 9 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The Identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Zachari, M., Rainard, J. M., Pandarakalam, G. C., Robinson, L., Gillespie, J., Rajamanickam, M., Hamon, V., Morrison, A., Ganley, I. G. & McElroy, S. P., 27 Feb 2020, In : Biochemical Journal. 477, 4, p. 801-814 14 p.

Research output: Contribution to journalArticle

Open Access
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8 Downloads (Pure)

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

Henrici, R. C., Edwards, R. L., Zoltner, M., van Schalkwyk, D. A., Hart, M. N., Mohring, F., Moon, R. W., Nofal, S. D., Patel, A., Flueck, C., Baker, D. A., Odom John, A. R., Field, M. C. & Sutherland, C. J., 25 Feb 2020, In : MBio. 11, 1, p. 1-16 16 p., e02918-19.

Research output: Contribution to journalArticle

Open Access
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16 Downloads (Pure)

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani: ACS Infectious Diseases

Wall, R. J., Carvalho, S., Milne, R., Bueren-Calabuig, J. A., Moniz, S., Cantizani-Perez, J., MacLean, L., Kessler, A., Cotillo, I., Sastry, L., Manthri, S., Patterson, S., Zuccotto, F., Thompson, S., Martin, J., Marco, M., Miles, T. J., De Rycker, M., Thomas, M. G., Fairlamb, A. H. & 2 others, Gilbert, I. H. & Wyllie, S., 13 Mar 2020, In : ACS Infectious Diseases. 6, 3, p. 515-528 14 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
26 Downloads (Pure)
Open Access
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25 Downloads (Pure)

Translations: from laboratory to print studio: LifeSpace , University of Dundee

Floyd, A., Hudson, S., Jones, A., Carvalho, S., Hallyburton, I. & Post, J., 2020

Research output: Non-textual formExhibition

University of Dundee, School of Life Sciences: Our Evaluation Story

Hardee, E., Cameron, A., Floyd, A. & Kennedy, D., Feb 2020, 8 p. Dundee : University of Dundee.

Research output: Other contribution

Open Access
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27 Downloads (Pure)
2019

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
130 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Müller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
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87 Downloads (Pure)

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Hulshof, L., Hack, D. P., Hasnoe, Q. C. J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W. H. I., van Aalderen, W. M. C., Van't Land, B., Kezic, S., Sprikkelman, A. B. & Middelkamp-Hup, M. A., Mar 2019, In : British Journal of Dermatology. 180, 3, p. 621-630 10 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
76 Downloads (Pure)

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In : Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Open Access
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62 Downloads (Pure)
Open Access
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125 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
69 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
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44 Downloads (Pure)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
46 Downloads (Pure)

Bifunctional chemical probes inducing protein-protein interactions

Maniaci, C. & Ciulli, A., Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 145-156 12 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
Open Access
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68 Downloads (Pure)

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S., Testa, A. & Ciulli, A., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry. 27, 12, p. 2466-2479 14 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Characterising Covalent Warhead Reactivity

Martin, J., Mackenzie, C., Fletcher, D. & Gilbert, I., 15 May 2019, In : Bioorganic & Medicinal Chemistry. 27, 10, p. 2066-2074 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
157 Downloads (Pure)

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., Aug 2019, In : Antimicrobial Agents and Chemotherapy. 63, 8, p. 1-19 19 p., e00795-19.

Research output: Contribution to journalArticle

Open Access
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60 Downloads (Pure)

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, A. H. & Patterson, S., 2019, In : Current Medicinal Chemistry. 26, 23, p. 4454-4475 22 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
164 Downloads (Pure)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
74 Downloads (Pure)

DiCre-Based Inducible Disruption of Leishmania Genes

Duncan, S. M., Myburgh, E., Alves-Ferreira, E. V. & Mottram, J. C., 2019, Leishmania: Methods and Protocols. Clos, J. (ed.). New York: Humana Press, Vol. 1971. p. 211-224 14 p. (Methods in Molecular Biology; vol. 1971).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Differentiation-Induced Remodelling of Store-Operated Calcium Entry Is Independent of Neuronal or Glial Phenotype but Modulated by Cellular Context

Whitworth, C. L., Redfern, C. P. F. & Cheek, T. R., 1 Feb 2019, In : Molecular Neurobiology. 56, 2, p. 857-872 16 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
101 Downloads (Pure)
Open Access
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2 Citations (Scopus)
107 Downloads (Pure)

Eat, play, learn well-a novel approach to co-production and analysis grid for environments linked to obesity to engage local communities in a child healthy weight action plan

Gillespie, J., Magee, E., White, A. & Stewart, L., Jan 2019, In : Public Health. 166, p. 99-107 9 p.

Research output: Contribution to journalArticle

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N., 1 Nov 2019, In : IUCrJ. 6, Part 6, p. 1014-1023 10 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
71 Downloads (Pure)

Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex

Boehm, C. & Field, M. C., 26 Jul 2019, In : Wellcome Open Research. 4, p. 1-19 19 p., 112.

Research output: Contribution to journalArticle

Open Access
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54 Downloads (Pure)

Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei

Wiedemar, N., Zwyer, M., Zoltner, M., Cal, M., Field, M. C. & Mäser, P., Oct 2019, In : FASEB bioAdvances. 1, 10, p. 595-608 14 p.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Fexinidazole for the treatment of human African trypanosomiasis

Fairlamb, A., Dec 2019, In : Drugs of Today . 55, 11, p. 705-712 8 p., 705.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies

Elhaji, Y., Sasseville, D., Pratt, M., Asai, Y., Matheson, K., McLean, W. H. I. & Hull, P., Jun 2019, In : Contact Dermatitis. 80, 6, p. 354-358 5 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
8 Downloads (Pure)

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G. T., Gibson, A., Cuny, G. D., Hedstrom, L. & Striepen, B., 30 Sep 2019, In : Proceedings of the National Academy of Sciences. 6 p.

Research output: Contribution to journalArticle

Open Access
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56 Downloads (Pure)

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L. A., Hunstman, S., Hu, D., Meade, K., Farber, H. J. & 21 others, Avila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., van der Zee, A. H. M., Burchard, E. G. & Pino-Yanes, M., Jun 2019, In : Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
33 Downloads (Pure)

High-Level Expression in Escherichia coli, Purification and Kinetic Characterization of LAPTc, a Trypanosoma cruzi M17-Aminopeptidase

Izquierdo, M., Aguado, M. E., Zoltner, M. & González-Bacerio, J., Apr 2019, In : Protein Journal. 38, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle