Biological Chemistry and Drug Discovery

2023

Crystallization of VHL-based PROTAC-induced ternary complexes

Wijaya, A. J., Farnaby, W. & Ciulli, A. (Lead / Corresponding author), 2023, Targeted Protein Degradation. Burslem, G. L. (ed.). Academic Press Inc., Vol. 681. p. 241-263 23 p. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

SBDD and Its Challenges

Chakraborti, S. (Lead / Corresponding author) & Sachchidanand, S., 2023, Current Trends in Computational Modeling for Drug Discovery. Kar, S. & Leszczynski, J. (eds.). 1 ed. Cham: Springer , p. 1-24 24 p. (Challenges and Advances in Computational Chemistry and Physics; vol. 35).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

2021

Nano and Microstructured Delivery Systems for Current Antileishmanial Drugs

Escrivani De Oliveira, D., Rossi-Bergmann, B., Mattos, G. C. & Sousa-Batista, A. J., 2021, Antiprotozoal Drug Development and Delivery. Vermelho, A. B. & Supuran, C. T. (eds.). Springer , p. 181–217 37 p. (Topics in Medicinal Chemistry; vol. 39).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2020

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9

Sateriale, A., Pawlowic, M., Vinayak, S., Brooks, C. & Striepen, B. (Lead / Corresponding author), 2020, Cryptosporidium. Mead, J. R. & Arrowood, M. J. (eds.). New York: Humana Press, p. 219-228 10 p. (Methods in Molecular Biology; vol. 2052).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

26 Citations (Scopus)

Structural and Biophysical Principles of Degrader Ternary Complexes

Zollman, D. & Ciulli, A., 8 Oct 2020, Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology. Weinmann, H. & Crews, C. (eds.). 74 ed. Royal Society of Chemistry, p. 14-54 41 p. (RSC Drug Discovery Series; vol. 2021-January, no. 74).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2017

European Lead Factory

Giordanetto, F., Jones, P., Nelson, A., Benningshof, J., Müller, G., Pannifer, A., Van Boeckel, S. & Tzalis, D. (Lead / Corresponding author), 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 505-519 15 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Medicinal Chemistry of Hybrids for Neurodegenerative Diseases

Uliassi, E., Prati, F., Bongarzone, S. & Bolognesi, M. L., Apr 2017, Design of Hybrid Molecules for Drug Development. Decker, M. (ed.). Elsevier, p. 259-277 19 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

2015

Pharmacological space

Hopkins, A. L., 2015, The practice of medicinal chemistry. Wermuth, C., Aldous, D., Raboisson, P. & Rognan, D. (eds.). 4th ed. Academic Press, p. 395-408 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

2014

Trypanosoma brucei subtelomeres: Monoallelic expression and antigenic variation

Figueiredo, L. M. (Lead / Corresponding author) & Horn, D., 1 Jan 2014, Subtelomeres. Louis, E. & Becker, M. (eds.). Berlin: Springer , p. 137-152 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2013

A mechanistic comparison of the varkud satellite and hairpin ribozymes

Wilson, T. J. & Lilley, D. M. J., 2013, Catalytic RNA. Soukup, G. A. (ed.). London: Academic Press, p. 93-121 29 p. (Progress in molecular biology and translational science; vol. 120).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

2012

Introduction: the case for polypharmacology

Hopkins, A. L., 2012, Polypharmacology in drug discovery. Peters, J.-U. (ed.). Hoboken: Wiley, p. 1-6 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

2010

Chemical synthesis of parasitic glycoconjugates and phosphoglycans

Al-Maharik, N., Tee, J. A. & Nikolaev, A. V., 2010, Microbial glycobiology: structures, relevance and applications. Moran, A. P., Holst, O., Brennan, P. J. & von Itzstein, M. (eds.). London: Academic Press, p. 477-548 72 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2009

Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

Heikkila, T. J., Surade, S., Silvestre, H. L., Dias, M. V. B., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A. H., Osborne, D., Abell, C. & Blundell, T. L., 2009, From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. L. & Spadon, P. (eds.). Springer Netherlands, p. 21-36 16 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Glycosylphosphatidylinositol anchors

Ferguson, M. A. J., Kinoshita, T. & Hart, G. W., 2009, Essentials of glycobiology. Varki, A. (ed.). 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 143-162 20 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2009, Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 143-144 2 p. (Advances in experimental medicine and biology; vol. 611).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2009, Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 525-526 2 p. (Advances in experimental medicine and biology; vol. 611).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

2008

Analysis of small GTPase function in trypanosomes

Field, M. C., Horn, D. & Carrington, M., 2008, Small GTPases in disease. Part A. Balch, W., Der, C. J. & Hall, A. (eds.). Amsterdam: Academic Press, p. 57-76 20 p. (Methods in Enzymology; vol. 438).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Histone deacetylases

Horn, D., 2008, Drug targets in kinetoplastid parasites. Majumder, H. K. (ed.). Berlin: Springer , p. 81-86 6 p. (Advances in experimental medicine and biology; vol. 625).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Pharmacological space

Hopkins, A. L., 2008, The practice of medicinal chemistry. Wermuth, C. G. (ed.). 3rd ed. London: Academic Press, p. 521-532 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

2001

Analyzing reverse gyrase activity.

Duguet, M., Jaxel, C., Déclais, A.-C., Confalonieri, F., Marsault, J., Bouthier, C. D. L. T., Nadal, M. & Portemer, C., 2001, DNA Topoisomerase Protocols. Osheroff, N. & Bjornsti, M. A. (eds.). Humana Press, Vol. 95. p. 35-49 (Methods in Molecular Biology; vol. 95).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

1997

The structure and biosynthesis of Trypanosomatid glycosylphosphatidylinositols

Ferguson, M. A. J., 1997, Trypanosomiasis and leishmaniasis : biology and control. Hide, G., Mottram, J. C., Coombs, G. H. & Holmes, P. H. (eds.). Wallingford: CAB International, p. 65-77 13 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1993

GPI membrane anchors: isolation and analysis

Ferguson, M. A. J., 1993, Glycobiology : a practical approach. Fukuda, M. & Kobata, A. (eds.). Oxford: IRL Press at Oxford University Press, p. 349-383 35 p. (Practical approach series; vol. 125).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1992

The chemical and enzymic analysis of GPI fine structure

Ferguson, M. A. J., 1992, Lipid modification of proteins : a practical approach. Hooper , N. M. & Turner, A. J. (eds.). Oxford: IRL Press at Oxford University Press, p. 191-230 40 p. (Practical approach series).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1990

Glycosyl-phosphatidylinositols

Ferguson, M. A. J., 1990, Biological Signal Transduction. Ross, E. M. & Wirtz, K. W. A. (eds.). New York: Springer Verlag, p. 331-348 18 p. ( NATO ASI series. Series H, Cell biology ; vol. 52).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

The glycolipid structure of glycosylphosphatidylinositol anchored membrane proteins

Ferguson, M. A. J. & Homans, S. W., 1990, Molecular and Cell Biology of Membrane Proteins: glycolipid anchors of cell-surface proteins. Turner, A. J. (ed.). New York: Ellis Horwood, p. 64-86 23 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1989

The membrane attachment of the variant surface glycoprotein coat of Trypanosoma brucei

Ferguson, M. A. J. & Homans, S. W., 1989, New Strategies in Parasitology: proceedings of an international symposium. McAdam, K. P. W. J. (ed.). Edinburgh: Churchill Livingstone, p. 120-139 20 p. (Frontiers of infectious diseases).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1988

Identification of glycosyl-phosphatidylinositol membrane anchors by fatty acid labelling

Ferguson, M. A. J., 1988, Post-translational modification of protein by lipids: a laboratory manual. Brodbeck, U. & Bordier, C. (eds.). Springer Verlag

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1987

Structural studies on the glycophospholipid membrane anchor of Trypanosoma brucei variant surface glycoprotein

Ferguson, M. A. J., Dwek, R. A., Homans, S. W. & Rademacher, T. W., 1987, Host-parasite cellular and molecular interactions in protozoal infections. Chang, K. P. & Snary, D. (eds.). Berlin: Springer Verlag, p. 19-28 10 p. (NATO ASI series. Series H: Cell biology; vol. 11).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1985

Stage-specific cell surface glycoprotein from Trypanosoma cruzi

Snary, D., Ferguson, M. A. J., Allen, A. K., Miles, M. A. & Sher, A., 1985, Vaccines 85: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases. Brown, F., Lerner, R. A. & Chanock, R. M. (eds.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 71-75 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Variant surface antigens of Trypanosoma brucei

Cross, G. A. M. & Ferguson, M. A. J., 1985, Vaccines 85: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases. Brown, F., Lerner, R. A. & Chanock, R. M. (eds.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Biological Chemistry and Drug Discovery

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