Biological Chemistry and Drug Discovery

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2019

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9

Sateriale, A., Pawlowic, M., Vinayak, S., Brooks, C. & Striepen, B., 27 Aug 2019, Cryptosporidium. Mead, J. R. & Arrowood, M. J. (eds.). New York: Humana Press, p. 219-228 10 p. (Methods in Molecular Biology; vol. 2052).

Research output: Chapter in Book/Report/Conference proceedingChapter

Clustered Regularly Interspaced Short Palindromic Repeats
Cryptosporidium parvum
Transfection
Infection
2017
1 Citation (Scopus)

European Lead Factory

Giordanetto, F., Jones, P., Nelson, A., Benningshof, J., Müller, G., Pannifer, A., Van Boeckel, S. & Tzalis, D., 13 Jun 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 505-519 15 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

Research output: Chapter in Book/Report/Conference proceedingChapter

Industrial plants
Screening
Throughput
Industry
Intellectual property
2 Citations (Scopus)

Medicinal Chemistry of Hybrids for Neurodegenerative Diseases

Uliassi, E., Prati, F., Bongarzone, S. & Bolognesi, M. L., Apr 2017, Design of Hybrid Molecules for Drug Development. Decker, M. (ed.). Elsevier Inc., p. 259-277 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurodegenerative diseases
Prions
Ligands
Molecules
Pharmaceutical Preparations
2015

Pharmacological space

Hopkins, A. L., 2015, The practice of medicinal chemistry. Wermuth, C., Aldous, D., Raboisson, P. & Rognan, D. (eds.). 4th ed. Academic Press, p. 395-408 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Pharmacology
Essential Drugs
Epigenomics
Pharmaceutical Preparations
2013
2 Citations (Scopus)

A mechanistic comparison of the varkud satellite and hairpin ribozymes

Wilson, T. J. & Lilley, D. M. J., 2013, Catalytic RNA. Soukup, G. A. (ed.). London: Academic Press, p. 93-121 29 p. (Progress in molecular biology and translational science; vol. 120).

Research output: Chapter in Book/Report/Conference proceedingChapter

Catalytic RNA
Transesterification
Guanine
Catalysis
Acids
2012
2 Citations (Scopus)

Introduction: the case for polypharmacology

Hopkins, A. L., 2012, Polypharmacology in drug discovery. Peters, J-U. (ed.). Hoboken: John Wiley & Sons Inc., p. 1-6 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2010

Chemical synthesis of parasitic glycoconjugates and phosphoglycans

Al-Maharik, N., Tee, J. A. & Nikolaev, A. V., 2010, Microbial glycobiology: structures, relevance and applications. Moran, A. P., Holst, O., Brennan, P. J. & von Itzstein, M. (eds.). London: Academic Press, p. 477-548 72 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycosylphosphatidylinositols
Glycoconjugates
Yeast
Ethers
Anchors
2009
2 Citations (Scopus)

Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

Heikkila, T. J., Surade, S., Silvestre, H. L., Dias, M. V. B., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A. H., Osborne, D., Abell, C. & Blundell, T. L., 2009, From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. L. & Spadon, P. (eds.). Springer Netherlands, p. 21-36 16 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Neglected Diseases
Tuberculosis
Malpractice
Microbial Drug Resistance

Glycosylphosphatidylinositol anchors

Ferguson, M. A. J., Kinoshita, T. & Hart, G. W., 2009, Essentials of glycobiology. Varki, A. (ed.). 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 143-162 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2009, Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 143-144 2 p. (Advances in experimental medicine and biology; vol. 611).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 2009, Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 525-526 2 p. (Advances in experimental medicine and biology; vol. 611).

Research output: Chapter in Book/Report/Conference proceedingChapter

2008
4 Citations (Scopus)

Analysis of small GTPase function in trypanosomes

Field, M. C., Horn, D. & Carrington, M., 2008, Small GTPases in disease. Part A. Balch, W., Der, C. J. & Hall, A. (eds.). Amsterdam: Academic Press, p. 57-76 20 p. (Methods in Enzymology; vol. 438).

Research output: Chapter in Book/Report/Conference proceedingChapter

Histone deacetylases

Horn, D., 2008, Drug targets in kinetoplastid parasites. Majumder, H. K. (ed.). Berlin: Springer , p. 81-86 6 p. (Advances in experimental medicine and biology; vol. 625).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Pharmacological space

Hopkins, A. L., 2008, The practice of medicinal chemistry. Wermuth, C. G. (ed.). 3rd ed. London: Academic Press, p. 521-532 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Pharmacology
Pharmaceutical Preparations
Proteins
Ligands
2001
5 Citations (Scopus)

Analyzing reverse gyrase activity.

Duguet, M., Jaxel, C., Déclais, A-C., Confalonieri, F., Marsault, J., Bouthier, C. D. L. T., Nadal, M. & Portemer, C., 2001, DNA Topoisomerase Protocols. Osheroff, N. & Bjornsti, M. A. (eds.). Humana Press, Vol. 95. p. 35-49 (Methods in Molecular Biology; vol. 95).

Research output: Chapter in Book/Report/Conference proceedingChapter

1997

The structure and biosynthesis of Trypanosomatid glycosylphosphatidylinositols

Ferguson, M. A. J., 1997, Trypanosomiasis and leishmaniasis : biology and control. Hide, G., Mottram, J. C., Coombs, G. H. & Holmes, P. H. (eds.). Wallingford: CAB International, p. 65-77 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1993
66 Citations (Scopus)

GPI membrane anchors: isolation and analysis

Ferguson, M. A. J., 1993, Glycobiology : a practical approach. Fukuda, M. & Kobata, A. (eds.). Oxford: IRL Press at Oxford University Press, p. 349-383 35 p. (Practical approach series; vol. 125).

Research output: Chapter in Book/Report/Conference proceedingChapter

1992

The chemical and enzymic analysis of GPI fine structure

Ferguson, M. A. J., 1992, Lipid modification of proteins : a practical approach. Hooper, N. M. & Turner, A. J. (eds.). Oxford: IRL Press at Oxford University Press, p. 191-230 40 p. (Practical approach series).

Research output: Chapter in Book/Report/Conference proceedingChapter

1990

Glycosyl-phosphatidylinositols

Ferguson, M. A. J., 1990, Biological Signal Transduction. Ross, E. M. & Wirtz, K. W. A. (eds.). New York: Springer Verlag, p. 331-348 18 p. ( NATO ASI series. Series H, Cell biology ; vol. 52).

Research output: Chapter in Book/Report/Conference proceedingChapter

The glycolipid structure of glycosylphosphatidylinositol anchored membrane proteins

Ferguson, M. A. J. & Homans, S. W., 1990, Molecular and Cell Biology of Membrane Proteins: glycolipid anchors of cell-surface proteins. Turner, A. J. (ed.). New York: Ellis Horwood, p. 64-86 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1989

The membrane attachment of the variant surface glycoprotein coat of Trypanosoma brucei

Ferguson, M. A. J. & Homans, S. W., 1989, New Strategies in Parasitology: proceedings of an international symposium. McAdam, K. P. W. J. (ed.). Edinburgh: Churchill Livingstone, p. 120-139 20 p. (Frontiers of infectious diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

Parasitology
Trypanosoma brucei brucei
Parasitic Diseases
Membrane Glycoproteins
Acquired Immunodeficiency Syndrome
1988

Identification of glycosyl-phosphatidylinositol membrane anchors by fatty acid labelling

Ferguson, M. A. J., 1988, Post-translational modification of protein by lipids: a laboratory manual. Brodbeck, U. & Bordier, C. (eds.). Springer Verlag

Research output: Chapter in Book/Report/Conference proceedingChapter

1987
39 Citations (Scopus)

Structural studies on the glycophospholipid membrane anchor of Trypanosoma brucei variant surface glycoprotein

Ferguson, M. A. J., Dwek, R. A., Homans, S. W. & Rademacher, T. W., 1987, Host-parasite cellular and molecular interactions in protozoal infections. Chang, K. P. & Snary, D. (eds.). Berlin: Springer Verlag, p. 19-28 10 p. (NATO ASI series. Series H: Cell biology; vol. 11).

Research output: Chapter in Book/Report/Conference proceedingChapter

glycophospholipids
variant surface glycoproteins
Trypanosoma brucei
antigenic variation
organisms
1985

Stage-specific cell surface glycoprotein from Trypanosoma cruzi

Snary, D., Ferguson, M. A. J., Allen, A. K., Miles, M. A. & Sher, A., 1985, Vaccines 85: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases. Brown, F., Lerner, R. A. & Chanock, R. M. (eds.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 71-75 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Citations (Scopus)

Variant surface antigens of Trypanosoma brucei

Cross, G. A. M. & Ferguson, M. A. J., 1985, Vaccines 85: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases. Brown, F., Lerner, R. A. & Chanock, R. M. (eds.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 57-60 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter