Biological Chemistry and Drug Discovery

  • United Kingdom

Research Output 1972 2020

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2020
13 Downloads (Pure)

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Discovery
Communicable Diseases
Infectious Disease Medicine
Pharmacokinetics
Learning
2019
4 Citations (Scopus)
101 Downloads (Pure)

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Phosphotransferases
Drosophila Proteins
Cell Polarity
Nuclear Envelope
55 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Müller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression
15 Downloads (Pure)

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In : Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Amino Acid Substitution
gamma-Aminobutyric Acid
Substitution reactions
Chemical activation
92 Downloads (Pure)
Open Access
File
Methylenetetrahydrofolate Dehydrogenase (NADP)
dehydrogenases
inhibitors
Ligands
enzymes
1 Citation (Scopus)
47 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
12 Downloads (Pure)

A platform for target prediction of phenotypic screening hit molecules

Homeyer, N., van Deursen, R., Ochoa-Montaño, B., Heikamp, K., Ray, P., Zuccotto, F., Blundell, T. L. & Gilbert, I. H., 24 Oct 2019, In : Journal of Molecular Graphics & Modelling. 95, p. 1-9 9 p., 107485.

Research output: Contribution to journalArticle

Open Access
File
Screening
screening
platforms
Ligands
Proteins
20 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins
Ligand-Gated Ion Channels
Bicuculline
Glycine
Glycine Receptors
Carrier Proteins
1 Citation (Scopus)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

Genome
Breast Neoplasms
Mutation
17 Citations (Scopus)
17 Downloads (Pure)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Adenosine Triphosphatases
Biophysics
Neoplasms
Chromatin Assembly and Disassembly
44 Downloads (Pure)
Open Access
File
Burkholderia pseudomallei
Adenosine Monophosphate
Anti-Bacterial Agents
Ligands
Enzymes
5 Citations (Scopus)

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S., Testa, A. & Ciulli, A., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry. 27, 12, p. 2466-2479 14 p.

Research output: Contribution to journalArticle

Open Access
Proteolysis
Ubiquitin-Protein Ligases
Degradation
Cullin Proteins
Ubiquitination
2 Citations (Scopus)
120 Downloads (Pure)

Characterising Covalent Warhead Reactivity

Martin, J., Mackenzie, C., Fletcher, D. & Gilbert, I., 15 May 2019, In : Bioorganic & Medicinal Chemistry. 27, 10, p. 2066-2074 9 p.

Research output: Contribution to journalArticle

Open Access
File
Toxicity
Pharmaceutical Preparations
Aptitude
Pharmacokinetics
Threonine
35 Downloads (Pure)

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M-V., Hutchinson, S., Horn, D. & Alsford, S., Aug 2019, In : Antimicrobial Agents and Chemotherapy. 63, 8, p. 1-19 19 p., e00795-19.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
miltefosine
Parasites
Pharmaceutical Preparations
Leishmania
1 Citation (Scopus)
49 Downloads (Pure)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylinositol 3-Kinases
Protein Isoforms
Phosphotransferases
Cells
Degradation
2 Citations (Scopus)
75 Downloads (Pure)

Differentiation-Induced Remodelling of Store-Operated Calcium Entry Is Independent of Neuronal or Glial Phenotype but Modulated by Cellular Context

Whitworth, C. L., Redfern, C. P. F. & Cheek, T. R., 1 Feb 2019, In : Molecular Neurobiology. 56, 2, p. 857-872 16 p.

Research output: Contribution to journalArticle

Open Access
File
Neuroglia
Calcium
Phenotype
Neurogenesis
Porins
1 Citation (Scopus)
78 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Drug Discovery
Modulators
Skin
Pharmaceutical Preparations

Eat, play, learn well-a novel approach to co-production and analysis grid for environments linked to obesity to engage local communities in a child healthy weight action plan

Gillespie, J., Magee, E., White, A. & Stewart, L., Jan 2019, In : Public Health. 166, p. 99-107 9 p.

Research output: Contribution to journalArticle

Obesity
Focus Groups
Weights and Measures
Public Health Practice
Health Priorities
43 Downloads (Pure)

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N., 1 Nov 2019, In : IUCrJ. 6, Part 6, p. 1014-1023 10 p.

Research output: Contribution to journalArticle

Open Access
File
acetylcholine
Glycine Receptors
homology
Binding sites
glycine
25 Downloads (Pure)

Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex

Boehm, C. & Field, M. C., 26 Jul 2019, In : Wellcome Open Research. 4, p. 1-19 19 p., 112.

Research output: Contribution to journalArticle

Open Access
File
Exocytosis
Vacuoles
Streptophyta
Euglenozoa
Conservation

Fexinidazole for the treatment of human African trypanosomiasis

Fairlamb, A., Dec 2019, In : Drugs of Today . 55, 11, p. 705-712 8 p., 705.

Research output: Contribution to journalArticle

African Trypanosomiasis
Trypanosoma brucei gambiense
Spinal Puncture
Therapeutics
Granulocyte-Macrophage Colony-Stimulating Factor
2 Citations (Scopus)

Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies

Elhaji, Y., Sasseville, D., Pratt, M., Asai, Y., Matheson, K., McLean, W. H. I. & Hull, P., Jun 2019, In : Contact Dermatitis. 80, 6, p. 354-358 5 p.

Research output: Contribution to journalArticle

Hypersensitivity
Mutation
Genes
Patch Tests
Dermatitis
33 Downloads (Pure)

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G. T., Gibson, A., Cuny, G. D., Hedstrom, L. & Striepen, B., 30 Sep 2019, In : Proceedings of the National Academy of Sciences. 6 p.

Research output: Contribution to journalArticle

Open Access
File
Cryptosporidium parvum
Cryptosporidium
Purine Nucleotides
Nucleotides
Parasites
2 Citations (Scopus)

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L. A., Hunstman, S., Hu, D., Meade, K., Farber, H. J. & 21 others, Avila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., van der Zee, A. H. M., Burchard, E. G. & Pino-Yanes, M., Jun 2019, In : Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Adrenal Cortex Hormones
Asthma
Hispanic Americans
Population

High-Level Expression in Escherichia coli, Purification and Kinetic Characterization of LAPTc, a Trypanosoma cruzi M17-Aminopeptidase

Izquierdo, M., Aguado, M. E., Zoltner, M. & González-Bacerio, J., Apr 2019, In : Protein Journal. 38, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

Leucyl Aminopeptidase
Aminopeptidases
Trypanosoma cruzi
Escherichia coli
Purification
6 Citations (Scopus)

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-Özguer, J., Koegl, M., McConnell, D. B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N. & 4 others, Traxler, E., Wieshofer, C., Zoephel, A. & Ettmayer, P., 14 Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2508–2520 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Proteolysis
Hepatocellular Carcinoma
Cell Line
Ubiquitin-Protein Ligases
5 Citations (Scopus)
22 Downloads (Pure)

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Eyerich, K., Brown, S. J., Perez White, B. E., Tanaka, R. J., Bissonette, R., Dhar, S., Bieber, T., Hijnen, D. J., Guttman-Yassky, E., Irvine, A., Thyssen, J. P., Vestergaard, C., Werfel, T., Wollenberg, A., Paller, A. S. & Reynolds, N. J., 1 Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Open Access
File
Eczema
Atopic Dermatitis
Therapeutics
Biological Models
Precision Medicine
17 Downloads (Pure)

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., Nov 2019, In : Cells. 8, 11, p. 1-18 18 p., 1468.

Research output: Contribution to journalArticle

Open Access
File
GTP Phosphohydrolases
Cyclic Nucleotides
Assays
Nucleotides
High-Throughput Screening Assays
4 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
57 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
3 Citations (Scopus)
80 Downloads (Pure)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H., 12 Mar 2019, In : Molecules and Cells. 24, 5, p. 1-16 16 p., 996.

Research output: Contribution to journalArticle

Open Access
File
Uridine Diphosphate Sugars
Small Molecule Libraries
Leishmania major
Biosensing Techniques
sugars
1 Citation (Scopus)
51 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, p. 1-15 15 p., e00309-19.

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence

Inhibition of CorA dependent Magnesium Homeostasis is cidal in Mycobacterium tuberculosis

Park, Y., Ahn, Y-M., Jonnala, S., Oh, S., Fisher, J. M., Goodwin, M. B., Loerger, T. R., Via, L. E., Bayliss, T., Green, S. R., Ray, P. C., Wyatt, P. G., Barry, C. E. & Boshoff, H. I., 23 Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-14 14 p., e01006-19.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Magnesium
Homeostasis
Amides
Symporters
24 Citations (Scopus)
240 Downloads (Pure)

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

Zoppi, V., Hughes, S. J., Maniaci, C., Testa, A., Gmaschitz, T., Wieshofer, C., Koegl, M., Riching, K. M., Daniels, D. L., Spallarossa, A. & Ciulli, A., 24 Jan 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 699-726 28 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitination
Ligases
Proteolysis
Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
6 Citations (Scopus)
147 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lysine-tRNA Ligase
Cryptosporidiosis
Cryptosporidium parvum
Malaria
Plasmodium falciparum
32 Downloads (Pure)

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations

Bueren-Calabuig, J., Bage, M., Cowling, V. & Pisliakov, A., 19 Sep 2019, In : Nucleic Acids Research. 47, 16, p. 8675-8692 18 p., gkz613.

Research output: Contribution to journalArticle

Open Access
File
Guanine
Methyltransferases
Molecular Dynamics Simulation
RNA
S-Adenosylmethionine

Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid

Novák Vanclová, A. M. G., Zoltner, M., Kelly, S., Soukal, P., Záhonová, K., Füssy, Z., Ebenezer, T. E., Lacová Dobáková, E., Eliáš, M., Lukeš, J., Field, M. C. & Hampl, V., 3 Oct 2019, In : New Phytologist. 15 p.

Research output: Contribution to journalArticle

Euglena gracilis
Plastids
plastids
History
history
80 Downloads (Pure)

Molecular and bioinformatics analyses reveal two differentially expressed intracellular GH1 β-glucosidases from the rare alkalophilic fungus Stachybotrys microspora

Abdeljalil, S., Borgi, I., Carvalho, S., Jmal-Hammami, L. & Gargouri, A., 30 Jun 2019, In : Gene. 703, p. 134-144 11 p.

Research output: Contribution to journalArticle

Open Access
File
Stachybotrys
Microsporidia
Glucosidases
Computational Biology
Fungi
1 Citation (Scopus)
38 Downloads (Pure)

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Correia Faria, J., Glover, L., Hutchinson, S., Boehm, C., Field, M. C. & Horn, D., 9 Jul 2019, In : Nature Communications. 10, p. 1-14 14 p., 3023.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma Variant Surface Glycoproteins
Trypanosoma brucei brucei
Membrane Glycoproteins
exclusion
Epigenomics
15 Downloads (Pure)

Multi-task learning with a natural metric for quantitative structure activity relationship learning

Sadawi, N., Olier, I., Vanschoren, J., Van Rijn, J. N., Besnard, J., Bickerton, R., Grosan, C., Soldatova, L. & King, R. D., 12 Nov 2019, In : Journal of Cheminformatics. 11, p. 1-13 13 p., 68.

Research output: Contribution to journalArticle

Open Access
File
activity structure
learning
Assays
drugs
drug
4 Citations (Scopus)
133 Downloads (Pure)

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 others, Valentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P. & Azas, N., 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Open Access
File
Pyridines
Inhibitory Concentration 50
sulfoxide
miltefosine
Display devices
1 Citation (Scopus)

Novel and recurrent mutations in keratin 1 cause epidermolytic ichthyosis and palmoplantar keratoderma

Smith, F. J. D., Kreuser-Genis, I. M., Jury, C. S., Wilson, N. J., Terron-Kwiatowski, A. & Zamiri, M., Jul 2019, In : Clinical and Experimental Dermatology. 44, 5, p. 528-534 7 p.

Research output: Contribution to journalArticle

Keratoderma, Palmoplantar, Epidermolytic
Epidermolytic Hyperkeratosis
Keratin-1
Palmoplantar Keratoderma
Mutation
86 Downloads (Pure)

Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound

Velasco, R. F., Guerrero, C., Fra, G., Moure, A., Miguel-Siles, J., Quesada-Campos, M. T., Ruiz-Gomez, J. R., Gilbert, I. H., Thomas, M. G. & Miles, T. J., 2 May 2019, In : Tetrahedron Letters. 60, 18, p. 1243-1247 5 p.

Research output: Contribution to journalArticle

Open Access
File
Sulfonamides
Cross Reactions
Research
2 Citations (Scopus)
36 Downloads (Pure)

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C., Suska, O. & Horn, D., 9 Jul 2019, In : MBio. 10, 4, p. 1-17 17 p., e01252-19.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
DNA Replication
DNA Damage
Replication Protein A
Chromosomes
2 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
51 Downloads (Pure)

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major

Moitra, S., Pawlowic, M. C., Hsu, F-F. & Zhang, K., 20 May 2019, In : Scientific Reports. 9, p. 1-13 13 p., 7602.

Research output: Contribution to journalArticle

Open Access
File
Leishmania major
Phosphatidylcholines
Parasites
Choline
Psychodidae
7 Citations (Scopus)
85 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites
1 Citation (Scopus)
26 Downloads (Pure)
Open Access
File
Trypanosoma brucei brucei
Proteome
Proteomics
Proteins
African Trypanosomiasis

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
Nucleosomes
DNA Repair
Chromatin