Biological Chemistry and Drug Discovery

  • United Kingdom

Research Output

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Review article
2020

100 years of suramin

Wiedemar, N., Hauser, D. A. & Mäser, P., Mar 2020, In : Antimicrobial Agents and Chemotherapy. 64, 3, p. 1-14 14 p., e01168.

Research output: Contribution to journalReview article

A One Health Approach to Tackle Cryptosporidiosis

Innes, E. A., Chalmers, R. M., Wells, B. & Pawlowic, M. C., Mar 2020, In : Trends in Parasitology. 36, 3, p. 290-303 14 p.

Research output: Contribution to journalReview article

2019

Bifunctional chemical probes inducing protein-protein interactions

Maniaci, C. & Ciulli, A., Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 145-156 12 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, A. H. & Patterson, S., 2019, In : Current Medicinal Chemistry. 26, 23, p. 4454-4475 22 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
164 Downloads (Pure)

Pore timing: the evolutionary origins of the nucleus and nuclear pore complex

Field, M. C. & Rout, M. P., 3 Apr 2019, In : F1000Research. 8, p. 1-11 11 p., 369.

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
85 Downloads (Pure)
2018

Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes

Quintana, J. F., Canavate Del Pino, R., Yamada, K., Zhang, N. & Field, M., 20 Jul 2018, In : Genes. 9, 7, 16 p., 368.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
144 Downloads (Pure)

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

Prati, F., Bottegoni, G., Bolognesi, M. L. & Cavalli, A., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.

Research output: Contribution to journalReview article

Open Access
File
40 Citations (Scopus)
77 Downloads (Pure)

Challenges and recent progress in drug discovery for tropical diseases

De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H., 25 Jul 2018, In : Nature. 559, 7715, p. 498-506 9 p.

Research output: Contribution to journalReview article

Open Access
File
26 Citations (Scopus)
193 Downloads (Pure)

Conservation and Variation in Strategies for DNA Replication of Kinetoplastid Nuclear Genomes

Marques, C. A. & McCulloch, R., Feb 2018, In : Current Genomics. 19, 2, p. 98-109 12 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Evolutionary origins and specialisation of membrane transport

Dacks, J. B. & Field, M. C., 1 Aug 2018, In : Current Opinion in Cell Biology. 53, p. 70-76 7 p.

Research output: Contribution to journalReview article

Open Access
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6 Citations (Scopus)
120 Downloads (Pure)

Evolution of protein trafficking in kinetoplastid parasites: complexity and pathogenesis

Venkatesh, D., Zhang, N., Zoltner, M., Canavate Del Pino, R. & Field, M. C., Nov 2018, In : Traffic. 19, 11, p. 803-812 10 p.

Research output: Contribution to journalReview article

Open Access
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63 Downloads (Pure)

Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A. & Horn, D., Jun 2018, In : Trends in Parasitology. 34, 6, p. 481-492 12 p.

Research output: Contribution to journalReview article

Open Access
File
14 Citations (Scopus)
119 Downloads (Pure)

Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective

Rainard, J. M., Pandarakalam, G. C. & McElroy, S. P., 1 Mar 2018, In : SLAS Discovery. 23, 3, p. 225-241 17 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
255 Downloads (Pure)
2017
Open Access
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120 Citations (Scopus)
259 Downloads (Pure)

Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Devlin, R., Marques, C. A. & McCulloch, R., Jun 2017, In : Current Genetics. 63, 3, p. 441-449 9 p.

Research output: Contribution to journalReview article

Open Access
File
8 Citations (Scopus)
171 Downloads (Pure)

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ

Slominski, A. T., Kim, T-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C. & Jetten, A. M., Oct 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 173, p. 42-56 15 p.

Research output: Contribution to journalReview article

Open Access
File
42 Citations (Scopus)
159 Downloads (Pure)

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

Ray, P. C., Kiczun, M., Huggett, M., Lim, A., Prati, F., Gilbert, I. H. & Wyatt, P. G., Jan 2017, In : Drug Discovery Today. 22, 1, p. 43-56 14 p.

Research output: Contribution to journalReview article

Open Access
File
16 Citations (Scopus)
302 Downloads (Pure)

Management of plantar keratodermas: Lessons from pachyonychia congenita

Porter, R. M., Bravo, A. A. & Smith, F. J. D., Sep 2017, In : Journal of the American Podiatric Medical Association. 107, 5, p. 428-435 8 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
Open Access
File
41 Citations (Scopus)
172 Downloads (Pure)

Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A., McCulloch, R., Tosi, L. R. O. & Elias, M. C., Nov 2017, In : Trends in Parasitology. 33, 11, p. 858-874 17 p.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
154 Downloads (Pure)

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies

Lucas, X. & Ciulli, A., Jun 2017, In : Current Opinion in Structural Biology. 44, p. 101-110 10 p.

Research output: Contribution to journalReview article

Open Access
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33 Citations (Scopus)
438 Downloads (Pure)

The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell

Rout, M. P. & Field, M. C., Jun 2017, In : Annual Review of Biochemistry. 86, p. 637-657 21 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)
2016

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journalReview article

Open Access
File
14 Citations (Scopus)
164 Downloads (Pure)

Drug Resistance in Eukaryotic Microorganisms

Fairlamb, A. H., Gow, N. A. R., Matthews, K. R. & P. Waters, A., Jul 2016, In : Nature Microbiology. 1, p. 1-14 14 p., 16092.

Research output: Contribution to journalReview article

Open Access
File
49 Citations (Scopus)
172 Downloads (Pure)

Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa

Duraisingh, M. T. & Horn, D., 11 May 2016, In : Cell Host & Microbe. 19, 5, p. 629-640 12 p.

Research output: Contribution to journalReview article

Open Access
File
23 Citations (Scopus)
122 Downloads (Pure)

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond

McLean, W., 26 Sep 2016, In : British Journal of Dermatology. 175, 52, p. 4-7 4 p.

Research output: Contribution to journalReview article

Open Access
File
27 Citations (Scopus)
173 Downloads (Pure)

From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?

Bolognesi, M. L., Gandini, A., Prati, F. & Uliassi, E., 8 Sep 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 7759-7770 12 p.

Research output: Contribution to journalReview article

Open Access
File
20 Citations (Scopus)
190 Downloads (Pure)

The ELF Honest Data Broker: Informatics enabling public-private collaboration in a precompetitive arena

Paillard, G., Cochrane, P., Jones, P. S., Van Hoorn, W. P., Caracoti, A., Van Vlijmen, H. & Pannifer, A. D., 1 Jan 2016, In : Drug Discovery Today. 21, 1, p. 97-102 6 p.

Research output: Contribution to journalReview article

Open Access
File
12 Citations (Scopus)
116 Downloads (Pure)
2013

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Baker, N., de Koning, H. P., Maeser, P. & Horn, D., Mar 2013, In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

Research output: Contribution to journalReview article

125 Citations (Scopus)

Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

Adung'a, V. O., Gadelha, C. & Field, M. C., Apr 2013, In : Traffic. 14, 4, p. 440-457 18 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Receptor-mediated endocytosis for drug delivery in African trypanosomes: Fulfilling Paul Ehrlich's vision of chemotherapy

Alsford, S., Field, M. C. & Horn, D., May 2013, In : Trends in Parasitology. 29, 5, p. 207-212 6 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)
2012

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

Alsford, S., duBois, K., Horn, D. & Field, M. C., 29 May 2012, In : Expert reviews in molecular medicine. 14, 20 p., ARTN e13.

Research output: Contribution to journalReview article

19 Citations (Scopus)
2011

Emerging role of surface plasmon resonance in fragment-based drug discovery

Navratilova, I. & Hopkins, A. L., Oct 2011, In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)

Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

Gilbert, I. H., Leroy, D. & Frearson, J. A., May 2011, In : Current Topics in Medicinal Chemistry. 11, 10, p. 1284-1291 8 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)
15 Citations (Scopus)

Methylglyoxal metabolism in trypanosomes and leishmania

Wyllie, S. & Fairlamb, A. H., May 2011, In : Seminars in Cell & Developmental Biology. 22, 3, p. 271-277 7 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)

Minimum information about a bioactive entity (MIABE)

Orchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., Lo Piparo, E. & 6 others, Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J., Sep 2011, In : Nature Reviews Drug Discovery. 10, 9, p. 661-669 9 p.

Research output: Contribution to journalReview article

67 Citations (Scopus)

Rapid Analysis of Pharmacology for Infectious Diseases

Hopkins, A. L., Bickerton, G. R., Carruthers, I. M., Boyer, S. K., Rubin, H. & Overington, J. P., May 2011, In : Current Topics in Medicinal Chemistry. 11, 10, p. 1292-1300 9 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Synthetic glycosylphosphatidylinositol (GPI) anchors: how these complex molecules have been made

Nikolaev, A. V. & Al-Maharik, N., 2011, In : Natural Product Reports. 28, 5, p. 970-1020 51 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

Nikolaev, A. V. & Sizova, O. V., Jul 2011, In : Biochemistry-Moscow. 76, 7, p. 761-773 13 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
61 Citations (Scopus)

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

Chen, S., Synowsky, S., Tinti, M. & MacKintosh, C., Nov 2011, In : Trends in Endocrinology and Metabolism. 22, 11, p. 429-436 8 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)

Virtual screening strategies in drug design – methods and applications

Bielska, E., Lucas, X., Czerwoniec, A., Kasprzak, J. M., Kaminska, K. H. & Bujnicki, J. M., 2011, In : BioTechnologia. 92, 3, p. 249-264 16 p.

Research output: Contribution to journalReview article

Open Access
File
34 Citations (Scopus)
153 Downloads (Pure)
2010

Assessing brain free fraction in early drug discovery

Read, K. D. & Braggio, S., Mar 2010, In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

Research output: Contribution to journalReview article

57 Citations (Scopus)

Drug discovery in academia: the third way?

Frearson, J. & Wyatt, P., Oct 2010, In : Expert Opinion on Drug Discovery. 5, 10, p. 909-919 11 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

Horn, D. & McCulloch, R., Dec 2010, In : Current Opinion in Microbiology. 13, 6, p. 700-705 6 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)

The tetrahydrobiopterin pathway and pain

Naylor, A. M., Pojasek, K. R., Hopkins, A. L. & Blagg, J., Jan 2010, In : Current Opinion in Investigational Drugs. 11, 1, p. 19-30 12 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Visualization of multiple alignments, phylogenies and gene family evolution

Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. & Barton, G. J., 1 Mar 2010, In : Nature Methods. 7, 3, p. S16-S25 10 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)
2009

DNA breaks as triggers for antigenic variation in African trypanosomes

Alsford, S., Horn, D. & Glover, L., 2009, In : Genome Biology. 10, 6, 4 p., ARTN 223.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Structure-based ligand design and the promise held for antiprotozoan drug discovery

Hunter, W. N., 1 May 2009, In : Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.

Research output: Contribution to journalReview article

39 Citations (Scopus)