Research output per year
Research output per year
Research output
- 1 - 50 out of 112 results
Search results
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2024
Toxoplasma protein export and effector function
Seizova, S., Ferrel, A., Boothroyd, J. (Lead / Corresponding author) & Tonkin, C. J., 3 Jan 2024, In: Nature Microbiology. 9, 1, p. 17-28 12 p.Research output: Contribution to journal › Review article › peer-review
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2023
Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38
Armstrong, J. F., Campo, B. (Lead / Corresponding author), Alexander, S. P. H., Arendse, L. B., Cheng, X., Davenport, A. P., Faccenda, E., Fidock, D. A., Godinez-Macias, K. P., Harding, S. D., Kato, N., Lee, M. C. S., Luth, M. R., Mazitschek, R., Mittal, N., Niles, J. C., Okombo, J., Ottilie, S., Pasaje, C. F. A. & Probst, A. S. & 9 others, , Aug 2023, In: British Journal of Pharmacology. 180, 15, p. 1899-1929 31 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile7 Citations (Scopus)99 Downloads (Pure) -
Anti-trypanosomatid drug discovery: progress and challenges
De Rycker, M., Wyllie, S., Horn, D., Read, K. D. & Gilbert, I. H. (Lead / Corresponding author), 31 Jan 2023, In: Nature Reviews Microbiology. 21, p. 35-50 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile77 Citations (Scopus)147 Downloads (Pure) -
Breaking free from the crystal lattice: Structural biology in solution to study protein degraders
Haubrich, K., Spiteri, V., Farnaby, W., Sobott, F. & Ciulli, A. (Lead / Corresponding author), Apr 2023, In: Current Opinion in Structural Biology. 79, 9 p., 102534.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)134 Downloads (Pure) -
Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes
Padilla-Mejia, N. E. (Lead / Corresponding author) & Field, M. C., 24 Oct 2023, In: FEBS Letters. 597, 20, p. 2501-2518 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)43 Downloads (Pure) -
2022
African trypanosome strategies for conquering new hosts and territories: the end of monophyly?
Lukeš, J. (Lead / Corresponding author), Kachale, A., Votýpka, J., Butenko, A. & Field, M. C., 1 Sept 2022, In: Trends in Parasitology. 38, 9, p. 724-736 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Citations (Scopus) -
Antiprotozoal agents: How have they changed over a decade?
Fernandes, V. D. S., da Rosa, R., Zimmermann, L. A., Rogério, K. R., Kümmerle, A. E., Bernardes, L. S. C. (Lead / Corresponding author) & Graebin, C. S. (Lead / Corresponding author), 1 Feb 2022, In: Archiv der Pharmazie. 355, 2, 2100338.Research output: Contribution to journal › Review article › peer-review
12 Citations (Scopus) -
A profile of research on the parasitic trypanosomatids and the diseases they cause
Horn, D. (Lead / Corresponding author), 13 Jan 2022, In: PLoS Neglected Tropical Diseases. 16, 1, p. 1-23 23 p., e0010040.Research output: Contribution to journal › Review article › peer-review
Open AccessFile25 Citations (Scopus)98 Downloads (Pure) -
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes
Duncan, S. M. & Ferguson, M. A. J. (Lead / Corresponding author), 16 Sept 2022, In: Biochemical Journal. 479, 17, p. 1743-1758 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)54 Downloads (Pure) -
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Diehl, C. J. & Ciulli, A. (Lead / Corresponding author), 19 Aug 2022, In: Chemical Society Reviews. 51, 19, p. 8216-8257 42 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile78 Citations (Scopus)193 Downloads (Pure) -
Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory
Cowan, A. D. & Ciulli, A. (Lead / Corresponding author), Jun 2022, In: Annual Review of Biochemistry. 91, 27, p. 295-319 25 p.Research output: Contribution to journal › Review article › peer-review
File46 Citations (Scopus)542 Downloads (Pure) -
Drug discovery research in Ghana, challenges, current efforts, and the way forward
Amewu, R. K. (Lead / Corresponding author), Amoateng, P., Arthur, P. K., Asare, P., Asiamah, I., Boamah, D., Darko Otchere, I., Dzidzor Amengor, C., Ekuadzi, E., Chibale, K., Farrell, S. J., Appiah-Oppong, R., Osei-Safo, D., David Read, K., Hugh Gilbert, I. & Yeboah-Manu, D., 15 Sept 2022, In: PLoS Neglected Tropical Diseases. 16, 9, 9 p., e0010645.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)70 Downloads (Pure) -
Genome-scale RNAi screens in African trypanosomes
Horn, D. (Lead / Corresponding author), 1 Feb 2022, In: Trends in Parasitology. 38, 2, p. 160-173 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)136 Downloads (Pure) -
High Throughput Phenotypic Screening of The Human Spermatozoon
Johnston, Z. C., Gruber, F. S., Brown, S., Norcross, N. R., Swedlow, J. R., Gilbert, I. H. & Barratt, C. (Lead / Corresponding author), Jan 2022, In: Reproduction. 163, 1, p. R1-R9 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)94 Downloads (Pure) -
Identification of Co-Existing Mutations and Gene Expression Trends Associated With K13-Mediated Artemisinin Resistance in Plasmodium falciparum
Rawat, M. (Lead / Corresponding author), Kanyal, A., Choubey, D., Deshmukh, B., Malhotra, R., Mamatharani, D., Rao, A. G. & Karmodiya, K. (Lead / Corresponding author), 6 Apr 2022, In: Frontiers in Genetics. 13, 18 p., 824483.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Citations (Scopus)31 Downloads (Pure) -
Male contraceptive development: A medicinal chemistry perspective
Norcross, N. R., Georgiou, I., Johnston, Z. C., Gruber, F. S., Swedlow, J. R., Read, K. D., Barratt, C. L. R. & Gilbert, I. H. (Lead / Corresponding author), 5 Dec 2022, In: European Journal of Medicinal Chemistry. 243, p. 1-8 8 p., 114709.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Citations (Scopus)206 Downloads (Pure) -
Microbe Profile: Euglena gracilis: photogenic, flexible and hardy
Zoltner, M. & Field, M. C. (Lead / Corresponding author), 30 Sept 2022, In: Microbiology. 168, 9, 3 p., 001241.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research
Kent, R. S., Briggs, E. M., Colon, B. L., Alvarez, C., Silva Pereira, S. & De Niz, M. (Lead / Corresponding author), 6 Jun 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 39 p., 900878.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)82 Downloads (Pure) -
Sending the message: specialized RNA export mechanisms in trypanosomes
Obado, S. O., Rout, M. P. & Field, M. C. (Lead / Corresponding author), Oct 2022, In: Trends in Parasitology. 38, 10, p. 854-867 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)72 Downloads (Pure) -
Targeting Epigenetic Modulators Using PROTAC Degraders: Current Status and Future Perspective
Webb, T., Craigon, C. & Ciulli, A. (Lead / Corresponding author), 1 May 2022, In: Bioorganic & Medicinal Chemistry Letters. 63, 11 p., 128653.Research output: Contribution to journal › Review article › peer-review
Open AccessFile24 Citations (Scopus)476 Downloads (Pure) -
The design of multi-target drugs to treat cardiovascular diseases: Two (or more) birds on one stone
Caruso, L., Nadur, N. F., da Fonseca, M. B., Ferreira, L. D. A. P., Lacerda, R. B., Graebin, C. S. & Kümmerle, A. E. (Lead / Corresponding author), 16 Feb 2022, In: Current Topics in Medicinal Chemistry. 22, 5, p. 366-394 29 p.Research output: Contribution to journal › Review article › peer-review
6 Citations (Scopus) -
2021
A nuclear enterprise: Zooming in on nuclear organization and gene expression control in the African trypanosome
Faria, J. R. C. (Lead / Corresponding author), Sept 2021, In: Parasitology. 148, 10, p. 1237-1253 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)139 Downloads (Pure) -
Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
Ramachandran, S. & Ciulli, A. (Lead / Corresponding author), Apr 2021, In: Current Opinion in Structural Biology. 67, p. 110-119 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile38 Citations (Scopus)843 Downloads (Pure) -
Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins
Quintana, J. F. & Field, M. C. (Lead / Corresponding author), Sept 2021, In: Parasitology. 148, 10, p. 1137-1142 6 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)54 Downloads (Pure) -
Evolution and diversification of the nuclear pore complex
Makarov, A. A., Padilla-Mejia, N. E. & Field, M. C. (Lead / Corresponding author), 27 Aug 2021, In: Biochemical Society Transactions. 49, 4, p. 1601-1619 19 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)104 Downloads (Pure) -
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
Crowe, C., Molyneux, S., Sharma, S., Zhang, Y., Gkotsi, D., Connaris, H. & Goss, R. (Lead / Corresponding author), 7 Sept 2021, In: Chemical Society Reviews. 50, 17, p. 9443-9481 40 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile61 Citations (Scopus)137 Downloads (Pure) -
MalDA, Accelerating Malaria Drug Discovery
Yang, T., Ottilie, S., Istvan, E. S., Godinez-Macias, K. P., Lukens, A. K., Baragaña, B., Campo, B., Walpole, C., Niles, J. C., Chibale, K., Dechering, K. J., Llinás, M., Lee, M. C. S., Kato, N., Wyllie, S., McNamara, C. W., Gamo, F. J., Burrows, J., Fidock, D. A. & Goldberg, D. E. & 4 others, , Jun 2021, In: Trends in Parasitology. 37, 6, p. 493-507 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile59 Citations (Scopus)79 Downloads (Pure) -
NET formation - mechanisms and how they relate to other cell death pathways
Rosazza, T., Warner, J. & Sollberger, G. (Lead / Corresponding author), 7 Jun 2021, In: FEBS Journal. 288, 11, p. 3334-3350 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile50 Citations (Scopus)141 Downloads (Pure) -
Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues
Makukhin, N. & Ciulli, A. (Lead / Corresponding author), Jan 2021, In: RSC Medicinal Chemistry. 12, 1, p. 8-23 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile19 Citations (Scopus)124 Downloads (Pure) -
Reductionist Pathways for Parasitism in Euglenozoans? Expanded Datasets Provide New Insights
Butenko, A. (Lead / Corresponding author), Hammond, M., Field, M. C., Ginger, M. L., Yurchenko, V. & Lukeš, J. (Lead / Corresponding author), 1 Feb 2021, In: Trends in Parasitology. 37, 2, p. 100-116 17 p.Research output: Contribution to journal › Review article › peer-review
30 Citations (Scopus) -
Therapeutic prospects of exon skipping for epidermolysis bullosa
Vermeer, F. C., Bremer, J., Sietsma, R. J., Sandilands, A., Hickerson, R. P., Bolling, M. C., Pasmooij, A. M. G., Lemmink, H. H., Swertz, M. A., Knoers, N. V. A. M., van der Velde, K. J. & van den Akker, P. C. (Lead / Corresponding author), 12 Nov 2021, In: International Journal of Molecular Sciences. 22, 22, 15 p., 12222.Research output: Contribution to journal › Review article › peer-review
Open AccessFile12 Citations (Scopus)108 Downloads (Pure) -
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective
Farnaby, W. (Lead / Corresponding author), Koegl, M. (Lead / Corresponding author), McConnell, D. B. & Ciulli, A., Apr 2021, In: Current Opinion in Pharmacology. 57, p. 175-183 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile35 Citations (Scopus)241 Downloads (Pure) -
2020
100 years of suramin
Wiedemar, N., Hauser, D. A. & Mäser, P., 21 Feb 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, p. 1-14 14 p., e01168.Research output: Contribution to journal › Review article › peer-review
Open AccessFile123 Citations (Scopus)2937 Downloads (Pure) -
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma
Moreno, L. (Lead / Corresponding author), Barone, G., DuBois, S. G., Molenaar, J., Fischer, M., Schulte, J., Eggert, A., Schleiermacher, G., Speleman, F., Chesler, L., Geoerger, B., Hogarty, M. D., Irwin, M. S., Bird, N., Blanchard, G. B., Buckland, S., Caron, H., Davis, S., De Wilde, B. & Deubzer, H. E. & 18 others, , Sept 2020, In: European Journal of Cancer. 136, p. 52-68 17 p.Research output: Contribution to journal › Review article › peer-review
41 Citations (Scopus) -
A One Health Approach to Tackle Cryptosporidiosis
Innes, E. A. (Lead / Corresponding author), Chalmers, R. M., Wells, B. & Pawlowic, M. C., Mar 2020, In: Trends in Parasitology. 36, 3, p. 290-303 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access119 Citations (Scopus) -
Targeting epigenetic reader domains by chemical biology
Cipriano, A., Sbardella, G. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), Aug 2020, In: Current Opinion in Chemical Biology. 57, p. 82-94 13 p.Research output: Contribution to journal › Review article › peer-review
21 Citations (Scopus) -
The effects of mutant Ras proteins on the cell signalome
Takács, T., Kudlik, G., Kurilla, A., Szeder, B., Buday, L. & Vas, V. (Lead / Corresponding author), Dec 2020, In: Cancer and Metastasis Reviews. 39, 4, p. 1051-1065 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile40 Citations (Scopus)81 Downloads (Pure) -
Thiyl Radicals: Versatile Reactive Intermediates for Cyclization of Unsaturated Substrates
Lynch, D. M. & Scanlan, E. M. (Lead / Corresponding author), 7 Jul 2020, In: Molecules. 25, 13, 40 p., 3094.Research output: Contribution to journal › Review article › peer-review
Open AccessFile19 Citations (Scopus)105 Downloads (Pure) -
Treating age-related multimorbidity: the drug discovery challenge
Ermogenous, C., Green, C., Jackson, T., Ferguson, M. & Lord, J. M. (Lead / Corresponding author), Aug 2020, In: Drug Discovery Today. 25, 8, p. 1403-1415 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile22 Citations (Scopus)189 Downloads (Pure) -
2019
Bifunctional chemical probes inducing protein-protein interactions
Maniaci, C. & Ciulli, A. (Lead / Corresponding author), Oct 2019, In: Current Opinion in Chemical Biology. 52, p. 145-156 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile75 Citations (Scopus)619 Downloads (Pure) -
Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis
Fairlamb, A. H. (Lead / Corresponding author) & Patterson, S., 2019, In: Current Medicinal Chemistry. 26, 23, p. 4454-4475 22 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile46 Citations (Scopus)689 Downloads (Pure) -
Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium
Lee, M. C. S., Lindner, S. E., Lopez-Rubio, J. J. (Lead / Corresponding author) & Llinás, M., Sept 2019, In: Briefings in Functional Genomics. 18, 5, p. 281-289 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile34 Citations (Scopus)123 Downloads (Pure) -
Pore timing: the evolutionary origins of the nucleus and nuclear pore complex
Field, M. C. (Lead / Corresponding author) & Rout, M. P. (Lead / Corresponding author), 3 Apr 2019, In: F1000Research. 8, p. 1-11 11 p., 369.Research output: Contribution to journal › Review article › peer-review
Open AccessFile21 Citations (Scopus)203 Downloads (Pure) -
2018
Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes
Quintana , J. F., Canavate Del Pino, R., Yamada, K., Zhang, N. & Field, M. (Lead / Corresponding author), 20 Jul 2018, In: Genes. 9, 7, 16 p., 368.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)205 Downloads (Pure) -
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease
Prati, F., Bottegoni, G., Bolognesi, M. L. & Cavalli, A. (Lead / Corresponding author), 8 Feb 2018, In: Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile99 Citations (Scopus)213 Downloads (Pure) -
Challenges and recent progress in drug discovery for tropical diseases
De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H. (Lead / Corresponding author), 25 Jul 2018, In: Nature. 559, 7715, p. 498-506 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile161 Citations (Scopus)305 Downloads (Pure) -
Conservation and Variation in Strategies for DNA Replication of Kinetoplastid Nuclear Genomes
Marques, C. A. & McCulloch, R., Feb 2018, In: Current Genomics. 19, 2, p. 98-109 12 p.Research output: Contribution to journal › Review article › peer-review
15 Citations (Scopus) -
Evolutionary origins and specialisation of membrane transport
Dacks, J. B. & Field, M. C. (Lead / Corresponding author), 1 Aug 2018, In: Current Opinion in Cell Biology. 53, p. 70-76 7 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile40 Citations (Scopus)276 Downloads (Pure) -
Evolution of protein trafficking in kinetoplastid parasites: complexity and pathogenesis
Venkatesh, D., Zhang, N., Zoltner, M., Canavate Del Pino, R. & Field, M. C. (Lead / Corresponding author), Nov 2018, In: Traffic. 19, 11, p. 803-812 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Citations (Scopus)139 Downloads (Pure) -
Genome-wide survey and phylogenetic analysis of histone acetyltransferases and histone deacetylases of Plasmodium falciparum
Kanyal, A., Rawat, M., Gurung, P., Choubey, D., Anamika, K. & Karmodiya, K., 21 May 2018, In: FEBS Journal. 285, 10, p. 1767-1782 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access35 Citations (Scopus)