Biological Chemistry and Drug Discovery

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  • 2023

    Anti-Infective Agents

    Gilbert, I., Baragana, B., Caldwell, N., Taylor, M., Forte, B., Cocco, M. & Jansen, C., 2 Nov 2023, IPC No. A61K31/519, A61P33/02, C07D487/04, Patent No. WO 2023/209336 A1, 20 Apr 2023, Priority date 26 Apr 2022, Priority No. GB202206076A

    Research output: Patent

  • 2020

    PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

    Ciulli, A., Dank, C., Diers, E., Farnaby, W., Roy, M., Steurer, S. & Trainor, N., 23 Apr 2020, Patent No. WO/2020/078933, 14 Oct 2019, Priority date 16 Oct 2018, Priority No. 18200596.7

    Research output: Patent

  • 2019

    BIFUNCTIONAL MOLECULES FOR TARGETING RPN11

    Ciulli, A., Testa, A., Hughes, S. & Butcher, S. P., 19 Dec 2019, Patent No. WO/2019/238817, 13 Jun 2019, Priority date 13 Jun 2018

    Research output: Patent

  • BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5

    Ciulli, A., Testa, A., Hughes, S. & Butcher, S. P., 19 Dec 2019, Patent No. WO/2019/238816, 13 Jun 2019

    Research output: Patent

  • BIFUNCTIONAL MOLECULES FOR TARGETING USP14

    Testa, A., Hughes, S., Butcher, S. P. & Ciulli, A., 19 Dec 2019, Patent No. WO/2019/238886, 13 Jun 2019

    Research output: Patent

  • 2018

    Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

    Ciulli, A. & Testa, A., 22 Mar 2018, IPC No. C07D 417/12 2006.1, C07D 417/14 2006.1, C07D 495/14 2006.1, A61K 31/427 2006.1, A61K 31/551 2006.1, A61P 35/00 2006.1, A61P 29/00 2006.1, Patent No. WO/2018/051107, 14 Sept 2017, Priority date 14 Sept 2016, Priority No. 1615617.6

    Research output: Patent

  • Small molecules

    Ciulli, A., Maniaci, C., Hughes, S. & Testa, A., 18 Oct 2018, IPC No. C07D 417/14 2006.1, C07K 5/062 2006.1, A61P 35/00 2006.1, A61K 38/05 2006.1, Patent No. WO/2018/189554, 13 Apr 2018, Priority date 14 Apr 2017, Priority No. 1706042.7 / 1706043.5

    Research output: Patent

  • 2016

    DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES

    Ciulli, A., Zengerle, M. & Chan, K. H., 22 Sept 2016, Patent No. WO/2016/146985, 14 Mar 2016, Priority date 13 Mar 2015

    Research output: Patent

  • 2015

    SONDES FONCTIONNELLES ENZYMATIQUES

    Translated title of the contribution: Enzymes functional probesShiao, E. L., Baud, M. G. J., Ciulli, A., Chan, K. H. & Zengerle, M., 4 Jun 2015, Patent No. WO/2015/079259, 28 Nov 2014, Priority date 28 Nov 2013, Priority No. 1320994.5 / 1401001.1

    Research output: Patent

  • 2013

    Anti-malarial agents

    Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A., 17 Oct 2013, IPC No. C07D 215/52 (2006.01), A61K 31/4725 (2006.01), A61P 33/06 (2006.01) , Patent No. PCT/GB2013/050633

    Research output: Patent

  • Improved sperm function / activity

    Barratt, C. & Wyatt, P., 18 Apr 2013, IPC No. A61K31/519; A61P15/00; A61K31/52; A61K31/437; A61K45/00; A61K31/551; A61K39/395; A61K31/47, Patent No. WO2013054111 A1

    Research output: Patent

  • 2012

    Morpholino compounds, uses and methods

    Besnard, J., Hopkins, A., Gilbert, I., Ruda, G. F. & Abecassis, K., 29 Nov 2012, Patent No. PCT/GB2012/051194, 25 May 2012

    Research output: Patent

  • 2011

    Cell migration modulating compounds

    Schor, A. M., Schor, S. L., Marquez, R. & Norman, D. G., 19 Oct 2011, Patent No. EP1917012

    Research output: Patent

  • Design of molecules

    Hopkins, A. & Besnard, J., 26 May 2011, Patent No. PCT/GB2010/051940

    Research output: Patent

  • 2010

    N-myristoyl transferase inhibitors

    Brand, S., Wyatt, P., Thompson, S., Smith, V., Bayliss, T., Harrison, J., Norcross, N., Cleghorn, L., Gilbert, I. & Brenk, R., 11 Mar 2010, IPC No. C07D 213/75 (2006.01), C07D 213/42 (2006.01), C07D 239/69 (2006.01), C07D 263/50 (2006.01), C07D 403/12 (2006.01), C07D 407/12 (2006.01), C07D 409/12 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01) , Patent No. PCT/GB2009/002084

    Research output: Patent