Biological Chemistry and Drug Discovery

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• A biophysical approach for the study of G-protein coupled receptor complexes

  Author: Aristotelous, T., 2017

  Supervisor: Hopkins, A. (Supervisor) & Hopkins Navratilova, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• African Trypanosome Genes Specifically Required for Fitness in vivo

  Author: Shrimpton, J. W., 2017

  Supervisor: Horn, D. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

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• Analysis and Prediction of Protein Structure

  Author: Barber, J., 2005

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Arsenic, antimony and visceral leishmaniasis

  Author: Perry, M. R., 2014

  Supervisor: Fairlamb, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi

  Author: Roberts, A., 2014

  Supervisor: Fairlamb, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Assessment of potential antibacterial drug targets

  Author: Diaz Saez, L., 2016

  Supervisor: Hunter, W. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains

  Author: Runcie, A. C., 2019

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Characterisation of protein-ligand interactions of glycine binding protein (GBP) as a model of the heteromeric glycine receptor

  Author: Jones, M., 2021

  Supervisor: Hunter, W. (Supervisor) & Hales, T. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Chemical synthesis of Leishmania lipophosphoglycan structures conjugated to a biotin moiety

  Author: Edgar, C. W., 2011

  Supervisor: Nikolaev, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Classification and Functional Annotation of Eukaryotic Protein Kinases

  Author: Miranda-Saavedra, D., 2007

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Computational prediction of human protein-protein interactions

  Author: Eckenrode Sokolowski, T., 2013

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Computational Prediction of Transcription Factor Binding Sites in Bacterial Genomes

  Author: Robert, C., 2010

  Supervisor: Barton, G. (Supervisor), Wright, F. (Supervisor) & Pritchard, L. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Cracking the Cryptosporidium Oocyst Wall Proteins

  Author: Bacchetti, R., 2022

  Supervisor: Pawlowic, M. (Supervisor) & Horn, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Defining D-Arabinose Metabolism in Leishmania major and Crithidia fasciculata

  Author: Iljazi, E., 2018

  Supervisor: Ferguson, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Design and Synthesis of Covalent Inhibitors as Novel Anti-Infective Compounds

  Author: Martin, J. S., 2021

  Supervisor: Gilbert, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Development and application of BromoTag : A “Bump-&-Hole”- PROTAC degron system for rapid, potent, and selective degradation of tagged target proteins

  Author: Craigon, C. G., 2022

  Supervisor: Ciulli, A. (Supervisor) & Blow, J. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Development and optimisation of biosensor analysis for wild-type G protein-coupled receptors

  Author: Shepherd, C., 2017

  Supervisor: Hopkins, A. (Supervisor), Hopkins Navratilova, I. (Supervisor) & Rawlins, P. (External person) (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Development of a high throughput ligand screening method and structural studies of pentameric ligand gated ion channels.

  Author: Trumper, P., 2014

  Supervisor: Hunter, W. (Supervisor) & Hales, T. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of mode of action tools using lysyl-tRNA synthetase to support Cryptosporidium drug discovery

  Author: Hanna, J., 2023

  Supervisor: Pawlowic, M. (Supervisor) & Wyllie, S. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Discovery of high quality molecular leads and screening collections for CNS drug targets

  Author: Farnaby, W., 2019

  Supervisor: Ciulli, A. (Supervisor) & Read, K. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Drug target deconvolution in Leishmania donovani

  Author: De Sousa Paradela, L., 2022

  Supervisor: Wyllie, S. (Supervisor) & Gilbert, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Early-stage drug discovery of HIV-1 frameshifting modulators

  Author: Fernandes, A. B., 2015

  Supervisor: Gray, D. (Supervisor) & Wilson, S. (External person) (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Elongin B/C-containing E3 ligases: fragment-based ligand design and examining resistance mechanisms for targeted protein degradation

  Author: Casement, R., 2023

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes

  Author: Grimaldi, R., 2014

  Supervisor: Fairlamb, A. (Supervisor) & Frearson, J. A. (External person) (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Exploring allosteric pockets in protein kinases: a multidisciplinary approach

  Author: Birced, I., 2015

  Supervisor: Hopkins, A. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

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• Folate transport and drug resistance in the African Trypanosome

  Author: Dewar, S., 2017

  Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Fragment-based approaches to probe the surface of the VHL E3 ligase

  Author: Castro, G., 2019

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Human protein-protein interaction prediction

  Author: McDowall, M., 2011

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases

  Author: Cardote, T. A. D. F., 2017

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular Characterisation of the Type VI Secretion System Effector Rhs1 from Serratia marcescens

  Author: Hagan, M. R., 2022

  Supervisor: Coulthurst, S. (Supervisor) & Hunter, B. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• New approaches to studying the GPI biosynthesis pathway in T. brucei: uncovering the missing links

  Author: Ji, Z., 2021

  Supervisor: Ferguson, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Nitroaromatic pro-drug activation and resistance in the African trypanosome

  Author: Sokolova, A. Y., 2011

  Supervisor: Fairlamb, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Oocyst development in the parasite Cryptosporidium parvum

  Author: Sands, E., 2023

  Supervisor: Pawlowic, M. (Supervisor) & Gilbert, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Origins and composition of the cullin-RING E3 ligases in trypanosomes

  Author: Canavate Del Pino, M. R., 2020

  Supervisor: Field, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Prediction and investigation of protein-protein interactions using structural data

  Author: Jefferson, E., 2006

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Prediction of Functional Positions in Protein Multiple Sequence Alignments

  Author: Manning, J., 2008

  Supervisor: Barton, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase

  Author: Kung, W., 2018

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Proteomic analysis of protein complexes and cell cycle regulation in Trypanosoma brucei

  Author: Crozier, T. W. M., 2016

  Supervisor: Ferguson, M. (Supervisor) & Lamond, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Rapid analysis of pharmacology for infectious diseases.

  Author: Carruthers, I. M., 2013

  Supervisor: Hopkins, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Recombinant production and investigation of neurotransmitter channels and transporters

  Author: Davis, S., 2022

  Supervisor: Hunter, W. (Supervisor) & Hales, T. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Regulation of Polarised Trafficking Machinery in Epithelial to Mesenchymal Transition

  Author: Watt, M. N., 2022

  Supervisor: Murray, D. (Supervisor) & Januschke, J. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

• Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase

  Author: Soares, P., 2018

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural and functional characterisation of proteins facilitating the capping and translocation of Streptococcal cell-wall polysaccharidess

  Author: Lucas, K., 2023

  Supervisor: Dorfmueller, H. (Supervisor) & Ferguson, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition

  Author: Barrack, K. L., 2013

  Supervisor: Hunter, W. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes

  Author: Amato, A., 2018

  Supervisor: Ciulli, A. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural studies to inform antimicrobial drug discovery and the basis of immunity against T6 effectors

  Author: O'Rourke, P., 2013

  Supervisor: Hunter, W. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structure and molecular recognition in riboswitches

  Author: Daldrop, P., 2011

  Supervisor: Brenk, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structure- based inhibitor design for key enzymes of Tryposoma brucei

  Author: Striker, W., 2014

  Supervisor: Brenk, R. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structure of T6SS components and assessment of potential Gram-ve drug targets

  Author: Rao, V. A., 2012

  Supervisor: Hunter, W. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structure of the LKB1-STRAD-MO25 tumour suppressor complex

  Author: Zeqiraj, E., 2009

  Supervisor: Alessi, D. (Supervisor) & Van Aalten, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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