Biological Chemistry and Drug Discovery

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• A biophysical approach for the study of G-protein coupled receptor complexes

  Aristotelous, T. (Author), Hopkins, A. (Supervisor) & Hopkins Navratilova, I. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• A Comprehensive Analysis of Components in SUMO Pathway

  Ward, A. (Author), Field, M. (Supervisor) & Horn, D. (Supervisor), 2022

  Student thesis: Master's Thesis › Master of Science

• African Trypanosome Genes Specifically Required for Fitness in vivo

  Shrimpton, J. W. (Author), Horn, D. (Supervisor), 2017

  Student thesis: Master's Thesis › Master of Science

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• Analysis and Prediction of Protein Structure

  Barber, J. (Author), Barton, G. (Supervisor), 2005

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Arsenic, antimony and visceral leishmaniasis

  Perry, M. R. (Author), Fairlamb, A. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi

  Roberts, A. (Author), Fairlamb, A. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Assessment of potential antibacterial drug targets

  Diaz Saez, L. (Author), Hunter, W. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains

  Runcie, A. C. (Author), Ciulli, A. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Characterisation of protein-ligand interactions of glycine binding protein (GBP) as a model of the heteromeric glycine receptor

  Jones, M. (Author), Hunter, W. (Supervisor) & Hales, T. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Chemical synthesis of Leishmania lipophosphoglycan structures conjugated to a biotin moiety

  Edgar, C. W. (Author), Nikolaev, A. (Supervisor), 2011

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Classification and Functional Annotation of Eukaryotic Protein Kinases

  Miranda-Saavedra, D. (Author), Barton, G. (Supervisor), 2007

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Computational prediction of human protein-protein interactions

  Eckenrode Sokolowski, T. (Author), Barton, G. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Computational Prediction of Transcription Factor Binding Sites in Bacterial Genomes

  Robert, C. (Author), Barton, G. (Supervisor), Wright, F. (Supervisor) & Pritchard, L. (Supervisor), 2010

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Cracking the Cryptosporidium Oocyst Wall Proteins

  Bacchetti, R. (Author), Pawlowic, M. (Supervisor) & Horn, D. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Defining D-Arabinose Metabolism in Leishmania major and Crithidia fasciculata

  Iljazi, E. (Author), Ferguson, M. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Design and Synthesis of Covalent Inhibitors as Novel Anti-Infective Compounds

  Martin, J. S. (Author), Gilbert, I. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Development and application of BromoTag : A “Bump-&-Hole”- PROTAC degron system for rapid, potent, and selective degradation of tagged target proteins

  Craigon, C. G. (Author), Ciulli, A. (Supervisor) & Blow, J. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development and optimisation of biosensor analysis for wild-type G protein-coupled receptors

  Shepherd, C. (Author), Hopkins, A. (Supervisor), Hopkins Navratilova, I. (Supervisor) & Rawlins, P. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Development of a high throughput ligand screening method and structural studies of pentameric ligand gated ion channels.

  Trumper, P. (Author), Hunter, W. (Supervisor) & Hales, T. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of mode of action tools using lysyl-tRNA synthetase to support Cryptosporidium drug discovery

  Hanna, J. C. (Author), Pawlowic, M. (Supervisor) & Wyllie, S. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of Next-Generation Protein Degradation Systems: BromoTag and Other PROTACs

  Bond, A. G. (Author), Ciulli, A. (Supervisor) & Sapkota, G. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Discovery of high quality molecular leads and screening collections for CNS drug targets

  Farnaby, W. (Author), Ciulli, A. (Supervisor) & Read, K. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Drug target deconvolution in Leishmania donovani

  De Sousa Paradela, L. (Author), Wyllie, S. (Supervisor) & Gilbert, I. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Early-stage drug discovery of HIV-1 frameshifting modulators

  Fernandes, A. B. (Author), Gray, D. (Supervisor) & Wilson, S. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Elongin B/C-containing E3 ligases: fragment-based ligand design and examining resistance mechanisms for targeted protein degradation

  Casement, R. (Author), Ciulli, A. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes

  Grimaldi, R. (Author), Fairlamb, A. (Supervisor) & Frearson, J. A. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Exploring allosteric pockets in protein kinases: a multidisciplinary approach

  Birced, I. (Author), Hopkins, A. (Supervisor), 2015

  Student thesis: Master's Thesis › Master of Science

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• Folate transport and drug resistance in the African Trypanosome

  Dewar, S. (Author), Fairlamb, A. (Supervisor) & Horn, D. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Fragment-based approaches to probe the surface of the VHL E3 ligase

  Castro, G. (Author), Ciulli, A. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Human protein-protein interaction prediction

  McDowall, M. (Author), Barton, G. (Supervisor), 2011

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification and characterisation of antibacterial Type VI Secretion System effectors produced by a clinical isolate of Serratia marcescens

  Stonier, B. J. (Author), Coulthurst, S. (Supervisor) & Wyllie, S. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases

  Cardote, T. A. D. F. (Author), Ciulli, A. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Molecular Characterisation of the Type VI Secretion System Effector Rhs1 from Serratia marcescens

  Hagan, M. R. (Author), Coulthurst, S. (Supervisor) & Hunter, B. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• New approaches to studying the GPI biosynthesis pathway in T. brucei: uncovering the missing links

  Ji, Z. (Author), Ferguson, M. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Nitroaromatic pro-drug activation and resistance in the African trypanosome

  Sokolova, A. Y. (Author), Fairlamb, A. (Supervisor), 2011

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Oocyst development in the parasite Cryptosporidium parvum

  Sands, E. (Author), Pawlowic, M. (Supervisor) & Gilbert, I. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Origins and composition of the cullin-RING E3 ligases in trypanosomes

  Canavate Del Pino, M. R. (Author), Field, M. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Precision mutagenesis of histone tail residues in trypanosomes

  Novotná, M. (Author), Horn, D. (Supervisor) & Field, M. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Prediction and investigation of protein-protein interactions using structural data

  Jefferson, E. (Author), Barton, G. (Supervisor), 2006

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Prediction of Functional Positions in Protein Multiple Sequence Alignments

  Manning, J. (Author), Barton, G. (Supervisor), 2008

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase

  Kung, W.-W. (Author), Ciulli, A. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Proteomic analysis of protein complexes and cell cycle regulation in Trypanosoma brucei

  Crozier, T. W. M. (Author), Ferguson, M. (Supervisor) & Lamond, A. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Rapid analysis of pharmacology for infectious diseases.

  Carruthers, I. M. (Author), Hopkins, A. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Recombinant production and investigation of neurotransmitter channels and transporters

  Davis, S. (Author), Hunter, W. (Supervisor) & Hales, T. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Regulation of Polarised Trafficking Machinery in Epithelial to Mesenchymal Transition

  Watt, M. N. (Author), Murray, D. (Supervisor) & Januschke, J. (Supervisor), 2022

  Student thesis: Master's Thesis › Master of Science

• Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase

  Soares, P. (Author), Ciulli, A. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural and functional characterisation of proteins facilitating the capping and translocation of Streptococcal cell-wall polysaccharidess

  Lucas, K. (Author), Dorfmueller, H. (Supervisor) & Ferguson, M. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Structural characterization of bacterial membrane proteins via molecular dynamics simulations and electrophysiology

  Tamburrino, G. (Author), Zachariae, U. (Supervisor) & Hunter, W. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition

  Barrack, K. L. (Author), Hunter, W. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes

  Amato, A. (Author), Ciulli, A. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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