Biological Chemistry and Drug Discovery

  • United Kingdom

Student theses

A biophysical approach for the study of G-protein coupled receptor complexes

Author: Aristotelous, T., 2017

Supervisor: Hopkins, A. (Supervisor) & Hopkins Navratilova, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

African Trypanosome Genes Specifically Required for Fitness in vivo

Author: Shrimpton, J. W., 2017

Supervisor: Horn, D. (Supervisor)

Student thesis: Master's ThesisMaster of Science

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Arsenic, antimony and visceral leishmaniasis

Author: Perry, M. R., 2014

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi

Author: Roberts, A., 2014

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Assessment of potential antibacterial drug targets

Author: Diaz Saez, L., 2016

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains

Author: Runcie, A. C., 2019

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Chemical synthesis of Leishmania lipophosphoglycan structures conjugated to a biotin moiety

Author: Edgar, C. W., 2011

Supervisor: Nikolaev, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Computational prediction of human protein-protein interactions

Author: Eckenrode Sokolowski, T., 2013

Supervisor: Barton, G. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Development and optimisation of biosensor analysis for wild-type G protein-coupled receptors

Author: Shepherd, C., 2017

Supervisor: Hopkins, A. (Supervisor), Hopkins Navratilova, I. (Supervisor) & Rawlins, P. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Development of a high throughput ligand screening method and structural studies of pentameric ligand gated ion channels.

Author: Trumper, P., 2014

Supervisor: Hunter, W. (Supervisor) & Hales, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Discovery of high quality molecular leads and screening collections for CNS drug targets

Author: Farnaby, W., 2019

Supervisor: Ciulli, A. (Supervisor) & Read, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Early-stage drug discovery of HIV-1 frameshifting modulators

Author: Fernandes, A. B., 2015

Supervisor: Gray, D. (Supervisor) & Wilson, S. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes

Author: Grimaldi, R., 2014

Supervisor: Fairlamb, A. (Supervisor) & Frearson, J. A. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Exploring allosteric pockets in protein kinases: a multidisciplinary approach

Author: Birced, I., 2015

Supervisor: Hopkins, A. (Supervisor)

Student thesis: Master's ThesisMaster of Science

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Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Fragment-based approaches to probe the surface of the VHL E3 ligase

Author: Castro, G., 2019

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Human protein-protein interaction prediction

Author: McDowall, M., 2011

Supervisor: Barton, G. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases

Author: Cardote, T. A. D. F., 2017

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Nitroaromatic pro-drug activation and resistance in the African trypanosome

Author: Sokolova, A. Y., 2011

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase

Author: Kung, W., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Proteomic analysis of protein complexes and cell cycle regulation in Trypanosoma brucei

Author: Crozier, T. W. M., 2016

Supervisor: Ferguson, M. (Supervisor) & Lamond, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Rapid analysis of pharmacology for infectious diseases.

Author: Carruthers, I. M., 2013

Supervisor: Hopkins, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase

Author: Soares, P., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition

Author: Barrack, K. L., 2013

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes

Author: Amato, A., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structural studies to inform antimicrobial drug discovery and the basis of immunity against T6 effectors

Author: O'Rourke, P., 2013

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structure and molecular recognition in riboswitches

Author: Daldrop, P., 2011

Supervisor: Brenk, R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structure- based inhibitor design for key enzymes of Tryposoma brucei

Author: Striker, W., 2014

Supervisor: Brenk, R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structure of T6SS components and assessment of potential Gram-ve drug targets

Author: Rao, V. A., 2012

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structure of the LKB1-STRAD-MO25 tumour suppressor complex

Author: Zeqiraj, E., 2009

Supervisor: Alessi, D. (Supervisor) & Van Aalten, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Studies of proteins implicated in the folding and processing of tubulin

Author: Fleming, J., 2012

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Synthesis of fragments of the capsular polysaccharide of Neisseria meningitidis (serogroup A) suitable for bioconjugation

Author: Black, A., 2014

Supervisor: Nikolaev, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Synthetic strategies for potential trypanocides

Author: Capes, A., 2011

Supervisor: Gilbert, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids

Author: Webster, L., 2014

Supervisor: Gilbert, I. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Targeting an E3 ubiquitin ligase Siah1 and a cysteine protease SENP1 using SPR and DSF-based fragment screening

Author: Rimsa, V., 2013

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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The Effects of Polysomal mRNA Association and Cap Methylation on Gene Expression in Trypanosoma brucei

Author: Kelner, A., 2014

Supervisor: Ferguson, M. (Supervisor) & Cowling, V. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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The Investigation of Oligosaccharyltransferase in Trypanosoma brucei

Author: Jinnelov, P., 2014

Supervisor: Ferguson, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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VHL inhibitors as chemical probes of the hypoxia signalling pathway

Author: Frost, J., 2018

Supervisor: Ciulli, A. (Supervisor) & Rocha, S. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

Author: Hutchinson, S. J., 2016

Supervisor: Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy