Biomarker and Drug Analysis Laboratory

  • United Kingdom

Research Output

  • 795 Citations
  • 16 h-Index
  • 35 Article
  • 3 Letter
  • 1 Meeting abstract
2018

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
165 Downloads (Pure)

Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial

Chalmers, J. D., Djamin, R. S., Schouten, M., Keir, H. R., Tan, B., Aerts, J. G. J. V., Huang, J. T-J. & van der Eerden, M., Oct 2018, In : ERJ Open Research. 4, 4, p. 1-4 4 p.

Research output: Contribution to journalArticle

Open Access
File
95 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
162 Downloads (Pure)

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
139 Downloads (Pure)
2017
Open Access
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7 Citations (Scopus)
255 Downloads (Pure)

Neutrophil elastase activity is associated with exacerbations and lung function decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393 10 p.

Research output: Contribution to journalArticle

Open Access
File
80 Citations (Scopus)
136 Downloads (Pure)
Open Access
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12 Citations (Scopus)
111 Downloads (Pure)

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In : Toxicological Sciences. 158, 2, p. 367-378 11 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
154 Downloads (Pure)
2016

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease

the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, Huang, J. T. J., Bolton, C. E., Miller, B. E., Tal-Singer, R., Rabinovich, R. A., Palmer, C. N. A., Thomson, N. C. & MacNee, W., 30 Sep 2016, In : European Respiratory Journal. 48, 4, p. 1215-1218 4 p.

Research output: Contribution to journalLetter

Open Access
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7 Citations (Scopus)
148 Downloads (Pure)

Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

Rabinovich, R. A., Miller, B. E., Wrobel, K., Ranjit, K., Williams, M. C., Drost, E., Edwards, L. D., Lomas, D. A., Rennard, S. I., Agustí, A., Tal-Singer, R., Vestbo, J., Wouters, E. F. M., John, M., Van Beek, E. J. R., Murchison, J. T., Bolton, C. E., Macnee, W. & Huang, J. T. J., 1 May 2016, In : European Respiratory Journal. 47, 5, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

Moffat, C., Buckland, S. T., Samson, A., McArthur, R., Chamosa Pino, V., Bollan, K. A., Huang, J. T-J. & Connolly, C., 28 Apr 2016, In : Scientific Reports. 6, p. 1-10 10 p., 24764.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
221 Downloads (Pure)
2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., Mar 2015, In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

Moffat, C., Pacheco, J. G., Sharp, S., Samson, A. J., Bollan, K. A., Huang, J., Buckland, S. T. & Connolly, C. N., May 2015, In : FASEB Journal. 29, 5, p. 2112-2119 8 p.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
264 Downloads (Pure)

Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

Li, C., Guan, G., Ling, Y., Hsu, Y-T., Song, S., Huang, J. T-J., Lang, S., Wang, R. K., Huang, Z. & Nabi, G., 1 Feb 2015, In : Cancer Letters. 357, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
21 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
Open Access
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9 Citations (Scopus)
134 Downloads (Pure)

PPARα is required for PPARδ action in regulation of body weight and hepatic steatosis in mice

Garbacz, W. G., Huang, J. T. J., Higgins, L. G., Wahli, W. & Palmer, C. N. A., 2015, In : PPAR Research. 2015, 15 p., 927057.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Prime mover or fellow traveller: 25-hydroxy vitamin D’s seasonal variation, cardiovascular disease and death in the Scottish Heart Health Extended Cohort (SHHEC)

Tunstall-Pedoe, H., Woodward, M., Hughes, M., Anderson, A., Kennedy, G., Belch, J., Kuulasmaa, K. & MORGAM Investigators, 21 Jun 2015, In : International Journal of Epidemiology. 44, 5, p. 1602-1612 11 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
124 Downloads (Pure)
7 Citations (Scopus)
2014

An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis

Devereux, G., Steele, S., Jagelman, T., Fielding, S., Muirhead, R., Brady, J., Grierson, C., Brooker, R., Winter, J., Fardon, T., McCormick, J., Huang, J. T. J. & Miller, D., Sep 2014, In : Journal of Cystic Fibrosis. 13, 5, p. 557-563 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
4 Citations (Scopus)
310 Downloads (Pure)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
89 Downloads (Pure)

BRCA1 is a histone-H2A-specific ubiquitin ligase

Kalb, R., Mallery, D. L., Larkin, C., Huang, J. T. J. & Hiom, K., 21 Aug 2014, In : Cell Reports. 8, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Open Access
File
57 Citations (Scopus)
196 Downloads (Pure)
49 Citations (Scopus)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
158 Downloads (Pure)
21 Citations (Scopus)

The SNAP trial: a randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - clinical effectiveness and safety until 2 years after delivery, with economic evaluation

Cooper, S., Lewis, S., Thornton, J. G., Marlow, N., Watts, K., Britton, J., Grainge, M. J., Taggar, J., Essex, H., Parrott, S., Dickinson, A., Whitemore, R., Coleman, T. & Smoking, Nicotine and Pregnancy (SNAP) Trial Team, Aug 2014, In : Health Technology Assessment. 18, 54, p. 1-128 128 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2013

A trans-acting protein effect causes severe eye malformation in the mp mouse

Rainger, J., Keighren, M., Keene, D. R., Charbonneau, N. L., Rainger, J. K., Fisher, M., Mella, S., Huang, J. T-J., Rose, L., Van't Hof, R., Sakai, L. Y., Jackson, I. J. & Fitzpatrick, D. R., 2013, In : PLoS Genetics. 9, 12, e1003998.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R., Thomson, N. C., Palmer, C. N. A., Devereux, G. & Huang, J. T-J., Aug 2013, In : Bioanalysis. 5, 16, p. 1991-2001 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
45 Citations (Scopus)
2012

Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease

Huang, J. T-J., Chaudhuri, R., Albarbarawi, O., Barton, A., Grierson, C., Rauchhaus, P., Weir, C. J., Messow, M., Stevens, N., McSharry, C., Feuerstein, G., Mukhopadhyay, S., Brady, J., Palmer, C. N. A., Miller, D. & Thomson, N. C., 16 Jan 2012, In : Thorax. 67, 6, p. 502-508 7 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
122 Downloads (Pure)

Large and small artery endothelial dysfunction in chronic fatigue syndrome

Newton, D. J., Kennedy, G., Chan, K. K. F., Lang, C. C., Belch, J. J. F. & Khan, F., 2012, In : International Journal of Cardiology. 154, 3, p. 335-336 2 p.

Research output: Contribution to journalLetter

12 Citations (Scopus)
8 Citations (Scopus)
2011

Application of novel method to quantify akt phosphorylation in breast cancer

Thompson, A., Atrih, A., Quinlan, P. R., Bray, S., Ferguson, M. & Huang, J., May 2011, In : Annals of Oncology. 22, S2, p. ii38-iii38 1 p., 65P.

Research output: Contribution to journalMeeting abstract

Development of F-18-fluorinatable dendrons and their application to cancer cell targeting

Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. A. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., 2011, In : New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

PChopper: high throughput peptide prediction for MRM/SRM transition design

Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J., 15 Aug 2011, In : BMC Bioinformatics. 12, p. - 9 p., 338.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers

Zhang, Y., Zhang, G., Clarke, P. A., Huang, J. T. J., Takahashi, E., Muirhead, D., Steenwyk, R. C. & Lin, Z., Jul 2011, In : Journal of Mass Spectrometry. 46, 7, p. 705-11 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)