Biomarker and Drug Analysis Laboratory

  • United Kingdom

Research Output 2011 2018

  • 667 Citations
  • 15 h-Index
  • 35 Article
  • 3 Letter
  • 1 Meeting abstract
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Article
2018
2 Citations (Scopus)
46 Downloads (Pure)

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
File
Isotopes
Dilution
Neurotransmitter Agents
Steroids
Brain
47 Downloads (Pure)

Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial

Chalmers, J. D., Djamin, R. S., Schouten, M., Keir, H. R., Tan, B., Aerts, J. G. J. V., Huang, J. T-J. & van der Eerden, M., Oct 2018, In : ERJ Open Research. 4, 4, p. 1-4 4 p.

Research output: Contribution to journalArticle

Open Access
File
Desmosine
Azithromycin
Randomized Controlled Trials
Biomarkers
Chronic Obstructive Pulmonary Disease
1 Citation (Scopus)
67 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
6 Citations (Scopus)
50 Downloads (Pure)

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Open Access
File
Lung Neoplasms
Cytochrome P-450 CYP3A
Therapeutics
Pharmaceutical Preparations
Cytochrome P-450 CYP1A2
2017
5 Citations (Scopus)
183 Downloads (Pure)
Open Access
File
Hypoglycemia
Hypoglycemic Agents
Rodentia
Type 1 Diabetes Mellitus
Brain-Derived Neurotrophic Factor
62 Citations (Scopus)
70 Downloads (Pure)

Neutrophil elastase activity is associated with exacerbations and lung function decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393 10 p.

Research output: Contribution to journalArticle

Open Access
File
Leukocyte Elastase
Bronchiectasis
Pancreatic Elastase
Sputum
Desmosine
8 Citations (Scopus)
69 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP1A1
Poisons
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glutathione Transferase
Premature Mortality
2 Citations (Scopus)
82 Downloads (Pure)

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In : Toxicological Sciences. 158, 2, p. 367-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
Untranslated RNA
Xenobiotics
Liver
Carcinogenesis
Biomarkers
2016
31 Citations (Scopus)

Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

Rabinovich, R. A., Miller, B. E., Wrobel, K., Ranjit, K., Williams, M. C., Drost, E., Edwards, L. D., Lomas, D. A., Rennard, S. I., Agustí, A., Tal-Singer, R., Vestbo, J., Wouters, E. F. M., John, M., Van Beek, E. J. R., Murchison, J. T., Bolton, C. E., Macnee, W. & Huang, J. T. J., 1 May 2016, In : European Respiratory Journal. 47, 5, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Desmosine
Emphysema
Chronic Obstructive Pulmonary Disease
Mortality
Elastin
31 Citations (Scopus)
149 Downloads (Pure)

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

Moffat, C., Buckland, S. T., Samson, A., McArthur, R., Chamosa Pino, V., Bollan, K. A., Huang, J. T-J. & Connolly, C., 28 Apr 2016, In : Scientific Reports. 6, p. 1-10 10 p., 24764.

Research output: Contribution to journalArticle

Open Access
File
Nicotinic Receptors
Bees
Neurons
Aptitude
Food Supply
2015
7 Citations (Scopus)

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., Mar 2015, In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

Isotope Labeling
Cell culture
Metabolism
Isotopes
Labeling
40 Citations (Scopus)
186 Downloads (Pure)

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

Moffat, C., Pacheco, J. G., Sharp, S., Samson, A. J., Bollan, K. A., Huang, J., Buckland, S. T. & Connolly, C. N., May 2015, In : FASEB Journal. 29, 5, p. 2112-2119 8 p.

Research output: Contribution to journalArticle

Open Access
File
Depolarization
Neurons
Brain
Plant Nectar
Bees
34 Citations (Scopus)

Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

Li, C., Guan, G., Ling, Y., Hsu, Y-T., Song, S., Huang, J. T-J., Lang, S., Wang, R. K., Huang, Z. & Nabi, G., 1 Feb 2015, In : Cancer Letters. 357, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Prostatic Neoplasms
Biopsy
Prostate
Prostatic Intraepithelial Neoplasia
16 Citations (Scopus)
Chronic Fatigue Syndrome
Cholecalciferol
Blood Vessels
Randomized Controlled Trials
Pulse Wave Analysis
40 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

Radiation
Skin Neoplasms
Carcinogens
Carcinogenesis
Pharmacology
7 Citations (Scopus)
70 Downloads (Pure)
Open Access
File
Pharmacodynamics
Pharmacokinetics
Cysteine
Animals
Chemical activation
11 Citations (Scopus)

PPARα is required for PPARδ action in regulation of body weight and hepatic steatosis in mice

Garbacz, W. G., Huang, J. T. J., Higgins, L. G., Wahli, W. & Palmer, C. N. A., 2015, In : PPAR Research. 2015, 15 p., 927057.

Research output: Contribution to journalArticle

PPAR alpha
Body Weight
Liver
Weight Loss
PPAR delta
13 Citations (Scopus)
64 Downloads (Pure)

Prime mover or fellow traveller: 25-hydroxy vitamin D’s seasonal variation, cardiovascular disease and death in the Scottish Heart Health Extended Cohort (SHHEC)

Tunstall-Pedoe, H., Woodward, M., Hughes, M., Anderson, A., Kennedy, G., Belch, J., Kuulasmaa, K. & MORGAM Investigators, 21 Jun 2015, In : International Journal of Epidemiology. 44, 5, p. 1602-1612 11 p.

Research output: Contribution to journalArticle

Open Access
File
Vitamins
Cardiovascular Diseases
Health
Blood Pressure
Social Adjustment
7 Citations (Scopus)

Quantitative urinary proteomics using stable isotope labelling by peptide dimethylation in patients with prostate cancer

Li, C., Zang, T., Wrobel, K., Huang, J. T. J. & Nabi, G., May 2015, In : Analytical and Bioanalytical Chemistry. 407, 12, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

Isotope Labeling
Isotopes
Proteomics
Labeling
Prostatic Neoplasms
2014
15 Citations (Scopus)

An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis

Devereux, G., Steele, S., Jagelman, T., Fielding, S., Muirhead, R., Brady, J., Grierson, C., Brooker, R., Winter, J., Fardon, T., McCormick, J., Huang, J. T. J. & Miller, D., Sep 2014, In : Journal of Cystic Fibrosis. 13, 5, p. 557-563 7 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Cystic Fibrosis
Observational Studies
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase Inhibitors
4 Citations (Scopus)
42 Downloads (Pure)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolism
Enzymes
Drug interactions
Pharmaceutical Preparations
Ions
48 Citations (Scopus)
115 Downloads (Pure)

BRCA1 is a histone-H2A-specific ubiquitin ligase

Kalb, R., Mallery, D. L., Larkin, C., Huang, J. T. J. & Hiom, K., 21 Aug 2014, In : Cell Reports. 8, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

Open Access
File
Ligases
Ubiquitin
Histones
Chromatin
Ubiquitin-Protein Ligases
42 Citations (Scopus)
Oxidative stress
Vegetables
Polyphenols
Fruits
Ascorbic Acid
32 Citations (Scopus)
93 Downloads (Pure)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
File
Kidney Neoplasms
Tumor Biomarkers
Proteomics
Renal Cell Carcinoma
Proteins
17 Citations (Scopus)
Proteome
Biomarkers
Serum
Proteomics
Firearms
22 Citations (Scopus)

The SNAP trial: a randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - clinical effectiveness and safety until 2 years after delivery, with economic evaluation

Cooper, S., Lewis, S., Thornton, J. G., Marlow, N., Watts, K., Britton, J., Grainge, M. J., Taggar, J., Essex, H., Parrott, S., Dickinson, A., Whitemore, R., Coleman, T. & Smoking, Nicotine and Pregnancy (SNAP) Trial Team, Aug 2014, In : Health Technology Assessment. 18, 54, p. 1-128 128 p.

Research output: Contribution to journalArticle

Nicotine
Cost-Benefit Analysis
Randomized Controlled Trials
Placebos
Safety
2013
3 Citations (Scopus)

A trans-acting protein effect causes severe eye malformation in the mp mouse

Rainger, J., Keighren, M., Keene, D. R., Charbonneau, N. L., Rainger, J. K., Fisher, M., Mella, S., Huang, J. T-J., Rose, L., Van't Hof, R., Sakai, L. Y., Jackson, I. J. & Fitzpatrick, D. R., 2013, In : PLoS Genetics. 9, 12, e1003998.

Research output: Contribution to journalArticle

gene fusion
Gene Fusion
eyes
limbs (animal)
exons
14 Citations (Scopus)

Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R., Thomson, N. C., Palmer, C. N. A., Devereux, G. & Huang, J. T-J., Aug 2013, In : Bioanalysis. 5, 16, p. 1991-2001 11 p.

Research output: Contribution to journalArticle

Isodesmosine
Desmosine
Isotopes
Dilution
Plasmas
39 Citations (Scopus)
Vitamin D
Blood Vessels
Randomized Controlled Trials
Health
Vascular Diseases
2012
45 Citations (Scopus)
56 Downloads (Pure)

Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease

Huang, J. T-J., Chaudhuri, R., Albarbarawi, O., Barton, A., Grierson, C., Rauchhaus, P., Weir, C. J., Messow, M., Stevens, N., McSharry, C., Feuerstein, G., Mukhopadhyay, S., Brady, J., Palmer, C. N. A., Miller, D. & Thomson, N. C., 16 Jan 2012, In : Thorax. 67, 6, p. 502-508 7 p.

Research output: Contribution to journalArticle

Open Access
File
Desmosine
Chronic Obstructive Pulmonary Disease
Biomarkers
Elastin
Lung Volume Measurements
8 Citations (Scopus)
2011
11 Citations (Scopus)

Development of F-18-fluorinatable dendrons and their application to cancer cell targeting

Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. A. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., 2011, In : New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PChopper: high throughput peptide prediction for MRM/SRM transition design

Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J., 15 Aug 2011, In : BMC Bioinformatics. 12, p. - 9 p., 338.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers

Zhang, Y., Zhang, G., Clarke, P. A., Huang, J. T. J., Takahashi, E., Muirhead, D., Steenwyk, R. C. & Lin, Z., Jul 2011, In : Journal of Mass Spectrometry. 46, 7, p. 705-11 7 p.

Research output: Contribution to journalArticle

Biomarkers
Assays
Throughput
Quality control
11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid