Cell and Developmental Biology

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Research Output 1986 2020

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Article
2020
2 Downloads (Pure)
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Primitive Streak
Germ Layers
Chick Embryo
Intercellular Junctions
Epithelial Cells

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In : BMC Biology. 18, 16 p., 15 (2020).

Research output: Contribution to journalArticle

Open Access
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adenosine deaminase
Synaptic Membranes
Adenosine Deaminase
autophagy
Autophagy
32 Downloads (Pure)
Open Access
File
Asymmetric Cell Division
Drosophila
Cell Polarity
Cell Division
Stem Cells
29 Downloads (Pure)

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In : EMBO Reports. 21, 1, p. 1-20 20 p., e48469.

Research output: Contribution to journalArticle

Open Access
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Amino Acid Transport Systems
Embryonic Structures
Morphogenesis
Tissue
Defects
2019
4 Citations (Scopus)
112 Downloads (Pure)

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Phosphotransferases
Drosophila Proteins
Cell Polarity
Nuclear Envelope

Analysis of DrkA kinase's role in STATa activation

Saga, Y., Iwade, Y., Araki, T., Ishikawa, M. & Kawata, T., 17 Jun 2019, In : Genes to Cells. 24, 6, p. 422-435 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Tyrosine
Dictyostelium
Phosphorylation
Protein-Tyrosine Kinases
1 Citation (Scopus)
87 Downloads (Pure)

A well supported multi gene phylogeny of 52 dictyostelia

Schilde, C., Lawal, H. M., Kin, K., Shibano-Hayakawa, I., Inouye, K. & Schaap, P., May 2019, In : Molecular Phylogenetics and Evolution. 134, p. 66-73 8 p.

Research output: Contribution to journalArticle

Open Access
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Phylogeny
phylogeny
gene
Genes
genome
3 Citations (Scopus)
96 Downloads (Pure)

CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

Research output: Contribution to journalArticle

Open Access
File
Somites
Periodicity
Clocks
Mesoderm
Ubiquitin-Protein Ligases
1 Citation (Scopus)
Cell Cycle
Mesoderm
Computational Model
oscillation
cell cycle
1 Citation (Scopus)

Challenges in developing collaborative interdisciplinary research between gastroenterologists and engineers

Cummins, G., Cox, B. F., Walker, J. D., Cochran, S. & Desmulliez, M. P. Y., 21 Jan 2019, In : Journal of Medical Engineering and Technology. 42, 6, p. 435-442 8 p.

Research output: Contribution to journalArticle

Gastroenterology
Engineers
Innovation
Health
Communication
1 Citation (Scopus)
35 Downloads (Pure)

Cyclic AMP induction of Dictyostelium prespore gene expression requires autophagy

Yamada, Y. & Schaap, P., 15 Aug 2019, In : Developmental Biology. 452, 2, p. 114-126 13 p.

Research output: Contribution to journalArticle

Open Access
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Dictyostelium
Autophagy
Cyclic AMP
Gene Expression
Spores
5 Citations (Scopus)
149 Downloads (Pure)

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Kabbara, S., Hérivaux, A., Dugé de Bernonville, T., Courdavault, V., Clastre, M., Gastebois, A., Osman, M., Hamze, M., Cock, J. M., Schaap, P. & Papon, N., Jan 2019, In : Genome Biology and Evolution. 11, 1, p. 86-108 23 p.

Research output: Contribution to journalArticle

Open Access
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histidine kinase
eukaryote
Eukaryota
eukaryotic cells
sensor
26 Downloads (Pure)

eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR

Wilczynska, A., Gillen, S. L., Schmidt, T., Meijer, H. A., Jukes-Jones, R., Langlais, C., Kopra, K., Lu, W-T., Godfrey, J. D., Hawley, B. R., Hodge, K., Zanivan, S., Cain, K., Le Quesne, J. & Bushell, M., 2 Dec 2019, In : Genome Biology. 20, 1, p. 1-21 21 p., 262.

Research output: Contribution to journalArticle

Open Access
File
5' Untranslated Regions
5' untranslated regions
purines
translation (genetics)
MicroRNAs
25 Downloads (Pure)

Evolution of multicellularity in Dictyostelia

Kawabe, Y., Du, Q., Schilde, C. & Schaap, P., 2019, In : International Journal of Developmental Biology. 63, 8-9-10, p. 359-369 11 p.

Research output: Contribution to journalArticle

Open Access
File
Dictyostelium
Amoebozoa
Gastropoda
Amoeba
Aptitude
24 Citations (Scopus)

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P. & Rocha, S., 15 Mar 2019, In : Science. 363, 6432, p. 1222-1226 5 p.

Research output: Contribution to journalArticle

Histone Demethylases
Histones
Methylation
Chromatin
Dioxygenases

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Catenins
Adenomatous Polyposis Coli
Proteomics
Phosphotransferases
Colorectal Neoplasms
23 Downloads (Pure)

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

Research output: Contribution to journalArticle

Open Access
File
Adenomatous Polyposis Coli
interleukins
epithelial cells
cytokines
Epithelial Cells
26 Downloads (Pure)

Modelling the effects of glucagon during glucose tolerance testing

Kelly, R. A., Fitches, M. J., Webb, S. D., Pop, S. R. & Chidlow, S. J., 12 Dec 2019, In : Theoretical biology & medical modelling. 16, 1, p. 1-17 17 p., 21.

Research output: Contribution to journalArticle

Open Access
File
Glucagon
Glucose
Insulin
Glucose Tolerance Test
Insulin Resistance
33 Downloads (Pure)

Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal

Canizares, M. A., Rodrigo Albors, A., Singer, G., Suttie, N., Gorkic, M., Felts, P. & Storey, K. G., 31 Oct 2019, In : Journal of Anatomy. 17 p.

Research output: Contribution to journalArticle

Open Access
File
spinal cord
canal
Spinal Cord
mice
cells
4 Citations (Scopus)
84 Downloads (Pure)

Oscillatory cAMP cell-cell signalling persists during multicellular Dictyostelium development

Singer, G., Araki, T. & Weijer, K., 23 Apr 2019, In : Communications Biology. 2, 1, p. 1-12 12 p., 139.

Research output: Contribution to journalArticle

Open Access
File
Gastropoda
Dictyostelium
Morphogenesis
Cell Movement
Cell Communication
27 Downloads (Pure)
Open Access
File
Amoeba
Phylogeny
Transcription Factors
Spores
Transcriptome

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Du, Q., Jovanović, S., Tulić, L., Tulić, I. & Jovanović, A., Oct 2019, In : Pregnancy Hypertension. 18, p. 96-98 3 p.

Research output: Contribution to journalArticle

Pregnancy Induced Hypertension
Myometrium
KATP Channels
Down-Regulation
Parturition
56 Downloads (Pure)

Pyrazinamide may possess cardioprotective properties

Sinha, S., Du, Q., Jovanovic, S., Sukhodub, A. & Jovanović, A., 27 Jun 2019, In : Journal of Antibiotics. 72, p. 714-717 4 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrazinamide
NAD
KATP Channels
Physiological Stress
Dinitrophenols

SILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signalling

Beati, H., Langlands, A., ten Have, S. & Müller, H. -A. J., 24 Dec 2019, In : Fly. 19 p.

Research output: Contribution to journalArticle

fibroblast growth factors
proteomics
Drosophila
embryo (animal)
mutants
3 Citations (Scopus)
127 Downloads (Pure)

SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain

Quan, C., Li, M., Du, Q., Chen, Q., Wang, H., Campbell, D. G., Fang, L., Xue, B., MacKintosh, C., Gao, X., Ouyang, K., Wang, H. & Chen, S., 1 Mar 2019, In : Circulation Research. 124, 5, p. 712-726 15 p.

Research output: Contribution to journalArticle

Open Access
File
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Phosphotransferases
Calcium
Cardiac Myocytes
53 Downloads (Pure)

The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase

Sala, K., Corbetta, A., Minici, C., Tonoli, D., Murray, D. H., Cammarota, E., Ribolla, L., Ramella, M., Fesce, R., Mazza, D., Degano, M. & de Curtis, I., 19 Sep 2019, In : Scientific Reports. 9, p. 1-14 14 p., 13530.

Research output: Contribution to journalArticle

Open Access
File
Cell Movement
Proteins
Electron Microscopy
Cell Membrane
Drive
2018
2 Citations (Scopus)
147 Downloads (Pure)

A Multicellular Model of Intestinal Crypt Buckling and Fission

Almet, A. A., Hughes, B. D., Landman, K. A., Näthke, I. S. & Osborne, J. M., Feb 2018, In : Bulletin of Mathematical Biology. 80, 2, p. 335-359 25 p.

Research output: Contribution to journalArticle

Open Access
File
intestinal crypts
buckling
Buckling
Organoids
Tissue
9 Citations (Scopus)
120 Downloads (Pure)

aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

Hannaford, M. R., Ramat, A., Loyer, N. & Januschke, J., 24 Jan 2018, In : eLife. 7, 22 p., e29939.

Research output: Contribution to journalArticle

Open Access
File
Actomyosin
Interphase
Nuclear Envelope
Neurology
Nervous System
105 Downloads (Pure)

A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Stewart, F., Verbeni, A., Qiu, Y., Cox, B., Vorstius, J., Newton, I., Huang, Z., Menciassi, A., Nathke, I. & Cochran, S., Jun 2018, In : Journal of Medical Robotics Research. 3, 2, 13 p., 1840001.

Research output: Contribution to journalArticle

Open Access
File
Capsule Endoscopes
Gastrointestinal Diseases
Pharmaceutical Preparations
Capsule Endoscopy
Crohn Disease
4 Citations (Scopus)
100 Downloads (Pure)

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo

Wang, G., Chen, E., Liang, C., Liang, J., Gao, L., Chuai, M., Münsterberg, A., Bao, Y., Cao, L. & Yang, X., Apr 2018, In : Molecular Neurobiology. 55, 4, p. 3523-3536 14 p.

Research output: Contribution to journalArticle

Open Access
File
Neural Crest
Autophagy
Chick Embryo
Neural Tube
Transfection
8 Citations (Scopus)
148 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
9 Citations (Scopus)
120 Downloads (Pure)

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

Wang, G., Liang, J., Gao, L-R., Si, Z-P., Zhang, X-T., Liang, G., Yan, Y., Li, K., Cheng, X., Bao, Y., Chuai, M., Chen, L-G., Lu, D-X. & Yang, X., 14 Feb 2018, In : Cell Death and Disease. 9, 2, p. 1-17 17 p., 234.

Research output: Contribution to journalArticle

Open Access
File
Cardiovascular System
Hyperglycemia
Autophagy
Chick Embryo
Embryonic Structures
105 Downloads (Pure)

Cell biological mechanisms regulating chick neurogenesis

Kasioulis, I. & Storey, K. G., 2018, In : International Journal of Developmental Biology. 62, 1/2/3, p. 167-175 9 p.

Research output: Contribution to journalArticle

Open Access
File
Neurogenesis
Centrosome
Neuroepithelial Cells
Biological Phenomena
Neurons
1 Citation (Scopus)
101 Downloads (Pure)

Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells

Kin, K., Forbes, G., Cassidy, A. & Schaap, P., 22 Oct 2018, In : BMC Genomics. 19, 1, p. 1-18 18 p., 764.

Research output: Contribution to journalArticle

Open Access
File
Dictyostelium
RNA
Spores
Transcriptome
Genes
4 Citations (Scopus)
132 Downloads (Pure)

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells

Langlands, A. J., Carroll, T. D., Chen, Y. & Nathke, I., 15 Feb 2018, In : Cell Death and Disease. 9, p. 1-10 10 p., 255.

Research output: Contribution to journalArticle

Open Access
File
Valproic Acid
Organoids
Growth
Cysts
Intestinal Polyposis
24 Citations (Scopus)
136 Downloads (Pure)

Critical Research Gaps and Recommendations to Inform Research Prioritisation for More Effective Prevention and Improved Outcomes in Colorectal Cancer

Lawler, M., Alsina, D., Adams, R., Anderson, A., Brown, G., Fearnhead, N. S., Fenwick, S. W., Halloran, S. P., Hochhauser, D., Hull, M. A., Koelzer, V. H., McNair, A. G. K., Monahan, K. J., Nathke, I., Norton, C., Novelli, M., Steele, R., Thomas, A. L., Wilde, L., Wilson, R. H. & 1 others, Tomlinson, I., 1 Jan 2018, In : Colorectal Cancer. 67, 1, p. 179-193 15 p.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Research
Communication
Pathology
Tumor Microenvironment
3 Citations (Scopus)
92 Downloads (Pure)

Cytoplasmic lattices are not linked to mouse 2-cell embryos developmental arrest

Longo, M., Boiani, M., Redi, C. A. & Monti, M., 24 Sep 2018, In : European Journal of Histochemistry. 62, 4, p. 267-270 4 p.

Research output: Contribution to journalArticle

Open Access
File
cell nucleolus
embryo (animal)
oocytes
mice
cells
1 Citation (Scopus)
138 Downloads (Pure)

Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia

Kawabe, Y., Morio, T., Tanaka, Y. & Schaap, P., 9 May 2018, In : EvoDevo. 9, 1, 11 p., 12.

Research output: Contribution to journalArticle

Open Access
File
Glycogen Synthase Kinase 3
encystment
spore
fruiting
starvation
2 Citations (Scopus)
142 Downloads (Pure)

Gut microbiota-derived endotoxin enhanced the incidence of cardia bifida during cardiogenesis

Zhang, J., Wang, G., Liu, J., Gao, L., Liu, M., Wang, C-J., Chuai, M., Bao, Y., Li, G., Li, R-M., Zhang, Y. & Yang, X., Dec 2018, In : Journal of Cellular Physiology. 233, 12, p. 9271-9283 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cardia
Endotoxins
Lipopolysaccharides
Incidence
Chick Embryo
23 Citations (Scopus)
101 Downloads (Pure)

High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging

Turtaev, S., Leite, I. T., Altwegg-Boussac, T., Pakan, J. M. P., Rochefort, N. L. & Čižmár, T., 21 Nov 2018, In : Light: Science and Applications. 7, p. 1-8 8 p., 92.

Research output: Contribution to journalArticle

Open Access
File
Endoscopy
Multimode fibers
brain
Brain
hippocampus
92 Downloads (Pure)

High salt-induced excess reactive oxygen species production resulted in heart tube malformation during gastrulation

Gao, L. R., Wang, G., Zhang, J., Li, S., Chuai, M., Bao, Y., Hocher, B. & Yang, X., Sep 2018, In : Journal of Cellular Physiology. 233, 9, p. 7120-7133 14 p.

Research output: Contribution to journalArticle

Open Access
File
Gastrulation
Congenital Heart Defects
Reactive Oxygen Species
Salts
Cell Movement
2 Citations (Scopus)
121 Downloads (Pure)

Insulin down-regulates cardioprotective SUR2A in the heart-derived H9c2 cells: A possible explanation for some adverse effects of insulin therapy

Du, Q., Jovanović, S., Sukhodub, A., Ngoi, Y. S., Lal, A., Zheleva, M. & Jovanović, A., Dec 2018, In : Biochemistry and Biophysics Reports. 16, p. 12-18 7 p.

Research output: Contribution to journalArticle

Open Access
File
Down-Regulation
Insulin
Glucose
KATP Channels
Physiological Stress
6 Citations (Scopus)
123 Downloads (Pure)

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase

Carroll, T., Newton, I., Chen, Y., Blow, J. & Nathke, I., 7 May 2018, In : Journal of Cell Biology. 217, 5, p. 1667-1685 19 p.

Research output: Contribution to journalArticle

Open Access
File
G1 Phase
Licensure
Stem Cells
Epithelium
Replication Origin
1 Citation (Scopus)
100 Downloads (Pure)

Lineage tracing of axial progenitors using Nkx1-2CreERT2 mice defines their trunk and tail contributions

Rodrigo Albors, A., Halley, P. & Storey, K., 10 Sep 2018, In : Development. 145, 19, p. 1-12 12 p., 164319.

Research output: Contribution to journalArticle

Open Access
File
Tail
Germ Layers
Mesoderm
Embryonic Structures
Neural Plate
3 Citations (Scopus)
123 Downloads (Pure)

Lipopolysaccharides (LPS) Induced Angiogenesis During Chicken Embryogenesis is Abolished by Combined ETA/ETB Receptor Blockade

Wang, G., Li, P-Z., Zhang, S-Y., Zhong, S., Chu, C., Zeng, S., Yan, Y., Cheng, X., Chuai, M., Hocher, B. & Yang, X., Aug 2018, In : Cellular Physiology and Biochemistry. 48, 5, p. 2084-2090 7 p.

Research output: Contribution to journalArticle

Open Access
File
Embryonic Development
Lipopolysaccharides
Chickens
Endothelins
Endothelin A Receptors
38 Citations (Scopus)
138 Downloads (Pure)

Modulators of 14-3-3 Protein-Protein Interactions

Stevers, L. M., Sijbesma, E., Botta, M., MacKintosh, C., Obsil, T., Landrieu, I., Cau, Y., Wilson, A. J., Karawajczyk, A., Eickhoff, J., Davis, J., Hann, M., O'Mahony, G., Doveston, R. G., Brunsveld, L. & Ottmann, C., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3755-3778 24 p.

Research output: Contribution to journalArticle

Open Access
File
14-3-3 Proteins
Proteins
Biological Products
7 Citations (Scopus)
84 Downloads (Pure)

Multiple roots of fruiting body formation in Amoebozoa

Hillmann, F., Forbes, G., Novohradská, S., Ferling, I., Riege, K., Groth, M., Westermann, M., Marz, M., Spaller, T., Winckler, T., Schaap, P. & Glöckner, G., 1 Feb 2018, In : Genome Biology and Evolution. 10, 2, p. 591-606 16 p.

Research output: Contribution to journalArticle

Open Access
File
Amoebozoa
fruiting
fruiting bodies
gene
Spores
3 Citations (Scopus)
115 Downloads (Pure)

Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse

Mastromina, I., Verrier, L., Clara Silva, J., Storey, K. & Dale, J., 30 Jul 2018, In : Development. 145, 14, p. 1-14 14 p., dev161091.

Research output: Contribution to journalArticle

Open Access
File
Somites
Maintenance
Notch Receptors
Genes
Informatics
2 Citations (Scopus)
104 Downloads (Pure)

Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity

Alsina-Beauchamp, D., Escós, A., Fajardo, P., González-Romero, D., Díaz-Mora, E., Risco, A., Martín-Serrano, M. A., Del Fresno, C., Dominguez-Andrés, J., Aparicio, N., Zur, R., Shpiro, N., Brown, G. D., Ardavín, C., Netea, M. G., Alemany, S., Sanz-Ezquerro, J. J. & Cuenda, A., 1 May 2018, In : Embo Molecular Medicine. 10, 5, p. 1-15 15 p., e8485.

Research output: Contribution to journalArticle

Open Access
File
Candidiasis
Myeloid Cells
Candida albicans
Immunity
Macrophages
9 Citations (Scopus)
74 Downloads (Pure)

Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cells in vitro

Verrier, L., Davidson, L., Gierlinski, M., Dady, A. & Storey, K., 12 Jul 2018, In : Development. 145, 16, 10 p., dev166215.

Research output: Contribution to journalArticle

Open Access
File
Stem Cells
Spinal Cord
Embryonic Structures
Clustered Regularly Interspaced Short Palindromic Repeats
Population