Cell Signalling and Immunology

Projects

Projects per year 2002 2009 2010 2013 2014 2016 2017 2020 2021 2032

• 8 Active
• 13 Not started
• 81 Finished

Projects per year

Search results

• Active

  Convergent Evolution and Functional Adaptation in Parasite Manipulation of TGF-B Signalling

  McSorley, H. (Investigator)

  1/04/25 → 31/01/30

  Project: Research

• Investigating Nutrient-Dependent Regulation of Microglia Function and Immune Responses

  Cantrell, D. (Investigator) & Lloyd, A. (Investigator)

  1/09/24 → 31/08/27

  Project: Research

• System Level Understanding of Protein Degradation Pathways in T Lymphocytes

  Cantrell, D. (Investigator)

  1/06/24 → 31/05/32

  Project: Research

  • Autophagy 100%
  • CD8+ T Cells 100%
  • Cytokine 100%
  • CD8 100%
  • T Cell 100%

• Identifying Novel Treatment Targets For Bile Acid Diarrhoea Through Interrogation Of Targeted Epithelial Barrier Disease Mechanisms And Discovery Science Proteomics In Human Gut Organoid Models - Joint with Imperial College, London

  Arthur, S. (Investigator) & McLean, M. H. (Investigator)

  1/09/23 → 28/02/26

  Project: Research

• Functional And Proteomic Characterisation Of Microglia Cell States In Neurodegeneration (Joint with The Francis Crick Institute) - Fellowship

  Lloyd, A. (Investigator)

  1/05/23 → 30/04/28

  Project: Research

• Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)

  Kulathu, Y. (Investigator), Labib, K. (Investigator), Masson, G. (Investigator), Moraga Gonzalez, I. (Investigator), Murray, D. (Investigator), Owen-Hughes, T. (Investigator), Stanley-Wall, N. (Investigator) & Wyatt, P. (Investigator)

  1/12/21 → 31/12/26

  Project: Research

  • Ubiquitin Ligase 100%
  • E3 Ligase 88%
  • Ubiquitination 74%
  • Bromodomain-containing Protein 4 (BRD4) 62%
  • Degrader 59%

• Halting Pulmonary Fibrosis Through Interference In The IL-25, IL-33 And TSLP Pathways ( PhD Studentship 2020)

  Arthur, S. (Investigator) & McSorley, H. (Investigator)

  20/10/21 → 20/10/25

  Project: Research

• Molecular Regulators of the Alarmin IL-33 in Health and Disease

  McSorley, H. (Investigator)

  1/07/21 → 30/06/26

  Project: Research

  • Interleukin-33 (IL-33) 100%
  • Interleukin-33 66%
  • Nematode 40%
  • Immune Response 38%
  • Cytokine 36%
• Not started

  Immune cell profiling and quality control position

  Howden, A. (Investigator)

  1/08/25 → 31/07/26

  Project: Research

• Xenograft Facility Establishment For Tracking Human Immune Cell Responses In Neurodegereration

  Lloyd, A. (Investigator)

  Project: Research

• Regulation and Function of Nucleoplasmin3 During Neuronal Differentiation (Clinical PhD Programme: Shuaibu Dambatta)

  Cantrell, D. (Investigator), Lambert, J. (Investigator), Marshall, S. (Investigator) & Storey, K. (Investigator)

  Project: Research

• Chemistry-based Precision Immunology - The European Training Network on Chemical Immunology

  Cantrell, D. (Investigator) & Sinclair, L. (Investigator)

  Project: Research

• Dundee cryo-CLEM platform

  Appleton, P. (Investigator), Owen-Hughes, T. (Investigator), Prescott, A. (Investigator), Sundaramoorthy, R. (Investigator) & Tanaka, T. (Investigator)

  Project: Research

• Lipid Induced Mitochondrial Dysfunction Vacation Scholarship

  Hundal, H. (Investigator)

  Project: Research

• Understanding the Regulation of Leukotriene Synthesis by Mast Cells (Vacation Scholarship)

  Arthur, S. (Investigator)

  Project: Research

• The Relationship Between Visceral Leishmaniasis and Arsenic Contamination in Groundwater in Bihar, India (Clinical PhD Programme: Meghan Perry)

  Cantrell, D. (Investigator), Fairlamb, A. (Investigator), Lambert, J. (Investigator) & Marshall, S. (Investigator)

  Project: Research

• Collating the NHS Art Collections

  Prescott, A. (Investigator)

  Project: Research

• Dundee Training Programme in Integrated Molecular, Cellular and Translational Biology

  Arthur, S. (Investigator), Coulthurst, S. (Investigator), Hay, R. (Investigator) & Muqit, M. (Investigator)

  Project: Research

• Defining the Role of Interleukin-33 in Gastrointestinal Fibrosis as a New Treatment Target for Crohn's Disease (PhD Studentship)

  McLean, M. H. (Investigator) & McSorley, H. (Investigator)

  Project: Research

• Neurosteroids: Modulation of Spinal Cord GABAa Receptors by Naturally Occuring Analgesics (Clinical PhD Programme: Stephen Humble)

  Belelli, D. (Investigator), Cantrell, D. (Investigator), Hales, T. (Investigator), Lambert, J. (Investigator) & Marshall, S. (Investigator)

  Project: Research

• Defining the Role of the LKB1 - AMPK Signalling Pathway in Cancer and DNA Damage (Clinical PhD Programme: Dr Madhumita Dandapani)

  Cantrell, D. (Investigator), Hardie, G. (Investigator), Lambert, J. (Investigator) & Marshall, S. (Investigator)

  Project: Research

• Finished

  Halting Pulmonary Fibrosis Through Interference In The IL-33 Pathway:How Does IL-33 Bolockade Affect Fibroblasts At The Single Cell Level?

  Arthur, S. (Investigator) & McSorley, H. (Investigator)

  1/06/24 → 31/05/25

  Project: Research

• High Dimensional Spectral Flow Cytometry For Immunology, Cell Biology And Infectious Diseases Research - Equipment

  Clarke, R. (Investigator) & McSorley, H. (Investigator)

  Medical Research Council

  1/07/23 → 29/02/24

  Project: Research

• Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D. (Investigator), Banerjee, S. (Investigator), Cantley, J. (Investigator), Corner, G. (Investigator), Hayes, J. (Investigator), Hoskins, P. (Investigator), Kang, L. (Investigator), McNeilly, A. (Investigator), McSorley, H. (Investigator), Murdoch, C. (Investigator) & Rena, G. (Investigator)

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Inflammation And Salt-Inducible Kinases - A Potential Novel Therapeutic Strategy In Patients With Heart Failure

  Arthur, S. (Investigator), Khan, F. (Investigator) & Mordi, I. (Investigator)

  1/08/22 → 31/01/24

  Project: Research

  • Inflammation 100%
  • Non Insulin Dependent Diabetes Mellitus 64%
  • Clinical Study 60%
  • Therapeutic Target 50%
  • Heart Failure with Preserved Ejection Fraction (HFpEF) 50%

• Modulation Of Immune Responses To Reduce Pathology in a Pre-Clinical Asthma Model

  McSorley, H. (Investigator)

  1/07/22 → 30/06/24

  Project: Research

• Identification of Schistosome-derived Immunomodulatory Proteins (Lead: UoD other inst Leiden University Medical Center) - Fellowship

  Arthur, S. (Investigator) & McSorley, H. (Investigator)

  Royal Society of Edinburgh

  31/03/22 → 29/09/22

  Project: Research

• Institutional Strategic Support Funds

  Cantrell, D. (Investigator)

  1/10/21 → 31/03/23

  Project: Research

  • Life Sciences 100%
  • Public Engagement 66%
  • Audio 65%
  • Video Project 65%
  • Dundee 56%

• Cells In Limbo: Mapping Senescent Cells And Their Associated Inflammatory Response In Human Brains With Alzheimers Disease (Lead: UCL)

  Cantrell, D. (Investigator) & Lloyd, A. (Investigator)

  1/04/21 → 30/06/23

  Project: Research

• Establish New Model Systems to Understand Human Neutrophil Biology

  Sollberger, G. (Investigator)

  Academy of Medical Sciences

  15/03/21 → 1/09/21

  Project: Research

  • Quantitative Proteomics 100%
  • Specific Infection 100%
  • Neutrophils 100%
  • Protein Signature 100%
  • Proteomics 100%

• A UK Underpinning Platform to Study Immunology and Immunopathology of COVID-19: The UK Coronovirus Immunology Consortium (University of Birmingham lead, Universities: Bristol, York, KCL, Cambridge, Manchester, Cardiff, Newcastle, Imperial College London, Edinburgh, Liverpool, Glasgow, Sheffield, Oxford, Bradford Teaching Hosp NHS, The Francis Crick Inst, Wellcome Trust Sanger Inst )

  Cantrell, D. (Investigator)

  Medical Research Council

  20/08/20 → 19/08/21

  Project: Research

  • T Cell Activation 100%
  • Proteome 100%
  • Neutrophils 100%
  • Acute Changes 100%
  • Extracellular Vesicles 100%

• Prevention of Severe RSV Infection by a Helminth-induced Serum Factor that Elicits Antiviral Monocytes? (Joint with the University of Edinburgh)

  McSorley, H. (Investigator)

  Medical Research Council

  1/08/20 → 31/07/23

  Project: Research

  • Monocytosis 100%
  • Respiratory Syncytial Virus Infection 100%
  • Helminths 100%
  • Helminth 100%
  • Lung 62%

• Rapid Research in Covid -19 Programme

  Barrable, A. (Investigator), Belch, J. (Investigator), Boehnke, J. (Investigator), Booth, D. (Investigator), Brown, A. (Investigator), Cantrell, D. (Investigator), Chalmers, J. (Investigator), Coleman, S. (Investigator), Connell, D. (Investigator), Cuschieri, A. (Investigator), Dicker, A. (Investigator), Doney, A. (Investigator), Eftimie, R. (Investigator), Fang, M. (Investigator), Farre, A. (Investigator), Gamble, C. (Investigator), Howden, A. (Investigator), Krstajic, N. (Investigator), Lamond, A. (Investigator), Moraga Gonzalez, I. (Investigator), Palmer, C. (Investigator), Parcell, B. (Investigator), Pearson, E. (Investigator), Shoemark, A. (Investigator) & Sixsmith, J. (Investigator)

  1/06/20 → 30/09/21

  Project: Research

  • COVID-19 100%
  • Neutrophils 66%
  • Hyperinflammation 33%
  • Resilience 33%
  • T Cell Activation 33%

• Defining the Oxidative Stress-Related Mechanisms by which Activation of the Transcription Factor Nrf2 Arrests and Resolves Liver Fibrosis

  Arthur, S. (Investigator), Dillon, J. (Investigator), Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator) & Henderson, C. (Investigator)

  Medical Research Council

  1/04/20 → 30/06/25

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Oxidative Stress 68%
  • Transcription Factor 49%
  • NFE2L2 46%
  • Transcription Factors 44%

• MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

  McSorley, H. (Investigator)

  Medical Research Council

  1/02/20 → 30/06/22

  Project: Research

  • Interleukin-33 100%
  • Interleukin-33 (IL-33) 96%
  • Cytokine 33%
  • Immune Response 30%
  • H. Polygyrus 29%

• A World Without Asthma - Natures Approach to Prevent Asthma by Targeting Barrier Immunity and Microbes (AWWA-NATURE) (Joint with Leiden University, Monash University and 5 Others) (Year 3)

  McSorley, H. (Investigator)

  1/01/20 → 1/01/24

  Project: Research

  • Interleukin-33 100%
  • Interleukin-33 (IL-33) 93%
  • H. Polygyrus 56%
  • Alarmins 50%
  • Helminths 48%

• C5aR a Novel Immunomodulator of Metabolic Signalling and Energy Metabolism in Skeletal Muscle

  Ganley, I. (Investigator), Hundal, H. (Investigator), Lipina, C. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  4/11/19 → 25/08/23

  Project: Research

  • Novel Immunomodulators 100%
  • C5a Receptor 100%
  • Receptor 1 100%
  • Complement Receptors 100%
  • Insulin Action 100%

• Microglia Proteome

  Cantrell, D. (Investigator)

  1/11/19 → 30/09/24

  Project: Research

• Unravelling how Protein Signalling Networks Integrate to Control T Cell Fate (Fellowship)

  Cantrell, D. (Investigator) & Marchingo, J. (Investigator)

  Walter and Eliza Hall Institute of Medical Research

  1/08/19 → 31/07/21

  Project: Research

  • Protein Energetics 100%
  • T Cell Immunity 100%
  • Protein Degradation 100%
  • Protein Synthesis 100%
  • T Cells 100%

• Delineating the Roles of GPR55 in Cellular Metaboloism and Energy Homeostasis (Joint with Robert Gordon University)

  Hundal, H. (Investigator) & Lipina, C. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/19 → 31/08/22

  Project: Research

  • Skeletal muscle 100%
  • Skeletal Muscle 94%
  • Insulin Signaling 56%
  • Impaired Insulin Secretion 50%
  • Integrated Stress Response 42%

• Elucidation of Mechanisms that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases

  Arthur, S. (Investigator) & Cohen, P. (Investigator)

  Medical Research Council

  1/04/18 → 31/03/23

  Project: Research

  • Ubiquitin Ligase 100%
  • Ubiquitin 92%
  • HOIL-1L 85%
  • E3 Ligase 84%
  • Salt-inducible Kinase 58%

• The Role of HMBS Phosphorylation in Acute Intermittent Porphyria

  Arthur, S. (Investigator), Ibbotson, S. (Investigator) & McGuire, V. (Investigator)

  1/03/18 → 29/02/20

  Project: Research

• Unravelling How Protein Signalling Networks Integrate to Control T Cell Fate (PIM PROTEOMICS)

  Cantrell, D. (Investigator) & Marchingo, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  14/07/17 → 13/07/19

  Project: Research

  • Cytotoxic T-Cell 100%
  • CD8+ T Cells 77%
  • CD8 66%
  • T Cell 66%
  • Cell Differentiation 40%

• Nutrient-Induced Mitochondrial Dysfunction and its Reciprocal Control by Inflammatory Signalling: Implications for Skeletal Muscle Insulin Action

  Hundal, H. (Investigator)

  Diabetes UK

  1/06/17 → 31/12/20

  Project: Research

• Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (ERC Starting Grant)

  Crocker, P. (Investigator) & Moraga Gonzalez, I. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/04/17 → 30/09/22

  Project: Research

  • Cytokine 100%
  • Cytokine Response 93%
  • Pleiotropy 79%
  • Functional Pleiotropy 78%
  • Interleukin-27 (IL-27) 70%

• Understanding the Role and Regulation of Lysosomal Adaptor Proteins During Infection

  McEwan, D. (Investigator)

  1/04/17 → 30/06/19

  Project: Research

  • Family Members 100%
  • Golgi Network 90%
  • ATG2 90%
  • ARL15 90%
  • Pleckstrin Homology Domain 90%

• Role of Salt Inducible Kinases in Autoimmunity

  Arthur, S. (Investigator) & Cohen, P. (Investigator)

  Versus Arthritis

  1/04/17 → 30/09/20

  Project: Research

  • SIK2 100%
  • SIK3 58%
  • Bleomycin-induced Lung Injury 50%
  • Thymic T Cell Development 50%
  • Fibrosis 50%

• Investigation of the Potential Role of Salt-Inducible Kinases in Endothelial Dysfunction and Atherosclerosis

  Arthur, S. (Investigator), Khan, F. (Investigator) & Lang, C. (Investigator)

  17/10/16 → 16/10/18

  Project: Research

• Institutional Strategic Support Fund (2016)

  Cantrell, D. (Investigator), Dinkova-Kostova, A. (Investigator), Kang, L. (Investigator), Murray, P. (Investigator) & Pearson, E. (Investigator)

  1/10/16 → 31/05/23

  Project: Research

  • Video Project 100%
  • Audio 100%
  • Dundee 89%
  • Life Sciences 42%
  • Growth Arrest 37%

• Fluorescence Activated Cell Sorting for Cell Biology and Immunology (Equipment Grant)

  Cantrell, D. (Investigator)

  1/09/16 → 1/12/19

  Project: Research

  • T Cell 100%
  • T Cells 72%
  • Cytotoxic T-Cell 55%
  • Cell Wall Proteome 50%
  • Proteomics 50%