Cell Signalling and Immunology

  • United Kingdom

Research Output

2020

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 4 Mar 2020, In : EMBO Reports. 21, 3, p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
46 Downloads (Pure)

A helminth-derived suppressor of ST2 blocks allergic responses

Vacca, F., Chauché, C., Jamwal, A., Hinchy, E. C., Heieis, G., Webster, H., Ogunkanbi, A., Sekne, Z., Gregory, W. F., Wear, M. A., Perona-Wright, G., Higgins, M. K. ., Nys, J., Cohen, E. S. & McSorley, H. J., 18 May 2020, In : eLife. 9, p. 1-20 20 p., e54017.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

AMP-Activated Protein Kinase: Friend or Foe in Cancer

Vara-ciruelos, D., Dandapani, M. & Hardie, D. G., 4 Mar 2020, In : Annual Review of Cancer Biology. 4, p. 1-16 16 p.

Research output: Contribution to journalReview article

Open Access
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AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner

Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J. A., Banzhaf, M., Lavery, G. G., Hardie, D. G., Hodson, D. J., Philp, A. & Lai, Y-C., 4 May 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 5, p. 6284-6301 18 p.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

Evans, A. M. & Hardie, D. G., 15 May 2020, In : International Journal of Molecular Sciences. 21, 10, p. 1-28 28 p., 3518.

Research output: Contribution to journalReview article

Open Access
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AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control

González, A., Hall, M. N., Lin, S-C. & Hardie, G., 3 Mar 2020, In : Cell Metabolism. 31, 3, p. 472-492 21 p.

Research output: Contribution to journalReview article

Antibody RING-Mediated Destruction of Endogenous Proteins

Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 25 May 2020, In : Molecular Cell. p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
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8 Downloads (Pure)

Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function

Shah, D., Nisr, R., Stretton, C., Krasteva-Christ, G. & Hundal, H., 23 Feb 2020, In : Journal of Cachexia, Sarcopenia and Muscle. 21 p.

Research output: Contribution to journalArticle

Open Access
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Characterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22

Di Carluccio, C., Crisman, E., Manabe, Y., Forgione, R. E., Lacetera, A., Amato, J., Pagano, B., Randazzo, A., Zampella, A., Lanzetta, R., Fukase, K., Molinaro, A., Crocker, P. R., Martín-Santamaría, S., Marchetti, R. & Silipo, A., 15 Jan 2020, In : ChemBioChem. 21, 1-2, p. 129-140 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Experience recruits MSK1 to expand the dynamic range of synapses and enhance cognition

Privitera, L., Morè, L., Cooper, D. D., Richardson, P., Tsogka, M., Hebenstreit, D., Arthur, J. S. C. & Frenguelli, B. G., 6 May 2020, In : Journal of Neuroscience.

Research output: Contribution to journalArticle

Open Access

Glucose Starvation Blocks Translation at Multiple Levels

Zhang, C. S., Hardie, D. G. & Lin, S. C., 4 Feb 2020, In : Cell Metabolism. 31, 2, p. 217-218 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In : JoVE: Journal of Visualized Experiments. 157, e58956.

Research output: Contribution to journalArticle

Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

Harper, A. A., Rimmer, K., Dyavanapalli, J., McArthur, J. R. & Adams, D. J., 15 Mar 2020, In : Neuropharmacology. 165, p. 1-8 8 p., 107932.

Research output: Contribution to journalArticle

Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

Sollberger, G., Streeck, R., Apel, F., Caffrey, B. E., Skoultchi, A. I. & Zychlinsky, A., 11 May 2020, In : eLife. 9, 71 p., e52563.

Research output: Contribution to journalArticle

Open Access

Mechanism of Activation of AMPK by Cordycepin

Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In : Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.

Research output: Contribution to journalArticle

Open Access
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-652 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

Petrova, T., Pesic, J., Pardali, K., Gaestel, M. & Arthur, J. S. C., 26 Feb 2020, In : Scientific Reports. 10, p. 1-15 15 p., 3479.

Research output: Contribution to journalArticle

Open Access
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26 Downloads (Pure)
Open Access
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1 Citation (Scopus)
19 Downloads (Pure)

Reply to comment from Carl Persson

McSorley, H. & Johansson, K., 14 Jan 2020, In : Pediatric Allergy and Immunology. 1 p.

Research output: Contribution to journalLetter

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In : EMBO Reports. 21, 1, p. 1-20 20 p., e48469.

Research output: Contribution to journalArticle

Open Access
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51 Downloads (Pure)
2019

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
161 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
104 Downloads (Pure)

CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
124 Downloads (Pure)

CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation

Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
164 Downloads (Pure)

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J. & Miron, V. E., 10 Jul 2019, In : Nature Neuroscience. 22, 7, p. 1046-1052 7 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
68 Downloads (Pure)
Open Access
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2 Citations (Scopus)
112 Downloads (Pure)

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In : Life Science Alliance. 2, 6, p. 1-19 19 p., e201900533.

Research output: Contribution to journalArticle

Open Access
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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
83 Downloads (Pure)
Open Access
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44 Downloads (Pure)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 1 Oct 2019, In : Annals of the Rheumatic Diseases. 78, 10, p. 1363-1370 8 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
236 Downloads (Pure)

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
131 Downloads (Pure)

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
109 Downloads (Pure)

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 17 Jan 2019, In : Immunology and Cell Biology. 97, 1, p. 54-71 18 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
183 Downloads (Pure)

Interleukin-33 in the developing lung—Roles in asthma and infection

Johansson, K. & McSorley, H. J., Aug 2019, In : Pediatric Allergy and Immunology. 30, 5, p. 503-510 8 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.

Research output: Contribution to journalArticle

Open Access
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Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

Research output: Contribution to journalArticle

Open Access
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l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway

Robertson-Gray, O. J., Walsh, S. K., Ryberg, E., Jönsson-Rylander, A. C., Lipina, C. & Wainwright, C. L., Jun 2019, In : Pharmacology Research and Perspectives. 7, 3, p. 1-12 12 p., e00487.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
66 Downloads (Pure)

Macrophage migration inhibitory factor (MIF) is essential for type 2 effector cell immunity to an intestinal helminth parasite

Filbey, K. J., Varyani, F., Harcus, Y., Hewitson, J. P., Smyth, D. J., McSorley, H. J., Ivens, A., Nylén, S., Rottenberg, M., Löser, S. & Maizels, R. M., 24 Oct 2019, In : Frontiers in Immunology. 10, 2375.

Research output: Contribution to journalArticle

Open Access
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Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
110 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
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53 Downloads (Pure)
Open Access
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2 Citations (Scopus)
158 Downloads (Pure)
Open Access
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60 Downloads (Pure)
Open Access
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6 Citations (Scopus)
6 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
151 Downloads (Pure)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract