Cell Signalling and Immunology

  • United Kingdom

Research Output 1987 2020

2020
12 Downloads (Pure)

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 3 Feb 2020, In : EMBO Reports. p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
File
Autophagy
Elongation
Seals
Recycling
Proteins
1 Citation (Scopus)

Characterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22

Di Carluccio, C., Crisman, E., Manabe, Y., Forgione, R. E., Lacetera, A., Amato, J., Pagano, B., Randazzo, A., Zampella, A., Lanzetta, R., Fukase, K., Molinaro, A., Crocker, P. R., Martín-Santamaría, S., Marchetti, R. & Silipo, A., 15 Jan 2020, In : ChemBioChem. 21, 1-2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Ig-like Lectin 2
Polysaccharides
B-Lymphocytes
Cells
Autoantigens

Glucose Starvation Blocks Translation at Multiple Levels

Zhang, C. S., Hardie, D. G. & Lin, S. C., 4 Feb 2020, In : Cell Metabolism. 31, 2, p. 217-218 2 p.

Research output: Contribution to journalReview article

Starvation
Glucose
Amino Acyl-tRNA Synthetases
AMP-Activated Protein Kinases
Cell Survival

Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

Harper, A. A., Rimmer, K., Dyavanapalli, J., McArthur, J. R. & Adams, D. J., 3 Jan 2020, In : Neuropharmacology. 165, p. 1-8 8 p., 107932.

Research output: Contribution to journalArticle

Ketamine
Nicotinic Receptors
Synaptic Transmission
Ganglia
Nicotine
12 Downloads (Pure)

Mechanism of Activation of AMPK by Cordycepin

Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In : Cell Chemical Biology. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Kinases
Chemical activation
Adenosine Monophosphate
Nucleotides
Diphosphates

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-652 10 p.

Research output: Contribution to journalArticle

Open Access
Cytokine Receptors
Dimerization
Janus Kinase 2
Mutation
Ligands
Open Access
T-cells
Proteome
Metabolic Networks and Pathways
Chemical activation
T-Lymphocytes
29 Downloads (Pure)

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In : EMBO Reports. 21, 1, p. 1-20 20 p., e48469.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport Systems
Embryonic Structures
Morphogenesis
Tissue
Defects
2019
2 Citations (Scopus)
110 Downloads (Pure)

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Autophagy
Vertebrates
Retina
Homeostasis
10 Citations (Scopus)
79 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes
3 Citations (Scopus)
96 Downloads (Pure)

CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

Research output: Contribution to journalArticle

Open Access
File
Somites
Periodicity
Clocks
Mesoderm
Ubiquitin-Protein Ligases
1 Citation (Scopus)
141 Downloads (Pure)

CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation

Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.

Research output: Contribution to journalArticle

Open Access
File
Activating Transcription Factor 4
Amino Acids
Cyclin-Dependent Kinases
alvocidib
Phosphotransferases
2 Citations (Scopus)
87 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Drug Discovery
Modulators
Skin
Pharmaceutical Preparations

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In : Life Science Alliance. 2, 6, p. 1-19 19 p., e201900533.

Research output: Contribution to journalArticle

Open Access
File
glomerulonephritis
Pathology
pathology
Glomerulonephritis
Liver
1 Citation (Scopus)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Skin
Genome-Wide Association Study
Keratinocytes
Skin Diseases
2 Citations (Scopus)
60 Downloads (Pure)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
File
Casein Kinase I
Spindle Apparatus
Phosphotransferases
Cells
Mitosis
22 Downloads (Pure)
Open Access
File
Organoids
Proteomics
Skin
Keratinocytes
Caspase 14
4 Citations (Scopus)
140 Downloads (Pure)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 12 Jul 2019, In : Annals of the Rheumatic Diseases. 8 p.

Research output: Contribution to journalArticle

Open Access
File
Systemic Lupus Erythematosus
Polymorphism
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
RNA Sequence Analysis
5 Citations (Scopus)
97 Downloads (Pure)

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.

Research output: Contribution to journalArticle

Open Access
File
Adiposity
G-Protein-Coupled Receptors
Insulin
Tissue
Insulin Resistance
4 Citations (Scopus)
59 Downloads (Pure)

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Food
Mitochondrial Dynamics
Lysosomes
2 Citations (Scopus)
148 Downloads (Pure)

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 17 Jan 2019, In : Immunology and Cell Biology. 97, 1, p. 54-71 18 p.

Research output: Contribution to journalArticle

Open Access
File
Neutrophil Infiltration
Mitogen-Activated Protein Kinase Kinases
p38 Mitogen-Activated Protein Kinases
Mast Cells
Cytokines
18 Downloads (Pure)

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.

Research output: Contribution to journalArticle

Open Access
File
Cytokine Receptors
Kinetics
Interleukin-6
Cytokines
Th17 Cells
23 Downloads (Pure)

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

Research output: Contribution to journalArticle

Open Access
File
Adenomatous Polyposis Coli
interleukins
epithelial cells
cytokines
Epithelial Cells
1 Citation (Scopus)
42 Downloads (Pure)

l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway

Robertson-Gray, O. J., Walsh, S. K., Ryberg, E., Jönsson-Rylander, A. C., Lipina, C. & Wainwright, C. L., Jun 2019, In : Pharmacology Research and Perspectives. 7, 3, p. 1-12 12 p., e00487.

Research output: Contribution to journalArticle

Open Access
File
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Cannabidiol
p38 Mitogen-Activated Protein Kinases

Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
T-Cell Antigen Receptor
Phosphotransferases
Adenosine Triphosphate
3 Citations (Scopus)

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.

Research output: Contribution to journalArticle

Obesity
Large Neutral Amino Acid-Transporter 1
Smegmamorpha
RNA Sequence Analysis
mechanistic target of rapamycin complex 1
4 Citations (Scopus)
86 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journalArticle

Open Access
File
Phenformin
AMP-Activated Protein Kinases
T-cells
Metformin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
33 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Phosphorylation
Phosphotransferases
SNARE Proteins
Substrates
2 Citations (Scopus)
114 Downloads (Pure)
Open Access
File
Skeletal Muscle Fibers
Insulin Resistance
Skeletal Muscle
Insulin
Muscle Cells
37 Downloads (Pure)
Open Access
File
Organoids
Crosstalk
Keratinocytes
Proteomics
Skin
2 Citations (Scopus)
Proteome
Cell Differentiation
T-Lymphocytes
Phenotype
Mass Spectrometry
4 Citations (Scopus)
127 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journalArticle

Open Access
File
Degradation
Clustered Regularly Interspaced Short Palindromic Repeats
Proteins
Ubiquitination
Phosphorylation

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

Ireland
Metformin
Blood Pressure
Physicians
Left Ventricular Hypertrophy
4 Citations (Scopus)
79 Downloads (Pure)

Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib

Bort, A., Sánchez, B. G., Mateos-Gómez, P. A., Vara-Ciruelos, D., Rodríguez-Henche, N. & Díaz-Laviada, I., May 2019, In : Molecular Oncology. 13, 5, p. 1311-1331 21 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Neoplastic Stem Cells
Liver Neoplasms
Hepatocellular Carcinoma
Stem Cells
2 Citations (Scopus)
61 Downloads (Pure)
Open Access
File
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Ubiquitin C
Macrophages
7 Citations (Scopus)
53 Downloads (Pure)

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †

Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In : Open Biology. 9, 7, p. 1-21 21 p., 190099.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Neoplasms
Tumors
DNA Damage
2 Citations (Scopus)
120 Downloads (Pure)

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Li, M., Zhang, C-S., Zong, Y., Feng, J-W., Ma, T., Hu, M., Lin, Z., Li, X., Xie, C., Wu, Y., Jiang, D., Li, Y., Zhang, C., Tian, X., Wang, W., Yang, Y., Chen, J., Cui, J., Wu, Y-Q., Chen, X. & 11 others, Liu, Q-F., Wu, J., Lin, S-Y., Ye, Z., Liu, Y., Piao, H-L., Yu, L., Zhou, Z., Xie, X-S., Hardie, D. G. & Lin, S-C., 3 Sep 2019, In : Cell Metabolism. 30, 3, p. 508-524.e12 17 p.

Research output: Contribution to journalArticle

Open Access
File
Transient Receptor Potential Channels
Fructose-Bisphosphate Aldolase
AMP-Activated Protein Kinases
Glucose
Endoplasmic Reticulum
2 Citations (Scopus)
147 Downloads (Pure)

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B. D., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journalArticle

Open Access
File
Scavenger Receptors
Macrophages
Interleukin-4
Inflammation
Chemical activation
2018
3 Citations (Scopus)

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journalArticle

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
26 Citations (Scopus)
113 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine
135 Citations (Scopus)
210 Downloads (Pure)

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Glucose
Adenosine Triphosphatases
Fructose-Bisphosphate Aldolase
Adenosine Triphosphate
12 Citations (Scopus)
127 Downloads (Pure)

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

Lum, F-M., Couderc, T., Chia, B-S., Ong, R-Y., Her, Z., Chow, A., Leo, Y-S., Kam, Y-W., Rénia, L., Lecuit, M. & Ng, L. F. P., 30 Jan 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 1860.

Research output: Contribution to journalArticle

Open Access
File
Chikungunya virus
Virus Diseases
Antibodies
Viral RNA
Viral Load
98 Citations (Scopus)
150 Downloads (Pure)

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Parkinson Disease
Dopaminergic Neurons
Microglia
Islets of Langerhans
2 Citations (Scopus)

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK

Fyffe, F. A., Hawley, S. A., Gray, A. & Hardie, D. G., 2018, AMPK : Methods and Protocols. Neumann, D. & Viollet, B. (eds.). New York: Humana Press, p. 69-86 18 p. (Methods in Molecular Biology; vol. 1732).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

AMP-Activated Protein Kinases
Adenosine Triphosphate
Adenosine Monophosphate
Ligands
Adenosine Diphosphate
2 Citations (Scopus)
98 Downloads (Pure)

Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ

Lu, H., Bogdanovic, E., Yu, Z., Cho, C., Liu, L., Ho, K., Guo, J., Yeung, L. S. N., Lehmann, R., Hundal, H. S., Giacca, A. & Fantus, I. G., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1658-1677 20 p.

Research output: Contribution to journalArticle

Open Access
File
Hyperinsulinism
Adipocytes
Hyperglycemia
Insulin Resistance
Insulin
4 Citations (Scopus)
124 Downloads (Pure)

Differential regulation of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. & Arthur, J. S. C., 16 Feb 2018, In : Journal of Biological Chemistry. 293, 7, p. 2302-2317 16 p.

Research output: Contribution to journalArticle

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
Toll-Like Receptor 4
Macrophages
Interleukin-10
B-Lymphocytes
6 Citations (Scopus)
95 Downloads (Pure)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Andersen, J. L., Gesser, B., Funder, E. D., Nielsen, C. J. F., Gotfred-Rasmussen, H., Rasmussen, M. K., Toth, R., Gothelf, K. V., Arthur, J. S. C., Iversen, L. & Nissen, P., 19 Oct 2018, In : Nature Communications. 9, 1, 9 p., 4344.

Research output: Contribution to journalArticle

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
inhibitors
Phosphotransferases
helices
Mitogens
4 Citations (Scopus)
154 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Modulators
Esters
Plasma (human)
Butyrylcholinesterase
5 Citations (Scopus)
109 Downloads (Pure)

Effects of sodium and amino acid substrate availability upon the expression and stability of the SNAT2 (SLC38A2) amino acid transporter

Hoffmann, T., Cwiklinski, E., Shah, D., Stretton, C., Hyde, R., Taylor, P. & Hundal, H., 7 Feb 2018, In : Frontiers in Pharmacology. 9, p. 1-9 9 p., 63.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport Systems
Sodium
Amino Acids
Protein Stability
Neutral Amino Acids
5 Citations (Scopus)
138 Downloads (Pure)

Expression of Siglec-E Alters the proteome of lipopolysaccharide (LPS)-activated macrophages but does not affect LPS-driven cytokine production or toll-like receptor 4 endocytosis

Nagala, M., McKenzie, E., Richards, H., Sharma, R., Thomson, S., Mastroeni, P. & Crocker, P., 15 Jan 2018, In : Frontiers in Immunology. 8, p. 1-17 17 p., 1926.

Research output: Contribution to journalArticle

Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
Toll-Like Receptor 4
Proteome
Endocytosis
Lipopolysaccharides