Cell Signalling and Immunology

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Research Output 1987 2019

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Article
2019
1 Citation (Scopus)
46 Downloads (Pure)

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journal › Article

Open Access
File
Mitochondrial Degradation
Autophagy
Vertebrates
Retina
Homeostasis
1 Citation (Scopus)
24 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journal › Article

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes
45 Downloads (Pure)

CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

Research output: Contribution to journal › Article

Open Access
File
Somites
Periodicity
Clocks
Mesoderm
Ubiquitin-Protein Ligases
82 Downloads (Pure)

CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation

Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.

Research output: Contribution to journal › Article

Open Access
File
Activating Transcription Factor 4
Amino Acids
Cyclin-Dependent Kinases
alvocidib
Phosphotransferases
50 Downloads (Pure)

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.

Research output: Contribution to journal › Article

Open Access
File
Lysosphingolipid Receptors
Drug Discovery
Modulators
Skin
Pharmaceutical Preparations

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journal › Article

Open Access
Atopic Dermatitis
Skin
Genome-Wide Association Study
Keratinocytes
Skin Diseases
6 Downloads (Pure)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.

Research output: Contribution to journal › Article

Open Access
File
Casein Kinase I
Spindle Apparatus
Phosphotransferases
Cells
Mitosis
53 Downloads (Pure)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 12 Jul 2019, In : Annals of the Rheumatic Diseases. 8 p.

Research output: Contribution to journal › Article

Open Access
File
Systemic Lupus Erythematosus
Polymorphism
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
RNA Sequence Analysis
3 Citations (Scopus)
49 Downloads (Pure)

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.

Research output: Contribution to journal › Article

Open Access
File
Adiposity
G-Protein-Coupled Receptors
Insulin
Tissue
Insulin Resistance
1 Citation (Scopus)

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases
Adenosine Monophosphate
Food
Mitochondrial Dynamics
Lysosomes
1 Citation (Scopus)
85 Downloads (Pure)

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 17 Jan 2019, In : Immunology and Cell Biology. 97, 1, p. 54-71 18 p.

Research output: Contribution to journal › Article

Open Access
File
Neutrophil Infiltration
Mitogen-Activated Protein Kinase Kinases
p38 Mitogen-Activated Protein Kinases
Mast Cells
Cytokines
12 Downloads (Pure)

l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway

Robertson-Gray, O. J., Walsh, S. K., Ryberg, E., Jönsson-Rylander, A. C., Lipina, C. & Wainwright, C. L., Jun 2019, In : Pharmacology Research and Perspectives. 7, 3, p. 1-12 12 p., e00487.

Research output: Contribution to journal › Article

Open Access
File
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Cannabidiol
p38 Mitogen-Activated Protein Kinases

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.

Research output: Contribution to journal › Article

Obesity
Large Neutral Amino Acid-Transporter 1
Smegmamorpha
RNA Sequence Analysis
mechanistic target of rapamycin complex 1
41 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journal › Article

Open Access
File
Phenformin
AMP-Activated Protein Kinases
T-cells
Metformin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
51 Downloads (Pure)

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading

Nisr, R., Shah, D., Ganley, I. & Hundal, H., 17 May 2019, In : Cellular and Molecular Life Sciences. 18 p.

Research output: Contribution to journal › Article

Open Access
File
Skeletal Muscle Fibers
Insulin Resistance
Skeletal Muscle
Insulin
Muscle Cells
1 Citation (Scopus)
65 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journal › Article

Open Access
File
Degradation
Clustered Regularly Interspaced Short Palindromic Repeats
Proteins
Ubiquitination
Phosphorylation
35 Downloads (Pure)

Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib

Bort, A., Sánchez, B. G., Mateos-Gómez, P. A., Vara-Ciruelos, D., Rodríguez-Henche, N. & Díaz-Laviada, I., May 2019, In : Molecular Oncology. 13, 5, p. 1311-1331 21 p.

Research output: Contribution to journal › Article

Open Access
File
AMP-Activated Protein Kinases
Neoplastic Stem Cells
Liver Neoplasms
Hepatocellular Carcinoma
Stem Cells
13 Downloads (Pure)

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

Kelsall, I., Zhang, R., Knebel, A., Arthur, S. & Cohen, P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences. 116, 27, p. 13293-13298 6 p.

Research output: Contribution to journal › Article

Open Access
File
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Ubiquitin C
Macrophages
7 Downloads (Pure)

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †

Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In : Open Biology. 9, 7, p. 1-21 21 p., 190099.

Research output: Contribution to journal › Article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Neoplasms
Tumors
DNA Damage
1 Citation (Scopus)
16 Downloads (Pure)

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Li, M., Zhang, C-S., Zong, Y., Feng, J-W., Ma, T., Hu, M., Lin, Z., Li, X., Xie, C., Wu, Y., Jiang, D., Li, Y., Zhang, C., Tian, X., Wang, W., Yang, Y., Chen, J., Cui, J., Wu, Y-Q., Chen, X. & 11 others, Liu, Q-F., Wu, J., Lin, S-Y., Ye, Z., Liu, Y., Piao, H-L., Yu, L., Zhou, Z., Xie, X-S., Hardie, D. G. & Lin, S-C., 3 Sep 2019, In : Cell Metabolism. 30, 3, p. 508-524.e12 17 p.

Research output: Contribution to journal › Article

Open Access
File
Transient Receptor Potential Channels
Fructose-Bisphosphate Aldolase
AMP-Activated Protein Kinases
Glucose
Endoplasmic Reticulum
58 Downloads (Pure)

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journal › Article

Open Access
File
Scavenger Receptors
Macrophages
Interleukin-4
Inflammation
Chemical activation
2018

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journal › Article

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
18 Citations (Scopus)
63 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journal › Article

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine
9 Citations (Scopus)
91 Downloads (Pure)

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

Lum, F-M., Couderc, T., Chia, B-S., Ong, R-Y., Her, Z., Chow, A., Leo, Y-S., Kam, Y-W., Rénia, L., Lecuit, M. & Ng, L. F. P., 30 Jan 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 1860.

Research output: Contribution to journal › Article

Open Access
File
Chikungunya virus
Virus Diseases
Antibodies
Viral RNA
Viral Load
63 Citations (Scopus)
95 Downloads (Pure)

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journal › Article

Open Access
File
Mitochondrial Degradation
Parkinson Disease
Dopaminergic Neurons
Microglia
Islets of Langerhans
2 Citations (Scopus)
58 Downloads (Pure)

Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ

Lu, H., Bogdanovic, E., Yu, Z., Cho, C., Liu, L., Ho, K., Guo, J., Yeung, L. S. N., Lehmann, R., Hundal, H. S., Giacca, A. & Fantus, I. G., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1658-1677 20 p.

Research output: Contribution to journal › Article

Open Access
File
Hyperinsulinism
Adipocytes
Hyperglycemia
Insulin Resistance
Insulin
4 Citations (Scopus)
93 Downloads (Pure)

Differential regulation of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. & Arthur, J. S. C., 16 Feb 2018, In : Journal of Biological Chemistry. 293, 7, p. 2302-2317 16 p.

Research output: Contribution to journal › Article

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
Toll-Like Receptor 4
Macrophages
Interleukin-10
B-Lymphocytes
4 Citations (Scopus)
59 Downloads (Pure)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Andersen, J. L., Gesser, B., Funder, E. D., Nielsen, C. J. F., Gotfred-Rasmussen, H., Rasmussen, M. K., Toth, R., Gothelf, K. V., Arthur, J. S. C., Iversen, L. & Nissen, P., 19 Oct 2018, In : Nature Communications. 9, 1, 9 p., 4344.

Research output: Contribution to journal › Article

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
inhibitors
Phosphotransferases
helices
Mitogens
2 Citations (Scopus)
78 Downloads (Pure)

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.

Research output: Contribution to journal › Article

Open Access
File
Lysosphingolipid Receptors
Modulators
Esters
Plasma (human)
Butyrylcholinesterase
4 Citations (Scopus)
69 Downloads (Pure)

Effects of sodium and amino acid substrate availability upon the expression and stability of the SNAT2 (SLC38A2) amino acid transporter

Hoffmann, T., Cwiklinski, E., Shah, D., Stretton, C., Hyde, R., Taylor, P. & Hundal, H., 7 Feb 2018, In : Frontiers in Pharmacology. 9, p. 1-9 9 p., 63.

Research output: Contribution to journal › Article

Open Access
File
Amino Acid Transport Systems
Sodium
Amino Acids
Protein Stability
Neutral Amino Acids
3 Citations (Scopus)
94 Downloads (Pure)

Expression of Siglec-E Alters the proteome of lipopolysaccharide (LPS)-activated macrophages but does not affect LPS-driven cytokine production or toll-like receptor 4 endocytosis

Nagala, M., McKenzie, E., Richards, H., Sharma, R., Thomson, S., Mastroeni, P. & Crocker, P., 15 Jan 2018, In : Frontiers in Immunology. 8, p. 1-17 17 p., 1926.

Research output: Contribution to journal › Article

Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
Toll-Like Receptor 4
Proteome
Endocytosis
Lipopolysaccharides
14 Citations (Scopus)
83 Downloads (Pure)

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

van Dinther, D., Veninga, H., Iborra, S., Borg, E. G. F., Hoogterp, L., Olesek, K., Beijer, M. R., Schetters, S. T. T., Kalay, H., Garcia-Vallejo, J. J., Franken, K. L., Cham, L. B., Lang, K. S., van Kooyk, Y., Sancho, D., Crocker, P. R. & den Haan, J. M. M., 6 Feb 2018, In : Cell Reports. 22, 6, p. 1484-1495 12 p.

Research output: Contribution to journal › Article

Open Access
File
Cross-Priming
T-cells
Macrophages
Dendritic Cells
T-Lymphocytes
8 Citations (Scopus)
50 Downloads (Pure)

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival

Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G., Feb 2018, In : Molecular Cancer Research. 16, 2, p. 345-357 13 p.

Research output: Contribution to journal › Article

Open Access
File
AMP-Activated Protein Kinases
Cell Survival
Protein Isoforms
Etoposide
DNA Damage
4 Citations (Scopus)
129 Downloads (Pure)

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

Research output: Contribution to journal › Article

Open Access
File
T-cells
Proteome
Interleukin-2
T-Lymphocytes
Cytotoxic T-Lymphocytes
21 Citations (Scopus)
106 Downloads (Pure)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 23-44 22 p.

Research output: Contribution to journal › Article

Open Access
File
Phosphorylation
Leucine
Parkinson Disease
Neutrophils
Phosphotransferases
10 Citations (Scopus)
92 Downloads (Pure)

Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

Ercoli, G., Fernandes, V. E., Chung, W. Y., Wanford, J. J., Thomson, S., Bayliss, C. D., Straatman, K., Crocker, P. R., Dennison, A., Martinez-Pomares, L., Andrew, P. W., Moxon, E. R. & Oggioni, M. R., 16 Apr 2018, In : Nature Microbiology. 3, 5, p. 600-610 11 p.

Research output: Contribution to journal › Article

Open Access
File
Streptococcus pneumoniae
Sepsis
Macrophages
Bacteria
Macrolides
4 Citations (Scopus)
55 Downloads (Pure)

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Thomas, E. C., Hook, S. C., Gray, A., Chadt, A., Carling, D., Al-Hasani, H., Heesom, K. J., Hardie, D. G. & Tavaré, J. M., 25 Sep 2018, In : The Biochemical journal. 475, 18, p. 2969-2983 35 p.

Research output: Contribution to journal › Article

Open Access
File
AMP-Activated Protein Kinases
Morbid Obesity
Protein Isoforms
Phosphorylation
Association reactions
1 Citation (Scopus)
44 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journal › Article

Open Access
File
homeostasis
protease
Oxidative stress
Endopeptidases
Oxidative Stress
4 Citations (Scopus)
160 Downloads (Pure)

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 117-135 19 p.

Research output: Contribution to journal › Article

Open Access
File
Phosphatidylinositol 3-Kinases
Intercellular Signaling Peptides and Proteins
Chemical activation
Phosphatidylinositols
Phosphotransferases
2 Citations (Scopus)

Multiplexed division tracking dyes for proliferation-based clonal lineage tracing

Horton, M. B., Prevedello, G., Marchingo, J. M., Zhou, J. H. S., Duffy, K. R., Heinzel, S. & Hodgkin, P. D., 1 Aug 2018, In : Journal of Immunology. 201, 3, p. 1097-1103 7 p.

Research output: Contribution to journal › Article

Coloring Agents
Cell Lineage
Cell Culture Techniques
T-Lymphocytes
In Vitro Techniques
8 Citations (Scopus)
80 Downloads (Pure)

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journal › Article

Open Access
File
Cell Movement
Actins
Clustered Regularly Interspaced Short Palindromic Repeats
Focal Adhesions
Osteosarcoma
11 Citations (Scopus)
5 Downloads (Pure)

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

Stathopoulou, C., Gangaplara, A., Mallett, G., Flomerfelt, F. A., Liniany, L. P., Knight, D., Samsel, L. A., Berlinguer-Palmini, R., Yim, J. J., Felizardo, T. C., Eckhaus, M. A., Edgington-Mitchell, L., Martinez-Fabregas, J., Zhu, J., Fowler, D. H., van Kasteren, S. I., Laurence, A., Bogyo, M., Watts, C., Shevach, E. M. & 1 others, Amarnath, S., 21 Aug 2018, In : Immunity. 49, 2, p. 247-263.e7 25 p.

Research output: Contribution to journal › Article

Open Access
File
asparaginylendopeptidase
Death Domain Receptors
Regulatory T-Lymphocytes
Transcription Factors
Down-Regulation
9 Citations (Scopus)
45 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journal › Article

Open Access
File
Phosphorylation
serine
Serine
phosphorylation
Chemical activation
16 Citations (Scopus)
104 Downloads (Pure)

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H. & Cantrell, D. A., 26 Apr 2018, In : Annual Review of Immunology. 36, p. 411-433 23 p.

Research output: Contribution to journal › Article

Open Access
File
Interleukin-2
T-Lymphocytes
STAT5 Transcription Factor
Janus Kinases
Interleukin-2 Receptors
5 Citations (Scopus)
55 Downloads (Pure)

Single cell analysis of kynurenine and System L amino acid transport in T cells

Sinclair, L., Neyens, D., Ramsay, G., Taylor, P. & Cantrell, D., 17 May 2018, In : Nature Communications. 9, 1, 11 p., 1981 (2018).

Research output: Contribution to journal › Article

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Amino Acid Transport System L
Single-Cell Analysis
Kynurenine
T-cells
Systems Analysis
3 Citations (Scopus)
97 Downloads (Pure)

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

Morgan, E. L., Wasson, C. W., Hanson, L., Kealy, D., Pentland, I., McGuire, V., Scarpini, C., Coleman, N., Arthur, J. S. C., Parish, J. L., Roberts, S. & Macdonald, A., 9 Apr 2018, In : PLoS Pathogens. 14, 4, p. 1-33 33 p., e1006975.

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Life Cycle Stages
Phosphorylation
Keratinocytes
STAT3 Transcription Factor
Cell Cycle
2 Citations (Scopus)
68 Downloads (Pure)

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Moral-Sanz, J., Lewis, S. A., MacMillan, S., Ross, F. A., Thomson, A., Viollet, B., Foretz, M., Moran, C., Hardie, D. G. & Evans, A. M., 2 Oct 2018, In : Science Signaling. 11, 550, 9 p., eaau0296.

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Open Access
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AMP-Activated Protein Kinases
Mitochondria
Vasoconstriction
Lung
Muscle
14 Citations (Scopus)
54 Downloads (Pure)

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human

Mir, R., Tonelli, F., Lis, P., Macartney, T., Polinski, N. K., Martinez, T. N., Chou, M-Y., Howden, A., König, T., Hotzy, C., Milenkovic, I., Brücke, T., Zimprich, A., Sammler, E. & Alessi, D., 6 Jun 2018, In : Biochemical Journal. 475, 11, p. 1861-1883 19 p.

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Phosphorylation
Parkinson Disease
Mutation
Proteins
Phosphotransferases
1 Citation (Scopus)
56 Downloads (Pure)

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

Wagle, M. V., Marchingo, J. M., Howitt, J., Tan, S. S., Goodnow, C. C. & Parish, I. A., 17 Jul 2018, In : Cell Reports. 24, 3, p. 577-584 8 p.

Research output: Contribution to journal › Article

Open Access
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T-cells
Ligases
Ubiquitin
T-Lymphocytes
Antigens
6 Citations (Scopus)
93 Downloads (Pure)

Tumor Necrosis Factor-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection

Shinde, P. V., Xu, H. C., Maney, S. K., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenberg, M., Trilling, M., Pozdeev, V. I., van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P. R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M. & 9 others, Ruland, J., Mak, T. W., Brenner, D., Pandyra, A. A., Hoell, J. I., Borkhardt, A., Häussinger, D., Lang, K. S. & Lang, P. A., Feb 2018, In : Journal of Virology. 92, 3, p. 1-18 18 p., e01637-17.

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Open Access
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Vesiculovirus
Vesicular Stomatitis
tumor necrosis factors
Virus Diseases
cell viability