Research Output per year
Research Output
2020
A conserved ATG2-GABARAP family interaction is critical for phagophore formation
Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 3 Feb 2020, In : EMBO Reports. p. 1-17 17 p., e48412.Research output: Contribution to journal › Article
Open Access
File
AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner
Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J. A., Banzhaf, M., Lavery, G. G., Hardie, D. G., Hodson, D. J., Philp, A. & Lai, Y-C., 22 Mar 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18 p.Research output: Contribution to journal › Article
Open Access
File
Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function
Shah, D., Nisr, R., Stretton, C., Krasteva-Christ, G. & Hundal, H., 23 Feb 2020, In : Journal of Cachexia, Sarcopenia and Muscle. 21 p.Research output: Contribution to journal › Article
Open Access
File
Characterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22
Di Carluccio, C., Crisman, E., Manabe, Y., Forgione, R. E., Lacetera, A., Amato, J., Pagano, B., Randazzo, A., Zampella, A., Lanzetta, R., Fukase, K., Molinaro, A., Crocker, P. R., Martín-Santamaría, S., Marchetti, R. & Silipo, A., 15 Jan 2020, In : ChemBioChem. 21, 1-2, p. 129-140 12 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In : JoVE: Journal of Visualized Experiments. 157, e58956.Research output: Contribution to journal › Article
Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ
Harper, A. A., Rimmer, K., Dyavanapalli, J., McArthur, J. R. & Adams, D. J., 15 Mar 2020, In : Neuropharmacology. 165, p. 1-8 8 p., 107932.Research output: Contribution to journal › Article
Mechanism of Activation of AMPK by Cordycepin
Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In : Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.Research output: Contribution to journal › Article
Open Access
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-652 10 p.Research output: Contribution to journal › Article
p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells
Petrova, T., Pesic, J., Pardali, K., Gaestel, M. & Arthur, J. S. C., 26 Feb 2020, In : Scientific Reports. 10, p. 1-15 15 p., 3479.Research output: Contribution to journal › Article
Open Access
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Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
Marchingo, J., Sinclair, L., Howden, A. & Cantrell, D., 4 Mar 2020, In : eLife. 9, p. 1-23 23 p., e53725.Research output: Contribution to journal › Article
Open Access
File
Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos
Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In : EMBO Reports. 21, 1, p. 1-20 20 p., e48469.Research output: Contribution to journal › Article
Open Access
File
2019
A comparative map of macroautophagy and mitophagy in the vertebrate eye
McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
129
Downloads
(Pure)
Antigen receptor control of methionine metabolism in T cells
Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.Research output: Contribution to journal › Article
Open Access
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10
Citations
(Scopus)
93
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(Pure)
CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock
Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.Research output: Contribution to journal › Article
Open Access
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5
Citations
(Scopus)
113
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(Pure)
CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation
Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.Research output: Contribution to journal › Article
Open Access
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1
Citation
(Scopus)
156
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(Pure)
Central nervous system regeneration is driven by microglia necroptosis and repopulation
Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J. & Miron, V. E., 10 Jul 2019, In : Nature Neuroscience. 22, 7, p. 1046-1052 7 p.Research output: Contribution to journal › Article
Open Access
File
14
Citations
(Scopus)
11
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(Pure)
Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)
Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.Research output: Contribution to journal › Article
Open Access
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2
Citations
(Scopus)
103
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(Pure)
Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice
Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In : Life Science Alliance. 2, 6, p. 1-19 19 p., e201900533.Research output: Contribution to journal › Article
Open Access
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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis
Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning
Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.Research output: Contribution to journal › Article
Open Access
File
3
Citations
(Scopus)
76
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(Pure)
Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In : Wellcome Open Research. 4, p. 134 28 p.Research output: Contribution to journal › Article
Open Access
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Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, , 12 Jul 2019, In : Annals of the Rheumatic Diseases. 8 p.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
160
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(Pure)
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues
Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.Research output: Contribution to journal › Article
Open Access
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5
Citations
(Scopus)
117
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(Pure)
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress
Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.Research output: Contribution to journal › Article
Open Access
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7
Citations
(Scopus)
84
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(Pure)
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3
McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 17 Jan 2019, In : Immunology and Cell Biology. 97, 1, p. 54-71 18 p.Research output: Contribution to journal › Article
Open Access
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3
Citations
(Scopus)
167
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(Pure)
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.Research output: Contribution to journal › Article
Open Access
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Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22
Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.Research output: Contribution to journal › Article
Open Access
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l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway
Robertson-Gray, O. J., Walsh, S. K., Ryberg, E., Jönsson-Rylander, A. C., Lipina, C. & Wainwright, C. L., Jun 2019, In : Pharmacology Research and Perspectives. 7, 3, p. 1-12 12 p., e00487.Research output: Contribution to journal › Article
Open Access
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1
Citation
(Scopus)
54
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(Pure)
Macrophage migration inhibitory factor (MIF) is essential for type 2 effector cell immunity to an intestinal helminth parasite
Filbey, K. J., Varyani, F., Harcus, Y., Hewitson, J. P., Smyth, D. J., McSorley, H. J., Ivens, A., Nylén, S., Rottenberg, M., Löser, S. & Maizels, R. M., 24 Oct 2019, In : Frontiers in Immunology. 10, 2375.Research output: Contribution to journal › Article
Open Access
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Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses
O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation
Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4Research output: Contribution to journal › Article
Open Access
File
7
Citations
(Scopus)
98
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(Pure)
Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44
Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.Research output: Contribution to journal › Article
Open Access
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Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
Nisr, R., Shah, D., Ganley, I. & Hundal, H., Dec 2019, In : Cellular and Molecular Life Sciences. 76, 24, p. 4887-4904 18 p.Research output: Contribution to journal › Article
Open Access
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2
Citations
(Scopus)
133
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(Pure)
Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 30 Sep 2019, In : Wellcome Open Research. 4, p. 1-21 21 p., 134.Research output: Contribution to journal › Article
Open Access
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Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation
Howden, A. J. M., Hukelmann, J. L., Brenes, A., Spinelli, L., Sinclair, L. V., Lamond, A. I. & Cantrell, D. A., 7 Oct 2019, In : Nature Immunology. 20, 11, p. 1542-1554 13 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader
Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.Research output: Contribution to journal › Article
Open Access
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4
Citations
(Scopus)
142
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(Pure)
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib
Bort, A., Sánchez, B. G., Mateos-Gómez, P. A., Vara-Ciruelos, D., Rodríguez-Henche, N. & Díaz-Laviada, I., May 2019, In : Molecular Oncology. 13, 5, p. 1311-1331 21 p.Research output: Contribution to journal › Article
Open Access
File
6
Citations
(Scopus)
93
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(Pure)
The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells
Kelsall, I., Zhang, R., Knebel, A., Arthur, S. & Cohen, P., 2 Jul 2019, In : Proceedings of the National Academy of Sciences. 116, 27, p. 13293-13298 6 p.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
74
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(Pure)
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †
Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In : Open Biology. 9, 7, p. 1-21 21 p., 190099.Research output: Contribution to journal › Article
Open Access
File
7
Citations
(Scopus)
68
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(Pure)
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
Li, M., Zhang, C-S., Zong, Y., Feng, J-W., Ma, T., Hu, M., Lin, Z., Li, X., Xie, C., Wu, Y., Jiang, D., Li, Y., Zhang, C., Tian, X., Wang, W., Yang, Y., Chen, J., Cui, J., Wu, Y-Q., Chen, X. & 11 others, , 3 Sep 2019, In : Cell Metabolism. 30, 3, p. 508-524.e12 17 p.Research output: Contribution to journal › Article
Open Access
File
7
Citations
(Scopus)
154
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(Pure)
Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages
Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B. D., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
164
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(Pure)
2018
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.Research output: Contribution to journal › Article
Open Access
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27
Citations
(Scopus)
127
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(Pure)
Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity
Lum, F-M., Couderc, T., Chia, B-S., Ong, R-Y., Her, Z., Chow, A., Leo, Y-S., Kam, Y-W., Rénia, L., Lecuit, M. & Ng, L. F. P., 30 Jan 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 1860.Research output: Contribution to journal › Article
Open Access
File
14
Citations
(Scopus)
144
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(Pure)
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.Research output: Contribution to journal › Article
Open Access
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106
Citations
(Scopus)
165
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(Pure)
Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ
Lu, H., Bogdanovic, E., Yu, Z., Cho, C., Liu, L., Ho, K., Guo, J., Yeung, L. S. N., Lehmann, R., Hundal, H. S., Giacca, A. & Fantus, I. G., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1658-1677 20 p.Research output: Contribution to journal › Article
Open Access
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2
Citations
(Scopus)
109
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(Pure)
Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion
Smith, K. A., Löser, S., Varyani, F., Harcus, Y., McSorley, H. J., McKenzie, A. N. J. & Maizels, R. M., 5 Oct 2018, In : eLife. 7, p. 1-18 18 p., e38269.Research output: Contribution to journal › Article
Open Access
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5
Citations
(Scopus)
13
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Differential regulation of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases
Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. & Arthur, J. S. C., 16 Feb 2018, In : Journal of Biological Chemistry. 293, 7, p. 2302-2317 16 p.Research output: Contribution to journal › Article
Open Access
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4
Citations
(Scopus)
134
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(Pure)
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Andersen, J. L., Gesser, B., Funder, E. D., Nielsen, C. J. F., Gotfred-Rasmussen, H., Rasmussen, M. K., Toth, R., Gothelf, K. V., Arthur, J. S. C., Iversen, L. & Nissen, P., 19 Oct 2018, In : Nature Communications. 9, 1, 9 p., 4344.Research output: Contribution to journal › Article
Open Access
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8
Citations
(Scopus)
111
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(Pure)
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1
Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.Research output: Contribution to journal › Article
Open Access
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5
Citations
(Scopus)
177
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(Pure)