Cell Signalling and Immunology

Research Output

Research Output per year

1982 2021

• 72952 Citations
• 129 h-Index
• 787 Article
• 61 Review article
• 18 Book/Film/Article review
• 13 Meeting abstract
• 53 More
  • 12 Comment/debate
  • 9 Editorial
  • 8 Chapter
  • 5 Conference contribution
  • 5 Chapter (peer-reviewed)
  • 5 Letter
  • 2 Poster
  • 2 Short survey
  • 1 Other chapter contribution
  • 1 Paper
  • 1 Special issue
  • 1 Exhibition
  • 1 Exhibition catalogue

Research Output per year

Research Output per year

Search results

• 2021

  Extracellular signal-regulated kinase (ERK) pathway control of CD8⁺ T cell differentiation

  Damasio, M. P., Marchingo, J. M., Spinelli, L., Hukelmann, J. L., Cantrell, D. A. & Howden, A. J. M., 13 Jan 2021, In: Biochemical Journal. 478, 1, p. 79-98 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T-cells
  • Extracellular Signal-Regulated MAP Kinases
  • Cell Differentiation
  • T-Lymphocytes
  • Antigen Receptors

• Mitogen and Stress-activated Protein Kinase 1 negatively regulates hippocampal neurogenesis

  Olateju, O. I., Morè, L., Arthur, J. S. C. & Frenguelli, B. G., 1 Jan 2021, In: Neuroscience. 452, p. 228-234 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mitogen and stress-activated protein kinase 1
  • Neurogenesis
  • Phosphotransferases
  • Brain-Derived Neurotrophic Factor
  • Neurons
  8 Downloads (Pure)

• The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways

  Gubas, A., Karantanou, C., Popovic, D., Tascher, G., Hoffmann, M. E., Platzek, A., Dawe, N., Dikic, I., Krause, D. S. & McEwan, D. G., 16 Jan 2021, In: FEBS Letters. 37 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • platelet protein P47
  • Pleckstrin Homology Domains
  • Lysosomes
  • Intercellular Signaling Peptides and Proteins
  • Phosphorylation

• Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

  Cui, L., Moraga, I., Lerbs, T., Van Neste, C., Wilmes, S., Tsutsumi, N., Trotman-Grant, A. C., Gakovic, M., Andrews, S., Gotlib, J., Darmanis, S., Enge, M., Quake, S., Hitchcock, I. S., Piehler, J., Garcia, K. C. & Wernig, G., 12 Jan 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 2, 10 p., e2017849118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thrombopoietin
  • Essential Thrombocythemia
  • Hematopoietic Stem Cells
  • Cell Differentiation
  • Thrombopoietin Receptors
  11 Downloads (Pure)
• 2020

  A conserved ATG2-GABARAP family interaction is critical for phagophore formation

  Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 4 Mar 2020, In: EMBO Reports. 21, 3, p. 1-17 17 p., e48412.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Autophagy
  • Elongation
  • human GABARAP protein
  • Recycling
  • Seals
  12 Citations (Scopus)

  119 Downloads (Pure)

• A helminth-derived suppressor of ST2 blocks allergic responses

  Vacca, F., Chauché, C., Jamwal, A., Hinchy, E. C., Heieis, G., Webster, H., Ogunkanbi, A., Sekne, Z., Gregory, W. F., Wear, M. A., Perona-Wright, G., Higgins, M. K. ., Nys, J., Cohen, E. S. & McSorley, H. J., 18 May 2020, In: eLife. 9, p. 1-20 20 p., e54017.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nematospiroides dubius
  • Alarmins
  • Interleukin-33
  • Helminths
  • Proteins
  4 Citations (Scopus)

  69 Downloads (Pure)

• AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner

  Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J. A., Banzhaf, M., Lavery, G. G., Hardie, D. G., Hodson, D. J., Philp, A. & Lai, Y-C., 4 May 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 5, p. 6284-6301 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondrial Degradation
  • Mitochondrial Dynamics
  • Adenosine Monophosphate
  • Protein Kinases
  • Chemical activation
  3 Citations (Scopus)

  77 Downloads (Pure)

• Antibody RING-Mediated Destruction of Endogenous Proteins

  Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T., 2 Jul 2020, In: Molecular Cell. 79, 1, p. 155-166 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Single-Domain Antibodies
  • Antibodies
  • Proteins
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex
  36 Downloads (Pure)

• A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine

  Chauché, C., Vacca, F., Chia, S. L., Richards, J., Gregory, W. F., Ogunkanbi, A., Wear, M. A. & McSorley, H. J., 30 Jun 2020, In: Frontiers in Immunology. 11, 10 p., 1363.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nematospiroides dubius
  • Alarmins
  • Interleukin-33
  • Cytokines
  • Nippostrongylus
  1 Citation (Scopus)

  20 Downloads (Pure)

• Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function

  Shah, D., Nisr, R., Stretton, C., Krasteva-Christ, G. & Hundal, H., 15 Jun 2020, In: Journal of Cachexia, Sarcopenia and Muscle. 11, 3, p. 838-858 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Caveolin 3
  • Skeletal Muscle
  • Mutation
  • Myoblasts
  • Limb-Girdle Muscular Dystrophies
  2 Citations (Scopus)

  50 Downloads (Pure)

• CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

  Martinez-Fabregas, J., Wang, L., Pohler, E., Cozzani, A., Wilmes, S., Kazemian, M., Mitra, S. & Moraga, I., 22 Dec 2020, In: Cell Reports. 33, 12, 26 p., 108545.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genes
  • Interleukin-6
  • Th1 Cells
  • Phosphorylation
  • Cytokines
  41 Downloads (Pure)

• Characterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22

  Di Carluccio, C., Crisman, E., Manabe, Y., Forgione, R. E., Lacetera, A., Amato, J., Pagano, B., Randazzo, A., Zampella, A., Lanzetta, R., Fukase, K., Molinaro, A., Crocker, P. R., Martín-Santamaría, S., Marchetti, R. & Silipo, A., 15 Jan 2020, In: ChemBioChem. 21, 1-2, p. 129-140 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 2
  • Cells
  • Polysaccharides
  • B-Lymphocytes
  • Nuclear magnetic resonance spectroscopy
  6 Citations (Scopus)

• Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

  Lawal, H. M., Schilde, C., Kin, K., Brown, M. W., James, J., Prescott, A. R. & Schaap, P., 29 May 2020, In: Scientific Reports. 10, 9 p., 8797.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cold Climate
  • Spores
  • Cysts
  • Organism Forms
  • Dictyostelium
  31 Downloads (Pure)

• Discovery of a new sialic acid binding region that regulates Siglec-7

  Yamakawa, N., Yasuda, Y., Yoshimura, A., Goshima, A., Crocker, P. R., Vergoten, G., Nishiura, Y., Takahashi, T., Hanashima, S., Matsumoto, K., Yamaguchi, Y., Tanaka, H., Kitajima, K. & Sato, C., 26 May 2020, In: Scientific Reports. 10, 14 p., 8647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins
  • N-Acetylneuraminic Acid
  • Binding Sites
  • Ligands
  • 1,1,1,2-tetrafluoro-2-chloroethane
  1 Citation (Scopus)

  36 Downloads (Pure)

• Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

  Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4104-4117 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amyloid
  • Obesity
  • Diet
  • Blood Vessels
  • Cyclic GMP-Dependent Protein Kinases
  1 Citation (Scopus)

  52 Downloads (Pure)

• Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

  Kalogeropulou, A. F., Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K. & Alessi, D. R., 27 Nov 2020, In: Biochemical Journal. 477, 22, p. 4397-4423 27 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphorylation
  • Nigericin
  • Monensin
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Gene encoding
  10 Downloads (Pure)

• Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

  Gorby, C., Sotolongo Bellón, J., Wilmes, S., Warda, W., Pohler, E., Fyfe, P. K., Cozzani, A., Ferrand, C., Walter, M. R., Mitra, S., Piehler, J. & Moraga, I., 15 Sep 2020, In: Science Signaling. 13, 649, 19 p., eabc0653.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-10
  • Ligands
  • T-cells
  • Interleukin-10 Receptors
  • Monocytes
  1 Citation (Scopus)

  168 Downloads (Pure)

• Experience recruits MSK1 to expand the dynamic range of synapses and enhance cognition

  Privitera, L., Morè, L., Cooper, D. D., Richardson, P., Tsogka, M., Hebenstreit, D., Arthur, J. S. C. & Frenguelli, B. G., 10 Jun 2020, In: Journal of Neuroscience. 40, 24, p. 4644-4660 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mitogen and stress-activated protein kinase 1
  • Synapses
  • Cognition
  • Mitogen-Activated Protein Kinases
  • Gene Expression
  3 Citations (Scopus)

  18 Downloads (Pure)

• Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

  Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In: JoVE: Journal of Visualized Experiments. 157, e58956.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphorylation
  • Leucine
  • Peptide Hydrolases
  • Blood
  • Neutrophils
  1 Citation (Scopus)

  9 Downloads (Pure)

• IL-33 facilitates rapid expulsion of the parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation

  Meiners, J., Reitz, M., Rüdiger, N., Turner, J-E., Heepmann, L., Rudolf, L., Hartmann, W., McSorley, H. & Breloer, M., 22 Dec 2020, In: PLoS Pathogens. 16, 12, 20 p., e1009121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Strongyloides ratti
  • Interleukin-9
  • Interleukin-33
  • Mast Cells
  • Intestines
  12 Downloads (Pure)

• Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

  Obst, J., Simon, E., Martin-Estebane, M., Pipi, E., Barkwill, L. M., Gonzalez-Rivera, I., Buchanan, F., Prescott, A. R., Faust, D., Fox, S., Brownlees, J., Taylor, D., Perry, V. H., Nuthall, H., Atkinson, P. J., Karran, E., Routledge, C. & Gomez-Nicola, D., 8 Oct 2020, In: Frontiers in Immunology. 11, 14 p., 579000.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colony-Stimulating Factor Receptors
  • Macrophage Colony-Stimulating Factor
  • Interleukins
  • Inhibition (Psychology)
  • Microglia
  33 Downloads (Pure)

• Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

  Harper, A. A., Rimmer, K., Dyavanapalli, J., McArthur, J. R. & Adams, D. J., 15 Mar 2020, In: Neuropharmacology. 165, p. 1-8 8 p., 107932.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ketamine
  • Nicotinic Receptors
  • Ganglia
  • Synaptic Transmission
  • Nicotine
  20 Downloads (Pure)

• Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

  Sollberger, G., Streeck, R., Apel, F., Caffrey, B. E., Skoultchi, A. I. & Zychlinsky, A., 27 May 2020, In: eLife. 9, p. 1-24 24 p., e52563.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stem cells
  • Bone
  • Histones
  • Neutrophils
  • Pathogens
  3 Citations (Scopus)

  21 Downloads (Pure)

• Loss of Mef2D function enhances TLR induced IL-10 production in macrophages

  Pattison, M. J., Naik, R. J., Reyskens, K. M. S. E. & Arthur, J. S. C., 21 Aug 2020, In: Bioscience Reports. 40, 8, p. 1-15 15 p., BSR20201859.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages
  • Interleukin-10
  • T-cells
  • Cytokines
  • Protein Isoforms
  15 Downloads (Pure)

• Mechanism of Activation of AMPK by Cordycepin

  Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In: Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cordycepin
  • AMP-Activated Protein Kinases
  • Chemical activation
  • Adenosine Monophosphate
  • Metabolism
  56 Downloads (Pure)

• Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

  Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Löchte, S., Stanly, T. A., Pulgar Prieto, K. D., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In: Science. 367, 6478, p. 643-652 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytokine Receptors
  • Dimerization
  • Janus Kinase 2
  • Mutation
  • Ligands
  16 Citations (Scopus)

  14 Downloads (Pure)

• Mono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells

  Nisr, R., Shah, D. & Hundal, H., Oct 2020, In: Cellular Physiology and Biochemistry. 54, 5, p. 975-993 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Monounsaturated Fatty Acids
  • Palmitates
  • Unsaturated Fatty Acids
  • Muscle Cells
  • Skeletal Muscle Fibers
  72 Downloads (Pure)

• Of Mosaicism and Mechanisms: How a JAK1 variant goes awry

  Ross, S. & Cantrell, D., 15 Sep 2020, In: Immunity. 53, 3, p. 481-484 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mosaicism
  • Precision Medicine
  • Immune System Diseases
  • Biochemistry
  • Immunity

• p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

  Petrova, T., Pesic, J., Pardali, K., Gaestel, M. & Arthur, J. S. C., 26 Feb 2020, In: Scientific Reports. 10, 15 p., 3479.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-33
  • p38 Mitogen-Activated Protein Kinases
  • Interleukin-13
  • Interleukin-6
  • Lymphocytes
  2 Citations (Scopus)

  53 Downloads (Pure)

• Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

  Marchingo, J., Sinclair, L., Howden, A. & Cantrell, D., 4 Mar 2020, In: eLife. 9, p. 1-23 23 p., e53725.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T-cells
  • Metabolic Networks and Pathways
  • Proteome
  • Chemical activation
  • Chemical analysis
  10 Citations (Scopus)

  48 Downloads (Pure)

• Role of Protein in Fungal Biomineralization of Copper Carbonate Nanoparticles

  Liu, F., Shah, D. S. & Gadd, G. M., 25 Jan 2021, In: Current biology : CB. 31, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • copper carbonate
  • Biomineralization
  • fungal proteins
  • biomineralization
  • Fungal Proteins
  50 Downloads (Pure)

• Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression

  Murugesan, G., Correia, V. G., Palma, A. S., Chai, W., Li, C., Feizi, T., Martin, E., Laux, B., Franz, A., Fuchs, K., Weigle, B. & Crocker, P. R., 30 May 2020, In: Glycobiology. p. 1-11 11 p., cwaa048.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sialosyl-Tn antigen
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Tumors
  • Tumor Cell Line
  • Cells
  45 Downloads (Pure)

• Single Cell Glucose Uptake Assays: A Cautionary Tale

  Sinclair, L. V., Barthelemy, C. & Cantrell, D. A., 17 Aug 2020, In: Immunometabolism. 2, 4, 13 p., e200029.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose
  • T-cells
  • Assays
  • Facilitative Glucose Transport Proteins
  • Glucose
  23 Downloads (Pure)

• The active inner life of naïve T cells

  Marchingo, J. M. & Cantrell, D. A., 1 Aug 2020, In: Nature Immunology. 21, 8, p. 827-828 2 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • T-Lymphocytes
  • Proteomics
  • Proteins
  1 Citation (Scopus)

  7 Downloads (Pure)

• Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10

  Forgione, R. E., Di Carluccio, C., Guzmán-Caldentey, J., Gaglione, R., Battista, F., Chiodo, F., Manabe, Y., Arciello, A., Del Vecchio, P., Fukase, K., Molinaro, A., Martín-Santamaría, S., Crocker, P. R., Marchetti, R. & Silipo, A., 26 Jun 2020, In: iScience. 23, 6, p. 1-29 29 p., 101231.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Polysaccharides
  • Epitope Mapping
  • Physiological Phenomena
  • Lectins
  2 Citations (Scopus)

  18 Downloads (Pure)

• Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

  Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In: EMBO Reports. 21, 1, p. 1-20 20 p., e48469.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amino Acid Transport Systems
  • Embryonic Structures
  • Morphogenesis
  • Tissue
  • Defects
  6 Citations (Scopus)

  84 Downloads (Pure)
• 2019

  A comparative map of macroautophagy and mitophagy in the vertebrate eye

  McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 2019, In: Autophagy. 15, 7, p. 1296-1308 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondrial Degradation
  • Autophagy
  • Vertebrates
  • Eye
  • Retina
  7 Citations (Scopus)

  243 Downloads (Pure)

• A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

  Minutti, C. M., Modak, R. V., Macdonald, F., Li, F., Smyth, D. J., Dorward, D. A., Blair, N., Husovsky, C., Muir, A., Giampazolias, E., Dobie, R., Maizels, R. M., Kendall, T. J., Griggs, D. W., Kopf, M., Henderson, N. C. & Zaiss, D. M., 19 Mar 2019, In: Immunity. 50, 3, p. 645-654.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amphiregulin
  • Pericytes
  • Transforming Growth Factor beta
  • Macrophages
  • Wounds and Injuries
  36 Citations (Scopus)

• Antigen receptor control of methionine metabolism in T cells

  Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In: eLife. 8, p. 1-29 29 p., e44210.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T-cells
  • Metabolism
  • Antigen Receptors
  • Methionine
  • Methylation
  27 Citations (Scopus)

  133 Downloads (Pure)

• CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

  Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In: EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Somites
  • Periodicity
  • Clocks
  • Mesoderm
  • Ubiquitin-Protein Ligases
  9 Citations (Scopus)

  162 Downloads (Pure)

• CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation

  Stretton, C., Lipina, C., Hyde, R., Cwiklinski, E., Hoffmann, T. M., Taylor, P. M. & Hundal, H. S., 1 Jun 2019, In: Biochimica et Biophysica Acta. Molecular Cell Research. 1866, 6, p. 978-991 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
  • Activating Transcription Factor 4
  • Amino Acids
  • Cyclin-Dependent Kinases
  • alvocidib
  3 Citations (Scopus)

  192 Downloads (Pure)

• Central nervous system regeneration is driven by microglia necroptosis and repopulation

  Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J. & Miron, V. E., 10 Jul 2019, In: Nature Neuroscience. 22, 7, p. 1046-1052 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microglia
  • Regeneration
  • Central Nervous System
  • Remyelination
  • Myelin Sheath
  48 Citations (Scopus)

  139 Downloads (Pure)

• Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

  Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Lysosphingolipid Receptors
  • Drug Discovery
  • Modulators
  • Skin
  • ponesimod
  2 Citations (Scopus)

  161 Downloads (Pure)

• Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

  Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In: Life Science Alliance. 2, 6, 19 p., e201900533.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glomerulonephritis
  • Liver
  • Pathology
  • pathology
  • Glomerulonephritis
  2 Citations (Scopus)

  36 Downloads (Pure)

• EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

  Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In: Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Atopic Dermatitis
  • filaggrin
  • Skin
  • Genome-Wide Association Study
  • Leucine
  7 Citations (Scopus)

  27 Downloads (Pure)

• FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

  Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In: EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Casein Kinase I
  • Spindle Apparatus
  • Cells
  • Phosphotransferases
  • Mitosis
  9 Citations (Scopus)

  109 Downloads (Pure)

• Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

  Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In: Wellcome Open Research. 4, p. 134 28 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • filaggrin
  • Organoids
  • Functional analysis
  • Proteomics
  • Keratinocytes
  78 Downloads (Pure)

• Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

  Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 1 Oct 2019, In: Annals of the Rheumatic Diseases. 78, 10, p. 1363-1370 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ubiquitin isopeptidase
  • Citrullination
  • Extracellular Traps
  • Genetic Variation
  • Systemic Lupus Erythematosus
  19 Citations (Scopus)

  300 Downloads (Pure)

• GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

  Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In: FASEB Journal. 33, 1, p. 1299-1312 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Adiposity
  • G-Protein-Coupled Receptors
  • Tissue
  • Insulin
  • Energy Metabolism
  15 Citations (Scopus)

  158 Downloads (Pure)

• Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

  Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In: Cell Research. 29, p. 460-473 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenosine Monophosphate
  • Nutrients
  • Mitochondrial Dynamics
  • Lysosomes
  • Mitochondria
  25 Citations (Scopus)

  137 Downloads (Pure)