Cell Signalling and Immunology

  • United Kingdom

Research Output 1987 2020

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Review article
2020

Glucose Starvation Blocks Translation at Multiple Levels

Zhang, C. S., Hardie, D. G. & Lin, S. C., 4 Feb 2020, In : Cell Metabolism. 31, 2, p. 217-218 2 p.

Research output: Contribution to journalReview article

Starvation
Glucose
Amino Acyl-tRNA Synthetases
AMP-Activated Protein Kinases
Cell Survival
2018
135 Citations (Scopus)
210 Downloads (Pure)

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Glucose
Adenosine Triphosphatases
Fructose-Bisphosphate Aldolase
Adenosine Triphosphate
34 Citations (Scopus)
121 Downloads (Pure)

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G., Jan 2018, In : Journal of the Royal Society Interface. 15, 138, 23 p., 20170774.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Fires
Adenosine Triphosphate
Proteins
Adenosine Diphosphate
1 Citation (Scopus)
118 Downloads (Pure)

Mapping determinants of cytokine signaling via protein engineering

Gorby, C., Martinez-Fabregas, J., Wilmes, S. & Moraga Gonzalez, I., 27 Sep 2018, In : Frontiers in Immunology. 9, 9 p., 2143.

Research output: Contribution to journalReview article

Open Access
File
Protein Engineering
Cytokines
Ligands
Janus Kinases
Cytokine Receptors
40 Citations (Scopus)

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

Sollberger, G., Tilley, D. O. & Zychlinsky, A., 12 Mar 2018, In : Developmental Cell. 44, 5, p. 542-553 12 p.

Research output: Contribution to journalReview article

Chromatin
Coagulation
Neutrophils
Tissue
Cell death
15 Citations (Scopus)
131 Downloads (Pure)

The regulation of lymphocyte activation and proliferation

Heinzel, S., Marchingo, J. M., Horton, M. B. & Hodgkin, P. D., Apr 2018, In : Current Opinion in Immunology. 51, p. 32-38 7 p.

Research output: Contribution to journalReview article

Open Access
File
Lymphocyte Activation
Antigens
Lymphocytes
T-Lymphocytes
Adaptive Immunity
2017
45 Citations (Scopus)
89 Downloads (Pure)

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Salt, I. P. & Hardie, D. G., 26 May 2017, In : Circulation Research. 120, 11, p. 1825-1841 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cardiovascular System
Blood Vessels
Homeostasis
Anti-Inflammatory Agents
26 Citations (Scopus)
124 Downloads (Pure)

AMP-activated protein kinase - not just an energy sensor

Hardie, D. G. & Lin, S-C., 22 Sep 2017, In : F1000 Research. 6, p. 1-11 11 p., 1724.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Sensors
Adenine Nucleotides
Adenosine Triphosphate
Eukaryota
7 Citations (Scopus)
126 Downloads (Pure)

Host-pathogen interactions and subversion of autophagy

McEwan, D. G., 12 Dec 2017, In : Essays in Biochemistry. 61, 6, p. 687-697 11 p.

Research output: Contribution to journalReview article

Open Access
File
Host-Pathogen Interactions
Autophagy
Pathogens
Oxygen supply
Amino Acids
35 Citations (Scopus)
123 Downloads (Pure)

Lipid modulation of skeletal muscle mass and function

Lipina, C. & Hundal, H. S., Apr 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 2, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
Skeletal Muscle
Lipids
Dietary Supplements
Fatty Acids
Obesity
3 Citations (Scopus)
138 Downloads (Pure)

The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

Lipina, C. & Hundal, H. S., 27 Jan 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 91-103 13 p.

Research output: Contribution to journalReview article

Open Access
File
Endocannabinoids
Nitric Oxide
Reactive Nitrogen Species
Signal Transduction
Homeostasis
249 Citations (Scopus)
140 Downloads (Pure)

The mechanisms of action of metformin

Rena, G., Hardie, D. G. & Pearson, E. R., Sep 2017, In : Diabetologia. 60, 9, p. 1577-1585 9 p.

Research output: Contribution to journalReview article

Open Access
File
Metformin
AMP-Activated Protein Kinases
Glycerolphosphate Dehydrogenase
Glucose
Health Services Needs and Demand
2016
270 Citations (Scopus)
277 Downloads (Pure)

AMPK: an energy-sensing pathway with multiple inputs and outputs

Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In : Trends in Cell Biology. 26, 3, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Phosphotransferases
Adenosine Triphosphate
Phosphorylation
18 Citations (Scopus)
122 Downloads (Pure)

Is REDD1 a Metabolic Éminence Grise?

Lipina, C. & Hundal, H., Dec 2016, In : Trends in Endocrinology and Metabolism. 27, 12, p. 868-880 13 p.

Research output: Contribution to journalReview article

Open Access
File
Aptitude
Islets of Langerhans
Energy Metabolism
DNA Damage
Cues
17 Citations (Scopus)
312 Downloads (Pure)

Lectin receptors expressed on myeloid cells

Brown, G. D. & Crocker, P. R., 23 Sep 2016, In : Microbiology Spectrum. 4, 5, p. 1-26 26 p.

Research output: Contribution to journalReview article

Open Access
File
Mitogen Receptors
Sialic Acid Binding Immunoglobulin-like Lectins
Myeloid Cells
Lectins
health and disease
41 Citations (Scopus)
130 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
File
Immunology
Allergy and Immunology
immunology
Theoretical Models
mathematical models
60 Citations (Scopus)
1634 Downloads (Pure)

Regulation of AMP-activated protein kinase by natural and synthetic activators

Grahame Hardie, D., Jan 2016, In : Acta Pharmaceutica Sinica B. 6, 1, p. 1-19 19 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Triphosphate
Herbivory
Herbal Medicine
Traditional Medicine
2015
239 Citations (Scopus)

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G., Apr 2015, In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Homeostasis
Phosphorylation
Physiological Stress
Lysosomes
2014
137 Citations (Scopus)
108 Downloads (Pure)

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

Hardie, D. G., Dec 2014, In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Salicylates
Metformin
Virus Diseases
Aspirin
98 Citations (Scopus)

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

Hardie, D. G., Jul 2014, In : Annual Review of Nutrition. 34, p. 31-55 25 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Kinases
Homeostasis
Adenosine Triphosphate
61 Citations (Scopus)
106 Downloads (Pure)

AMPK: a cellular energy sensor primarily regulated by AMP

Gowans, G. J. & Hardie, D. G., 1 Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Adenosine Triphosphate
Adenosine Diphosphate
Sensors
70 Citations (Scopus)

Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T. & Cowling, V. H., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 231-242 12 p.

Research output: Contribution to journalReview article

Gene expression
Gene Expression
Transcription
Messenger RNA
Processing
101 Citations (Scopus)

Caspase-1: The inflammasome and beyond

Sollberger, G., Strittmatter, G. E., Garstkiewicz, M., Sand, J. & Beer, H. D., 1 Feb 2014, In : Innate Immunity. 20, 2, p. 115-125 11 p.

Research output: Contribution to journalReview article

Open Access
File
Inflammasomes
Caspase 1
Caspase 7
Interleukin-18
Glycolysis
77 Citations (Scopus)

The balancing act of neutrophils

Bardoel, B. W., Kenny, E. F., Sollberger, G. & Zychlinsky, A., 14 May 2014, In : Cell Host and Microbe. 15, 5, p. 526-536 11 p.

Research output: Contribution to journalReview article

Neutrophils
Poisons
Infection
Autoimmune Diseases
2013
42 Citations (Scopus)

AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Salicylates
Pharmaceutical Preparations
Aspirin
Prostaglandin-Endoperoxide Synthases
2012
229 Citations (Scopus)
110 Downloads (Pure)

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

Hardie, D. G., Ross, F. A. & Hawley, S. A., 26 Oct 2012, In : Chemistry & Biology. 19, 10, p. 1222-36 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cyclic AMP-Dependent Protein Kinases
Metformin
Adenosine Triphosphate
Medical problems
1853 Citations (Scopus)
148 Downloads (Pure)

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A. & Hawley, S. A., 1 Apr 2012, In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Homeostasis
Adenosine Triphosphate
Food
Biosynthetic Pathways
23 Citations (Scopus)

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases

Leslie, N. R., Dixon, M. J., Schenning, M., Gray, A. & Batty, I. H., Jan 2012, In : Advances in Biological Regulation. 52, 1, p. 205-213 9 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)

The endosome-lysosome pathway and information generation in the immune system

Watts, C., Jan 2012, In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21 8 p.

Research output: Contribution to journalReview article

2011
112 Citations (Scopus)

AMP-activated protein kinase: also regulated by ADP?

Hardie, D. G., Carling, D. & Gamblin, S. J., Sep 2011, In : Trends in Biochemical Sciences. 36, 9, p. 470-477 8 p.

Research output: Contribution to journalReview article

876 Citations (Scopus)

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G., 15 Sep 2011, In : Genes & Development. 25, 18, p. 1895-1908 14 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)

Homeostasis in the vertebrate lens: mechanisms of solute exchange

Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M., 27 Apr 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277 13 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

Lipina, C. & Hundal, H. S., Jul 2011, In : Diabetologia. 54, 7, p. 1596-1607 12 p.

Research output: Contribution to journalReview article

2010
17 Citations (Scopus)

Myc regulation of mRNA cap methylation

Cowling, V. H. & Cole, M. D., Jun 2010, In : Genes and Cancer. 1, 6, p. 576-579 4 p.

Research output: Contribution to journalReview article

Methylation
myc Genes
Messenger RNA
RNA Polymerase II
Genes
6 Citations (Scopus)

Myc up-regulates formation of the mRNA methyl cap

Cowling, V. H., Dec 2010, In : Biochemical Society Transactions. 38, p. 1598-1601 4 p.

Research output: Contribution to journalReview article

71 Citations (Scopus)

Regulation of mRNA cap methylation

Cowling, V. H., 15 Jan 2010, In : Biochemical Journal. 425, p. 295-302 8 p.

Research output: Contribution to journalReview article

103 Citations (Scopus)

TLR signalling regulated antigen presentation in dendritic cells

Watts, C., West, M. A. & Zaru, R., Feb 2010, In : Current Opinion in Immunology. 22, 1, p. 124-130 7 p.

Research output: Contribution to journalReview article

2009
194 Citations (Scopus)

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

Hundal, H. S. & Taylor, P. M., Apr 2009, In : American Journal of Physiology, Endocrinology and Metabolism. 296, 4, p. E603-E613 11 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)

AMP-activated protein kinase: a sensor of glycogen as well as AMP and ATP?

McBride, A. & Hardie, D. G., May 2009, In : Acta Physiologica. 196, 1, p. 99-113 15 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)

Diverse regulatory roles for lysosomal proteases in the immune response

Colbert, J. D., Matthews, S. P., Miller, G. & Watts, C., Nov 2009, In : European Journal of Immunology. 39, 11, p. 2955-2965 11 p.

Research output: Contribution to journalReview article

2008
166 Citations (Scopus)

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease

Hardie, D. G., Tontonoz, P. (ed.) & Nagy, L. (ed.), 9 Jan 2008, In : FEBS Letters. 582, 1, p. 81-89 9 p.

Research output: Contribution to journalReview article

103 Citations (Scopus)

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D. & Cowling, V. H., Oct 2008, In : Nature Reviews Molecular Cell Biology. 9, 10, p. 810-815 6 p.

Research output: Contribution to journalReview article

2004
183 Citations (Scopus)

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

Watts, C., Jul 2004, In : Nature Immunology. 5, 7, p. 685-692 8 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

The intermediate filament systems in the eye lens

Der Perng, M., Sandilands, A., Kuszak, J., Dahm, R., Wegener, A., Prescott, A. R. & Quinlan, R. A., 1 Dec 2004, In : Methods in Cell Biology. 2004, 78, p. 597-624 28 p.

Research output: Contribution to journalReview article

2002
26 Citations (Scopus)

Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

Shi, Y-B., Ritchie, J. W. A. & Taylor, P. M., 2002, In : Pharmacology & Therapeutics. 94, 3, p. 235-251 17 p.

Research output: Contribution to journalReview article

1998
1187 Citations (Scopus)

The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?

Hardie, D. G., Carling, D. & Carlson, M., Jul 1998, In : Annual Review of Biochemistry. 67, p. 821-855 35 p.

Research output: Contribution to journalReview article

1992
10 Citations (Scopus)

T lymphocyte activation signals

Cantrell, D. A., Graves, J. D., Izquierdo, M., Lucas, S. & Downward, J., 1992, In : Ciba Foundation Symposium. 164, p. 208-218; discussion 218-222

Research output: Contribution to journalReview article

Lymphocyte Activation
Protein Kinase C
T-Lymphocytes
T-Cell Antigen Receptor
CD2 Antigens