Cell Signalling and Immunology

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Review article
2020

AMP-Activated Protein Kinase: Friend or Foe in Cancer

Vara-ciruelos, D., Dandapani, M. & Hardie, D. G., 4 Mar 2020, In : Annual Review of Cancer Biology. 4, p. 1-16 16 p.

Research output: Contribution to journalReview article

Open Access
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7 Downloads (Pure)

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

Evans, A. M. & Hardie, D. G., 15 May 2020, In : International Journal of Molecular Sciences. 21, 10, p. 1-28 28 p., 3518.

Research output: Contribution to journalReview article

Open Access
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AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control

González, A., Hall, M. N., Lin, S-C. & Hardie, G., 3 Mar 2020, In : Cell Metabolism. 31, 3, p. 472-492 21 p.

Research output: Contribution to journalReview article

Glucose Starvation Blocks Translation at Multiple Levels

Zhang, C. S., Hardie, D. G. & Lin, S. C., 4 Feb 2020, In : Cell Metabolism. 31, 2, p. 217-218 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2019

Interleukin-33 in the developing lung—Roles in asthma and infection

Johansson, K. & McSorley, H. J., Aug 2019, In : Pediatric Allergy and Immunology. 30, 5, p. 503-510 8 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Worms: Pernicious parasites or allies against allergies?

McSorley, H. J., Chayé, M. A. M. & Smits, H. H., Jun 2019, In : Parasite Immunology. 41, 6, p. 1-13 13 p., e12574.

Research output: Contribution to journalReview article

Open Access
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3 Citations (Scopus)
20 Downloads (Pure)
2018

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
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158 Citations (Scopus)
310 Downloads (Pure)

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G., Jan 2018, In : Journal of the Royal Society Interface. 15, 138, 23 p., 20170774.

Research output: Contribution to journalReview article

Open Access
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40 Citations (Scopus)
143 Downloads (Pure)

Mapping determinants of cytokine signaling via protein engineering

Gorby, C., Martinez-Fabregas, J., Wilmes, S. & Moraga Gonzalez, I., 27 Sep 2018, In : Frontiers in Immunology. 9, 9 p., 2143.

Research output: Contribution to journalReview article

Open Access
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141 Downloads (Pure)

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Maizels, R. M., Smits, H. H. & McSorley, H. J., 20 Nov 2018, In : Immunity. 49, 5, p. 801-818 18 p.

Research output: Contribution to journalReview article

Open Access
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23 Citations (Scopus)
20 Downloads (Pure)

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

Sollberger, G., Tilley, D. O. & Zychlinsky, A., 12 Mar 2018, In : Developmental Cell. 44, 5, p. 542-553 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)

The regulation of lymphocyte activation and proliferation

Heinzel, S., Marchingo, J. M., Horton, M. B. & Hodgkin, P. D., Apr 2018, In : Current Opinion in Immunology. 51, p. 32-38 7 p.

Research output: Contribution to journalReview article

Open Access
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16 Citations (Scopus)
171 Downloads (Pure)
2017

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Salt, I. P. & Hardie, D. G., 26 May 2017, In : Circulation Research. 120, 11, p. 1825-1841 17 p.

Research output: Contribution to journalReview article

Open Access
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49 Citations (Scopus)
104 Downloads (Pure)

AMP-activated protein kinase - not just an energy sensor

Hardie, D. G. & Lin, S-C., 22 Sep 2017, In : F1000 Research. 6, p. 1-11 11 p., 1724.

Research output: Contribution to journalReview article

Open Access
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33 Citations (Scopus)
150 Downloads (Pure)

Host-pathogen interactions and subversion of autophagy

McEwan, D. G., 12 Dec 2017, In : Essays in Biochemistry. 61, 6, p. 687-697 11 p.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
153 Downloads (Pure)

Lipid modulation of skeletal muscle mass and function

Lipina, C. & Hundal, H. S., Apr 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 2, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
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38 Citations (Scopus)
150 Downloads (Pure)

The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

Lipina, C. & Hundal, H. S., 27 Jan 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 91-103 13 p.

Research output: Contribution to journalReview article

Open Access
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3 Citations (Scopus)
164 Downloads (Pure)

The mechanisms of action of metformin

Rena, G., Hardie, D. G. & Pearson, E. R., Sep 2017, In : Diabetologia. 60, 9, p. 1577-1585 9 p.

Research output: Contribution to journalReview article

Open Access
File
292 Citations (Scopus)
257 Downloads (Pure)
2016

AMPK: an energy-sensing pathway with multiple inputs and outputs

Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In : Trends in Cell Biology. 26, 3, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
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300 Citations (Scopus)
305 Downloads (Pure)

Is REDD1 a Metabolic Éminence Grise?

Lipina, C. & Hundal, H., Dec 2016, In : Trends in Endocrinology and Metabolism. 27, 12, p. 868-880 13 p.

Research output: Contribution to journalReview article

Open Access
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18 Citations (Scopus)
145 Downloads (Pure)

Lectin receptors expressed on myeloid cells

Brown, G. D. & Crocker, P. R., 23 Sep 2016, In : Microbiology Spectrum. 4, 5, p. 1-26 26 p.

Research output: Contribution to journalReview article

Open Access
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17 Citations (Scopus)
347 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
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49 Citations (Scopus)
156 Downloads (Pure)

Regulation of AMP-activated protein kinase by natural and synthetic activators

Grahame Hardie, D., Jan 2016, In : Acta Pharmaceutica Sinica B. 6, 1, p. 1-19 19 p.

Research output: Contribution to journalReview article

Open Access
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61 Citations (Scopus)
1662 Downloads (Pure)
2015

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G., Apr 2015, In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

Research output: Contribution to journalReview article

243 Citations (Scopus)
2014

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

Hardie, D. G., Dec 2014, In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

Research output: Contribution to journalReview article

Open Access
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143 Citations (Scopus)
132 Downloads (Pure)

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

Hardie, D. G., Jul 2014, In : Annual Review of Nutrition. 34, p. 31-55 25 p.

Research output: Contribution to journalReview article

104 Citations (Scopus)

AMPK: a cellular energy sensor primarily regulated by AMP

Gowans, G. J. & Hardie, D. G., 1 Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

Research output: Contribution to journalReview article

Open Access
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63 Citations (Scopus)
127 Downloads (Pure)

Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T. & Cowling, V. H., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 231-242 12 p.

Research output: Contribution to journalReview article

75 Citations (Scopus)

Caspase-1: The inflammasome and beyond

Sollberger, G., Strittmatter, G. E., Garstkiewicz, M., Sand, J. & Beer, H. D., 1 Feb 2014, In : Innate Immunity. 20, 2, p. 115-125 11 p.

Research output: Contribution to journalReview article

Open Access
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106 Citations (Scopus)
39 Downloads (Pure)

Helminths and Immunological Tolerance

Johnston, C. J. C., McSorley, H. J., Anderton, S. M., Wigmore, S. J. & Maizels, R. M., 27 Jan 2014, In : Transplantation. 97, 2, p. 127-132 6 p.

Research output: Contribution to journalReview article

Open Access
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20 Citations (Scopus)
20 Downloads (Pure)

The balancing act of neutrophils

Bardoel, B. W., Kenny, E. F., Sollberger, G. & Zychlinsky, A., 14 May 2014, In : Cell Host and Microbe. 15, 5, p. 526-536 11 p.

Research output: Contribution to journalReview article

78 Citations (Scopus)
2013

AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

Research output: Contribution to journalReview article

44 Citations (Scopus)
2012

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

Hardie, D. G., Ross, F. A. & Hawley, S. A., 26 Oct 2012, In : Chemistry & Biology. 19, 10, p. 1222-36 15 p.

Research output: Contribution to journalReview article

Open Access
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236 Citations (Scopus)
133 Downloads (Pure)

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A. & Hawley, S. A., 1 Apr 2012, In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

Research output: Contribution to journalReview article

Open Access
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1934 Citations (Scopus)
176 Downloads (Pure)

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases

Leslie, N. R., Dixon, M. J., Schenning, M., Gray, A. & Batty, I. H., Jan 2012, In : Advances in Biological Regulation. 52, 1, p. 205-213 9 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)

The endosome-lysosome pathway and information generation in the immune system

Watts, C., Jan 2012, In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21 8 p.

Research output: Contribution to journalReview article

81 Citations (Scopus)
2011

AMP-activated protein kinase: also regulated by ADP?

Hardie, D. G., Carling, D. & Gamblin, S. J., Sep 2011, In : Trends in Biochemical Sciences. 36, 9, p. 470-477 8 p.

Research output: Contribution to journalReview article

114 Citations (Scopus)

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G., 15 Sep 2011, In : Genes & Development. 25, 18, p. 1895-1908 14 p.

Research output: Contribution to journalReview article

899 Citations (Scopus)

Homeostasis in the vertebrate lens: mechanisms of solute exchange

Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M., 27 Apr 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277 13 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

Lipina, C. & Hundal, H. S., Jul 2011, In : Diabetologia. 54, 7, p. 1596-1607 12 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)
2010

Myc regulation of mRNA cap methylation

Cowling, V. H. & Cole, M. D., Jun 2010, In : Genes and Cancer. 1, 6, p. 576-579 4 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Myc up-regulates formation of the mRNA methyl cap

Cowling, V. H., Dec 2010, In : Biochemical Society Transactions. 38, p. 1598-1601 4 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Regulation of mRNA cap methylation

Cowling, V. H., 15 Jan 2010, In : Biochemical Journal. 425, p. 295-302 8 p.

Research output: Contribution to journalReview article

75 Citations (Scopus)

TLR signalling regulated antigen presentation in dendritic cells

Watts, C., West, M. A. & Zaru, R., Feb 2010, In : Current Opinion in Immunology. 22, 1, p. 124-130 7 p.

Research output: Contribution to journalReview article

104 Citations (Scopus)
2009

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

Hundal, H. S. & Taylor, P. M., Apr 2009, In : American Journal of Physiology, Endocrinology and Metabolism. 296, 4, p. E603-E613 11 p.

Research output: Contribution to journalReview article

197 Citations (Scopus)

AMP-activated protein kinase: a sensor of glycogen as well as AMP and ATP?

McBride, A. & Hardie, D. G., May 2009, In : Acta Physiologica. 196, 1, p. 99-113 15 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)

Diverse regulatory roles for lysosomal proteases in the immune response

Colbert, J. D., Matthews, S. P., Miller, G. & Watts, C., Nov 2009, In : European Journal of Immunology. 39, 11, p. 2955-2965 11 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)
2008

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease

Hardie, D. G., Tontonoz, P. (ed.) & Nagy, L. (ed.), 9 Jan 2008, In : FEBS Letters. 582, 1, p. 81-89 9 p.

Research output: Contribution to journalReview article

166 Citations (Scopus)

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D. & Cowling, V. H., Oct 2008, In : Nature Reviews Molecular Cell Biology. 9, 10, p. 810-815 6 p.

Research output: Contribution to journalReview article

104 Citations (Scopus)
2004

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

Watts, C., Jul 2004, In : Nature Immunology. 5, 7, p. 685-692 8 p.

Research output: Contribution to journalReview article

186 Citations (Scopus)