Cellular Medicine

Research Output

2020

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., Jan 2020, In : Redox Biology. 28, p. 1-15 15 p., 101321.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
68 Downloads (Pure)

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 23 Mar 2020, In : EMBO Journal. p. 1-16 16 p., e103180.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Mode of presentation and skin thickening on ultrasound may predict nodal burden in breast cancer patients with a positive axillary core biopsy

Choong, W. L., Evans, A., Purdie, C., Wang, H., Donnan, P. T., Lawson, B. & Macaskill, J., Apr 2020, In : British Journal of Radiology. 93, 1108, p. 1-7 7 p., 20190711.

Research output: Contribution to journalArticle

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., 20 Mar 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
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5 Downloads (Pure)
2019

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In : Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
105 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In : Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
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55 Downloads (Pure)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer

Al-hattali, S., Vinnicombe, S. J., Gowdh, N. M., Evans, A., Armstrong, S., Adamson, D., Purdie, C. A. & Macaskill, E. J., 26 Dec 2019, In : Cancer Imaging. 19, 1, p. 1-9 9 p., 91.

Research output: Contribution to journalArticle

Open Access
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31 Downloads (Pure)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
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4 Citations (Scopus)
136 Downloads (Pure)

Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes

Akentieva, N. P., Sanina, N. A., Gizatullin, A. R., Shkondina, N. I., Prikhodchenko, T. R., Shram, S. I., Zhelev, N. & Aldoshin, S. M., 11 Nov 2019, In : Frontiers in Pharmacology. 10, p. 1-10 21 p., 1277.

Research output: Contribution to journalArticle

Open Access
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DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A-L., La, H. M., Rossello, F. J., Änkö, M-L., Fuller-Pace, F. V. & Hobbs, R. M., 23 May 2019, In : Nature Communications. 10, 1, p. 1-21 21 p., 2278.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
92 Downloads (Pure)

Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

Elabd, S., Jabeen, N. A., Gerber, V., Peravali, R., Bourdon, J-C., Kancherla, S., Vallone, D. & Blattner, C., 19 Jul 2019, In : PLoS ONE. 14, 7, p. 1-18 18 p., e0220069.

Research output: Contribution to journalArticle

Open Access
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Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
124 Downloads (Pure)

Dual-specificity MAP kinase phosphatases in health and disease

Seternes, O-M., Kidger, A. M. & Keyse, S., 1 Jan 2019, In : BBA - Molecular Cell Research. 1866, 1, p. 124-143 20 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
158 Downloads (Pure)

Editorial: Metformin: Beyond Diabetes

Bost, F., Rena, G. & Viollet, B., 6 Dec 2019, In : Frontiers in endocrinology. 10, p. 1-3 3 p., 851.

Research output: Contribution to journalArticle

Open Access
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28 Downloads (Pure)

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

Atanasova, V. S., Pourreyron, C., Farshchian, M., Lawler, M. E., Brown, C. A., Watt, S., Wright, S., Warkala, M., Guttmann-Gruber, C., Pinon-Hofbauer, J., Fuentes, I., Prisco, M., Rashidghamat, E., Has, C., Salas-Alanis, J. C., Palisson, F., Hovnanian, A., McGrath, J. A., Mellerio, J., Bauer, J. W. & 1 others, South, A. P., Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
14 Downloads (Pure)

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Banerjee, S., Wei, T., Wang, J., Lee, J. J., Gutierrez, H. L., Chapman, O., Wiley, S. E., Mayfield, J. E., Tandon, V., Juarez, E. F., Chavez, L., Liang, R., Sah, R. L., Costello, C., Mesirov, J. P., de la Vega, L., Cooper, K. L., Dixon, J. E., Xiao, J. & Lei, X., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24881-24891 11 p.

Research output: Contribution to journalArticle

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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
98 Downloads (Pure)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
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45 Downloads (Pure)
Open Access
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1 Citation (Scopus)
119 Downloads (Pure)

New developments for prevention of type 1 diabetes: a paradigm shift?

Schofield, C. & Sutherland, C., 2 Jan 2019, In : British Journal of Hospital Medicine. 80, 1, p. 4-5 2 p.

Research output: Contribution to journalEditorial

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

Open Access
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2 Citations (Scopus)
33 Downloads (Pure)

Paracetamol-induced liver injury modelled in Xenopus laevis embryos

Saide, K., Sherwood, V. & Wheeler, G. N., 1 Mar 2019, In : Toxicology Letters. 302, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
131 Downloads (Pure)

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2

Morrugares, R., Correa-Sáez, A., Moreno Dorta, R., Garrido-Rodríguez, M., Muñoz, E., de la Vega, L. & Calzado, M. A., 11 Oct 2019, In : Cellular and Molecular Life Sciences. 19 p.

Research output: Contribution to journalArticle

Open Access
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67 Downloads (Pure)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
57 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
61 Downloads (Pure)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
185 Downloads (Pure)

Preoperative prediction of margin requirement following a core biopsy result suggestive of a phyllodes tumour

Mberu, V., Macaskill, E. J., Purdie, C. & Evans, A., 17 Dec 2019, In : Clinical Radiology. 7 p.

Research output: Contribution to journalArticle

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
76 Downloads (Pure)

The circular RNome of primary breast cancer

Smid, M., Wilting, S. M., Uhr, K., Rodríguez-González, F. G., De Weerd, V., Prager-Van Der Smissen, W. J. C., Van Der Vlugt-Daane, M., Van Galen, A., Nik-Zainal, S., Butler, A., Martin, S., Davies, H. R., Staaf, J., Van De Vijver, M. J., Richardson, A. L., MacGrogan, G., Salgado, R., Van Den Eynden, G. G. G. M., Purdie, C. A., Thompson, A. M. & 21 others, Caldas, C., Span, P. N., Sweep, F. C. G. J., Simpson, P. T., Lakhani, S. R., Van Laere, S., Desmedt, C., Paradiso, A., Eyfjord, J., Broeks, A., Vincent-Salomon, A., Futreal, A. P., Knappskog, S., King, T., Viari, A., Børresen-Dale, A. L., Stunnenberg, H. G., Stratton, M., Foekens, J. A., Sieuwerts, A. M. & Martens, J. W. M., 1 Mar 2019, In : Genome Research. 29, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases

Anbarasan, T. & Bourdon, J-C., 11 Dec 2019, In : International Journal of Molecular Sciences. 20, 24, p. 1-20 20 p., 6257.

Research output: Contribution to journalReview article

Open Access
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The enemy within: Designing a cell-based gameplay system for cancer education

Sloan, R. J. S. & Saurin, A., 17 Oct 2019, CHI PLAY '19: Extended Abstracts of the Annual Symposium on Computer-Human Interaction in Play. New York: Association for Computing Machinery, p. 117-123 7 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

McHugh, A., Fernandes, K., Chinner, N., Ibrahim, A. F. M., Garg, A. K., Boag, G., Hepburn, L. A., Proby, C. M., Leigh, I. M. & Saville, M. K., 6 Nov 2019, In : Journal of Investigative Dermatology. 17 p.

Research output: Contribution to journalArticle

Open Access
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The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T. R. J., Barry, S. T., Sansom, O. J., Kocher, H. M. & 1 others, Marshall, J. F., 1 Jul 2019, In : Journal of Pathology. 11 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
76 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
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The non-structural NS1 protein of influenza viruses modulates TP53 splicing through the host factor CPSF4

Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J-C., Marcel, V., Boivin, G., Rosa-Calatrava, M. & Terrier, O., Mar 2019, In : Journal of Virology. 93, 7, p. 1-19 19 p., e02168-18.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
150 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
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87 Citations (Scopus)
136 Downloads (Pure)

What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?

Hayman, L., Chaudhry, W. R., Revin, V. V., Zhelev, N. & Bourdon, J-C., Feb 2019, In : Expert Review of Molecular Diagnostics. 19, 2, p. 149-159 11 p.

Research output: Contribution to journalReview article

Open Access
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1 Citation (Scopus)
48 Downloads (Pure)

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers

Liu, Y., Nekulova, M., Nenutil, R., Horakova, I., Appleyard, M. V., Murray, K., Holcakova, J., Galoczova, M., Quinlan, P., Jordan, L. B., Purdie, C. A., Vojtesek, B., Thompson, A. M. & Coates, P. J., 7 Oct 2019, In : Journal of Pathology: Clinical Research. 11 p.

Research output: Contribution to journalArticle

Open Access
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27 Downloads (Pure)
2018

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
127 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
129 Downloads (Pure)

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E. & Guo, X., 7 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. 8155-8160 6 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
4 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
151 Downloads (Pure)

Correction: The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth

Hanson, K., Robinson, S. D., Al-Yousuf, K., Hendry, A. E., Sexton, D. W., Sherwood, V. & Wheeler, G. N., 27 Nov 2018, In : Oncotarget. 9, 93, p. 36645 1 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
80 Downloads (Pure)

Cutaneous immunohistochemical staining pattern of p53β isoforms

Ko, C. J., Myung, P., Leffell, D. J. & Bourdon, J-C., Dec 2018, In : Journal of Clinical Pathology. 71, 12, p. 1120-1122 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Deficiency in Protein Tyrosine Phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegović, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 14 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
99 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
148 Downloads (Pure)