Cellular Medicine

Research Output 1984 2019

2019
2 Citations (Scopus)
40 Downloads (Pure)

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In : Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cross-Over Studies
Tobacco
Blood Vessels
Healthy Volunteers
Smoking
1 Citation (Scopus)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

Genome
Breast Neoplasms
Mutation

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., 5 Sep 2019, In : Redox Biology. 101321.

Research output: Contribution to journalArticle

Open Access
Cannabidiol
Keratinocytes
Antioxidants
Heme Oxygenase-1
Skin
21 Downloads (Pure)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A-L., La, H. M., Rossello, F. J., Änkö, M-L., Fuller-Pace, F. V. & Hobbs, R. M., 23 May 2019, In : Nature Communications. 10, 1, p. 1-21 21 p., 2278.

Research output: Contribution to journalArticle

Open Access
File
spermatogenesis
Spermatogonia
maintenance
Spermatogenesis
Genes
12 Downloads (Pure)

Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

Elabd, S., Jabeen, N. A., Gerber, V., Peravali, R., Bourdon, J-C., Kancherla, S., Vallone, D. & Blattner, C., 19 Jul 2019, In : PLoS ONE. 14, 7, 18 p., e0220069.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Cell proliferation
Zebrafish
Stem cells
Danio rerio
1 Citation (Scopus)
49 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Centromere
Protein Isoforms
Personnel
M Phase Cell Cycle Checkpoints
4 Citations (Scopus)
89 Downloads (Pure)

Dual-specificity MAP kinase phosphatases in health and disease

Seternes, O-M., Kidger, A. M. & Keyse, S., 1 Jan 2019, In : BBA - Molecular Cell Research. 1866, 1, p. 124-143 20 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphotransferases
Health
MAP Kinase Signaling System
Genetic Models

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Fenretinide
Phenotype
Dipeptidyl Peptidase 4
Glucose
Retinol-Binding Proteins

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

Atanasova, V. S., Pourreyron, C., Farshchian, M., Lawler, M. E., Brown, C. A., Watt, S., Wright, S., Warkala, M., Guttmann-Gruber, C., Pinon-Hofbauer, J., Fuentes, I., Prisco, M., Rashidghamat, E., Has, C., Salas-Alanis, J. C., Palisson, F., Hovnanian, A., McGrath, J. A., Mellerio, J., Bauer, J. W. & 1 others, South, A. P., Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Squamous Cell Carcinoma
Therapeutics
Skin
ON 01910
1 Citation (Scopus)
48 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
Hairless Mouse
histone deacetylase
Histone Deacetylase Inhibitors
squamous cell carcinoma
Squamous Cell Carcinoma
1 Citation (Scopus)
49 Downloads (Pure)
Open Access
File
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Transcription Factors
Proteins
Assays

New developments for prevention of type 1 diabetes: a paradigm shift?

Schofield, C. & Sutherland, C., 2 Jan 2019, In : British Journal of Hospital Medicine. 80, 1, p. 4-5 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
76 Downloads (Pure)

Paracetamol-induced liver injury modelled in Xenopus laevis embryos

Saide, K., Sherwood, V. & Wheeler, G. N., 1 Mar 2019, In : Toxicology Letters. 302, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access
File
Xenopus laevis
Acetaminophen
Liver
Embryonic Structures
Wounds and Injuries
7 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphorylation
Behavior Control
Phosphoprotein Phosphatases
2 Citations (Scopus)
114 Downloads (Pure)

Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor B superfamily type 1 receptors

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
LY-2157299
Bone Morphogenetic Proteins
Growth Factor Receptors
Activin Receptors
13 Downloads (Pure)

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Lithium
Biomarkers
Alzheimer Disease
Clinical Trials
Cognitive Dysfunction
3 Citations (Scopus)

The circular RNome of primary breast cancer

Smid, M., Wilting, S. M., Uhr, K., Rodríguez-González, F. G., De Weerd, V., Prager-Van Der Smissen, W. J. C., Van Der Vlugt-Daane, M., Van Galen, A., Nik-Zainal, S., Butler, A., Martin, S., Davies, H. R., Staaf, J., Van De Vijver, M. J., Richardson, A. L., MacGrogan, G., Salgado, R., Van Den Eynden, G. G. G. M., Purdie, C. A., Thompson, A. M. & 21 others, Caldas, C., Span, P. N., Sweep, F. C. G. J., Simpson, P. T., Lakhani, S. R., Van Laere, S., Desmedt, C., Paradiso, A., Eyfjord, J., Broeks, A., Vincent-Salomon, A., Futreal, A. P., Knappskog, S., King, T., Viari, A., Børresen-Dale, A. L., Stunnenberg, H. G., Stratton, M., Foekens, J. A., Sieuwerts, A. M. & Martens, J. W. M., 1 Mar 2019, In : Genome Research. 29, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
RNA
circular RNA
Aromatase Inhibitors
Computer Simulation
12 Downloads (Pure)

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T. R. J., Barry, S. T., Sansom, O. J., Kocher, H. M. & 1 others, Marshall, J. F., 1 Jul 2019, In : Journal of Pathology. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pancreatic Neoplasms
Integrins
Adenocarcinoma
Therapeutics
Growth
34 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
File
Sirolimus
Histone Deacetylases
Phosphorylation
NF-E2 Transcription Factor
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)
87 Downloads (Pure)

The non-structural NS1 protein of influenza viruses modulates TP53 splicing through the host factor CPSF4

Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J-C., Marcel, V., Boivin, G., Rosa-Calatrava, M. & Terrier, O., Mar 2019, In : Journal of Virology. 93, 7, p. 1-19 19 p., e02168-18.

Research output: Contribution to journalArticle

Open Access
File
Cleavage And Polyadenylation Specificity Factor
Integration Host Factors
Influenza A virus
Orthomyxoviridae
alternative splicing
19 Citations (Scopus)
49 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
Chronic Disease
NF-E2-Related Factor 2
Ubiquitin-Protein Ligases
Cytoprotection
Neurodegenerative Diseases

What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?

Hayman, L., Chaudhry, W. R., Revin, V. V., Zhelev, N. & Bourdon, J-C., Feb 2019, In : Expert Review of Molecular Diagnostics. 19, 2, p. 149-159 11 p.

Research output: Contribution to journalReview article

Protein Isoforms
Biomarkers
Neoplasms
Oncogenes
Regeneration
2018
4 Citations (Scopus)
58 Downloads (Pure)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacokinetics
Neoplasms
Cell Membrane Permeability
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
8 Citations (Scopus)
65 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
File
Pentoses
Pentose Phosphate Pathway
Macrophages
Hypercholesterolemia
Metabolism
3 Citations (Scopus)
80 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Mitosis
Degradation
Ubiquitin-Protein Ligases
Isoleucine
47 Downloads (Pure)

Correction: The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth

Hanson, K., Robinson, S. D., Al-Yousuf, K., Hendry, A. E., Sexton, D. W., Sherwood, V. & Wheeler, G. N., 27 Nov 2018, In : Oncotarget. 9, 93, p. 36645 1 p.

Research output: Contribution to journalArticle

Open Access
File
leflunomide
Antirheumatic Agents
Mitogen-Activated Protein Kinase Kinases
Melanoma
Growth

Cutaneous immunohistochemical staining pattern of p53β isoforms

Ko, C. J., Myung, P., Leffell, D. J. & Bourdon, J-C., Dec 2018, In : Journal of Clinical Pathology. 71, 12, p. 1120-1122 3 p.

Research output: Contribution to journalArticle

Protein Isoforms
Staining and Labeling
Skin
Cytoplasm
Mutation
4 Citations (Scopus)
40 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegović, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 14 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
1 Citation (Scopus)
66 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
1 Citation (Scopus)

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Localized Scleroderma
Fibroblasts
Myofibroblasts
Transforming Growth Factors
Therapeutics
53 Downloads (Pure)

Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes

Nguyen Van Long, F., Lardy-Cleaud, A., Bray, S., Chabaud, S., Dubois, T., Diot, A., Thompson, A. M., Bourdon, J-C., Perol, D., Bouvet, P., Diaz, J-J. & Marcel, V., 22 Oct 2018, In : Cancers. 10, 10, p. 1-11 11 p., 390.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Breast Neoplasms
Triple Negative Breast Neoplasms
Messenger RNA
Neoplasms

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., Prichodchenko, T. R., Zhelev, N. & Aldoshin, S. M., Nov 2018, In : Doklady Biochemistry and Biophysics. 483, 1, p. 337-340 4 p.

Research output: Contribution to journalArticle

Fibroblasts
Cell Survival
Iron Compounds
Mitochondrial Membrane Potential
Sulfur

Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193)

Huang, W., Thomas, B., Flynn, R. A., Gavzy, S. J., Wu, L., Kim, S. V., Hall, J. A., Miraldi, E. R., Ng, C. P., Rigo, F., Meadows, S., Montoya, N. R., Herrera, N. G., Domingos, A. I., Rastinejad, F., Myers, R. M., Fuller-Pace, F. V., Bonneau, R., Chang, H. Y., Acuto, O. & 1 others, Littman, D. R., 4 Oct 2018, In : Nature. 562, 7725, 1 p.

Research output: Contribution to journalComment/debate

Long Noncoding RNA
Th17 Cells
History

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

Tilmant, K., Gerets, H., De Ron, P., Hanon, E., Bento-Pereira, C. & Atienzar, F. A., 1 Oct 2018, In : Toxicology in Vitro. 52, p. 374-383 10 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Energy Metabolism
Screening
Poisons
Pharmaceutical Preparations
10 Citations (Scopus)
51 Downloads (Pure)

Kinase and Phosphatase Cross-Talk at the Kinetochore

Saurin, A. T., 19 Jun 2018, In : Frontiers in Cell and Developmental Biology. 6, p. 1-23 23 p., 62.

Research output: Contribution to journalReview article

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphotransferases
Enzymes
M Phase Cell Cycle Checkpoints
7 Citations (Scopus)
57 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Huntington Disease
Animal Behavior
Aberrations
Visual Cortex
4 Citations (Scopus)
78 Downloads (Pure)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

Open Access
File
isothiocyanates
heat stress
transcription factors
Vegetables
Glucosinolates
5 Citations (Scopus)
59 Downloads (Pure)

Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI

Evans, A., Whelehan, P., Thompson, A., Purdie, C., Jordan, L., Macaskill, J., Waugh, S., Fuller-Pace, F., Brauer, K. & Vinnicombe, S., Aug 2018, In : European Journal of Ultrasound. 39, 04, p. 422-431 10 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Magnetic Resonance Imaging
Breast Neoplasms
Drug Therapy
Sensitivity and Specificity
2 Citations (Scopus)
55 Downloads (Pure)

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S. & Pharoah, P., 1 Jun 2018, In : Breast Cancer Research and Treatment. 171, 2, p. 383-389 7 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Breast Neoplasms
Survival
Biopsy
Neoplasms
1 Citation (Scopus)
46 Downloads (Pure)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 22 May 2018, In : Nature Communications. 9, 1, p. 2071 2071.

Research output: Contribution to journalArticle

Open Access
File
document markup languages
inhibitors
Publications
Tumors
tumors
1 Citation (Scopus)

The collagen prolyl hydroxylases are bifunctional growth regulators in melanoma

Atkinson, A., Renziehausen, A., Wang, H., Nigro, C. L., Lattanzio, L., Merlano, M., Rao, B., Weir, L., Evans, A., Matin, R., Harwood, C., Szlosarek, P., Pickering, J. G., Fleming, C., Sim, V. R., Li, S., Vasta, J. T., Raines, R. T., Boniol, M., Thompson, A. & 3 others, Proby, C., Crook, T. & Syed, N., 16 Nov 2018, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Melanoma
Collagen
Growth
Tumors
17 Citations (Scopus)
71 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
Azathioprine
Tumors
tumors
signatures
Skin
1 Citation (Scopus)
58 Downloads (Pure)

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

Research output: Contribution to journalArticle

Open Access
File
Polyomavirus
Squamous Cell Carcinoma
Skin
Mutation
Warts
22 Citations (Scopus)
125 Downloads (Pure)

The role of Nrf2 signaling in counteracting neurodegenerative diseases

Dinkova-Kostova, A. T., Kostov, R. V. & Kazantsev, A. G., 1 Oct 2018, In : FEBS Journal. 285, 19, p. 3576-3590 15 p.

Research output: Contribution to journalReview article

Open Access
File
Neurodegenerative diseases
Neurodegenerative Diseases
Antioxidants
Detoxification
NF-E2 Transcription Factor
59 Downloads (Pure)

Timed degradation of Mcl-1 controls mitotic cell death

Clarke, P. R., Allan, L. A. & Skowyra, A., 2 Nov 2018, In : Molecular and Cellular Oncology. 5, 6, p. 1-4 4 p., e1516450.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Proteasome Endopeptidase Complex
Ubiquitin
Mitosis
Proteolysis
3 Citations (Scopus)
Cullin Proteins
NF-E2-Related Factor 2
Zinc
Transcription Factors
Switches
2017
3 Citations (Scopus)
47 Downloads (Pure)

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKa pathway

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. & Delibegovic, M., Jun 2017, In : Molecular Metabolism. 6, 8, p. 845-853

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Apolipoproteins E
Atherosclerotic Plaques
Interleukin-10
Atherosclerosis
6 Citations (Scopus)
8 Downloads (Pure)

Pharamcological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in LDLR-/- mouse model of atherosclerosis

Thompson, D., Morrice, N., Grant, L., Lees, E. K., Mody, N., Wilson, H. & Delibegovic, M., 29 Sep 2017, In : Clinical Science. 131, 20, p. 2489-2501

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Atherosclerotic Plaques
Atherosclerosis
Insulin Receptor
Cardiovascular Diseases