Cellular Medicine

Research Output 1984 2020

1984
64 Citations (Scopus)

Genetic recombination can generate altered restriction specificity

Fuller-Pace, F. V., Bullas, L. R., Delius, H. & Murray, N. E., 1 Oct 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 19 I, p. 6095-6099 5 p.

Research output: Contribution to journalArticle

Open Access
Genetic Recombination
Salmonella
Conserved Sequence
Genes
Heteroduplex Analysis
1985
58 Citations (Scopus)

EcoA and EcoE: Alternatives to the EcoK family of type I restriction and modification systems of Escherichia coli

Fuller-Pace, F. V., Cowan, G. M. & Murray, N. E., 5 Nov 1985, In : Journal of Molecular Biology. 186, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

DNA Restriction-Modification Enzymes
Escherichia coli
Genes
Peptides
Type I Site Specific Deoxyribonucleases
1986
62 Citations (Scopus)
Type I Site Specific Deoxyribonucleases
Peptides
DNA
Genes
Salmonella typhimurium
1987
43 Citations (Scopus)

Analysis of the genomic l rna segment from lymphocytic choriomeningitis virus

Singh, M. K., Fuller-Pace, F. V., Buchmeier, M. J. & Southern, P. J., 1 Dec 1987, In : Virology. 161, 2, p. 448-456 9 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Proteins
Reassortant Viruses
Arenavirus
1988
36 Citations (Scopus)

Distribution and diversity of hsd genes in Escherichia coli and other enteric bacteria.

Daniel, A. S., Fuller-Pace, F. V., Legge, D. M. & Murray, N. E., 1 Apr 1988, In : Journal of Bacteriology. 170, 4, p. 1775-1782 8 p.

Research output: Contribution to journalArticle

Enterobacteriaceae
Citrobacter freundii
Escherichia coli
DNA Restriction-Modification Enzymes
Genes
18 Citations (Scopus)

Temporal analysis of transcription and replication during acute infection with lymphocytic choriomeningitis virus

Fuller-Pace, F. V. & Southern, P. J., 1 Jan 1988, In : Virology. 162, 1, p. 260-263 4 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Nucleoproteins
Infection
RNA Precursors

The role of the viral polymerase in acute and persistent lcmv infection

Fuller-Pace, F. V. & Southern, P. J., 1 Sep 1988, In : Virus Research. 11, SUPPL. 1, p. 35 1 p.

Research output: Contribution to journalArticle

1989
26 Citations (Scopus)
RNA-directed RNA polymerase
Lymphocytic choriomeningitis virus
RNA Replicase
Viral RNA
Cell Extracts
20 Citations (Scopus)

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Williams, R. J., McCarthy, A. D. & Sutherland, C. D., 8 Jun 1989, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1003, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Esterification
Sterol O-Acyltransferase
Rats
Cholesterol
Enterocytes
1990
10 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
Serine
Protein Kinase C
210 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
AMP-Activated Protein Kinases
Liver
Rats
Enzymes
1991
4 Citations (Scopus)

Adenosine Monophosphate-Activated Protein Kinase: Hydroxymethylglutaryl-CoA Reductase Kinase

Carling, D., Clarke, P. R. & Hardie, D. G., 1 Jan 1991, In : Methods in Enzymology. 200, C, p. 362-371 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
Adenosine Monophosphate
Protein Kinases
Phosphotransferases
Acetyl-CoA Carboxylase
43 Citations (Scopus)

Regulation of p34cdc2 protein kinase: New insights into protein phosphorylation and the cell cycle

Clarke, P. R. & Karsenti, E., Nov 1991, In : Journal of Cell Science. 100, 3, p. 409-414 6 p.

Research output: Contribution to journalComment/debate

1992

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

Hoffmann, I., Clarke, P., Karsenti, E. & Draetta, G., 1 Jan 1992, In : Biology of the Cell. 76, 2, p. 213 1 p.

Research output: Contribution to journalArticle

Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 19, 1 p.

Research output: Contribution to journalComment/debate

86 Citations (Scopus)

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

MACKINTOSH, R. W., DAVIES, S. P., CLARKE, P. R., WEEKES, J., GILLESPIE, J. G., GIBB, B. J. & HARDIE, D. G., 1 Jan 1992, In : European Journal of Biochemistry. 209, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Oxidoreductases
Phosphotransferases
Terpenes
Enzymes
30 Citations (Scopus)

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 9, p. 6183-6187 5 p.

Research output: Contribution to journalArticle

Cyclin B
Cyclin A
Membrane Fusion
Phosphotransferases
Fusion reactions
496 Citations (Scopus)

Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. & Williams, L. T., 1 Aug 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 15, p. 6896-6900 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Dermis
Wound Healing
Fibroblast Growth Factor Receptors
Fibroblast Growth Factor 2
1993
138 Citations (Scopus)

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

Hope, A. G., Downie, D. L., Sutherland, L. A., Lambert, J. J., Peters, J. A. & Burchell, B., 15 Apr 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 245, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Organism Cloning
Clone Cells
Hybridomas
Alternative Splicing
146 Citations (Scopus)

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts

Clarke, P. R., Hoffmann, I., Draetta, G. & Karsenti, E., 1 Apr 1993, In : Molecular Biology of the Cell. 4, 4, p. 397-411 15 p.

Research output: Contribution to journalArticle

Cyclin B
Protein Phosphatase 2
Xenopus
Ovum
Cell Cycle
15 Citations (Scopus)

Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase

Davies, S. J., D'Sousa, R., Philips, H., Mattey, D., Hiley, C., Hayes, J. D., Aber, G. M. & Strange, R. C., 11 Jun 1993, In : Biochimica et Biophysica Acta: General Subjects. 1157, 2, p. 204-8 5 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
Glutathione Transferase
Superoxide Dismutase
Kidney
Mesangial Cells
535 Citations (Scopus)

Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G., 1 Dec 1993, In : EMBO Journal. 12, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

Cyclin B
Phosphorylation
Mitosis
Amplification
Chemical activation
66 Citations (Scopus)

Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia

Chu, A., Dinkova, A., Davin, L. B., Bedgar, D. L. & Lewis, N. G., 25 Dec 1993, In : Journal of Biological Chemistry. 268, 36, p. 27026-27033 8 p.

Research output: Contribution to journalArticle

Forsythia
NADP
Hydrides
Lignans
Ether
1994
149 Citations (Scopus)

RNA helicases: modulators of RNA structure

Fuller-Pace, F. V., Aug 1994, In : Trends in Cell Biology. 4, 8, p. 271-274 4 p.

Research output: Contribution to journalArticle

RNA Helicases
RNA
Proteins
Ribonucleoproteins
Adenosine Triphosphate
42 Citations (Scopus)

Signal Transduction: Switching off MAP kinases

Clarke, P. R., 1 Jan 1994, In : Current Biology. 4, 7, p. 647-650 4 p.

Research output: Contribution to journalArticle

Signal transduction
mitogen-activated protein kinase
signal transduction
Signal Transduction
Phosphotransferases
1995
23 Citations (Scopus)

Cyclin-Dependent Kinases: CAK-handed kinase activation

Clarke, P. R., 1 Jan 1995, In : Current Biology. 5, 1, p. 40-42 3 p.

Research output: Contribution to journalArticle

Open Access
cyclin-dependent kinase
Cyclin-Dependent Kinases
phosphotransferases (kinases)
Phosphotransferases
Chemical activation

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Hoffmann, I., Clarke, P. R. & Draetta, G., 1 Jan 1995, In : Advances in Molecular and Cell Biology. 13, C, p. 151-164 14 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Cyclin B
Eukaryotic Cells
Biochemistry
Cell Cycle
1996
156 Citations (Scopus)

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia: Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase

Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A. & Lewis, N. G., 26 Nov 1996, In : Journal of Biological Chemistry. 271, 46, p. 29473-29482 10 p.

Research output: Contribution to journalArticle

Open Access
vestitone reductase
Forsythia
Lignans
Cloning
Purification
46 Citations (Scopus)

Apoptosis: Does stress kill?

Cosulich, S. & Clarke, P., 1 Jan 1996, In : Current Biology. 6, 12, p. 1586-1588 3 p.

Research output: Contribution to journalArticle

Open Access
Heat-Shock Proteins
Protein Kinases
Cell Death
apoptosis
Apoptosis
50 Citations (Scopus)

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, S. C., Green, S. & Clarke, P. R., 1 Aug 1996, In : Current Biology. 6, 8, p. 997-1005 9 p.

Research output: Contribution to journalArticle

cell free system
Cell-Free System
Peptide Hydrolases
proteinases
Chemical activation
38 Citations (Scopus)

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

Le Romancer, M., Cosulich, S. C., Jackson, S. P. & Clarke, P. R., 1 Dec 1996, In : Journal of Cell Science. 109, 13, p. 3121-3127 7 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Xenopus
Ovum
Catalytic Domain
DNA Cleavage
351 Citations (Scopus)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Phosphotransferases
Enzymes
Dual Specificity Phosphatase 1
Mitogen-Activated Protein Kinase 8

Nuclear proenkephalin induces cell death in a P53 dose-dependent manner

Devvar, D. A., Spraggon, C., Midgeley, C., Lane, D., Prescott, A. & Spruce, B. A., 1 Nov 1996, In : Biochemical Society Transactions. 24, 4, p. 571S 1 p., E51.

Research output: Contribution to journalArticle

Cell death
Cell Death
Fibroblasts
Cells
Secretory Pathway
1997
67 Citations (Scopus)

Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis

Cosulich, S. C., Horiuchi, H., Zerial, M., Clarke, P. R. & Woodman, P. G., 5 Nov 1997, In : EMBO Journal. 16, 20, p. 6182-6191 10 p.

Research output: Contribution to journalArticle

Endosomes
Fusion reactions
Apoptosis
Membranes
Cytophagocytosis
31 Citations (Scopus)

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

Gang, D. R., Dinkova-Kostova, A. T., Davin, L. B. & Lewis, N. G., 1 Dec 1997, In : ACS Symposium Series. 658, p. 58-89 32 p.

Research output: Contribution to journalArticle

vestitone reductase
Lignans
Oxidoreductases
Phosphorylation
Pathogens
155 Citations (Scopus)

Regulation of apoptosis by BH3 domains in a cell-free system

Cosulich, S. C., Worrall, V., Hedge, P. J., Green, S. & Clarke, P. R., 1 Dec 1997, In : Current Biology. 7, 12, p. 913-920 8 p.

Research output: Contribution to journalArticle

Open Access
cell free system
Cell-Free System
sequence homology
apoptosis
Apoptosis
26 Citations (Scopus)

Xenopus Ran-binding protein 1: Molecular interactions and effects on nuclear assembly in Xenopus egg extracts

Nicolas, F. J., Zhang, C., Hughes, M., Goldberg, M. W., Watton, S. J. & Clarke, P. R., 1 Dec 1997, In : Journal of Cell Science. 110, 24, p. 3019-3030 12 p.

Research output: Contribution to journalArticle

Karyopherins
Xenopus
Ovum
Cell Nucleus Active Transport
Nuclear Pore Complex Proteins
1998
171 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Superoxides
ferulic acid
Enzymes
Carbon Monoxide
1999
95 Citations (Scopus)

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, E., Savory, P., Cosulich, S., Clarke, P. & Woodman, P., 11 Mar 1999, In : Oncogene. 18, 10, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

Caspase 2
Caspase 3
Initiator Caspases
Caspases
Effector Caspases
72 Citations (Scopus)

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P. J. & Clarke, P. R., 11 Feb 1999, In : Current Biology. 9, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

cytochrome c
caspases
Caspases
Cytochromes c
Amplification

Inhibition, rather than activation, of p38 accounts for the cardioprotective effect of ischaemic preconditioning

Saurin, A. T., Foley, C. A., Mockridge, J., Heads, R. J. & Marber, M. S., 1 May 1999, In : Heart. 81, SUPPL. 1

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein Kinase C
Ischemia
Mitogen-Activated Protein Kinases
Muscle Cells
125 Citations (Scopus)

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, C., Hughes, M. & Clarke, P. R., 15 Jul 1999, In : Journal of Cell Science. 112, 14, p. 2453-2461 9 p.

Research output: Contribution to journalArticle

Xenopus
Guanosine Triphosphate
Microtubules
Ovum
Interphase
151 Citations (Scopus)

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

Gang, D. R., Costa, M. A., Fujita, M., Dinkova-Kostova, A. T., Wang, H. B., Burlat, V., Martin, W., Sarkanen, S., Davin, L. B. & Lewis, N. G., Mar 1999, In : Chemistry and Biology. 6, 3, p. 143-151 9 p.

Research output: Contribution to journalArticle

Open Access
Lignans
Lignin
Biosynthesis
Protein Array Analysis
Proteins
201 Citations (Scopus)

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T. & Talalay, P., 1 May 1999, In : Carcinogenesis. 20, 5, p. 911-914 4 p.

Research output: Contribution to journalArticle

Open Access
Curcumin
NAD(P)H Dehydrogenase (Quinone)
Aryl Hydrocarbon Receptors
Enzyme Induction
Enzymes
2000
154 Citations (Scopus)

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, C. & Clarke, P. R., 26 May 2000, In : Science. 288, 5470, p. 1429-1432 4 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Nuclear Envelope
Xenopus
Chromatin
Ovum
207 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Quinones
Toxicity
Hydroquinones
Dicumarol
26 Citations (Scopus)

Ran alters nuclear pore complex conformation

Goldberg, M. W., Rutherford, S. A., Hughes, M., Cotter, L. A., Bagley, S., Kiseleva, E., Allen, T. D. & Clarke, P. R., 14 Jul 2000, In : Journal of Molecular Biology. 300, 3, p. 519-529 11 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cytoskeleton
Nucleoplasmins
Monomeric GTP-Binding Proteins
Nuclear Envelope
84 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
apoptosis
peptides
Apoptosis
Peptides
50 Citations (Scopus)

Substrate specificity determinants of the checkpoint protein kinase Chk1

Hutchins, J. R. A., Hughes, M. & Clarke, P. R., 21 Jan 2000, In : FEBS Letters. 466, 1, p. 91-95 5 p.

Research output: Contribution to journalArticle

Substrate Specificity
Protein Kinases
Peptides
Phosphorylation
Schizosaccharomyces