Cellular Medicine

Research Output 1984 2020

156 Citations (Scopus)

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia: Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase

Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A. & Lewis, N. G., 26 Nov 1996, In : Journal of Biological Chemistry. 271, 46, p. 29473-29482 10 p.

Research output: Contribution to journalArticle

Open Access
vestitone reductase
Forsythia
Lignans
Cloning
Purification
6 Citations (Scopus)
80 Downloads (Pure)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacokinetics
Neoplasms
Cell Membrane Permeability
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
2 Citations (Scopus)
65 Downloads (Pure)

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In : Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cross-Over Studies
Tobacco
Blood Vessels
Healthy Volunteers
Smoking
14 Citations (Scopus)
89 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
File
Pentoses
Pentose Phosphate Pathway
Macrophages
Hypercholesterolemia
Metabolism
4 Citations (Scopus)

Adenosine Monophosphate-Activated Protein Kinase: Hydroxymethylglutaryl-CoA Reductase Kinase

Carling, D., Clarke, P. R. & Hardie, D. G., 1 Jan 1991, In : Methods in Enzymology. 200, C, p. 362-371 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
Adenosine Monophosphate
Protein Kinases
Phosphotransferases
Acetyl-CoA Carboxylase
16 Citations (Scopus)

A gradient signal orchestrates the mitotic spindle

Clarke, P. R., 26 Aug 2005, In : Science. 309, 5739, p. 1334-1335 2 p.

Research output: Contribution to journalReview article

122 Citations (Scopus)

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Muqit, M. M. K., Abou-Sleiman, P. M., Saurin, A. T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M. D., Venner, K., Matilla, A., Healy, D. G., Gilks, W. P., Lees, A. J., Holton, J., Revesz, T., Parker, P. J., Harvey, R. J., Wood, N. W. & Latchman, D. S., Jul 2006, In : Journal of Neurochemistry. 98, 1, p. 156-169 14 p.

Research output: Contribution to journalArticle

Parkinson Disease
Lewy Bodies
Mitochondria
Mitochondrial Proteins
Brain
43 Citations (Scopus)

Analysis of the genomic l rna segment from lymphocytic choriomeningitis virus

Singh, M. K., Fuller-Pace, F. V., Buchmeier, M. J. & Southern, P. J., 1 Dec 1987, In : Virology. 161, 2, p. 448-456 9 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Proteins
Reassortant Viruses
Arenavirus
2 Citations (Scopus)

Anchoring RCC1 by the tail

Clarke, P. R., 1 May 2007, In : Nature Cell Biology. 9, 5, p. 485-487 3 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Spindle Apparatus
Cell Nucleus Active Transport
Nuclear Envelope
Post Translational Protein Processing
46 Citations (Scopus)

Apoptosis: Does stress kill?

Cosulich, S. & Clarke, P., 1 Jan 1996, In : Current Biology. 6, 12, p. 1586-1588 3 p.

Research output: Contribution to journalArticle

Open Access
Heat-Shock Proteins
Protein Kinases
Cell Death
apoptosis
Apoptosis
17 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In : Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Drug Therapy
Calcinosis
Neoplasms
Biopsy
5 Citations (Scopus)
103 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Mitosis
Degradation
Ubiquitin-Protein Ligases
Isoleucine
1 Citation (Scopus)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

Genome
Breast Neoplasms
Mutation
1 Citation (Scopus)

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In : British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journalEditorial

95 Citations (Scopus)

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, E., Savory, P., Cosulich, S., Clarke, P. & Woodman, P., 11 Mar 1999, In : Oncogene. 18, 10, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

Caspase 2
Caspase 3
Initiator Caspases
Caspases
Effector Caspases
50 Citations (Scopus)

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, S. C., Green, S. & Clarke, P. R., 1 Aug 1996, In : Current Biology. 6, 8, p. 997-1005 9 p.

Research output: Contribution to journalArticle

cell free system
Cell-Free System
Peptide Hydrolases
proteinases
Chemical activation
72 Citations (Scopus)

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P. J. & Clarke, P. R., 11 Feb 1999, In : Current Biology. 9, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

cytochrome c
caspases
Caspases
Cytochromes c
Amplification
14 Citations (Scopus)

Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

Dinkova-Kostova, A. T., Cory, A. H., Bozak, R. E., Hicks, R. J. & Cory, J. G., 8 Jan 2007, In : Cancer Letters. 245, 1-2, p. 341-349 9 p.

Research output: Contribution to journalArticle

Caspases
Leukemia
Apoptosis
Caspase 3
Caspase 10
28 Downloads (Pure)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., 6 Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
File
Brassica
Pharmacodynamics
beverages
public health
bioavailability
10 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
Serine
Protein Kinase C
21 Downloads (Pure)

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., 5 Sep 2019, In : Redox Biology. 28, p. 1-15 15 p., 101321.

Research output: Contribution to journalArticle

Open Access
File
Cannabidiol
Keratinocytes
Antioxidants
Heme Oxygenase-1
Skin

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

Hoffmann, I., Clarke, P., Karsenti, E. & Draetta, G., 1 Jan 1992, In : Biology of the Cell. 76, 2, p. 213 1 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Cell Biology: Ran, Mitosis and the Cancer Connection

Sanderson, H. S. & Clarke, P. R., 20 Jun 2006, In : Current Biology. 16, 12, p. R466-R468 3 p.

Research output: Contribution to journalShort survey

Open Access
Cytology
mitotic spindle apparatus
Spindle Apparatus
Monomeric GTP-Binding Proteins
guanosinetriphosphatase
109 Citations (Scopus)

Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

Dinkova-Kostova, A. T., Fahey, J. W. & Talalay, P., 2004, In : Methods in Enzymology. 382, p. 423-448 26 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Chemoprotection against cancer: An idea whose time has come

Dinkova-Kostova, A. T., 1 Mar 2007, In : Alternative Therapies in Health and Medicine. 13, 2, p. S122-S127

Research output: Contribution to journalArticle

171 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Superoxides
ferulic acid
Enzymes
Carbon Monoxide
72 Citations (Scopus)

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

Fahey, J. W., Stephenson, K. K., Dinkova-Kostova, A. T., Egner, P. A., Kensler, T. W. & Talalay, P., 1 Jul 2005, In : Carcinogenesis. 26, 7, p. 1247-1255 9 p.

Research output: Contribution to journalArticle

Open Access
Tetrapyrroles
Chlorophyll
Carotenoids
Genes
Polyenes
154 Citations (Scopus)

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, C. & Clarke, P. R., 26 May 2000, In : Science. 288, 5470, p. 1429-1432 4 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Nuclear Envelope
Xenopus
Chromatin
Ovum
38 Citations (Scopus)

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

Le Romancer, M., Cosulich, S. C., Jackson, S. P. & Clarke, P. R., 1 Dec 1996, In : Journal of Cell Science. 109, 13, p. 3121-3127 7 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Xenopus
Ovum
Catalytic Domain
DNA Cleavage
30 Citations (Scopus)

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

Clarke, C. A. L., Bennett, L. N. & Clarke, P. R., 21 Oct 2005, In : Journal of Biological Chemistry. 280, 42, p. 35337-35345 9 p.

Research output: Contribution to journalArticle

Caspase 7
DNA Damage
Apoptosis
Phosphorylation
DNA
67 Citations (Scopus)

Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis

Cosulich, S. C., Horiuchi, H., Zerial, M., Clarke, P. R. & Woodman, P. G., 5 Nov 1997, In : EMBO Journal. 16, 20, p. 6182-6191 10 p.

Research output: Contribution to journalArticle

Endosomes
Fusion reactions
Apoptosis
Membranes
Cytophagocytosis
138 Citations (Scopus)

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

Hope, A. G., Downie, D. L., Sutherland, L. A., Lambert, J. J., Peters, J. A. & Burchell, B., 15 Apr 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 245, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Organism Cloning
Clone Cells
Hybridomas
Alternative Splicing
37 Citations (Scopus)

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

Zhang, C., Golderg, M. W., Moore, W. J., Allen, T. D. & Clarke, P. R., 1 Nov 2002, In : European Journal of Cell Biology. 81, 11, p. 623-633 11 p.

Research output: Contribution to journalReview article

Nuclear Pore
Nuclear Envelope
Chromatin
Guanosine Triphosphate
Membranes
57 Downloads (Pure)

Correction: The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth

Hanson, K., Robinson, S. D., Al-Yousuf, K., Hendry, A. E., Sexton, D. W., Sherwood, V. & Wheeler, G. N., 27 Nov 2018, In : Oncotarget. 9, 93, p. 36645 1 p.

Research output: Contribution to journalArticle

Open Access
File
leflunomide
Antirheumatic Agents
Mitogen-Activated Protein Kinase Kinases
Melanoma
Growth

Cutaneous immunohistochemical staining pattern of p53β isoforms

Ko, C. J., Myung, P., Leffell, D. J. & Bourdon, J-C., Dec 2018, In : Journal of Clinical Pathology. 71, 12, p. 1120-1122 3 p.

Research output: Contribution to journalArticle

Protein Isoforms
Staining and Labeling
Skin
Cytoplasm
Mutation
23 Citations (Scopus)

Cyclin-Dependent Kinases: CAK-handed kinase activation

Clarke, P. R., 1 Jan 1995, In : Current Biology. 5, 1, p. 40-42 3 p.

Research output: Contribution to journalArticle

Open Access
cyclin-dependent kinase
Cyclin-Dependent Kinases
phosphotransferases (kinases)
Phosphotransferases
Chemical activation

Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes

Akentieva, N. P., Sanina, N. A., Gizatullin, A. R., Shkondina, N. I., Prikhodchenko, T. R., Shram, S. I., Zhelev, N. & Aldoshin, S. M., 11 Nov 2019, In : Frontiers in Pharmacology. 10, p. 1-10 21 p., 1277.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibroblasts
Doxorubicin
Mitochondria
Nitric Oxide
2 Citations (Scopus)
48 Downloads (Pure)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A-L., La, H. M., Rossello, F. J., Änkö, M-L., Fuller-Pace, F. V. & Hobbs, R. M., 23 May 2019, In : Nature Communications. 10, 1, p. 1-21 21 p., 2278.

Research output: Contribution to journalArticle

Open Access
File
spermatogenesis
Spermatogonia
maintenance
Spermatogenesis
Genes
5 Citations (Scopus)
62 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegović, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 14 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
34 Downloads (Pure)

Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

Elabd, S., Jabeen, N. A., Gerber, V., Peravali, R., Bourdon, J-C., Kancherla, S., Vallone, D. & Blattner, C., 19 Jul 2019, In : PLoS ONE. 14, 7, 18 p., e0220069.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Cell proliferation
Zebrafish
Stem cells
Danio rerio
146 Citations (Scopus)

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts

Clarke, P. R., Hoffmann, I., Draetta, G. & Karsenti, E., 1 Apr 1993, In : Molecular Biology of the Cell. 4, 4, p. 397-411 15 p.

Research output: Contribution to journalArticle

Cyclin B
Protein Phosphatase 2
Xenopus
Ovum
Cell Cycle
21 Citations (Scopus)

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

Hutchins, J. R. A., Dikovskaya, D. & Clarke, P. R., 25 Sep 2002, In : FEBS Letters. 528, 1-3, p. 267-271 5 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Xenopus Proteins
Protein Phosphatase 2
Phosphorylation
14-3-3 Proteins
26 Citations (Scopus)
RNA-directed RNA polymerase
Lymphocytic choriomeningitis virus
RNA Replicase
Viral RNA
Cell Extracts
5 Citations (Scopus)
94 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
2 Citations (Scopus)
19 Downloads (Pure)

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
Localized Scleroderma
Fibroblasts
Myofibroblasts
Transforming Growth Factors
Therapeutics
351 Citations (Scopus)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Phosphotransferases
Enzymes
Dual Specificity Phosphatase 1
Mitogen-Activated Protein Kinase 8
19 Citations (Scopus)
10 Downloads (Pure)

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance

Khalil, H. S., Mitev, V., Vlaykova, T., Cavicchi, L. & Zhelev, N., 20 May 2015, In : Journal of Biotechnology. 202, p. 40-49 10 p.

Research output: Contribution to journalArticle

Open Access
File
Systems Biology
Cell growth
Pharmaceutical Preparations
Animals
Testing
36 Citations (Scopus)

Distribution and diversity of hsd genes in Escherichia coli and other enteric bacteria.

Daniel, A. S., Fuller-Pace, F. V., Legge, D. M. & Murray, N. E., 1 Apr 1988, In : Journal of Bacteriology. 170, 4, p. 1775-1782 8 p.

Research output: Contribution to journalArticle

Enterobacteriaceae
Citrobacter freundii
Escherichia coli
DNA Restriction-Modification Enzymes
Genes
108 Citations (Scopus)

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. & Marber, M. S., 8 Aug 2003, In : Circulation Research. 93, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Myocardial Ischemia
Ischemia
Wounds and Injuries
Phosphorylation
2 Citations (Scopus)
83 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Centromere
Protein Isoforms
Personnel
M Phase Cell Cycle Checkpoints