Cellular Medicine

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia: Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase

Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A. & Lewis, N. G., 26 Nov 1996, In: Journal of Biological Chemistry. 271, 46, p. 29473-29482 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

168 Citations (Scopus)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In: Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

34 Citations (Scopus)

164 Downloads (Pure)

Activation of GCN2 by the ribosomal P-stalk

Inglis, A. J., Masson, G. R., Shao, S., Perisic, O., McLaughlin, S. H., Hegde, R. S. & Williams, R. L., 12 Mar 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4946-4954 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

43 Citations (Scopus)

16 Downloads (Pure)

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

Zhou, Y., Bastian, I. N., Long, M. D., Dow, M., Li, W., Ngu, R. K., Antonucci, L., Huang, J. Y., Phung, Q. T., Zhao, X., Banerjee, S., Lin, X-J., Wang, H., Dang, B., Choi, S., Karin, D., Su, H., Ellisman, M. H., Jamieson, C., Bosenberg, M. & 12 others, Cheng, Z., Haybaeck, J., Kenner, L., Fisch, K. M., Bourgon, R., Hernandez, G., Lill, J. R., Liu, S., Carter, H., Mellman, I., Karin, M. & Shalapour, S., 23 Feb 2021, In: Proceedings of the National Academy of Sciences. 118, 8, 12 p., e2025840118.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Downloads (Pure)

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, (E-pub ahead of print) In: Medicinal Research Reviews. 41, 2, p. 785-802 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

5 Citations (Scopus)

35 Downloads (Pure)

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In: Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

160 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In: Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

48 Citations (Scopus)

170 Downloads (Pure)

Adenosine Monophosphate-Activated Protein Kinase: Hydroxymethylglutaryl-CoA Reductase Kinase

Carling, D., Clarke, P. R. & Hardie, D. G., 1 Jan 1991, In: Methods in Enzymology. 200, C, p. 362-371 10 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

A gradient signal orchestrates the mitotic spindle

Clarke, P. R., 26 Aug 2005, In: Science. 309, 5739, p. 1334-1335 2 p.

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Alterations in protein p53 expression during the development of pressure overload-induced left ventricular hypertrophy in rats

Stoyanova, V. & Zhelev, N., Jan 2008, In: Biotechnology and Biotechnological Equipment. 22, 4, p. 977-983 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

17 Downloads (Pure)

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Muqit, M. M. K., Abou-Sleiman, P. M., Saurin, A. T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M. D., Venner, K., Matilla, A., Healy, D. G., Gilks, W. P., Lees, A. J., Holton, J., Revesz, T., Parker, P. J., Harvey, R. J., Wood, N. W. & Latchman, D. S., Jul 2006, In: Journal of Neurochemistry. 98, 1, p. 156-169 14 p.

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes

Barratt, M. J., Hazzalin, C. A., Zhelev, N. & Mahadevan, L. C., 1 Oct 1994, In: EMBO Journal. 13, 19, p. 4524-4535 12 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Analysis of the genomic l rna segment from lymphocytic choriomeningitis virus

Singh, M. K., Fuller-Pace, F. V., Buchmeier, M. J. & Southern, P. J., 1 Dec 1987, In: Virology. 161, 2, p. 448-456 9 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Anchoring RCC1 by the tail

Clarke, P. R., 1 May 2007, In: Nature Cell Biology. 9, 5, p. 485-487 3 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E. & Guo, X., 7 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. 8155-8160 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

58 Citations (Scopus)

34 Downloads (Pure)

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins

Cozza, G., Salvi, M., Banerjee, S., Tibaldi, E., Tagliabracci, V. S., Dixon, J. E. & Pinna, L. A., Oct 2015, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1718-1726 9 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Anisomycin and rapamycin define an area upstream of p70/85(S6k) containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction

Kardalinou, E., Zhelev, N., Hazzalin, C. A. & Mahadevan, L. C., Feb 1994, In: Molecular and Cellular Biology. 14, 2, p. 1066-1074 9 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Apoptosis: Does stress kill?

Cosulich, S. & Clarke, P., 1 Jan 1996, In: Current Biology. 6, 12, p. 1586-1588 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Citations (Scopus)

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 1 Feb 2021, In: Environmental Pollution. 270, 12 p., 116053.

Research output: Contribution to journal › Article › peer-review

A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: Affinity, stoichiometry, and thermodynamics

Zheleva, D. I., Zhelev, N. Z., Fischer, P. M., Duff, S. V., Warbrick, E., Blake, D. G. & Lane, D. P., 27 May 2000, In: Biochemistry. 39, 25, p. 7388-7397 10 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death

Easton, J. A., Alboulshi, A. K., Kamps, M. A. F., Brouns, G. H., Broers, M. R., Coull, B. J., Oji, V., van Geel, M., van Steensel, M. A. M. & Martin, P. E., Oct 2019, In: Experimental Dermatology. p. 1106-1113 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

198 Downloads (Pure)

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Anandapadamanaban, M., Masson, G. R., Perisic, O., Berndt, A., Kaufman, J., Johnson, C. M., Santhanam, B., Rogala, K. B., Sabatini, D. M. & Williams, R. L., 11 Oct 2019, In: Science. 366, 6462, p. 203-210 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

28 Citations (Scopus)

10 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In: Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

39 Downloads (Pure)

Are trainees working in obstetrics and gynecology confident and competent in the care of frail gynecological oncology patients?

Audit and Research in Gynaecological Oncology (ARGO) Collaborative, Owens, G. L., Sivalingam, V., Abdelrahman, M., Beirne, J. P., Blake, D., Collins, A., Davies, R., Dilley, J., Farquharson, M., Frimpong, D., Gomes, N., Hawco, S., Ilenkovan, N., Jones, E., Jones, S. E. F., Khan, T., Leung, E., Otify, M., Parnell, L. & 8 others, Rimmer, M. P., Ryan, N., Sanderson, P., Stocker, L., Wilkinson, M., Wong, S., Bharathan, R. & Wan, Y-L. L., 1 Dec 2020, In: International Journal of Gynecological Cancer. 30, p. 1959-1965 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

26 Downloads (Pure)

Assessment of left ventricular structure and function in rats subjected to pressure-overload hypertrophy in time

Stoyanova, V., Zhelev, N., Ghenev, E. & Bosheva, M., 26 Jan 2009, In: Kardiologia Polska. 67, 1, p. 27-34 8 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Assessment of ROS Production in the Mitochondria of Live Cells

Angelova, P. R., Dinkova-Kostova, A. T. & Abramov, A. Y., 2021, Reactive Oxygen Species. Espada, J. (ed.). New York: Humana Press, p. 33-42 10 p. (Methods in Molecular Biology; vol. 2202).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In: The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journal › Article › peer-review

Open Access

File

13 Citations (Scopus)

149 Downloads (Pure)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In: Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (Nature Communications, (2020), 11, 1, (4748), 10.1038/s41467-020-18151-y)

Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Li, Y., Kelso, S., MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Saksena, G., Ellrott, K., Wendl, M. C., Wheeler, D. A., Getz, G., Simpson, J. T., Gerstein, M. B., Ding, L. & 1 others, PCAWG Consortium, 30 Dec 2020, In: Nature Communications. 11, 1 p., 6232.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

File

8 Downloads (Pure)

Azathioprine: friend or foe?

Leigh, I. M., Proby, C. M., Inman, G. J. & Harwood, C. A., May 2019, In: British Journal of Dermatology. 180, 5, p. 961-963 3 p.

Research output: Contribution to journal › Editorial › peer-review

2 Citations (Scopus)

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, E., Savory, P., Cosulich, S., Clarke, P. & Woodman, P., 11 Mar 1999, In: Oncogene. 18, 10, p. 1781-1787 7 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, S. C., Green, S. & Clarke, P. R., 1 Aug 1996, In: Current Biology. 6, 8, p. 997-1005 9 p.

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P. J. & Clarke, P. R., 11 Feb 1999, In: Current Biology. 9, 3, p. 147-150 4 p.

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Bioluminescent imaging of Cdk2 inhibition in vivo

Zhang, G. J., Safran, M., Wei, W., Sorensen, E., Lassota, P., Zhelev, N., Neuberg, D. S., Shapiro, G. & Kaelin, W. G., 1 Jun 2004, In: Nature Medicine. 10, 6, p. 643-648 6 p.

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (Scopus)

21 Downloads (Pure)

Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

Dinkova-Kostova, A. T., Cory, A. H., Bozak, R. E., Hicks, R. J. & Cory, J. G., 8 Jan 2007, In: Cancer Letters. 245, 1-2, p. 341-349 9 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer

Al-hattali, S., Vinnicombe, S. J., Gowdh, N. M., Evans, A., Armstrong, S., Adamson, D., Purdie, C. A. & Macaskill, E. J., 26 Dec 2019, In: Cancer Imaging. 19, 1, p. 1-9 9 p., 91.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

22 Downloads (Pure)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

46 Citations (Scopus)

264 Downloads (Pure)

Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase

Clarke, P. R. & Grahame Hardie, D., 20 Aug 1990, In: FEBS Letters. 269, 1, p. 213-217 5 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Can activation of NRF2 be a strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

37 Citations (Scopus)

45 Downloads (Pure)

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., Jan 2020, In: Redox Biology. 28, p. 1-15 15 p., 101321.

Research output: Contribution to journal › Article › peer-review

Open Access

File

27 Citations (Scopus)

66 Downloads (Pure)

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

Hoffmann, I., Clarke, P., Karsenti, E. & Draetta, G., 1 Jan 1992, In: Biology of the Cell. 76, 2, p. 213 1 p.

Research output: Contribution to journal › Article › peer-review

Cell Biology: Ran, Mitosis and the Cancer Connection

Sanderson, H. S. & Clarke, P. R., 20 Jun 2006, In: Current Biology. 16, 12, p. R466-R468 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

26 Citations (Scopus)

Changes in a nuclear matrix antigen during the cell cycle: interphase and mitotic cells

Todorov, I. T., Philipova, P. N., Zhelev, N. Z. & Hadjiolov, A. A., 1988, In: Biology of the Cell. 62, 2, p. 105-110 6 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Characteristics and outcomes of over 300,000 COVID-19 individuals with history of cancer in the United States and Spain

Roel, E., Pistillo, A., Recalde, M., Sena, A. G., Fernandez-Bertolin, S., Aragon, M., Puente, D., Ahmed, W-U-R., Alghoul, H., Alser, O., Alshammari, T. M., Areia, C., Blacketer, C., Carter, W., Casajust, P., Culhane, A. C., Dawoud, D., DeFalco, F., DuVall, S. L., Falconer, T. & 33 others, Golozar, A., Gong, M., Hester, L., Hripcsak, G., Tan, E. H., Jeon, H., Jonnagaddala, J., Lai, L. Y., Lynch, K. E., Matheny, M. E., Morales, D. R., Natarajan, K., Nyberg, F., Ostropolets, A., Posada, J. D., Prats-Uribe, A., Reich, C. G., Rivera, D. R., Schilling, L. M., Soerjomataram, I., Shah, K., Shah, N. H., Shen, Y., Spotnitz, M., Subbian, V., Suchard, M. A., Trama, A., Zhang, L., Zhang, Y., Ryan, P. B., Prieto-Alhambra, D., Kostka, K. & Duarte-Salles, T., 16 Jul 2021, (E-pub ahead of print) In: Cancer Epidemiology, Biomarkers and Prevention.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Downloads (Pure)

Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

Dinkova-Kostova, A. T., Fahey, J. W. & Talalay, P., 2004, In: Methods in Enzymology. 382, p. 423-448 26 p.

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Chemoprotection against cancer: An idea whose time has come

Dinkova-Kostova, A. T., 1 Mar 2007, In: Alternative Therapies in Health and Medicine. 13, 2, p. S122-S127

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: Correlation of potencies as phase 2 enzyme inducers and radical scavengers

Dinkova-Kostova, A. T., Abeygunawardana, C. & Talalay, P., 17 Dec 1998, In: Journal of Medicinal Chemistry. 41, 26, p. 5287-5296 10 p.

Research output: Contribution to journal › Article › peer-review

179 Citations (Scopus)

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

Fahey, J. W., Stephenson, K. K., Dinkova-Kostova, A. T., Egner, P. A., Kensler, T. W. & Talalay, P., 1 Jul 2005, In: Carcinogenesis. 26, 7, p. 1247-1255 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Citations (Scopus)

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, C. & Clarke, P. R., 26 May 2000, In: Science. 288, 5470, p. 1429-1432 4 p.

Research output: Contribution to journal › Article › peer-review

158 Citations (Scopus)

Cellular Medicine

Research output

Search results