Cellular Medicine

Research Output 1984 2020

1998
171 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Superoxides
ferulic acid
Enzymes
Carbon Monoxide
1999
96 Citations (Scopus)

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, E., Savory, P., Cosulich, S., Clarke, P. & Woodman, P., 11 Mar 1999, In : Oncogene. 18, 10, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

Caspase 2
Caspase 3
Initiator Caspases
Caspases
Effector Caspases
72 Citations (Scopus)

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P. J. & Clarke, P. R., 11 Feb 1999, In : Current Biology. 9, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

cytochrome c
caspases
Caspases
Cytochromes c
Amplification

Inhibition, rather than activation, of p38 accounts for the cardioprotective effect of ischaemic preconditioning

Saurin, A. T., Foley, C. A., Mockridge, J., Heads, R. J. & Marber, M. S., 1 May 1999, In : Heart. 81, SUPPL. 1

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein Kinase C
Ischemia
Mitogen-Activated Protein Kinases
Muscle Cells
126 Citations (Scopus)

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, C., Hughes, M. & Clarke, P. R., 15 Jul 1999, In : Journal of Cell Science. 112, 14, p. 2453-2461 9 p.

Research output: Contribution to journalArticle

Xenopus
Guanosine Triphosphate
Microtubules
Ovum
Interphase
151 Citations (Scopus)

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

Gang, D. R., Costa, M. A., Fujita, M., Dinkova-Kostova, A. T., Wang, H. B., Burlat, V., Martin, W., Sarkanen, S., Davin, L. B. & Lewis, N. G., Mar 1999, In : Chemistry and Biology. 6, 3, p. 143-151 9 p.

Research output: Contribution to journalArticle

Open Access
Lignans
Lignin
Biosynthesis
Protein Array Analysis
Proteins
201 Citations (Scopus)

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T. & Talalay, P., 1 May 1999, In : Carcinogenesis. 20, 5, p. 911-914 4 p.

Research output: Contribution to journalArticle

Open Access
Curcumin
NAD(P)H Dehydrogenase (Quinone)
Aryl Hydrocarbon Receptors
Enzyme Induction
Enzymes
2000
58 Citations (Scopus)

A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: Affinity, stoichiometry, and thermodynamics

Zheleva, D. I., Zhelev, N. Z., Fischer, P. M., Duff, S. V., Warbrick, E., Blake, D. G. & Lane, D. P., 27 May 2000, In : Biochemistry. 39, 25, p. 7388-7397 10 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Thermodynamics
Stoichiometry
Peptides
Assays
155 Citations (Scopus)

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, C. & Clarke, P. R., 26 May 2000, In : Science. 288, 5470, p. 1429-1432 4 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Nuclear Envelope
Xenopus
Chromatin
Ovum
208 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Quinones
Toxicity
Hydroquinones
Dicumarol
53 Citations (Scopus)

Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Kovárová, H., Hajdúch, M., Koínková, G., Halada, P., Krupiková, S., Gouldsworthy, A., Zhelev, N. & Strnad, M., Nov 2000, In : Electrophoresis. 21, 17, p. 3757-3764 8 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Proteomics
Proteins
Glycolysis
rho Guanine Nucleotide Dissociation Inhibitor alpha
26 Citations (Scopus)

Ran alters nuclear pore complex conformation

Goldberg, M. W., Rutherford, S. A., Hughes, M., Cotter, L. A., Bagley, S., Kiseleva, E., Allen, T. D. & Clarke, P. R., 14 Jul 2000, In : Journal of Molecular Biology. 300, 3, p. 519-529 11 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cytoskeleton
Nucleoplasmins
Monomeric GTP-Binding Proteins
Nuclear Envelope
85 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
apoptosis
peptides
Apoptosis
Peptides
130 Citations (Scopus)

Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin

Fischer, P. M., Zhelev, N. Z., Wang, S., Melville, J. E., Fåhraeus, R. & Lane, D. P., Feb 2000, In : Journal of Peptide Research. 55, 2, p. 163-172 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Peptides
Substitution reactions
Homeodomain Proteins
Cyclic Peptides
50 Citations (Scopus)

Substrate specificity determinants of the checkpoint protein kinase Chk1

Hutchins, J. R. A., Hughes, M. & Clarke, P. R., 21 Jan 2000, In : FEBS Letters. 466, 1, p. 91-95 5 p.

Research output: Contribution to journalArticle

Substrate Specificity
Protein Kinases
Peptides
Phosphorylation
Schizosaccharomyces
136 Citations (Scopus)

The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes

Saurin, A. T., Martin, J. L., Heads, R. J., Foley, C., Mockridge, J. W., Wright, M. J., Wang, Y. & Marber, M. S., 1 Nov 2000, In : FASEB Journal. 14, 14, p. 2237-2246 10 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Muscle Cells
Ischemia
Chemical activation
Protein Kinase C
2001
114 Citations (Scopus)

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Curman, D., Cinel, B., Williams, D. E., Rundle, N., Block, W. D., Goodarzi, A. A., Hutchins, J. R., Clarke, P. R., Zhou, B. B., Lees-Miller, S. P., Andersen, R. J. & Roberge, M., 25 Jan 2001, In : Journal of Biological Chemistry. 276, 21, p. 17914-17919 6 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
Porifera
Alkaloids
Protein Kinases
Inhibitory Concentration 50
161 Citations (Scopus)
Open Access
Retinal Pigments
Keratinocytes
Leukemia
Oxidants
Antioxidants
105 Citations (Scopus)

Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Clarke, P. R. & Zhang, C., 1 Sep 2001, In : Trends in Cell Biology. 11, 9, p. 366-371 6 p.

Research output: Contribution to journalReview article

Cell Nucleus Active Transport
GTP Phosphohydrolases
Eukaryotic Cells
Cell Cycle
Karyopherins
25 Citations (Scopus)

Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury

Rakhit, R. D., Kabir, A. N. M., Mockridge, J. W., Saurin, A. & Marber, M. S., 7 Sep 2001, In : Biochemical and Biophysical Research Communications. 286, 5, p. 995-1002 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
GTP-Binding Proteins
Nitric Oxide
Ischemia
Chemical activation
24 Citations (Scopus)

Therapeutic potential of ischaemic preconditioning

Edwards, R. J., Saurin, A. T., Rakhit, R. D. & Marber, M. S., 24 Dec 2001, In : British Journal of Clinical Pharmacology. 50, 2, p. 87-97 11 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)
ran GTP-Binding Protein
Schizosaccharomyces
Nuclear Proteins
Xenopus
Guanosine Triphosphate
2002
37 Citations (Scopus)

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

Zhang, C., Golderg, M. W., Moore, W. J., Allen, T. D. & Clarke, P. R., 1 Nov 2002, In : European Journal of Cell Biology. 81, 11, p. 623-633 11 p.

Research output: Contribution to journalReview article

Nuclear Pore
Nuclear Envelope
Chromatin
Guanosine Triphosphate
Membranes
21 Citations (Scopus)

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

Hutchins, J. R. A., Dikovskaya, D. & Clarke, P. R., 25 Sep 2002, In : FEBS Letters. 528, 1-3, p. 267-271 5 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Xenopus Proteins
Protein Phosphatase 2
Phosphorylation
14-3-3 Proteins
1 Citation (Scopus)
60 Citations (Scopus)

Highly potent p21WAF1-derived peptide inhibitors of CDK-mediated pRb phosphorylation: Delineation and structural insight into their interactions with cyclin A

Zheleva, D. I., McInnes, C., Gavine, A. L., Zhelev, N. Z., Fischer, P. M. & Lane, D. P., Nov 2002, In : Journal of Peptide Research. 60, 5, p. 257-270 14 p.

Research output: Contribution to journalArticle

Cyclin A
Phosphorylation
Cyclins
Peptides
Structure-Activity Relationship
176 Citations (Scopus)

Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

Chen, D., Washbrook, E., Sarwar, N., Bates, G. J., Pace, P. E., Thirunuvakkarasu, V., Taylor, J., Epstein, R. J., Fuller-Pace, F. V., Egly, J. M., Coombes, R. C. & Ali, S., 1 Jan 2002, In : Oncogene. 21, 32, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Serine
Immune Sera
Signal Transduction
Phosphorylation
66 Citations (Scopus)
Edible Plants
Enzymes
Neoplasms
Carcinogenesis
Animal Models
263 Citations (Scopus)

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Ye, L., Dinkova-Kostova, A. T., Wade, K. L., Zhang, Y., Shapiro, T. A. & Talalay, P., 12 Jan 2002, In : Clinica Chimica Acta. 316, 1-2, p. 43-53 11 p.

Research output: Contribution to journalArticle

Isothiocyanates
Plasma (human)
Pharmacokinetics
Brassica
Erythrocytes
117 Citations (Scopus)

Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts

Saurin, A. T., Pennington, D. J., Raat, N. J. H., Latchman, D. S., Owen, M. J. & Marber, M. S., 15 Aug 2002, In : Cardiovascular Research. 55, 3, p. 672-680 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Ischemic Preconditioning
Protein Kinase C
Buffers
Genes
30 Citations (Scopus)

The importin-β P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope

Timinszky, G., Tirián, L., Nagy, F. T., Tóth, G., Perczel, A., Kiss-László, Z., Boros, I., Clarke, P. R. & Szabad, J., 15 May 2002, In : Journal of Cell Science. 115, 8, p. 1675-1687 13 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Envelope
Mutant Proteins
Chromosome Segregation
Mutation
2003
108 Citations (Scopus)

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. & Marber, M. S., 8 Aug 2003, In : Circulation Research. 93, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Myocardial Ischemia
Ischemia
Wounds and Injuries
Phosphorylation
224 Citations (Scopus)

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova-Kostova, A. T. & Holtzclaw, W. D., 1 Jan 2003, In : Advances in Enzyme Regulation. 43, 1, p. 121-134 14 p.

Research output: Contribution to journalArticle

Cysteine
Carcinogenesis
Oxygen
Sulfhydryl Compounds
Antioxidant Response Elements
81 Citations (Scopus)

New Lupane Derived Compounds with Pro-Apoptotic Activity in Cancer Cells: Synthesis and Structure-Activity Relationships

Šarek, J., Klinot, J., Džubák, P., Klinotová, E., Nosková, V., Křeček, V., Kořínková, G., Thomson, J. O., Janošt'Áková, A., Wang, S., Parsons, S., Fischer, P. M., Zhelev, N. Z. & Hajdúch, M., 4 Dec 2003, In : Journal of Medicinal Chemistry. 46, 25, p. 5402-5415 14 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Pentacyclic Triterpenes
Neoplasms
Tumor Cell Line
Ketones
35 Citations (Scopus)
cdc25 Phosphatases
Cyclin B
Calcium-Calmodulin-Dependent Protein Kinases
Xenopus
Ovum
2004
80 Citations (Scopus)

Bioluminescent imaging of Cdk2 inhibition in vivo

Zhang, G. J., Safran, M., Wei, W., Sorensen, E., Lassota, P., Zhelev, N., Neuberg, D. S., Shapiro, G. & Kaelin, W. G., 1 Jun 2004, In : Nature Medicine. 10, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Luciferases
alvocidib
Cells
110 Citations (Scopus)

Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

Dinkova-Kostova, A. T., Fahey, J. W. & Talalay, P., 2004, In : Methods in Enzymology. 382, p. 423-448 26 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
Oxidative Stress
Cysteine
Sulfhydryl Compounds
Oxidants
Genes
28 Citations (Scopus)

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

Zoete, V., Rougée, M., Dinkova-Kostova, A. T., Talalay, P. & Bensasson, R. V., 1 Jun 2004, In : Free Radical Biology and Medicine. 36, 11, p. 1418-1423 6 p.

Research output: Contribution to journalArticle

Molecular orbitals
Oxidation-Reduction
Electrons
Enzymes
NAD(P)H Dehydrogenase (Quinone)
18 Citations (Scopus)

Spatial and temporal control of nuclear envelope assembly by Ran GTPase.

Clarke, P. R. & Zhang, C., 1 Jan 2004, In : Symposia of the Society for Experimental Biology. 56, p. 193-204 12 p.

Research output: Contribution to journalReview article

GTP Phosphohydrolases
Nuclear Envelope
Guanosine Triphosphate
beta Karyopherins
Chromatin
104 Citations (Scopus)
53 Downloads (Pure)

The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

Wilson, B. J., Bates, G. J., Nicol, S. M., Gregory, D. J., Perkins, N. D. & Fuller-Pace, F. V., 6 Aug 2004, In : BMC Molecular Biology. 5, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
DEAD-box RNA Helicases
Histone Deacetylase 1
RNA Precursors
RNA Helicases
Co-Repressor Proteins
129 Citations (Scopus)

The "Prochaska" Microtiter Plate Bioassay for Inducers of NQO1

Fahey, J. W., Dinkova-Kostova, A. T., Stephenson, K. K. & Talalay, P., 2004, In : Methods in Enzymology. 382, p. 243-258 16 p.

Research output: Contribution to journalArticle

220 Citations (Scopus)

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

Saurin, A. T., Neubert, H., Brennan, J. P. & Eaton, P., 28 Dec 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 17982-17987 6 p.

Research output: Contribution to journalArticle

Sulfenic Acids
Hydrogen Peroxide
Proteins
Biotin
Sulfhydryl Compounds
2005
16 Citations (Scopus)

A gradient signal orchestrates the mitotic spindle

Clarke, P. R., 26 Aug 2005, In : Science. 309, 5739, p. 1334-1335 2 p.

Research output: Contribution to journalReview article

73 Citations (Scopus)

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

Fahey, J. W., Stephenson, K. K., Dinkova-Kostova, A. T., Egner, P. A., Kensler, T. W. & Talalay, P., 1 Jul 2005, In : Carcinogenesis. 26, 7, p. 1247-1255 9 p.

Research output: Contribution to journalArticle

Open Access
Tetrapyrroles
Chlorophyll
Carotenoids
Genes
Polyenes
31 Citations (Scopus)

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

Clarke, C. A. L., Bennett, L. N. & Clarke, P. R., 21 Oct 2005, In : Journal of Biological Chemistry. 280, 42, p. 35337-35345 9 p.

Research output: Contribution to journalArticle

Caspase 7
DNA Damage
Apoptosis
Phosphorylation
DNA
71 Citations (Scopus)

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, C. A. L. & Clarke, P. R., 1 Jun 2005, In : Biochemical Journal. 388, 2, p. 705-712 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Cell-Free System
Cells
Automatic teller machines
DNA
18 Citations (Scopus)

Effects of the cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) on the physiology of cultured human keratinocytes

Atanasova, G., Jans, R., Zhelev, N., Mitev, V. & Poumay, Y., 15 Sep 2005, In : Biochemical Pharmacology. 70, 6, p. 824-836 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Physiology
Keratinocytes
p38 Mitogen-Activated Protein Kinases
Cells
153 Citations (Scopus)

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein

Dinkova-Kostova, A. T., Holtzclaw, W. D. & Wakabayashi, N., 10 May 2005, In : Biochemistry. 44, 18, p. 6889-6899 11 p.

Research output: Contribution to journalArticle

Metalloproteins
Oxidants
Zinc
Sensors
Sulfhydryl Compounds