Cellular Medicine

Research Output 1984 2020

26 Citations (Scopus)
RNA-directed RNA polymerase
Lymphocytic choriomeningitis virus
RNA Replicase
Viral RNA
Cell Extracts
7 Citations (Scopus)
126 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
2 Citations (Scopus)
51 Downloads (Pure)

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
Localized Scleroderma
Fibroblasts
Myofibroblasts
Transforming Growth Factors
Therapeutics
2 Citations (Scopus)

Differential genetic advantages in youth and in aging, or how to die healthy

Khalil, H. S., Petkova, R. & Zhelev, N., 1 Feb 2012, In : Biotechnology and Biotechnological Equipment. 26, 1, p. 2703-2711 9 p.

Research output: Contribution to journalReview article

Cell Aging
Social Conditions
Life Expectancy
History
Alleles
352 Citations (Scopus)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Phosphotransferases
Enzymes
Dual Specificity Phosphatase 1
Mitogen-Activated Protein Kinase 8
20 Citations (Scopus)
33 Downloads (Pure)

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance

Khalil, H. S., Mitev, V., Vlaykova, T., Cavicchi, L. & Zhelev, N., 20 May 2015, In : Journal of Biotechnology. 202, p. 40-49 10 p.

Research output: Contribution to journalArticle

Open Access
File
Systems Biology
Cell growth
Pharmaceutical Preparations
Animals
Testing
36 Citations (Scopus)

Distribution and diversity of hsd genes in Escherichia coli and other enteric bacteria.

Daniel, A. S., Fuller-Pace, F. V., Legge, D. M. & Murray, N. E., 1 Apr 1988, In : Journal of Bacteriology. 170, 4, p. 1775-1782 8 p.

Research output: Contribution to journalArticle

Enterobacteriaceae
Citrobacter freundii
Escherichia coli
DNA Restriction-Modification Enzymes
Genes
108 Citations (Scopus)

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. & Marber, M. S., 8 Aug 2003, In : Circulation Research. 93, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Myocardial Ischemia
Ischemia
Wounds and Injuries
Phosphorylation
2 Citations (Scopus)
109 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Centromere
Protein Isoforms
Personnel
M Phase Cell Cycle Checkpoints
71 Citations (Scopus)

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, C. A. L. & Clarke, P. R., 1 Jun 2005, In : Biochemical Journal. 388, 2, p. 705-712 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Cell-Free System
Cells
Automatic teller machines
DNA
1 Citation (Scopus)
88 Downloads (Pure)

Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes

Nguyen Van Long, F., Lardy-Cleaud, A., Bray, S., Chabaud, S., Dubois, T., Diot, A., Thompson, A. M., Bourdon, J-C., Perol, D., Bouvet, P., Diaz, J-J. & Marcel, V., 22 Oct 2018, In : Cancers. 10, 10, p. 1-11 11 p., 390.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Breast Neoplasms
Triple Negative Breast Neoplasms
Messenger RNA
Neoplasms
5 Citations (Scopus)
139 Downloads (Pure)

Dual-specificity MAP kinase phosphatases in health and disease

Seternes, O-M., Kidger, A. M. & Keyse, S., 1 Jan 2019, In : BBA - Molecular Cell Research. 1866, 1, p. 124-143 20 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphotransferases
Health
MAP Kinase Signaling System
Genetic Models
58 Citations (Scopus)

EcoA and EcoE: Alternatives to the EcoK family of type I restriction and modification systems of Escherichia coli

Fuller-Pace, F. V., Cowan, G. M. & Murray, N. E., 5 Nov 1985, In : Journal of Molecular Biology. 186, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

DNA Restriction-Modification Enzymes
Escherichia coli
Genes
Peptides
Type I Site Specific Deoxyribonucleases
14 Downloads (Pure)

Editorial: Metformin: Beyond Diabetes

Bost, F., Rena, G. & Viollet, B., 6 Dec 2019, In : Frontiers in endocrinology. 10, p. 1-3 3 p., 851.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., Prichodchenko, T. R., Zhelev, N. & Aldoshin, S. M., Nov 2018, In : Doklady Biochemistry and Biophysics. 483, 1, p. 337-340 4 p.

Research output: Contribution to journalArticle

Fibroblasts
Cell Survival
Iron Compounds
Mitochondrial Membrane Potential
Sulfur
31 Downloads (Pure)

Effect of liquid nitrogen pre-treatment on various types of wool waste fibres for biogas production

Kuzmanova, E., Zhelev, N. & Akunna, J. C., May 2018, In : Heliyon. 4, 5, p. 1-11 11 p., e00619.

Research output: Contribution to journalArticle

Open Access
File
wool
biogas
liquid
nitrogen
methane
17 Citations (Scopus)

Effect of salinity on the synthesis of ribulose-1,5-bisphosphate carboxylase/oxygenase in barley leaves

Miteva, T. S., Zh. Zhelev, N. & Popova, L. P., May 1992, In : Journal of Plant Physiology. 140, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

Ribulose-Bisphosphate Carboxylase
Oxygenases
Salinity
ribulose 1,5-diphosphate
ribulose-bisphosphate carboxylase

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Fenretinide
Phenotype
Dipeptidyl Peptidase 4
Glucose
Retinol-Binding Proteins
6 Citations (Scopus)

Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes

Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y. & Mitev, V. I., 1 Oct 2007, In : Oncology Reports. 18, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Keratinocytes
Phosphorylation
Pharmacologic Actions
Mitogen-Activated Protein Kinase 3
18 Citations (Scopus)

Effects of the cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) on the physiology of cultured human keratinocytes

Atanasova, G., Jans, R., Zhelev, N., Mitev, V. & Poumay, Y., 15 Sep 2005, In : Biochemical Pharmacology. 70, 6, p. 824-836 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Physiology
Keratinocytes
p38 Mitogen-Activated Protein Kinases
Cells

Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 19, 1 p.

Research output: Contribution to journalComment/debate

Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193)

Huang, W., Thomas, B., Flynn, R. A., Gavzy, S. J., Wu, L., Kim, S. V., Hall, J. A., Miraldi, E. R., Ng, C. P., Rigo, F., Meadows, S., Montoya, N. R., Herrera, N. G., Domingos, A. I., Rastinejad, F., Myers, R. M., Fuller-Pace, F. V., Bonneau, R., Chang, H. Y., Acuto, O. & 1 others, Littman, D. R., 4 Oct 2018, In : Nature. 562, 7725, 1 p.

Research output: Contribution to journalComment/debate

Long Noncoding RNA
Th17 Cells
History

Erratum to: A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

McNeilly, A. D., Williamson, R., Balfour, D. J. K., Stewart, C. A. & Sutherland, C., 1 Jan 2013, In : Diabetologia. 56, 1, p. 230 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
20 Citations (Scopus)

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Williams, R. J., McCarthy, A. D. & Sutherland, C. D., 8 Jun 1989, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1003, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Esterification
Sterol O-Acyltransferase
Rats
Cholesterol
Enterocytes
86 Citations (Scopus)

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

MACKINTOSH, R. W., DAVIES, S. P., CLARKE, P. R., WEEKES, J., GILLESPIE, J. G., GIBB, B. J. & HARDIE, D. G., 1 Jan 1992, In : European Journal of Biochemistry. 209, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Oxidoreductases
Phosphotransferases
Terpenes
Enzymes
28 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Fructose
Liver Cirrhosis
Fats
Endoplasmic Reticulum Stress
64 Citations (Scopus)

Genetic recombination can generate altered restriction specificity

Fuller-Pace, F. V., Bullas, L. R., Delius, H. & Murray, N. E., 1 Oct 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 19 I, p. 6095-6099 5 p.

Research output: Contribution to journalArticle

Open Access
Genetic Recombination
Salmonella
Conserved Sequence
Genes
Heteroduplex Analysis
60 Citations (Scopus)

Highly potent p21WAF1-derived peptide inhibitors of CDK-mediated pRb phosphorylation: Delineation and structural insight into their interactions with cyclin A

Zheleva, D. I., McInnes, C., Gavine, A. L., Zhelev, N. Z., Fischer, P. M. & Lane, D. P., Nov 2002, In : Journal of Peptide Research. 60, 5, p. 257-270 14 p.

Research output: Contribution to journalArticle

Cyclin A
Phosphorylation
Cyclins
Peptides
Structure-Activity Relationship
3 Citations (Scopus)

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

Atanasova, V. S., Pourreyron, C., Farshchian, M., Lawler, M. E., Brown, C. A., Watt, S., Wright, S., Warkala, M., Guttmann-Gruber, C., Pinon-Hofbauer, J., Fuentes, I., Prisco, M., Rashidghamat, E., Has, C., Salas-Alanis, J. C., Palisson, F., Hovnanian, A., McGrath, J. A., Mellerio, J., Bauer, J. W. & 1 others, South, A. P., Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Squamous Cell Carcinoma
Therapeutics
Skin
ON 01910
2 Citations (Scopus)

Immunolokalizatsiia iadryshkovogo belka B23 v tsentrosomakh v mitoze.

Translated title of the contribution: Immunolocalization of nucleolar protein B23 in mitotic centrosomesZatsepina, O. V., Zhelev, N. Z. & Jordan, G. J., Nov 1995, In : Molekuliarnaia biologiia. 29, 6, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Implementation of light-scattering instrumentation: Innovation, design and development

White, R., Zhelev, N. & Bradley, D., 10 Jan 2012, Mechatronics and Manufacturing Engineering: Research and Development. Davim, J. P. (ed.). Elsevier Ltd, p. 1-45 45 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Light scattering
Agglomeration
Innovation
Pulse amplitude modulation
Finance
224 Citations (Scopus)

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova-Kostova, A. T. & Holtzclaw, W. D., 1 Jan 2003, In : Advances in Enzyme Regulation. 43, 1, p. 121-134 14 p.

Research output: Contribution to journalArticle

Cysteine
Carcinogenesis
Oxygen
Sulfhydryl Compounds
Antioxidant Response Elements
38 Citations (Scopus)
99 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
stem cells
Stem cells
deactivation
Squamous Cell Carcinoma
Stem Cells
1 Citation (Scopus)
34 Downloads (Pure)

Individual capacity for repair of DNA damage and potential uses of stem cell lines for clinical applications: a matter of (genomic) integrity

Petkova, R., Zhelev, N., Pankov, R. & Chakarov, S., 2018, In : Biotechnology and Biotechnological Equipment. 32, 6, p. 1352-1358 7 p.

Research output: Contribution to journalReview article

Open Access
File
DNA Damage
Stem Cells
Cell Line
Pluripotent Stem Cells
Safety
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Air Pollutants
Transcription Factors
Antioxidants
117 Citations (Scopus)

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts

Dinkova-Kostova, A. T., Fahey, J. W., Wade, K. L., Jenkins, S. N., Shapiro, T. A., Fuchs, E. J., Kerns, M. L. & Talalay, P., 1 Apr 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 4, p. 847-851 5 p.

Research output: Contribution to journalArticle

Open Access
Brassica
Skin
Enzymes
Safety
Heme Oxygenase-1

Inhibition, rather than activation, of p38 accounts for the cardioprotective effect of ischaemic preconditioning

Saurin, A. T., Foley, C. A., Mockridge, J., Heads, R. J. & Marber, M. S., 1 May 1999, In : Heart. 81, SUPPL. 1

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein Kinase C
Ischemia
Mitogen-Activated Protein Kinases
Muscle Cells
29 Downloads (Pure)

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Banerjee, S., Wei, T., Wang, J., Lee, J. J., Gutierrez, H. L., Chapman, O., Wiley, S. E., Mayfield, J. E., Tandon, V., Juarez, E. F., Chavez, L., Liang, R., Sah, R. L., Costello, C., Mesirov, J. P., de la Vega, L., Cooper, K. L., Dixon, J. E., Xiao, J. & Lei, X., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24881-24891 11 p.

Research output: Contribution to journalArticle

Open Access
File
Triple Negative Breast Neoplasms
Multiple Myeloma
Proteasome Inhibitors
Proteasome Endopeptidase Complex
Tumor Burden
30 Citations (Scopus)

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 9, p. 6183-6187 5 p.

Research output: Contribution to journalArticle

Cyclin B
Cyclin A
Membrane Fusion
Phosphotransferases
Fusion reactions
114 Citations (Scopus)

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Curman, D., Cinel, B., Williams, D. E., Rundle, N., Block, W. D., Goodarzi, A. A., Hutchins, J. R., Clarke, P. R., Zhou, B. B., Lees-Miller, S. P., Andersen, R. J. & Roberge, M., 25 Jan 2001, In : Journal of Biological Chemistry. 276, 21, p. 17914-17919 6 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
Porifera
Alkaloids
Protein Kinases
Inhibitory Concentration 50
1 Citation (Scopus)
80 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
Hairless Mouse
histone deacetylase
Histone Deacetylase Inhibitors
squamous cell carcinoma
Squamous Cell Carcinoma
2 Citations (Scopus)

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

Tilmant, K., Gerets, H., De Ron, P., Hanon, E., Bento-Pereira, C. & Atienzar, F. A., 1 Oct 2018, In : Toxicology in Vitro. 52, p. 374-383 10 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Energy Metabolism
Screening
Poisons
Pharmaceutical Preparations

In vivo assessment of left ventricular hypertrophy in rats: Necropsy validation

Stoyanova, V., Dobreva, B., Ghenev, E. & Zhelev, N., Jan 2006, In : Biotechnology and Biotechnological Equipment. 20, 2, p. 124-132 9 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Abdominal Aorta
Control Groups
Organ Size
Thoracotomy

Isolation of U5 snRNP particles.

Pironcheva, G., Zhelev, N. & Russev, G., 1988, In : Cytobios. 56, 224, p. 39-44 6 p.

Research output: Contribution to journalArticle

U5 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins
Ammonium Chloride
DEAE-Cellulose
Connective Tissue Diseases
152 Citations (Scopus)

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein

Dinkova-Kostova, A. T., Holtzclaw, W. D. & Wakabayashi, N., 10 May 2005, In : Biochemistry. 44, 18, p. 6889-6899 11 p.

Research output: Contribution to journalArticle

Metalloproteins
Oxidants
Zinc
Sensors
Sulfhydryl Compounds
13 Citations (Scopus)
97 Downloads (Pure)

Kinase and Phosphatase Cross-Talk at the Kinetochore

Saurin, A. T., 19 Jun 2018, In : Frontiers in Cell and Developmental Biology. 6, p. 1-23 23 p., 62.

Research output: Contribution to journalReview article

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphotransferases
Enzymes
M Phase Cell Cycle Checkpoints
498 Citations (Scopus)

Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. & Williams, L. T., 1 Aug 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 15, p. 6896-6900 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Dermis
Wound Healing
Fibroblast Growth Factor Receptors
Fibroblast Growth Factor 2
9 Citations (Scopus)
8 Downloads (Pure)

Laser light scattering applications in biotechnology

Zhelev, N. & Barudov, S., 15 Apr 2014, In : Biotechnology and Biotechnological Equipment. 19, 3, p. 3-8 6 p.

Research output: Contribution to journalArticle

Open Access
File
Biotechnology
Lasers
Light
Protein Conformation
Nucleic Acids
16 Citations (Scopus)

Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase

Davies, S. J., D'Sousa, R., Philips, H., Mattey, D., Hiley, C., Hayes, J. D., Aber, G. M. & Strange, R. C., 11 Jun 1993, In : Biochimica et Biophysica Acta: General Subjects. 1157, 2, p. 204-8 5 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
Glutathione Transferase
Superoxide Dismutase
Kidney
Mesangial Cells