Cellular Medicine

Research Output

Article

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
72 Downloads (Pure)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

352 Citations (Scopus)

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance

Khalil, H. S., Mitev, V., Vlaykova, T., Cavicchi, L. & Zhelev, N., 20 May 2015, In : Journal of Biotechnology. 202, p. 40-49 10 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
43 Downloads (Pure)

Distribution and diversity of hsd genes in Escherichia coli and other enteric bacteria.

Daniel, A. S., Fuller-Pace, F. V., Legge, D. M. & Murray, N. E., 1 Apr 1988, In : Journal of Bacteriology. 170, 4, p. 1775-1782 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. & Marber, M. S., 8 Aug 2003, In : Circulation Research. 93, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
120 Downloads (Pure)

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, C. A. L. & Clarke, P. R., 1 Jun 2005, In : Biochemical Journal. 388, 2, p. 705-712 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes

Nguyen Van Long, F., Lardy-Cleaud, A., Bray, S., Chabaud, S., Dubois, T., Diot, A., Thompson, A. M., Bourdon, J-C., Perol, D., Bouvet, P., Diaz, J-J. & Marcel, V., 22 Oct 2018, In : Cancers. 10, 10, p. 1-11 11 p., 390.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
112 Downloads (Pure)

Dual-specificity MAP kinase phosphatases in health and disease

Seternes, O-M., Kidger, A. M. & Keyse, S., 1 Jan 2019, In : BBA - Molecular Cell Research. 1866, 1, p. 124-143 20 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
157 Downloads (Pure)

EcoA and EcoE: Alternatives to the EcoK family of type I restriction and modification systems of Escherichia coli

Fuller-Pace, F. V., Cowan, G. M. & Murray, N. E., 5 Nov 1985, In : Journal of Molecular Biology. 186, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Editorial: Metformin: Beyond Diabetes

Bost, F., Rena, G. & Viollet, B., 6 Dec 2019, In : Frontiers in endocrinology. 10, p. 1-3 3 p., 851.

Research output: Contribution to journalArticle

Open Access
File
28 Downloads (Pure)

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., Prichodchenko, T. R., Zhelev, N. & Aldoshin, S. M., Nov 2018, In : Doklady Biochemistry and Biophysics. 483, 1, p. 337-340 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effect of liquid nitrogen pre-treatment on various types of wool waste fibres for biogas production

Kuzmanova, E., Zhelev, N. & Akunna, J. C., May 2018, In : Heliyon. 4, 5, p. 1-11 11 p., e00619.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
41 Downloads (Pure)

Effect of salinity on the synthesis of ribulose-1,5-bisphosphate carboxylase/oxygenase in barley leaves

Miteva, T. S., Zh. Zhelev, N. & Popova, L. P., May 1992, In : Journal of Plant Physiology. 140, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes

Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y. & Mitev, V. I., 1 Oct 2007, In : Oncology Reports. 18, 4, p. 999-1005 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of the cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) on the physiology of cultured human keratinocytes

Atanasova, G., Jans, R., Zhelev, N., Mitev, V. & Poumay, Y., 15 Sep 2005, In : Biochemical Pharmacology. 70, 6, p. 824-836 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide

Qiu, Y., Poppleton, E., Mekkat, A., Yu, H., Banerjee, S., Wiley, S. E., Dixon, J. E., Kaplan, D. L., Lin, Y. S. & Brodsky, B., 18 Dec 2018, In : Biophysical Journal. 115, 12, p. 2327-2335 9 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Williams, R. J., McCarthy, A. D. & Sutherland, C. D., 8 Jun 1989, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1003, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

MACKINTOSH, R. W., DAVIES, S. P., CLARKE, P. R., WEEKES, J., GILLESPIE, J. G., GIBB, B. J. & HARDIE, D. G., 1 Jan 1992, In : European Journal of Biochemistry. 209, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
Open Access
File
31 Citations (Scopus)
131 Downloads (Pure)

Genetic recombination can generate altered restriction specificity

Fuller-Pace, F. V., Bullas, L. R., Delius, H. & Murray, N. E., 1 Oct 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 19 I, p. 6095-6099 5 p.

Research output: Contribution to journalArticle

Open Access
64 Citations (Scopus)

Highly potent p21WAF1-derived peptide inhibitors of CDK-mediated pRb phosphorylation: Delineation and structural insight into their interactions with cyclin A

Zheleva, D. I., McInnes, C., Gavine, A. L., Zhelev, N. Z., Fischer, P. M. & Lane, D. P., Nov 2002, In : Journal of Peptide Research. 60, 5, p. 257-270 14 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

Atanasova, V. S., Pourreyron, C., Farshchian, M., Lawler, M. E., Brown, C. A., Watt, S., Wright, S., Warkala, M., Guttmann-Gruber, C., Pinon-Hofbauer, J., Fuentes, I., Prisco, M., Rashidghamat, E., Has, C., Salas-Alanis, J. C., Palisson, F., Hovnanian, A., McGrath, J. A., Mellerio, J., Bauer, J. W. & 1 others, South, A. P., Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
9 Downloads (Pure)

Immunolokalizatsiia iadryshkovogo belka B23 v tsentrosomakh v mitoze.

Translated title of the contribution: Immunolocalization of nucleolar protein B23 in mitotic centrosomesZatsepina, O. V., Zhelev, N. Z. & Jordan, G. J., Nov 1995, In : Molekuliarnaia biologiia. 29, 6, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova-Kostova, A. T. & Holtzclaw, W. D., 1 Jan 2003, In : Advances in Enzyme Regulation. 43, 1, p. 121-134 14 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
114 Downloads (Pure)

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts

Dinkova-Kostova, A. T., Fahey, J. W., Wade, K. L., Jenkins, S. N., Shapiro, T. A., Fuchs, E. J., Kerns, M. L. & Talalay, P., 1 Apr 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 4, p. 847-851 5 p.

Research output: Contribution to journalArticle

Open Access
117 Citations (Scopus)

Inhibition, rather than activation, of p38 accounts for the cardioprotective effect of ischaemic preconditioning

Saurin, A. T., Foley, C. A., Mockridge, J., Heads, R. J. & Marber, M. S., 1 May 1999, In : Heart. 81, SUPPL. 1

Research output: Contribution to journalArticle

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Banerjee, S., Wei, T., Wang, J., Lee, J. J., Gutierrez, H. L., Chapman, O., Wiley, S. E., Mayfield, J. E., Tandon, V., Juarez, E. F., Chavez, L., Liang, R., Sah, R. L., Costello, C., Mesirov, J. P., de la Vega, L., Cooper, K. L., Dixon, J. E., Xiao, J. & Lei, X., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24881-24891 11 p.

Research output: Contribution to journalArticle

Open Access
File
43 Downloads (Pure)

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 9, p. 6183-6187 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Curman, D., Cinel, B., Williams, D. E., Rundle, N., Block, W. D., Goodarzi, A. A., Hutchins, J. R., Clarke, P. R., Zhou, B. B., Lees-Miller, S. P., Andersen, R. J. & Roberge, M., 25 Jan 2001, In : Journal of Biological Chemistry. 276, 21, p. 17914-17919 6 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
94 Downloads (Pure)

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

Tilmant, K., Gerets, H., De Ron, P., Hanon, E., Bento-Pereira, C. & Atienzar, F. A., 1 Oct 2018, In : Toxicology in Vitro. 52, p. 374-383 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vivo assessment of left ventricular hypertrophy in rats: Necropsy validation

Stoyanova, V., Dobreva, B., Ghenev, E. & Zhelev, N., Jan 2006, In : Biotechnology and Biotechnological Equipment. 20, 2, p. 124-132 9 p.

Research output: Contribution to journalArticle

Isolation of U5 snRNP particles.

Pironcheva, G., Zhelev, N. & Russev, G., 1988, In : Cytobios. 56, 224, p. 39-44 6 p.

Research output: Contribution to journalArticle

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein

Dinkova-Kostova, A. T., Holtzclaw, W. D. & Wakabayashi, N., 10 May 2005, In : Biochemistry. 44, 18, p. 6889-6899 11 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. & Williams, L. T., 1 Aug 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 15, p. 6896-6900 5 p.

Research output: Contribution to journalArticle

499 Citations (Scopus)

Laser light scattering applications in biotechnology

Zhelev, N. & Barudov, S., 15 Apr 2014, In : Biotechnology and Biotechnological Equipment. 19, 3, p. 3-8 6 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
17 Downloads (Pure)

Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase

Davies, S. J., D'Sousa, R., Philips, H., Mattey, D., Hiley, C., Hayes, J. D., Aber, G. M. & Strange, R. C., 11 Jun 1993, In : Biochimica et Biophysica Acta: General Subjects. 1157, 2, p. 204-8 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
44 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
116 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
119 Downloads (Pure)

Monoclonal antibody against a nuclear matrix antigen in proliferating human cells

Philipova, R. N., Zhelev, N. Z., Todorov, I. T. & Hadjiolov, A. A., 1987, In : Biology of the Cell. 60, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells

Todorov, I. T., Philipova, R. N., Zhelev, N. Z. & Hadjiolov, A. A., Mar 1987, In : Cell Biology International Reports. 11, 3, p. 181-187 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKa pathway

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. & Delibegovic, M., Jun 2017, In : Molecular Metabolism. 6, 8, p. 845-853

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
103 Downloads (Pure)

New approaches to rapid screening for protein aggregates by light scattering

Zhelev, N., Khalil, H. S. & White, R., 16 Apr 2014, In : Biotechnology and Biotechnological Equipment. 27, 6, p. 4327-4331 5 p.

Research output: Contribution to journalArticle

New Lupane Derived Compounds with Pro-Apoptotic Activity in Cancer Cells: Synthesis and Structure-Activity Relationships

Šarek, J., Klinot, J., Džubák, P., Klinotová, E., Nosková, V., Křeček, V., Kořínková, G., Thomson, J. O., Janošt'Áková, A., Wang, S., Parsons, S., Fischer, P. M., Zhelev, N. Z. & Hajdúch, M., 4 Dec 2003, In : Journal of Medicinal Chemistry. 46, 25, p. 5402-5415 14 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)