Cellular Medicine

Research Output 1984 2020

2004
18 Citations (Scopus)

Spatial and temporal control of nuclear envelope assembly by Ran GTPase.

Clarke, P. R. & Zhang, C., 1 Jan 2004, In : Symposia of the Society for Experimental Biology. 56, p. 193-204 12 p.

Research output: Contribution to journalReview article

GTP Phosphohydrolases
Nuclear Envelope
Guanosine Triphosphate
beta Karyopherins
Chromatin
103 Citations (Scopus)
42 Downloads (Pure)

The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

Wilson, B. J., Bates, G. J., Nicol, S. M., Gregory, D. J., Perkins, N. D. & Fuller-Pace, F. V., 6 Aug 2004, In : BMC Molecular Biology. 5, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
DEAD-box RNA Helicases
Histone Deacetylase 1
RNA Precursors
RNA Helicases
Co-Repressor Proteins
128 Citations (Scopus)

The "Prochaska" Microtiter Plate Bioassay for Inducers of NQO1

Fahey, J. W., Dinkova-Kostova, A. T., Stephenson, K. K. & Talalay, P., 2004, In : Methods in Enzymology. 382, p. 243-258 16 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

Saurin, A. T., Neubert, H., Brennan, J. P. & Eaton, P., 28 Dec 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 17982-17987 6 p.

Research output: Contribution to journalArticle

Sulfenic Acids
Hydrogen Peroxide
Proteins
Biotin
Sulfhydryl Compounds
2003
108 Citations (Scopus)

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

Tanno, M., Bassi, R., Gorog, D. A., Saurin, A. T., Jiang, J., Heads, R. J., Martin, J. L., Davis, R. J., Flavell, R. A. & Marber, M. S., 8 Aug 2003, In : Circulation Research. 93, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Myocardial Ischemia
Ischemia
Wounds and Injuries
Phosphorylation
223 Citations (Scopus)

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Talalay, P., Dinkova-Kostova, A. T. & Holtzclaw, W. D., 1 Jan 2003, In : Advances in Enzyme Regulation. 43, 1, p. 121-134 14 p.

Research output: Contribution to journalArticle

Cysteine
Carcinogenesis
Oxygen
Sulfhydryl Compounds
Antioxidant Response Elements
35 Citations (Scopus)
cdc25 Phosphatases
Cyclin B
Calcium-Calmodulin-Dependent Protein Kinases
Xenopus
Ovum
2002
37 Citations (Scopus)

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

Zhang, C., Golderg, M. W., Moore, W. J., Allen, T. D. & Clarke, P. R., 1 Nov 2002, In : European Journal of Cell Biology. 81, 11, p. 623-633 11 p.

Research output: Contribution to journalReview article

Nuclear Pore
Nuclear Envelope
Chromatin
Guanosine Triphosphate
Membranes
21 Citations (Scopus)

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

Hutchins, J. R. A., Dikovskaya, D. & Clarke, P. R., 25 Sep 2002, In : FEBS Letters. 528, 1-3, p. 267-271 5 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Xenopus Proteins
Protein Phosphatase 2
Phosphorylation
14-3-3 Proteins
1 Citation (Scopus)
175 Citations (Scopus)

Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

Chen, D., Washbrook, E., Sarwar, N., Bates, G. J., Pace, P. E., Thirunuvakkarasu, V., Taylor, J., Epstein, R. J., Fuller-Pace, F. V., Egly, J. M., Coombes, R. C. & Ali, S., 1 Jan 2002, In : Oncogene. 21, 32, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Serine
Immune Sera
Signal Transduction
Phosphorylation
66 Citations (Scopus)
Edible Plants
Enzymes
Neoplasms
Carcinogenesis
Animal Models
261 Citations (Scopus)

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Ye, L., Dinkova-Kostova, A. T., Wade, K. L., Zhang, Y., Shapiro, T. A. & Talalay, P., 12 Jan 2002, In : Clinica Chimica Acta. 316, 1-2, p. 43-53 11 p.

Research output: Contribution to journalArticle

Isothiocyanates
Plasma (human)
Pharmacokinetics
Brassica
Erythrocytes
117 Citations (Scopus)

Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts

Saurin, A. T., Pennington, D. J., Raat, N. J. H., Latchman, D. S., Owen, M. J. & Marber, M. S., 15 Aug 2002, In : Cardiovascular Research. 55, 3, p. 672-680 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Ischemic Preconditioning
Protein Kinase C
Buffers
Genes
30 Citations (Scopus)

The importin-β P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope

Timinszky, G., Tirián, L., Nagy, F. T., Tóth, G., Perczel, A., Kiss-László, Z., Boros, I., Clarke, P. R. & Szabad, J., 15 May 2002, In : Journal of Cell Science. 115, 8, p. 1675-1687 13 p.

Research output: Contribution to journalArticle

Karyopherins
Nuclear Envelope
Mutant Proteins
Chromosome Segregation
Mutation
2001
114 Citations (Scopus)

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Curman, D., Cinel, B., Williams, D. E., Rundle, N., Block, W. D., Goodarzi, A. A., Hutchins, J. R., Clarke, P. R., Zhou, B. B., Lees-Miller, S. P., Andersen, R. J. & Roberge, M., 25 Jan 2001, In : Journal of Biological Chemistry. 276, 21, p. 17914-17919 6 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
Porifera
Alkaloids
Protein Kinases
Inhibitory Concentration 50
160 Citations (Scopus)
Open Access
Retinal Pigments
Keratinocytes
Leukemia
Oxidants
Antioxidants
105 Citations (Scopus)

Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Clarke, P. R. & Zhang, C., 1 Sep 2001, In : Trends in Cell Biology. 11, 9, p. 366-371 6 p.

Research output: Contribution to journalReview article

Cell Nucleus Active Transport
GTP Phosphohydrolases
Eukaryotic Cells
Cell Cycle
Karyopherins
25 Citations (Scopus)

Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury

Rakhit, R. D., Kabir, A. N. M., Mockridge, J. W., Saurin, A. & Marber, M. S., 7 Sep 2001, In : Biochemical and Biophysical Research Communications. 286, 5, p. 995-1002 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
GTP-Binding Proteins
Nitric Oxide
Ischemia
Chemical activation
24 Citations (Scopus)

Therapeutic potential of ischaemic preconditioning

Edwards, R. J., Saurin, A. T., Rakhit, R. D. & Marber, M. S., 24 Dec 2001, In : British Journal of Clinical Pharmacology. 50, 2, p. 87-97 11 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)
ran GTP-Binding Protein
Schizosaccharomyces
Nuclear Proteins
Xenopus
Guanosine Triphosphate
2000
154 Citations (Scopus)

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, C. & Clarke, P. R., 26 May 2000, In : Science. 288, 5470, p. 1429-1432 4 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Nuclear Envelope
Xenopus
Chromatin
Ovum
207 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Quinones
Toxicity
Hydroquinones
Dicumarol
26 Citations (Scopus)

Ran alters nuclear pore complex conformation

Goldberg, M. W., Rutherford, S. A., Hughes, M., Cotter, L. A., Bagley, S., Kiseleva, E., Allen, T. D. & Clarke, P. R., 14 Jul 2000, In : Journal of Molecular Biology. 300, 3, p. 519-529 11 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cytoskeleton
Nucleoplasmins
Monomeric GTP-Binding Proteins
Nuclear Envelope
84 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
apoptosis
peptides
Apoptosis
Peptides
50 Citations (Scopus)

Substrate specificity determinants of the checkpoint protein kinase Chk1

Hutchins, J. R. A., Hughes, M. & Clarke, P. R., 21 Jan 2000, In : FEBS Letters. 466, 1, p. 91-95 5 p.

Research output: Contribution to journalArticle

Substrate Specificity
Protein Kinases
Peptides
Phosphorylation
Schizosaccharomyces
135 Citations (Scopus)

The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes

Saurin, A. T., Martin, J. L., Heads, R. J., Foley, C., Mockridge, J. W., Wright, M. J., Wang, Y. & Marber, M. S., 1 Nov 2000, In : FASEB Journal. 14, 14, p. 2237-2246 10 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Muscle Cells
Ischemia
Chemical activation
Protein Kinase C
1999
95 Citations (Scopus)

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, E., Savory, P., Cosulich, S., Clarke, P. & Woodman, P., 11 Mar 1999, In : Oncogene. 18, 10, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

Caspase 2
Caspase 3
Initiator Caspases
Caspases
Effector Caspases
72 Citations (Scopus)

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P. J. & Clarke, P. R., 11 Feb 1999, In : Current Biology. 9, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

cytochrome c
caspases
Caspases
Cytochromes c
Amplification

Inhibition, rather than activation, of p38 accounts for the cardioprotective effect of ischaemic preconditioning

Saurin, A. T., Foley, C. A., Mockridge, J., Heads, R. J. & Marber, M. S., 1 May 1999, In : Heart. 81, SUPPL. 1

Research output: Contribution to journalArticle

Ischemic Preconditioning
Protein Kinase C
Ischemia
Mitogen-Activated Protein Kinases
Muscle Cells
125 Citations (Scopus)

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, C., Hughes, M. & Clarke, P. R., 15 Jul 1999, In : Journal of Cell Science. 112, 14, p. 2453-2461 9 p.

Research output: Contribution to journalArticle

Xenopus
Guanosine Triphosphate
Microtubules
Ovum
Interphase
151 Citations (Scopus)

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

Gang, D. R., Costa, M. A., Fujita, M., Dinkova-Kostova, A. T., Wang, H. B., Burlat, V., Martin, W., Sarkanen, S., Davin, L. B. & Lewis, N. G., Mar 1999, In : Chemistry and Biology. 6, 3, p. 143-151 9 p.

Research output: Contribution to journalArticle

Open Access
Lignans
Lignin
Biosynthesis
Protein Array Analysis
Proteins
201 Citations (Scopus)

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T. & Talalay, P., 1 May 1999, In : Carcinogenesis. 20, 5, p. 911-914 4 p.

Research output: Contribution to journalArticle

Open Access
Curcumin
NAD(P)H Dehydrogenase (Quinone)
Aryl Hydrocarbon Receptors
Enzyme Induction
Enzymes
1998
171 Citations (Scopus)
NAD(P)H Dehydrogenase (Quinone)
Superoxides
ferulic acid
Enzymes
Carbon Monoxide
1997
67 Citations (Scopus)

Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis

Cosulich, S. C., Horiuchi, H., Zerial, M., Clarke, P. R. & Woodman, P. G., 5 Nov 1997, In : EMBO Journal. 16, 20, p. 6182-6191 10 p.

Research output: Contribution to journalArticle

Endosomes
Fusion reactions
Apoptosis
Membranes
Cytophagocytosis
31 Citations (Scopus)

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

Gang, D. R., Dinkova-Kostova, A. T., Davin, L. B. & Lewis, N. G., 1 Dec 1997, In : ACS Symposium Series. 658, p. 58-89 32 p.

Research output: Contribution to journalArticle

vestitone reductase
Lignans
Oxidoreductases
Phosphorylation
Pathogens
155 Citations (Scopus)

Regulation of apoptosis by BH3 domains in a cell-free system

Cosulich, S. C., Worrall, V., Hedge, P. J., Green, S. & Clarke, P. R., 1 Dec 1997, In : Current Biology. 7, 12, p. 913-920 8 p.

Research output: Contribution to journalArticle

Open Access
cell free system
Cell-Free System
sequence homology
apoptosis
Apoptosis
26 Citations (Scopus)

Xenopus Ran-binding protein 1: Molecular interactions and effects on nuclear assembly in Xenopus egg extracts

Nicolas, F. J., Zhang, C., Hughes, M., Goldberg, M. W., Watton, S. J. & Clarke, P. R., 1 Dec 1997, In : Journal of Cell Science. 110, 24, p. 3019-3030 12 p.

Research output: Contribution to journalArticle

Karyopherins
Xenopus
Ovum
Cell Nucleus Active Transport
Nuclear Pore Complex Proteins
1996
156 Citations (Scopus)

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia: Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase

Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A. & Lewis, N. G., 26 Nov 1996, In : Journal of Biological Chemistry. 271, 46, p. 29473-29482 10 p.

Research output: Contribution to journalArticle

Open Access
vestitone reductase
Forsythia
Lignans
Cloning
Purification
46 Citations (Scopus)

Apoptosis: Does stress kill?

Cosulich, S. & Clarke, P., 1 Jan 1996, In : Current Biology. 6, 12, p. 1586-1588 3 p.

Research output: Contribution to journalArticle

Open Access
Heat-Shock Proteins
Protein Kinases
Cell Death
apoptosis
Apoptosis
50 Citations (Scopus)

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, S. C., Green, S. & Clarke, P. R., 1 Aug 1996, In : Current Biology. 6, 8, p. 997-1005 9 p.

Research output: Contribution to journalArticle

cell free system
Cell-Free System
Peptide Hydrolases
proteinases
Chemical activation
38 Citations (Scopus)

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

Le Romancer, M., Cosulich, S. C., Jackson, S. P. & Clarke, P. R., 1 Dec 1996, In : Journal of Cell Science. 109, 13, p. 3121-3127 7 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Xenopus
Ovum
Catalytic Domain
DNA Cleavage
351 Citations (Scopus)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Phosphotransferases
Enzymes
Dual Specificity Phosphatase 1
Mitogen-Activated Protein Kinase 8

Nuclear proenkephalin induces cell death in a P53 dose-dependent manner

Devvar, D. A., Spraggon, C., Midgeley, C., Lane, D., Prescott, A. & Spruce, B. A., 1 Nov 1996, In : Biochemical Society Transactions. 24, 4, p. 571S 1 p., E51.

Research output: Contribution to journalArticle

Cell death
Cell Death
Fibroblasts
Cells
Secretory Pathway
1995
23 Citations (Scopus)

Cyclin-Dependent Kinases: CAK-handed kinase activation

Clarke, P. R., 1 Jan 1995, In : Current Biology. 5, 1, p. 40-42 3 p.

Research output: Contribution to journalArticle

Open Access
cyclin-dependent kinase
Cyclin-Dependent Kinases
phosphotransferases (kinases)
Phosphotransferases
Chemical activation

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Hoffmann, I., Clarke, P. R. & Draetta, G., 1 Jan 1995, In : Advances in Molecular and Cell Biology. 13, C, p. 151-164 14 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Cyclin B
Eukaryotic Cells
Biochemistry
Cell Cycle
1994
149 Citations (Scopus)

RNA helicases: modulators of RNA structure

Fuller-Pace, F. V., Aug 1994, In : Trends in Cell Biology. 4, 8, p. 271-274 4 p.

Research output: Contribution to journalArticle

RNA Helicases
RNA
Proteins
Ribonucleoproteins
Adenosine Triphosphate
42 Citations (Scopus)

Signal Transduction: Switching off MAP kinases

Clarke, P. R., 1 Jan 1994, In : Current Biology. 4, 7, p. 647-650 4 p.

Research output: Contribution to journalArticle

Signal transduction
mitogen-activated protein kinase
signal transduction
Signal Transduction
Phosphotransferases
1993
138 Citations (Scopus)

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

Hope, A. G., Downie, D. L., Sutherland, L. A., Lambert, J. J., Peters, J. A. & Burchell, B., 15 Apr 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 245, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Organism Cloning
Clone Cells
Hybridomas
Alternative Splicing
146 Citations (Scopus)

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts

Clarke, P. R., Hoffmann, I., Draetta, G. & Karsenti, E., 1 Apr 1993, In : Molecular Biology of the Cell. 4, 4, p. 397-411 15 p.

Research output: Contribution to journalArticle

Cyclin B
Protein Phosphatase 2
Xenopus
Ovum
Cell Cycle