Cellular Medicine

Research Output

Kinase and Phosphatase Cross-Talk at the Kinetochore

Saurin, A. T., 19 Jun 2018, In : Frontiers in Cell and Developmental Biology. 6, p. 1-23 23 p., 62.

Research output: Contribution to journalReview article

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15 Citations (Scopus)
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Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. & Williams, L. T., 1 Aug 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 15, p. 6896-6900 5 p.

Research output: Contribution to journalArticle

499 Citations (Scopus)

Laser light scattering applications in biotechnology

Zhelev, N. & Barudov, S., 15 Apr 2014, In : Biotechnology and Biotechnological Equipment. 19, 3, p. 3-8 6 p.

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10 Citations (Scopus)
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Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase

Davies, S. J., D'Sousa, R., Philips, H., Mattey, D., Hiley, C., Hayes, J. D., Aber, G. M. & Strange, R. C., 11 Jun 1993, In : Biochimica et Biophysica Acta: General Subjects. 1157, 2, p. 204-8 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

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1 Citation (Scopus)
116 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

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11 Citations (Scopus)
119 Downloads (Pure)

Monoclonal antibody against a nuclear matrix antigen in proliferating human cells

Philipova, R. N., Zhelev, N. Z., Todorov, I. T. & Hadjiolov, A. A., 1987, In : Biology of the Cell. 60, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells

Todorov, I. T., Philipova, R. N., Zhelev, N. Z. & Hadjiolov, A. A., Mar 1987, In : Cell Biology International Reports. 11, 3, p. 181-187 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKa pathway

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. & Delibegovic, M., Jun 2017, In : Molecular Metabolism. 6, 8, p. 845-853

Research output: Contribution to journalArticle

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7 Citations (Scopus)
103 Downloads (Pure)

New approaches to rapid screening for protein aggregates by light scattering

Zhelev, N., Khalil, H. S. & White, R., 16 Apr 2014, In : Biotechnology and Biotechnological Equipment. 27, 6, p. 4327-4331 5 p.

Research output: Contribution to journalArticle

New developments for prevention of type 1 diabetes: a paradigm shift?

Schofield, C. & Sutherland, C., 2 Jan 2019, In : British Journal of Hospital Medicine. 80, 1, p. 4-5 2 p.

Research output: Contribution to journalEditorial

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

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1 Citation (Scopus)
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New Lupane Derived Compounds with Pro-Apoptotic Activity in Cancer Cells: Synthesis and Structure-Activity Relationships

Šarek, J., Klinot, J., Džubák, P., Klinotová, E., Nosková, V., Křeček, V., Kořínková, G., Thomson, J. O., Janošt'Áková, A., Wang, S., Parsons, S., Fischer, P. M., Zhelev, N. Z. & Hajdúch, M., 4 Dec 2003, In : Journal of Medicinal Chemistry. 46, 25, p. 5402-5415 14 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R., 30 Mar 2010, In : Science Signaling. 3, 115, p. - 13 p., ra25.

Research output: Contribution to journalArticle

92 Citations (Scopus)

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Nothing in excess - lessons learned from the expression of high-mobility group proteins type A in non-cancer and cancer cells

Petkova, R., Tummala, H. & Zhelev, N., 1 Nov 2011, In : Biotechnology and Biotechnological Equipment. 25, 4, p. 2572-2575 4 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

Liby, K., Honda, T., Williams, C. R., Risingsong, R., Royce, D. B., Suh, N., Dinkova-Kostova, A. T., Stephenson, K. K., Talalay, P., Sundararajan, C., Gribble, G. W. & Sporn, M. B., 1 Jul 2007, In : Molecular Cancer Therapeutics. 6, 7, p. 2113-2119 7 p.

Research output: Contribution to journalArticle

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56 Citations (Scopus)

Nuclear proenkephalin induces cell death in a P53 dose-dependent manner

Devvar, D. A., Spraggon, C., Midgeley, C., Lane, D., Prescott, A. & Spruce, B. A., 1 Nov 1996, In : Biochemical Society Transactions. 24, 4, p. 571S 1 p., E51.

Research output: Contribution to journalArticle

Paracetamol-induced liver injury modelled in Xenopus laevis embryos

Saide, K., Sherwood, V. & Wheeler, G. N., 1 Mar 2019, In : Toxicology Letters. 302, p. 83-91 9 p.

Research output: Contribution to journalArticle

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1 Citation (Scopus)
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208 Citations (Scopus)

Pharamcological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in LDLR-/- mouse model of atherosclerosis

Thompson, D., Morrice, N., Grant, L., Lees, E. K., Mody, N., Wilson, H. & Delibegovic, M., 29 Sep 2017, In : Clinical Science. 131, 20, p. 2489-2501

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7 Citations (Scopus)
36 Downloads (Pure)

Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription

Khalil, H. S., Tummala, H., Hupp, T. R. & Zhelev, N., 1 Jun 2012, In : Experimental Biology and Medicine. 237, 6, p. 622-634 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

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7 Citations (Scopus)
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Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant defenses against electrophiles and oxidants

Dinkova-Kostova, A. T., Cheah, J., Samouilov, A., Zweier, J. L., Bozak, R. E., Hicks, R. J. & Talalay, P., 1 May 2007, In : Medicinal Chemistry. 3, 3, p. 261-268 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G., 1 Dec 1993, In : EMBO Journal. 12, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

538 Citations (Scopus)

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2

Morrugares, R., Correa-Sáez, A., Moreno Dorta, R., Garrido-Rodríguez, M., Muñoz, E., de la Vega, L. & Calzado, M. A., 11 Oct 2019, In : Cellular and Molecular Life Sciences. 19 p.

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Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

Wu, Z., Jiang, Q., Clarke, P. R. & Zhang, C., 1 Aug 2013, In : Journal of Cell Science. 126, 15, p. 3417-3428 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

Chen, D., Washbrook, E., Sarwar, N., Bates, G. J., Pace, P. E., Thirunuvakkarasu, V., Taylor, J., Epstein, R. J., Fuller-Pace, F. V., Egly, J. M., Coombes, R. C. & Ali, S., 1 Jan 2002, In : Oncogene. 21, 32, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

Research output: Contribution to journalArticle

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Phosphorylation-related accumulation of the 125K nuclear matrix protein mitotin in human mitotic cells

Zhelev, N. Z., Todorov, I. T., Philipova, R. N. & Hadjiolov, A. A., Jan 1990, In : Journal of Cell Science. 95, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

Gang, D. R., Dinkova-Kostova, A. T., Davin, L. B. & Lewis, N. G., 1 Dec 1997, In : ACS Symposium Series. 658, p. 58-89 32 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Physical and Chemical Processes and the Morphofunctional Characteristics of Human Erythrocytes in Hyperglycaemia

Revin, V. V., Klenova, N. A., Gromova, N. V., Grunyushkin, I. P., Solomadin, I. N., Tychkov, A. Y., Pestryakova, A. A., Sadykhova, A. V., Revina, E. S., Prosnikova, K. V., Bourdon, J-C. & Zhelev, N., 30 Aug 2017, In : Frontiers in Physiology. 8, 606.

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2 Citations (Scopus)
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162 Citations (Scopus)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

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2 Citations (Scopus)
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Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast

Cornblatt, B. S., Ye, L., Dinkova-Kostova, A. T., Erb, M., Fahey, J. W., Singh, N. K., Chen, M. S. A., Stierer, T., Garrett-Mayer, E., Argani, P., Davidson, N. E., Talalay, P., Kensler, T. W. & Visvanathan, K., 1 Jul 2007, In : Carcinogenesis. 28, 7, p. 1485-1490 6 p.

Research output: Contribution to journalArticle

214 Citations (Scopus)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

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3 Citations (Scopus)
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Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI

Evans, A., Whelehan, P., Thompson, A., Purdie, C., Jordan, L., Macaskill, J., Waugh, S., Fuller-Pace, F., Brauer, K. & Vinnicombe, S., Aug 2018, In : European Journal of Ultrasound. 39, 04, p. 422-431 10 p.

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10 Citations (Scopus)
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Preoperative prediction of margin requirement following a core biopsy result suggestive of a phyllodes tumour

Mberu, V., Macaskill, E. J., Purdie, C. & Evans, A., 17 Dec 2019, In : Clinical Radiology. 7 p.

Research output: Contribution to journalArticle

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S. & Pharoah, P., 1 Jun 2018, In : Breast Cancer Research and Treatment. 171, 2, p. 383-389 7 p.

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3 Citations (Scopus)
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66 Citations (Scopus)
114 Citations (Scopus)

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

Dinkova-Kostova, A. T., Jenkins, S. N., Fahey, J. W., Ye, L., Wehage, S. L., Liby, K. T., Stephenson, K. K., Wade, K. L. & Talalay, P., 28 Aug 2006, In : Cancer Letters. 240, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c

Martin, M. C., Allan, L. A., Lickrish, M., Sampson, C., Morrice, N. & Clarke, P. R., 15 Apr 2005, In : Journal of Biological Chemistry. 280, 15, p. 15449-15455 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Protein kinases, from B to C

Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B. & Parker, P. J., 1 Nov 2007, In : Biochemical Society Transactions. 35, 5, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Kovárová, H., Hajdúch, M., Koínková, G., Halada, P., Krupiková, S., Gouldsworthy, A., Zhelev, N. & Strnad, M., Nov 2000, In : Electrophoresis. 21, 17, p. 3757-3764 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 22 May 2018, In : Nature Communications. 9, 1, p. 2071 2071.

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2 Citations (Scopus)
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QTL meta-analysis of root traits in Brassica napus under contrasting phosphorus supply in two growth systems

Zhang, Y., Thomas, C. L., Xiang, J., Long, Y., Wang, X., Zou, J., Luo, Z., Ding, G., Cai, H., Graham, N. S., Hammond, J. P., King, G. J., White, P. J., Xu, F., Broadley, M. R., Shi, L. & Meng, J., 14 Sep 2016, In : Scientific Reports. 6, p. 1-12 12 p., 33113.

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20 Citations (Scopus)
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Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Ye, L., Dinkova-Kostova, A. T., Wade, K. L., Zhang, Y., Shapiro, T. A. & Talalay, P., 12 Jan 2002, In : Clinica Chimica Acta. 316, 1-2, p. 43-53 11 p.

Research output: Contribution to journalArticle

265 Citations (Scopus)