Cellular Medicine

Research Output 1984 2020

176 Citations (Scopus)

Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

Chen, D., Washbrook, E., Sarwar, N., Bates, G. J., Pace, P. E., Thirunuvakkarasu, V., Taylor, J., Epstein, R. J., Fuller-Pace, F. V., Egly, J. M., Coombes, R. C. & Ali, S., 1 Jan 2002, In : Oncogene. 21, 32, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Serine
Immune Sera
Signal Transduction
Phosphorylation
1 Citation (Scopus)
26 Downloads (Pure)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

Research output: Contribution to journalArticle

Open Access
File
Karyopherins
Cyclin B1
Spindle Apparatus
Phosphorylation
Mitosis
31 Citations (Scopus)

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

Gang, D. R., Dinkova-Kostova, A. T., Davin, L. B. & Lewis, N. G., 1 Dec 1997, In : ACS Symposium Series. 658, p. 58-89 32 p.

Research output: Contribution to journalArticle

vestitone reductase
Lignans
Oxidoreductases
Phosphorylation
Pathogens
2 Citations (Scopus)
92 Downloads (Pure)

Physical and Chemical Processes and the Morphofunctional Characteristics of Human Erythrocytes in Hyperglycaemia

Revin, V. V., Klenova, N. A., Gromova, N. V., Grunyushkin, I. P., Solomadin, I. N., Tychkov, A. Y., Pestryakova, A. A., Sadykhova, A. V., Revina, E. S., Prosnikova, K. V., Bourdon, J-C. & Zhelev, N., 30 Aug 2017, In : Frontiers in Physiology. 8, 606.

Research output: Contribution to journalArticle

Open Access
File
Chemical Phenomena
Physical Phenomena
Hyperglycemia
Hemoglobins
Erythrocytes
161 Citations (Scopus)
Open Access
Retinal Pigments
Keratinocytes
Leukemia
Oxidants
Antioxidants
1 Citation (Scopus)
35 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphorylation
Behavior Control
Phosphoprotein Phosphatases
212 Citations (Scopus)

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast

Cornblatt, B. S., Ye, L., Dinkova-Kostova, A. T., Erb, M., Fahey, J. W., Singh, N. K., Chen, M. S. A., Stierer, T., Garrett-Mayer, E., Argani, P., Davidson, N. E., Talalay, P., Kensler, T. W. & Visvanathan, K., 1 Jul 2007, In : Carcinogenesis. 28, 7, p. 1485-1490 6 p.

Research output: Contribution to journalArticle

Brassica
Chemoprevention
Breast
Glucosinolates
Heme Oxygenase-1
2 Citations (Scopus)
151 Downloads (Pure)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
Activin Receptors
LY-2157299
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
9 Citations (Scopus)
100 Downloads (Pure)

Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI

Evans, A., Whelehan, P., Thompson, A., Purdie, C., Jordan, L., Macaskill, J., Waugh, S., Fuller-Pace, F., Brauer, K. & Vinnicombe, S., Aug 2018, In : European Journal of Ultrasound. 39, 04, p. 422-431 10 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Magnetic Resonance Imaging
Breast Neoplasms
Drug Therapy
Sensitivity and Specificity

Preoperative prediction of margin requirement following a core biopsy result suggestive of a phyllodes tumour

Mberu, V., Macaskill, E. J., Purdie, C. & Evans, A., 17 Dec 2019, In : Clinical Radiology. 7 p.

Research output: Contribution to journalArticle

Phyllodes Tumor
Biopsy
Elasticity Imaging Techniques
Mammography
Chi-Square Distribution
2 Citations (Scopus)
75 Downloads (Pure)

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S. & Pharoah, P., 1 Jun 2018, In : Breast Cancer Research and Treatment. 171, 2, p. 383-389 7 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Breast Neoplasms
Survival
Biopsy
Neoplasms
66 Citations (Scopus)
Edible Plants
Enzymes
Neoplasms
Carcinogenesis
Animal Models
114 Citations (Scopus)
Oxidative Stress
Cysteine
Sulfhydryl Compounds
Oxidants
Genes
163 Citations (Scopus)

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

Dinkova-Kostova, A. T., Jenkins, S. N., Fahey, J. W., Ye, L., Wehage, S. L., Liby, K. T., Stephenson, K. K., Wade, K. L. & Talalay, P., 28 Aug 2006, In : Cancer Letters. 240, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

Brassica
Ultraviolet Rays
Carcinogenesis
Skin
Radiation
79 Citations (Scopus)

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c

Martin, M. C., Allan, L. A., Lickrish, M., Sampson, C., Morrice, N. & Clarke, P. R., 15 Apr 2005, In : Journal of Biological Chemistry. 280, 15, p. 15449-15455 7 p.

Research output: Contribution to journalArticle

Cytochromes c1
Caspase 9
Cyclic AMP-Dependent Protein Kinases
Cytochromes c
Chemical activation
31 Citations (Scopus)

Protein kinases, from B to C

Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B. & Parker, P. J., 1 Nov 2007, In : Biochemical Society Transactions. 35, 5, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Catalytic Domain
Phosphorylation
Protein Kinase C
Ground state
1 Citation (Scopus)
68 Downloads (Pure)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 22 May 2018, In : Nature Communications. 9, 1, p. 2071 2071.

Research output: Contribution to journalArticle

Open Access
File
document markup languages
inhibitors
Publications
Tumors
tumors
20 Citations (Scopus)
84 Downloads (Pure)

QTL meta-analysis of root traits in Brassica napus under contrasting phosphorus supply in two growth systems

Zhang, Y., Thomas, C. L., Xiang, J., Long, Y., Wang, X., Zou, J., Luo, Z., Ding, G., Cai, H., Graham, N. S., Hammond, J. P., King, G. J., White, P. J., Xu, F., Broadley, M. R., Shi, L. & Meng, J., 14 Sep 2016, In : Scientific Reports. 6, p. 1-12 12 p., 33113.

Research output: Contribution to journalArticle

Open Access
File
Brassica napus
Quantitative Trait Loci
Phosphorus
Meta-Analysis
Growth
263 Citations (Scopus)

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Ye, L., Dinkova-Kostova, A. T., Wade, K. L., Zhang, Y., Shapiro, T. A. & Talalay, P., 12 Jan 2002, In : Clinica Chimica Acta. 316, 1-2, p. 43-53 11 p.

Research output: Contribution to journalArticle

Isothiocyanates
Plasma (human)
Pharmacokinetics
Brassica
Erythrocytes
26 Citations (Scopus)

Ran alters nuclear pore complex conformation

Goldberg, M. W., Rutherford, S. A., Hughes, M., Cotter, L. A., Bagley, S., Kiseleva, E., Allen, T. D. & Clarke, P. R., 14 Jul 2000, In : Journal of Molecular Biology. 300, 3, p. 519-529 11 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cytoskeleton
Nucleoplasmins
Monomeric GTP-Binding Proteins
Nuclear Envelope
105 Citations (Scopus)

Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Clarke, P. R. & Zhang, C., 1 Sep 2001, In : Trends in Cell Biology. 11, 9, p. 366-371 6 p.

Research output: Contribution to journalReview article

Cell Nucleus Active Transport
GTP Phosphohydrolases
Eukaryotic Cells
Cell Cycle
Karyopherins
125 Citations (Scopus)

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, C., Hughes, M. & Clarke, P. R., 15 Jul 1999, In : Journal of Cell Science. 112, 14, p. 2453-2461 9 p.

Research output: Contribution to journalArticle

Xenopus
Guanosine Triphosphate
Microtubules
Ovum
Interphase
85 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
apoptosis
peptides
Apoptosis
Peptides
46 Downloads (Pure)

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Lithium
Biomarkers
Alzheimer Disease
Clinical Trials
Cognitive Dysfunction
28 Citations (Scopus)

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

Zoete, V., Rougée, M., Dinkova-Kostova, A. T., Talalay, P. & Bensasson, R. V., 1 Jun 2004, In : Free Radical Biology and Medicine. 36, 11, p. 1418-1423 6 p.

Research output: Contribution to journalArticle

Molecular orbitals
Oxidation-Reduction
Electrons
Enzymes
NAD(P)H Dehydrogenase (Quinone)
151 Citations (Scopus)

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

Gang, D. R., Costa, M. A., Fujita, M., Dinkova-Kostova, A. T., Wang, H. B., Burlat, V., Martin, W., Sarkanen, S., Davin, L. B. & Lewis, N. G., Mar 1999, In : Chemistry and Biology. 6, 3, p. 143-151 9 p.

Research output: Contribution to journalArticle

Open Access
Lignans
Lignin
Biosynthesis
Protein Array Analysis
Proteins
155 Citations (Scopus)

Regulation of apoptosis by BH3 domains in a cell-free system

Cosulich, S. C., Worrall, V., Hedge, P. J., Green, S. & Clarke, P. R., 1 Dec 1997, In : Current Biology. 7, 12, p. 913-920 8 p.

Research output: Contribution to journalArticle

Open Access
cell free system
Cell-Free System
sequence homology
apoptosis
Apoptosis
35 Citations (Scopus)
cdc25 Phosphatases
Cyclin B
Calcium-Calmodulin-Dependent Protein Kinases
Xenopus
Ovum
213 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
AMP-Activated Protein Kinases
Liver
Rats
Enzymes
43 Citations (Scopus)

Regulation of p34cdc2 protein kinase: New insights into protein phosphorylation and the cell cycle

Clarke, P. R. & Karsenti, E., Nov 1991, In : Journal of Cell Science. 100, 3, p. 409-414 6 p.

Research output: Contribution to journalComment/debate

201 Citations (Scopus)

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T. & Talalay, P., 1 May 1999, In : Carcinogenesis. 20, 5, p. 911-914 4 p.

Research output: Contribution to journalArticle

Open Access
Curcumin
NAD(P)H Dehydrogenase (Quinone)
Aryl Hydrocarbon Receptors
Enzyme Induction
Enzymes
66 Citations (Scopus)

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

Kerns, M. L., DePianto, D., Dinkova-Kostova, A. T., Talalay, P. & Coulombe, P. A., 4 Sep 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14460-14465 6 p.

Research output: Contribution to journalArticle

Open Access
Epidermolysis Bullosa Simplex
Keratins
Skin
Keratinocytes
Intermediate Filaments
149 Citations (Scopus)

RNA helicases: modulators of RNA structure

Fuller-Pace, F. V., Aug 1994, In : Trends in Cell Biology. 4, 8, p. 271-274 4 p.

Research output: Contribution to journalArticle

RNA Helicases
RNA
Proteins
Ribonucleoproteins
Adenosine Triphosphate
25 Citations (Scopus)

Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury

Rakhit, R. D., Kabir, A. N. M., Mockridge, J. W., Saurin, A. & Marber, M. S., 7 Sep 2001, In : Biochemical and Biophysical Research Communications. 286, 5, p. 995-1002 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
GTP-Binding Proteins
Nitric Oxide
Ischemia
Chemical activation
8 Citations (Scopus)
22 Downloads (Pure)

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Revin, V. V., Gromova, N. V., Revina, E. S., Martynova, M. I., Seikina, A. I., Revina, N. V., Imarova, O. G., Solomadin, I. N., Tychkov, A. Y. & Zhelev, N., 2016, In : BioMed Research International. 2016, p. 1-11 11 p., 3429604.

Research output: Contribution to journalArticle

Open Access
File
Membrane Lipids
Hemoglobins
Cardiovascular Diseases
Erythrocytes
Interference Microscopy
220 Citations (Scopus)

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical phase I study

Shapiro, T. A., Fahey, J. W., Dinkova-Kostova, A. T., Holtzclaw, W. D., Stephenson, K. K., Wade, K. L., Ye, L. & Talalay, P., 5 Oct 2006, In : Nutrition and Cancer. 55, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Isothiocyanates
Glucosinolates
sprouts (food)
Brassica
isothiocyanates
42 Citations (Scopus)

Signal Transduction: Switching off MAP kinases

Clarke, P. R., 1 Jan 1994, In : Current Biology. 4, 7, p. 647-650 4 p.

Research output: Contribution to journalArticle

Signal transduction
mitogen-activated protein kinase
signal transduction
Signal Transduction
Phosphotransferases
19 Downloads (Pure)

Some problems and errors in cytogenetic biodosimetry

Mosse, I., Kilchevsky, A., Nikolova, N. & Zhelev, N., 4 May 2017, In : Biotechnology and Biotechnological Equipment. 31, 3, p. 460-468 9 p.

Research output: Contribution to journalReview article

Open Access
File
Radiation Tolerance
Cytogenetics
Alleles
Binomial Distribution
Interspersed Repetitive Sequences
18 Citations (Scopus)

Spatial and temporal control of nuclear envelope assembly by Ran GTPase.

Clarke, P. R. & Zhang, C., 1 Jan 2004, In : Symposia of the Society for Experimental Biology. 56, p. 193-204 12 p.

Research output: Contribution to journalReview article

GTP Phosphohydrolases
Nuclear Envelope
Guanosine Triphosphate
beta Karyopherins
Chromatin
66 Citations (Scopus)

Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia

Chu, A., Dinkova, A., Davin, L. B., Bedgar, D. L. & Lewis, N. G., 25 Dec 1993, In : Journal of Biological Chemistry. 268, 36, p. 27026-27033 8 p.

Research output: Contribution to journalArticle

Forsythia
NADP
Hydrides
Lignans
Ether
50 Citations (Scopus)

Substrate specificity determinants of the checkpoint protein kinase Chk1

Hutchins, J. R. A., Hughes, M. & Clarke, P. R., 21 Jan 2000, In : FEBS Letters. 466, 1, p. 91-95 5 p.

Research output: Contribution to journalArticle

Substrate Specificity
Protein Kinases
Peptides
Phosphorylation
Schizosaccharomyces
117 Citations (Scopus)

Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts

Saurin, A. T., Pennington, D. J., Raat, N. J. H., Latchman, D. S., Owen, M. J. & Marber, M. S., 15 Aug 2002, In : Cardiovascular Research. 55, 3, p. 672-680 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Ischemic Preconditioning
Protein Kinase C
Buffers
Genes
18 Citations (Scopus)

Temporal analysis of transcription and replication during acute infection with lymphocytic choriomeningitis virus

Fuller-Pace, F. V. & Southern, P. J., 1 Jan 1988, In : Virology. 162, 1, p. 260-263 4 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Nucleoproteins
Infection
RNA Precursors

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Hoffmann, I., Clarke, P. R. & Draetta, G., 1 Jan 1995, In : Advances in Molecular and Cell Biology. 13, C, p. 151-164 14 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Cyclin B
Eukaryotic Cells
Biochemistry
Cell Cycle
9 Citations (Scopus)

The circular RNome of primary breast cancer

Smid, M., Wilting, S. M., Uhr, K., Rodríguez-González, F. G., De Weerd, V., Prager-Van Der Smissen, W. J. C., Van Der Vlugt-Daane, M., Van Galen, A., Nik-Zainal, S., Butler, A., Martin, S., Davies, H. R., Staaf, J., Van De Vijver, M. J., Richardson, A. L., MacGrogan, G., Salgado, R., Van Den Eynden, G. G. G. M., Purdie, C. A., Thompson, A. M. & 21 others, Caldas, C., Span, P. N., Sweep, F. C. G. J., Simpson, P. T., Lakhani, S. R., Van Laere, S., Desmedt, C., Paradiso, A., Eyfjord, J., Broeks, A., Vincent-Salomon, A., Futreal, A. P., Knappskog, S., King, T., Viari, A., Børresen-Dale, A. L., Stunnenberg, H. G., Stratton, M., Foekens, J. A., Sieuwerts, A. M. & Martens, J. W. M., 1 Mar 2019, In : Genome Research. 29, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
RNA
circular RNA
Aromatase Inhibitors
Computer Simulation
4 Citations (Scopus)
29 Downloads (Pure)

The collagen prolyl hydroxylases are bifunctional growth regulators in melanoma

Atkinson, A., Renziehausen, A., Wang, H., Nigro, C. L., Lattanzio, L., Merlano, M., Rao, B., Weir, L., Evans, A., Matin, R., Harwood, C., Szlosarek, P., Pickering, J. G., Fleming, C., Sim, V. R., Li, S., Vasta, J. T., Raines, R. T., Boniol, M., Thompson, A. & 3 others, Proby, C., Crook, T. & Syed, N., 16 Nov 2018, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Open Access
File
Prolyl Hydroxylases
Melanoma
Collagen
Growth
Tumors
7 Citations (Scopus)

The Crm de la crème of mitosis

Clarke, P. R., 1 Jun 2005, In : Nature Cell Biology. 7, 6, p. 551-552 2 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Mitosis
Kinetochores
Monomeric GTP-Binding Proteins
Guanosine Triphosphate
105 Downloads (Pure)

The effect of experimental hyperoxia on erythrocytes’ oxygen-transport function

Revin, V. V., Gromova, N. V., Revina, E. S., Grunyushkin, I. P., Tychkov, A. Y., Samonova, A. Y., Kukina, A. N., Moskovkin, A. A., Bourdon, J. C. & Zhelev, N., 2018, In : Biotechnology and Biotechnological Equipment. 32, 5, p. 1236-1250 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hyperoxia
Erythrocytes
Oxygen
Erythrocyte Membrane
Ions
17 Downloads (Pure)

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases

Anbarasan, T. & Bourdon, J-C., 11 Dec 2019, In : International Journal of Molecular Sciences. 20, 24, p. 1-20 20 p., 6257.

Research output: Contribution to journalReview article

Open Access
File
physiology
Physiology
emerging
Protein Isoforms
cancer