Cellular Medicine

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Article

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R., 30 Mar 2010, In : Science Signaling. 3, 115, p. - 13 p., ra25.

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92 Citations (Scopus)

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S., den Breems, N., Dimon, M., Arron, S. T., Kluk, M. J., Aster, J. C., McHugh, A., Xue, D. J., Dayal, J. H. S., Robinson, K. S., Rizvi, S. M. H., Proby, C. M., Harwood, C. A. & Leigh, I. M., Oct 2014, In : Journal of Investigative Dermatology. 134, 10, p. 2630-2638 9 p.

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134 Citations (Scopus)

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

Liby, K., Honda, T., Williams, C. R., Risingsong, R., Royce, D. B., Suh, N., Dinkova-Kostova, A. T., Stephenson, K. K., Talalay, P., Sundararajan, C., Gribble, G. W. & Sporn, M. B., 1 Jul 2007, In : Molecular Cancer Therapeutics. 6, 7, p. 2113-2119 7 p.

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56 Citations (Scopus)

Nuclear proenkephalin induces cell death in a P53 dose-dependent manner

Devvar, D. A., Spraggon, C., Midgeley, C., Lane, D., Prescott, A. & Spruce, B. A., 1 Nov 1996, In : Biochemical Society Transactions. 24, 4, p. 571S 1 p., E51.

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Paracetamol-induced liver injury modelled in Xenopus laevis embryos

Saide, K., Sherwood, V. & Wheeler, G. N., 1 Mar 2019, In : Toxicology Letters. 302, p. 83-91 9 p.

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Pharamcological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in LDLR-/- mouse model of atherosclerosis

Thompson, D., Morrice, N., Grant, L., Lees, E. K., Mody, N., Wilson, H. & Delibegovic, M., 29 Sep 2017, In : Clinical Science. 131, 20, p. 2489-2501

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Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription

Khalil, H. S., Tummala, H., Hupp, T. R. & Zhelev, N., 1 Jun 2012, In : Experimental Biology and Medicine. 237, 6, p. 622-634 13 p.

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11 Citations (Scopus)

Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant defenses against electrophiles and oxidants

Dinkova-Kostova, A. T., Cheah, J., Samouilov, A., Zweier, J. L., Bozak, R. E., Hicks, R. J. & Talalay, P., 1 May 2007, In : Medicinal Chemistry. 3, 3, p. 261-268 8 p.

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38 Citations (Scopus)

Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G., 1 Dec 1993, In : EMBO Journal. 12, 1, p. 53-63 11 p.

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538 Citations (Scopus)

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2

Morrugares, R., Correa-Sáez, A., Moreno Dorta, R., Garrido-Rodríguez, M., Muñoz, E., de la Vega, L. & Calzado, M. A., 11 Oct 2019, In : Cellular and Molecular Life Sciences. 19 p.

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Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

Wu, Z., Jiang, Q., Clarke, P. R. & Zhang, C., 1 Aug 2013, In : Journal of Cell Science. 126, 15, p. 3417-3428 12 p.

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19 Citations (Scopus)

Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

Chen, D., Washbrook, E., Sarwar, N., Bates, G. J., Pace, P. E., Thirunuvakkarasu, V., Taylor, J., Epstein, R. J., Fuller-Pace, F. V., Egly, J. M., Coombes, R. C. & Ali, S., 1 Jan 2002, In : Oncogene. 21, 32, p. 4921-4931 11 p.

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176 Citations (Scopus)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

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Phosphorylation-related accumulation of the 125K nuclear matrix protein mitotin in human mitotic cells

Zhelev, N. Z., Todorov, I. T., Philipova, R. N. & Hadjiolov, A. A., Jan 1990, In : Journal of Cell Science. 95, 1, p. 59-64 6 p.

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12 Citations (Scopus)

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

Gang, D. R., Dinkova-Kostova, A. T., Davin, L. B. & Lewis, N. G., 1 Dec 1997, In : ACS Symposium Series. 658, p. 58-89 32 p.

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31 Citations (Scopus)

Physical and Chemical Processes and the Morphofunctional Characteristics of Human Erythrocytes in Hyperglycaemia

Revin, V. V., Klenova, N. A., Gromova, N. V., Grunyushkin, I. P., Solomadin, I. N., Tychkov, A. Y., Pestryakova, A. A., Sadykhova, A. V., Revina, E. S., Prosnikova, K. V., Bourdon, J-C. & Zhelev, N., 30 Aug 2017, In : Frontiers in Physiology. 8, 606.

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162 Citations (Scopus)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

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Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast

Cornblatt, B. S., Ye, L., Dinkova-Kostova, A. T., Erb, M., Fahey, J. W., Singh, N. K., Chen, M. S. A., Stierer, T., Garrett-Mayer, E., Argani, P., Davidson, N. E., Talalay, P., Kensler, T. W. & Visvanathan, K., 1 Jul 2007, In : Carcinogenesis. 28, 7, p. 1485-1490 6 p.

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214 Citations (Scopus)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

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Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI

Evans, A., Whelehan, P., Thompson, A., Purdie, C., Jordan, L., Macaskill, J., Waugh, S., Fuller-Pace, F., Brauer, K. & Vinnicombe, S., Aug 2018, In : European Journal of Ultrasound. 39, 04, p. 422-431 10 p.

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Preoperative prediction of margin requirement following a core biopsy result suggestive of a phyllodes tumour

Mberu, V., Macaskill, E. J., Purdie, C. & Evans, A., 17 Dec 2019, In : Clinical Radiology. 7 p.

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Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S. & Pharoah, P., 1 Jun 2018, In : Breast Cancer Research and Treatment. 171, 2, p. 383-389 7 p.

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114 Citations (Scopus)

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

Dinkova-Kostova, A. T., Jenkins, S. N., Fahey, J. W., Ye, L., Wehage, S. L., Liby, K. T., Stephenson, K. K., Wade, K. L. & Talalay, P., 28 Aug 2006, In : Cancer Letters. 240, 2, p. 243-252 10 p.

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165 Citations (Scopus)

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c

Martin, M. C., Allan, L. A., Lickrish, M., Sampson, C., Morrice, N. & Clarke, P. R., 15 Apr 2005, In : Journal of Biological Chemistry. 280, 15, p. 15449-15455 7 p.

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80 Citations (Scopus)

Protein kinases, from B to C

Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B. & Parker, P. J., 1 Nov 2007, In : Biochemical Society Transactions. 35, 5, p. 1013-1017 5 p.

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31 Citations (Scopus)

Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Kovárová, H., Hajdúch, M., Koínková, G., Halada, P., Krupiková, S., Gouldsworthy, A., Zhelev, N. & Strnad, M., Nov 2000, In : Electrophoresis. 21, 17, p. 3757-3764 8 p.

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53 Citations (Scopus)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 22 May 2018, In : Nature Communications. 9, 1, p. 2071 2071.

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QTL meta-analysis of root traits in Brassica napus under contrasting phosphorus supply in two growth systems

Zhang, Y., Thomas, C. L., Xiang, J., Long, Y., Wang, X., Zou, J., Luo, Z., Ding, G., Cai, H., Graham, N. S., Hammond, J. P., King, G. J., White, P. J., Xu, F., Broadley, M. R., Shi, L. & Meng, J., 14 Sep 2016, In : Scientific Reports. 6, p. 1-12 12 p., 33113.

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Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Ye, L., Dinkova-Kostova, A. T., Wade, K. L., Zhang, Y., Shapiro, T. A. & Talalay, P., 12 Jan 2002, In : Clinica Chimica Acta. 316, 1-2, p. 43-53 11 p.

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265 Citations (Scopus)

Ran alters nuclear pore complex conformation

Goldberg, M. W., Rutherford, S. A., Hughes, M., Cotter, L. A., Bagley, S., Kiseleva, E., Allen, T. D. & Clarke, P. R., 14 Jul 2000, In : Journal of Molecular Biology. 300, 3, p. 519-529 11 p.

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26 Citations (Scopus)

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, C., Hughes, M. & Clarke, P. R., 15 Jul 1999, In : Journal of Cell Science. 112, 14, p. 2453-2461 9 p.

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126 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

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85 Citations (Scopus)

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

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Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

Zoete, V., Rougée, M., Dinkova-Kostova, A. T., Talalay, P. & Bensasson, R. V., 1 Jun 2004, In : Free Radical Biology and Medicine. 36, 11, p. 1418-1423 6 p.

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28 Citations (Scopus)

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

Gang, D. R., Costa, M. A., Fujita, M., Dinkova-Kostova, A. T., Wang, H. B., Burlat, V., Martin, W., Sarkanen, S., Davin, L. B. & Lewis, N. G., Mar 1999, In : Chemistry and Biology. 6, 3, p. 143-151 9 p.

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152 Citations (Scopus)

Regulation of apoptosis by BH3 domains in a cell-free system

Cosulich, S. C., Worrall, V., Hedge, P. J., Green, S. & Clarke, P. R., 1 Dec 1997, In : Current Biology. 7, 12, p. 913-920 8 p.

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156 Citations (Scopus)
35 Citations (Scopus)
213 Citations (Scopus)

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T. & Talalay, P., 1 May 1999, In : Carcinogenesis. 20, 5, p. 911-914 4 p.

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201 Citations (Scopus)

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

Kerns, M. L., DePianto, D., Dinkova-Kostova, A. T., Talalay, P. & Coulombe, P. A., 4 Sep 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14460-14465 6 p.

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67 Citations (Scopus)

RNA helicases: modulators of RNA structure

Fuller-Pace, F. V., Aug 1994, In : Trends in Cell Biology. 4, 8, p. 271-274 4 p.

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149 Citations (Scopus)

Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury

Rakhit, R. D., Kabir, A. N. M., Mockridge, J. W., Saurin, A. & Marber, M. S., 7 Sep 2001, In : Biochemical and Biophysical Research Communications. 286, 5, p. 995-1002 8 p.

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25 Citations (Scopus)

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Revin, V. V., Gromova, N. V., Revina, E. S., Martynova, M. I., Seikina, A. I., Revina, N. V., Imarova, O. G., Solomadin, I. N., Tychkov, A. Y. & Zhelev, N., 2016, In : BioMed Research International. 2016, p. 1-11 11 p., 3429604.

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Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical phase I study

Shapiro, T. A., Fahey, J. W., Dinkova-Kostova, A. T., Holtzclaw, W. D., Stephenson, K. K., Wade, K. L., Ye, L. & Talalay, P., 5 Oct 2006, In : Nutrition and Cancer. 55, 1, p. 53-62 10 p.

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223 Citations (Scopus)

Saponins from Tribulus terrestris L. are less toxic for normal human fibroblasts than for many cancer lines: Influence on apoptosis and proliferation

Neychev, V. K., Nikolova, E., Zhelev, N. & Mitev, V. I., 1 Jan 2007, In : Experimental Biology and Medicine. 232, 1, p. 126-133 8 p.

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31 Citations (Scopus)

Signalling to chromatin and the superinduction of proto-oncogenes

Zhelev, N., Kardalinou, E., Hazzalin, C. A., Cano, E., Barratt, M. J. & Mahadevan, L. C., 1 Nov 1993, In : Biochemical Society Transactions. 21, 4, p. 907-911 5 p.

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5 Citations (Scopus)

Signal Transduction: Switching off MAP kinases

Clarke, P. R., 1 Jan 1994, In : Current Biology. 4, 7, p. 647-650 4 p.

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42 Citations (Scopus)