Cellular Medicine

Research Output 1984 2020

1997
26 Citations (Scopus)

Xenopus Ran-binding protein 1: Molecular interactions and effects on nuclear assembly in Xenopus egg extracts

Nicolas, F. J., Zhang, C., Hughes, M., Goldberg, M. W., Watton, S. J. & Clarke, P. R., 1 Dec 1997, In : Journal of Cell Science. 110, 24, p. 3019-3030 12 p.

Research output: Contribution to journalArticle

Karyopherins
Xenopus
Ovum
Cell Nucleus Active Transport
Nuclear Pore Complex Proteins
1996
156 Citations (Scopus)

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia: Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase

Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A. & Lewis, N. G., 26 Nov 1996, In : Journal of Biological Chemistry. 271, 46, p. 29473-29482 10 p.

Research output: Contribution to journalArticle

Open Access
vestitone reductase
Forsythia
Lignans
Cloning
Purification
46 Citations (Scopus)

Apoptosis: Does stress kill?

Cosulich, S. & Clarke, P., 1 Jan 1996, In : Current Biology. 6, 12, p. 1586-1588 3 p.

Research output: Contribution to journalArticle

Open Access
Heat-Shock Proteins
Protein Kinases
Cell Death
apoptosis
Apoptosis
50 Citations (Scopus)

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, S. C., Green, S. & Clarke, P. R., 1 Aug 1996, In : Current Biology. 6, 8, p. 997-1005 9 p.

Research output: Contribution to journalArticle

cell free system
Cell-Free System
Peptide Hydrolases
proteinases
Chemical activation
38 Citations (Scopus)

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

Le Romancer, M., Cosulich, S. C., Jackson, S. P. & Clarke, P. R., 1 Dec 1996, In : Journal of Cell Science. 109, 13, p. 3121-3127 7 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Xenopus
Ovum
Catalytic Domain
DNA Cleavage
351 Citations (Scopus)

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S. & Keyse, S. M., 15 Jul 1996, In : EMBO Journal. 15, 14, p. 3621-32 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Phosphotransferases
Enzymes
Dual Specificity Phosphatase 1
Mitogen-Activated Protein Kinase 8

Nuclear proenkephalin induces cell death in a P53 dose-dependent manner

Devvar, D. A., Spraggon, C., Midgeley, C., Lane, D., Prescott, A. & Spruce, B. A., 1 Nov 1996, In : Biochemical Society Transactions. 24, 4, p. 571S 1 p., E51.

Research output: Contribution to journalArticle

Cell death
Cell Death
Fibroblasts
Cells
Secretory Pathway
1995
23 Citations (Scopus)

Cyclin-Dependent Kinases: CAK-handed kinase activation

Clarke, P. R., 1 Jan 1995, In : Current Biology. 5, 1, p. 40-42 3 p.

Research output: Contribution to journalArticle

Open Access
cyclin-dependent kinase
Cyclin-Dependent Kinases
phosphotransferases (kinases)
Phosphotransferases
Chemical activation

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Hoffmann, I., Clarke, P. R. & Draetta, G., 1 Jan 1995, In : Advances in Molecular and Cell Biology. 13, C, p. 151-164 14 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Cyclin B
Eukaryotic Cells
Biochemistry
Cell Cycle
1994
149 Citations (Scopus)

RNA helicases: modulators of RNA structure

Fuller-Pace, F. V., Aug 1994, In : Trends in Cell Biology. 4, 8, p. 271-274 4 p.

Research output: Contribution to journalArticle

RNA Helicases
RNA
Proteins
Ribonucleoproteins
Adenosine Triphosphate
42 Citations (Scopus)

Signal Transduction: Switching off MAP kinases

Clarke, P. R., 1 Jan 1994, In : Current Biology. 4, 7, p. 647-650 4 p.

Research output: Contribution to journalArticle

Signal transduction
mitogen-activated protein kinase
signal transduction
Signal Transduction
Phosphotransferases
1993
139 Citations (Scopus)

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

Hope, A. G., Downie, D. L., Sutherland, L. A., Lambert, J. J., Peters, J. A. & Burchell, B., 15 Apr 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 245, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Organism Cloning
Clone Cells
Hybridomas
Alternative Splicing
146 Citations (Scopus)

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts

Clarke, P. R., Hoffmann, I., Draetta, G. & Karsenti, E., 1 Apr 1993, In : Molecular Biology of the Cell. 4, 4, p. 397-411 15 p.

Research output: Contribution to journalArticle

Cyclin B
Protein Phosphatase 2
Xenopus
Ovum
Cell Cycle
15 Citations (Scopus)

Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase

Davies, S. J., D'Sousa, R., Philips, H., Mattey, D., Hiley, C., Hayes, J. D., Aber, G. M. & Strange, R. C., 11 Jun 1993, In : Biochimica et Biophysica Acta: General Subjects. 1157, 2, p. 204-8 5 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
Glutathione Transferase
Superoxide Dismutase
Kidney
Mesangial Cells
535 Citations (Scopus)

Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G., 1 Dec 1993, In : EMBO Journal. 12, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

Cyclin B
Phosphorylation
Mitosis
Amplification
Chemical activation
66 Citations (Scopus)

Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia

Chu, A., Dinkova, A., Davin, L. B., Bedgar, D. L. & Lewis, N. G., 25 Dec 1993, In : Journal of Biological Chemistry. 268, 36, p. 27026-27033 8 p.

Research output: Contribution to journalArticle

Forsythia
NADP
Hydrides
Lignans
Ether
1992

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

Hoffmann, I., Clarke, P., Karsenti, E. & Draetta, G., 1 Jan 1992, In : Biology of the Cell. 76, 2, p. 213 1 p.

Research output: Contribution to journalArticle

Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 19, 1 p.

Research output: Contribution to journalComment/debate

86 Citations (Scopus)

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

MACKINTOSH, R. W., DAVIES, S. P., CLARKE, P. R., WEEKES, J., GILLESPIE, J. G., GIBB, B. J. & HARDIE, D. G., 1 Jan 1992, In : European Journal of Biochemistry. 209, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Oxidoreductases
Phosphotransferases
Terpenes
Enzymes
30 Citations (Scopus)

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A

Thomas, L., Clarke, P. R., Pagano, M. & Gruenberg, J., 1 Jan 1992, In : Journal of Biological Chemistry. 267, 9, p. 6183-6187 5 p.

Research output: Contribution to journalArticle

Cyclin B
Cyclin A
Membrane Fusion
Phosphotransferases
Fusion reactions
498 Citations (Scopus)

Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. & Williams, L. T., 1 Aug 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 15, p. 6896-6900 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Dermis
Wound Healing
Fibroblast Growth Factor Receptors
Fibroblast Growth Factor 2
1991
4 Citations (Scopus)

Adenosine Monophosphate-Activated Protein Kinase: Hydroxymethylglutaryl-CoA Reductase Kinase

Carling, D., Clarke, P. R. & Hardie, D. G., 1 Jan 1991, In : Methods in Enzymology. 200, C, p. 362-371 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
Adenosine Monophosphate
Protein Kinases
Phosphotransferases
Acetyl-CoA Carboxylase
43 Citations (Scopus)

Regulation of p34cdc2 protein kinase: New insights into protein phosphorylation and the cell cycle

Clarke, P. R. & Karsenti, E., Nov 1991, In : Journal of Cell Science. 100, 3, p. 409-414 6 p.

Research output: Contribution to journalComment/debate

1990
10 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
Serine
Protein Kinase C
213 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
AMP-Activated Protein Kinases
Liver
Rats
Enzymes
1989
26 Citations (Scopus)
RNA-directed RNA polymerase
Lymphocytic choriomeningitis virus
RNA Replicase
Viral RNA
Cell Extracts
20 Citations (Scopus)

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Williams, R. J., McCarthy, A. D. & Sutherland, C. D., 8 Jun 1989, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1003, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Esterification
Sterol O-Acyltransferase
Rats
Cholesterol
Enterocytes
1988
36 Citations (Scopus)

Distribution and diversity of hsd genes in Escherichia coli and other enteric bacteria.

Daniel, A. S., Fuller-Pace, F. V., Legge, D. M. & Murray, N. E., 1 Apr 1988, In : Journal of Bacteriology. 170, 4, p. 1775-1782 8 p.

Research output: Contribution to journalArticle

Enterobacteriaceae
Citrobacter freundii
Escherichia coli
DNA Restriction-Modification Enzymes
Genes
18 Citations (Scopus)

Temporal analysis of transcription and replication during acute infection with lymphocytic choriomeningitis virus

Fuller-Pace, F. V. & Southern, P. J., 1 Jan 1988, In : Virology. 162, 1, p. 260-263 4 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Nucleoproteins
Infection
RNA Precursors

The role of the viral polymerase in acute and persistent lcmv infection

Fuller-Pace, F. V. & Southern, P. J., 1 Sep 1988, In : Virus Research. 11, SUPPL. 1, p. 35 1 p.

Research output: Contribution to journalArticle

1987
44 Citations (Scopus)

Analysis of the genomic l rna segment from lymphocytic choriomeningitis virus

Singh, M. K., Fuller-Pace, F. V., Buchmeier, M. J. & Southern, P. J., 1 Dec 1987, In : Virology. 161, 2, p. 448-456 9 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
RNA
Proteins
Reassortant Viruses
Arenavirus
1986
62 Citations (Scopus)
Type I Site Specific Deoxyribonucleases
Peptides
DNA
Genes
Salmonella typhimurium
1985
58 Citations (Scopus)

EcoA and EcoE: Alternatives to the EcoK family of type I restriction and modification systems of Escherichia coli

Fuller-Pace, F. V., Cowan, G. M. & Murray, N. E., 5 Nov 1985, In : Journal of Molecular Biology. 186, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

DNA Restriction-Modification Enzymes
Escherichia coli
Genes
Peptides
Type I Site Specific Deoxyribonucleases
1984
64 Citations (Scopus)

Genetic recombination can generate altered restriction specificity

Fuller-Pace, F. V., Bullas, L. R., Delius, H. & Murray, N. E., 1 Oct 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 19 I, p. 6095-6099 5 p.

Research output: Contribution to journalArticle

Open Access
Genetic Recombination
Salmonella
Conserved Sequence
Genes
Heteroduplex Analysis