Cellular Medicine

Research Output 1984 2020

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2019
2 Citations (Scopus)
65 Downloads (Pure)

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In : Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cross-Over Studies
Tobacco
Blood Vessels
Healthy Volunteers
Smoking
19 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In : Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Drug Therapy
Calcinosis
Neoplasms
Biopsy
1 Citation (Scopus)

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 7 Feb 2019, In : Nature. 566, 7742, p. E1 1 p.

Research output: Contribution to journalArticle

Genome
Breast Neoplasms
Mutation
21 Downloads (Pure)

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., 5 Sep 2019, In : Redox Biology. 28, p. 1-15 15 p., 101321.

Research output: Contribution to journalArticle

Open Access
File
Cannabidiol
Keratinocytes
Antioxidants
Heme Oxygenase-1
Skin

Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes

Akentieva, N. P., Sanina, N. A., Gizatullin, A. R., Shkondina, N. I., Prikhodchenko, T. R., Shram, S. I., Zhelev, N. & Aldoshin, S. M., 11 Nov 2019, In : Frontiers in Pharmacology. 10, p. 1-10 21 p., 1277.

Research output: Contribution to journalArticle

Open Access
File
Cardiac Myocytes
Fibroblasts
Doxorubicin
Mitochondria
Nitric Oxide
2 Citations (Scopus)
48 Downloads (Pure)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A-L., La, H. M., Rossello, F. J., Änkö, M-L., Fuller-Pace, F. V. & Hobbs, R. M., 23 May 2019, In : Nature Communications. 10, 1, p. 1-21 21 p., 2278.

Research output: Contribution to journalArticle

Open Access
File
spermatogenesis
Spermatogonia
maintenance
Spermatogenesis
Genes
36 Downloads (Pure)

Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

Elabd, S., Jabeen, N. A., Gerber, V., Peravali, R., Bourdon, J-C., Kancherla, S., Vallone, D. & Blattner, C., 19 Jul 2019, In : PLoS ONE. 14, 7, 18 p., e0220069.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Cell proliferation
Zebrafish
Stem cells
Danio rerio
2 Citations (Scopus)
84 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Centromere
Protein Isoforms
Personnel
M Phase Cell Cycle Checkpoints
4 Citations (Scopus)
117 Downloads (Pure)

Dual-specificity MAP kinase phosphatases in health and disease

Seternes, O-M., Kidger, A. M. & Keyse, S., 1 Jan 2019, In : BBA - Molecular Cell Research. 1866, 1, p. 124-143 20 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphotransferases
Health
MAP Kinase Signaling System
Genetic Models

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Fenretinide
Phenotype
Dipeptidyl Peptidase 4
Glucose
Retinol-Binding Proteins
2 Citations (Scopus)

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

Atanasova, V. S., Pourreyron, C., Farshchian, M., Lawler, M. E., Brown, C. A., Watt, S., Wright, S., Warkala, M., Guttmann-Gruber, C., Pinon-Hofbauer, J., Fuentes, I., Prisco, M., Rashidghamat, E., Has, C., Salas-Alanis, J. C., Palisson, F., Hovnanian, A., McGrath, J. A., Mellerio, J., Bauer, J. W. & 1 others, South, A. P., Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Squamous Cell Carcinoma
Therapeutics
Skin
ON 01910
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Air Pollutants
Transcription Factors
Antioxidants
5 Downloads (Pure)

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Banerjee, S., Wei, T., Wang, J., Lee, J. J., Gutierrez, H. L., Chapman, O., Wiley, S. E., Mayfield, J. E., Tandon, V., Juarez, E. F., Chavez, L., Liang, R., Sah, R. L., Costello, C., Mesirov, J. P., de la Vega, L., Cooper, K. L., Dixon, J. E., Xiao, J. & Lei, X., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
Triple Negative Breast Neoplasms
Multiple Myeloma
Proteasome Inhibitors
Proteasome Endopeptidase Complex
Tumor Burden
1 Citation (Scopus)
63 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
Hairless Mouse
histone deacetylase
Histone Deacetylase Inhibitors
squamous cell carcinoma
Squamous Cell Carcinoma
5 Downloads (Pure)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
Neurodegenerative diseases
Physiology
Object recognition
Neurology
Carrier Proteins
1 Citation (Scopus)
80 Downloads (Pure)
Open Access
File
NF-E2 Transcription Factor
NF-E2-Related Factor 2
Transcription Factors
Proteins
Assays
1 Citation (Scopus)
91 Downloads (Pure)

Paracetamol-induced liver injury modelled in Xenopus laevis embryos

Saide, K., Sherwood, V. & Wheeler, G. N., 1 Mar 2019, In : Toxicology Letters. 302, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access
File
Xenopus laevis
Acetaminophen
Liver
Embryonic Structures
Wounds and Injuries
34 Downloads (Pure)

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2

Morrugares, R., Correa-Sáez, A., Moreno Dorta, R., Garrido-Rodríguez, M., Muñoz, E., de la Vega, L. & Calzado, M. A., 11 Oct 2019, In : Cellular and Molecular Life Sciences. 19 p.

Research output: Contribution to journalArticle

Open Access
File
TYK2 Kinase
Phosphorylation
Neoplasms
Ubiquitin-Protein Ligases
Post Translational Protein Processing
18 Downloads (Pure)

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, L., Mohd, K. S., Ren, H., Xin, G., Jiang, Q., Clarke, P. R. & Zhang, C., 23 Sep 2019, In : Journal of Cell Science. 132, 18, p. 1-12 12 p., jcs232314.

Research output: Contribution to journalArticle

Open Access
File
Karyopherins
Cyclin B1
Spindle Apparatus
Phosphorylation
Mitosis
26 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphorylation
Behavior Control
Phosphoprotein Phosphatases
2 Citations (Scopus)
139 Downloads (Pure)

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
Activin Receptors
LY-2157299
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
38 Downloads (Pure)

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Lithium
Biomarkers
Alzheimer Disease
Clinical Trials
Cognitive Dysfunction
9 Citations (Scopus)

The circular RNome of primary breast cancer

Smid, M., Wilting, S. M., Uhr, K., Rodríguez-González, F. G., De Weerd, V., Prager-Van Der Smissen, W. J. C., Van Der Vlugt-Daane, M., Van Galen, A., Nik-Zainal, S., Butler, A., Martin, S., Davies, H. R., Staaf, J., Van De Vijver, M. J., Richardson, A. L., MacGrogan, G., Salgado, R., Van Den Eynden, G. G. G. M., Purdie, C. A., Thompson, A. M. & 21 others, Caldas, C., Span, P. N., Sweep, F. C. G. J., Simpson, P. T., Lakhani, S. R., Van Laere, S., Desmedt, C., Paradiso, A., Eyfjord, J., Broeks, A., Vincent-Salomon, A., Futreal, A. P., Knappskog, S., King, T., Viari, A., Børresen-Dale, A. L., Stunnenberg, H. G., Stratton, M., Foekens, J. A., Sieuwerts, A. M. & Martens, J. W. M., 1 Mar 2019, In : Genome Research. 29, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
RNA
circular RNA
Aromatase Inhibitors
Computer Simulation
14 Downloads (Pure)

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

McHugh, A., Fernandes, K., Chinner, N., Ibrahim, A. F. M., Garg, A. K., Boag, G., Hepburn, L. A., Proby, C. M., Leigh, I. M. & Saville, M. K., 6 Nov 2019, In : Journal of Investigative Dermatology. 37 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Skin
Anaphase-Promoting Complex-Cyclosome
Therapeutics
Ubiquitin
1 Citation (Scopus)
41 Downloads (Pure)

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Reader, C. S., Vallath, S., Steele, C. W., Haider, S., Brentnall, A., Desai, A., Moore, K. M., Jamieson, N. B., Chang, D., Bailey, P., Scarpa, A., Lawlor, R., Chelala, C., Keyse, S. M., Biankin, A., Morton, J. P., Evans, T. R. J., Barry, S. T., Sansom, O. J., Kocher, H. M. & 1 others, Marshall, J. F., 1 Jul 2019, In : Journal of Pathology. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pancreatic Neoplasms
Integrins
Adenocarcinoma
Therapeutics
Growth
46 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
File
Sirolimus
Histone Deacetylases
Phosphorylation
NF-E2 Transcription Factor
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)
114 Downloads (Pure)

The non-structural NS1 protein of influenza viruses modulates TP53 splicing through the host factor CPSF4

Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J-C., Marcel, V., Boivin, G., Rosa-Calatrava, M. & Terrier, O., Mar 2019, In : Journal of Virology. 93, 7, p. 1-19 19 p., e02168-18.

Research output: Contribution to journalArticle

Open Access
File
Cleavage And Polyadenylation Specificity Factor
Integration Host Factors
Influenza A virus
Orthomyxoviridae
alternative splicing

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers

Liu, Y., Nekulova, M., Nenutil, R., Horakova, I., Appleyard, M. V., Murray, K., Holcakova, J., Galoczova, M., Quinlan, P., Jordan, L. B., Purdie, C. A., Vojtesek, B., Thompson, A. M. & Coates, P. J., 7 Oct 2019, In : Journal of Pathology: Clinical Research.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Mesenchymal Stromal Cells
Breast Neoplasms
Phenotype
Neoplasms
2018
6 Citations (Scopus)
80 Downloads (Pure)

A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Sun, K., Mikule, K., Wang, Z., Poon, G., Vaidyanathan, A., Smith, G., Zhang, Z. Y., Hanke, J., Ramaswamy, S. & Wang, J., 14 Dec 2018, In : Oncotarget. 9, 98, p. 37080-37096 17 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacokinetics
Neoplasms
Cell Membrane Permeability
niraparib
Poly(ADP-ribose) Polymerase Inhibitors
14 Citations (Scopus)
92 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
File
Pentoses
Pentose Phosphate Pathway
Macrophages
Hypercholesterolemia
Metabolism
5 Citations (Scopus)
106 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Mitosis
Degradation
Ubiquitin-Protein Ligases
Isoleucine
59 Downloads (Pure)

Correction: The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth

Hanson, K., Robinson, S. D., Al-Yousuf, K., Hendry, A. E., Sexton, D. W., Sherwood, V. & Wheeler, G. N., 27 Nov 2018, In : Oncotarget. 9, 93, p. 36645 1 p.

Research output: Contribution to journalArticle

Open Access
File
leflunomide
Antirheumatic Agents
Mitogen-Activated Protein Kinase Kinases
Melanoma
Growth

Cutaneous immunohistochemical staining pattern of p53β isoforms

Ko, C. J., Myung, P., Leffell, D. J. & Bourdon, J-C., Dec 2018, In : Journal of Clinical Pathology. 71, 12, p. 1120-1122 3 p.

Research output: Contribution to journalArticle

Protein Isoforms
Staining and Labeling
Skin
Cytoplasm
Mutation
6 Citations (Scopus)
63 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegović, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 14 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
5 Citations (Scopus)
96 Downloads (Pure)

DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing

Chakraborty, P., Huang, J. & Hiom, K., 19 Oct 2018, In : Nature Communications. 9, 9, p. 1-14 14 p., 4346.

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
splicing
RNA
cells
Chromosome Fragility
2 Citations (Scopus)
21 Downloads (Pure)

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., Inman, G., Harper, J., Kinsler, V. & O'Shaughnessy, R., 26 Oct 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
File
Localized Scleroderma
Fibroblasts
Myofibroblasts
Transforming Growth Factors
Therapeutics
68 Downloads (Pure)

Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes

Nguyen Van Long, F., Lardy-Cleaud, A., Bray, S., Chabaud, S., Dubois, T., Diot, A., Thompson, A. M., Bourdon, J-C., Perol, D., Bouvet, P., Diaz, J-J. & Marcel, V., 22 Oct 2018, In : Cancers. 10, 10, p. 1-11 11 p., 390.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Breast Neoplasms
Triple Negative Breast Neoplasms
Messenger RNA
Neoplasms
1 Citation (Scopus)

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., Prichodchenko, T. R., Zhelev, N. & Aldoshin, S. M., Nov 2018, In : Doklady Biochemistry and Biophysics. 483, 1, p. 337-340 4 p.

Research output: Contribution to journalArticle

Fibroblasts
Cell Survival
Iron Compounds
Mitochondrial Membrane Potential
Sulfur
9 Downloads (Pure)

Effect of liquid nitrogen pre-treatment on various types of wool waste fibres for biogas production

Kuzmanova, E., Zhelev, N. & Akunna, J. C., May 2018, In : Heliyon. 4, 5, p. 1-11 11 p., e00619.

Research output: Contribution to journalArticle

Open Access
File
wool
biogas
liquid
nitrogen
methane
23 Citations (Scopus)
98 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Fructose
Liver Cirrhosis
Fats
Endoplasmic Reticulum Stress
2 Citations (Scopus)

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

Tilmant, K., Gerets, H., De Ron, P., Hanon, E., Bento-Pereira, C. & Atienzar, F. A., 1 Oct 2018, In : Toxicology in Vitro. 52, p. 374-383 10 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Energy Metabolism
Screening
Poisons
Pharmaceutical Preparations
9 Citations (Scopus)
83 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Huntington Disease
Animal Behavior
Aberrations
Visual Cortex
7 Citations (Scopus)
91 Downloads (Pure)

Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Ultrasound, Shear Wave Elastography and MRI

Evans, A., Whelehan, P., Thompson, A., Purdie, C., Jordan, L., Macaskill, J., Waugh, S., Fuller-Pace, F., Brauer, K. & Vinnicombe, S., Aug 2018, In : European Journal of Ultrasound. 39, 04, p. 422-431 10 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Magnetic Resonance Imaging
Breast Neoplasms
Drug Therapy
Sensitivity and Specificity
2 Citations (Scopus)
69 Downloads (Pure)

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S. & Pharoah, P., 1 Jun 2018, In : Breast Cancer Research and Treatment. 171, 2, p. 383-389 7 p.

Research output: Contribution to journalArticle

Open Access
File
Elasticity Imaging Techniques
Breast Neoplasms
Survival
Biopsy
Neoplasms
1 Citation (Scopus)
60 Downloads (Pure)

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 22 May 2018, In : Nature Communications. 9, 1, p. 2071 2071.

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inhibitors
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Tumors
tumors
4 Citations (Scopus)
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The collagen prolyl hydroxylases are bifunctional growth regulators in melanoma

Atkinson, A., Renziehausen, A., Wang, H., Nigro, C. L., Lattanzio, L., Merlano, M., Rao, B., Weir, L., Evans, A., Matin, R., Harwood, C., Szlosarek, P., Pickering, J. G., Fleming, C., Sim, V. R., Li, S., Vasta, J. T., Raines, R. T., Boniol, M., Thompson, A. & 3 others, Proby, C., Crook, T. & Syed, N., 16 Nov 2018, In : Journal of Investigative Dermatology.

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Prolyl Hydroxylases
Melanoma
Collagen
Growth
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The effect of experimental hyperoxia on erythrocytes’ oxygen-transport function

Revin, V. V., Gromova, N. V., Revina, E. S., Grunyushkin, I. P., Tychkov, A. Y., Samonova, A. Y., Kukina, A. N., Moskovkin, A. A., Bourdon, J. C. & Zhelev, N., 2018, In : Biotechnology and Biotechnological Equipment. 32, 5, p. 1236-1250 15 p.

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Hyperoxia
Erythrocytes
Oxygen
Erythrocyte Membrane
Ions
21 Citations (Scopus)
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The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

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Azathioprine
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tumors
signatures
Skin
3 Citations (Scopus)
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The role of APETALA1 in petal number robustness

Monniaux, M., Pieper, B., McKim, S. M., Routier-Kierzkowska, A. L., Kierzkowski, D., Smith, R. S. & Hay, A., 18 Oct 2018, In : eLife. 7, p. 1-22 22 p., e39399.

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Nucleic Acid Regulatory Sequences
Arabidopsis
Cardamine
Quantitative Trait Loci
3 Citations (Scopus)
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The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Purdie, K. J., Proby, C. M., Rizvi, H., Griffin, H., Doorbar, J., Sommerlad, M., Feltkamp, M. C., Van der Meijden, E., Inman, G. J., South, A. P., Leigh, I. M. & Harwood, C. A., 14 Aug 2018, In : Frontiers in Microbiology. 9, 16 p., 1806.

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Polyomavirus
Squamous Cell Carcinoma
Skin
Mutation
Warts