Centre for Advanced Scientific Technologies

  • United Kingdom

Research Output

  • 1354 Citations
  • 14 h-Index
  • 45 Article
  • 3 Conference contribution
  • 1 Chapter
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2020

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
40 Downloads (Pure)

Measurement of eroded dentine tubule patency and roughness following novel dab-on or brushing abrasion

Olley, R. C., Mohsen, B. M., Alhaij, S. & Appleton, P. L., 5 May 2020, In : Journal of Dentistry. 103358.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mechanism of Activation of AMPK by Cordycepin

Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In : Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.

Research output: Contribution to journalArticle

Open Access
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47 Downloads (Pure)

Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers

Schubert, M., Woolfson, L., Barnard, I. R. M., Dorward, A. M., Casement, B., Morton, A., Robertson, G. B., Appleton, P. L., Miles, G. B., Tucker, C. S., Pitt, S. J. & Gather, M. C., Jul 2020, In : Nature Photonics. 14, 7, p. 452-458 7 p.

Research output: Contribution to journalArticle

Novel Confocal-Laser-Scanning-Microscopy and conventional measures investigating eroded dentine following dentifrice dab-on and brushing abrasion

Olley, R. C., Alhaij, S., Mohsen, B. M., Appleton, P. L., Chadwick, R. G. & Ball, G., Mar 2020, In : Heliyon. 6, 3, p. 1-8 8 p., e03282.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
32 Downloads (Pure)

Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy

Motyl, A. A. L., Faller, K. M. E., Groen, E. J. N., Kline, R. A., Eaton, S. L., Ledahawsky, L. M., Chaytow, H., Lamont, D. J., Wishart, T. M., Huang, Y-T. & Gillingwater, T. H., 9 Jul 2020, In : Human Molecular Genetics.

Research output: Contribution to journalArticle

Open Access

Semi-automated quantitation of mitophagy in cells and tissues

Montava-Garriga, L., Singh, F., Ball, G. & Ganley, I., Jan 2020, In : Mechanisms of Ageing and Development. 185, p. 1-12 12 p., 111196.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
83 Downloads (Pure)
2019

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
187 Downloads (Pure)

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., 5 Feb 2019, In : Scientific Reports. 9, 1, p. 1-11 11 p., 1407.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
119 Downloads (Pure)

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice

Kline, R. A., Dissanayake, K. N., Hurtado, M. L., Martínez, N. W., Ahl, A., Mole, A. J., Lamont, D. J., Court, F. A., Ribchester, R. R., Wishart, T. M. & Murray, L. M., 1 Oct 2019, In : Neurobiology of Disease. 130, p. 1-16 16 p., 104496.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
104 Downloads (Pure)

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Hesse, R., Hurtado, M. L., Jackson, R. J., Eaton, S. L., Herrmann, A. G., Colom-Cadena, M., Tzioras, M., King, D., Rose, J., Tulloch, J., McKenzie, C-A., Smith, C., Henstridge, C., Lamont, D., Wishart, T. M. & Spires-Jones, T. L., 2019, In : Acta Neuropathologica Communications. 7, p. 1-18 18 p., 214.

Research output: Contribution to journalArticle

Open Access
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58 Downloads (Pure)

Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model

Plummer, S., Beaumont, B., Wallace, S., Ball, G., Wright, J., McInnes, L., Currie, R., Peffer, R. & Cowie, D., 2019, In : Toxicology Reports. 6, p. 998-1005 8 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
74 Downloads (Pure)

Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke

Vadgama, N., Lamont, D., Hardy, J., Nasir, J. & Lovering, R. C., 15 Jun 2019, In : Molecular and Cellular Biochemistry. 456, 1-2, p. 157-165 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 1 Sep 2019, In : EMBO Reports. 20, 9, p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
95 Downloads (Pure)

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Open Access
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14 Downloads (Pure)

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Chen, Y., Vandereyken, M., Newton, I., Moraga Gonzalez, I., Nathke, I. & Swamy, M., 26 Nov 2019, In : PLoS Biology. 17, 11, p. 1-23 23 p., e3000540.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
59 Downloads (Pure)
Open Access
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1 Citation (Scopus)
137 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. & Hardie, D. G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4 15 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
126 Downloads (Pure)

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging

Graham, L. C., Naldrett, M. J., Kohama, S. G., Smith, C., Lamont, D. J., McColl, B. W., Gillingwater, T. H., Skehel, P., Urbanski, H. F. & Wishart, T. M., 23 Apr 2019, In : Cell Reports. 27, 4, p. 1018-1026.e4 14 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
108 Downloads (Pure)

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

Mattos, E. C., Canuto, G., Varón, N. C. M., Magalhães, R. D. M., Crozier, T. W. M., Lamont, D. J., Tavares, M. F. M., Colli, W., Ferguson, M. A. J. & Alves, M. J. M., 6 Feb 2019, In : PLoS Neglected Tropical Diseases. 13, 2, p. 1-27 27 p., e0007103.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
118 Downloads (Pure)

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit

Young, D. F., Wignall-Fleming, E. B., Busse, D. C., Pickin, M. J., Hankinson, J., Randall, E. M., Tavendale, A., Davison, A. J., Lamont, D., Tregoning, J. S., Goodbourn, S. & Randall, R. E., 11 Feb 2019, In : PLoS Pathogens. 15, 2, p. 1-24 24 p., e1007561.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
119 Downloads (Pure)
2018

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
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126 Citations (Scopus)
184 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
131 Downloads (Pure)

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

Shorrock, H. K., van der Hoorn, D., Boyd, P. J., Llavero Hurtado, M., Lamont, D. J., Wirth, B., Sleigh, J. N., Schiavo, G., Wishart, T. M., Groen, E. J. N. & Gillingwater, T. H., 1 Oct 2018, In : Brain. 141, 10, p. 2878-2894 17 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
120 Downloads (Pure)
Open Access
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7 Citations (Scopus)
150 Downloads (Pure)
2017

Cellular and Molecular Anatomy of the Human Neuromuscular Junction

Jones, R. A., Harrison, C., Eaton, S. L., Llavero Hurtado, M., Graham, L. C., Alkhammash, L., Oladiran, O. A., Gale, A., Lamont, D. J., Simpson, H., Simmen, M. W., Soeller, C., Wishart, T. M. & Gillingwater, T. H., 28 Nov 2017, In : Cell Reports. 21, 9, p. 2348-2356 9 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
167 Downloads (Pure)

DBR-free semiconductor disc laser on SiC heatspreader emitting 10.1 W at 1007 nm

Mirkhanov, S., Quarterman, A. H., Kahle, H., Bek, R., Pecoroni, R., Smyth, C. J. C., Vollmer, S., Swift, S., Michler, P., Jetter, M. & Wilcox, K. G., 13 Nov 2017, In : Electronics Letters. 53, 23, p. 1537-1539 3 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
188 Downloads (Pure)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A., 10 Oct 2017, In : Nature Communications. 8, p. 1-14 14 p., 830.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
186 Downloads (Pure)

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Almine, J. F., O'Hare, C. A. J., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M. & Unterholzner, L., 13 Feb 2017, In : Nature Communications. 8, p. 1-15 15 p., 14392.

Research output: Contribution to journalArticle

Open Access
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98 Citations (Scopus)
253 Downloads (Pure)

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G., 20 Jul 2017, In : Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
151 Downloads (Pure)

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

Catenaccio, A., Llavero Hurtado, M., Diaz, P., Lamont, D. J., Wishart, T. M. & Court, F. A., 9 Nov 2017, In : Cell Death and Disease. 8, 11, p. 1-14 14 p., e3166.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
178 Downloads (Pure)

Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

Ly, T., Whigham, A., Clarke, R., Brenes-Murillo, A. J., Estes, B., Madhessian, D., Lundberg, E., Wadsworth, P. & Lamond, A. I., 20 Oct 2017, In : eLife. 6, p. 1-35 35 p., e27574.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
207 Downloads (Pure)

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture

Graham, L. C., Eaton, S. L., Brunton, P. J., Atrih, A., Smith, C., Lamont, D. J., Gillingwater, T. H., Pennetta, G., Skehel, P. A. & Wishart, T. M., 27 Oct 2017, In : Molecular Neurodegeneration. 12, p. 1-16 16 p., 77.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
165 Downloads (Pure)

Regulation of membrane ruffling by polarized STIM1 and ORAI1in cortactin-rich domains

M. López-Guerrero, A., Tomas-Martin, P., Pascual-Caro, C., Macartney, T., Rojas-Fernandez, A., Ball, G., Alessi, D. R., Pozo-Guisado, E. & Martin-Romero, F. J., 24 Mar 2017, In : Scientific Reports. 7, 15 p., 383.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
126 Downloads (Pure)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

Amorim, I. S., Graham, L. C., Carter, R. N., Morton, N. M., Hammachi, F., Kunath, T., Pennetta, G., Carpanini, S. M., Manson, J. C., Lamont, D. J., Wishart, T. M. & Gillingwater, T. H., 15 Jan 2017, In : Journal of Cell Science. 130, 2, p. 325-331 7 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
171 Downloads (Pure)

Strategic and practical guidelines for successful structured illumination microscopy

Demmerle, J., Innocent, C., North, A. J., Ball, G., Müller, M., Miron, E., Matsuda, A., Dobbie, I. M., Markaki, Y. & Schermelleh, L., 1 May 2017, In : Nature Protocols. 12, 5, p. 988-1010 23 p.

Research output: Contribution to journalArticle

Open Access
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76 Citations (Scopus)
375 Downloads (Pure)

Structural basis of PROTAC cooperative recognition for selective protein degradation

Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A., May 2017, In : Nature Chemical Biology. 13, 5, p. 514-521 11 p.

Research output: Contribution to journalArticle

Open Access
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201 Citations (Scopus)
363 Downloads (Pure)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In : Scientific Reports. 7, p. 1-12 12 p., 11023.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
199 Downloads (Pure)
2016
Open Access
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7 Citations (Scopus)
174 Downloads (Pure)

Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes

Betz, B. B., Jenks, S. J., Cronshaw, A. D., Lamont, D. J., Cairns, C., Manning, J. R., Goddard, J., Webb, D. J., Mullins, J. J., Hughes, J., Mclachlan, S., Strachan, M. W. J., Price, J. F. & Conway, B. R., May 2016, In : Kidney International. 89, 5, p. 1125-1135 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2015

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis

Grant, N. J., Coates, P. J., Woods, Y. L., Bray, S. E., Morrice, N. A., Hastie, C. J., Lamont, D. J., Carey, F. A. & Sutherland, C., 10 Nov 2015, In : BMC Cancer. 15, 16 p., 885.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
172 Downloads (Pure)

Proteomic profiling of cranial (superior) cervical ganglia reveals beta-amyloid and ubiquitin proteasome system perturbations in an equine multiple system neuropathy

McGorum, B. C., Pirie, R. S., Eaton, S. L., Keen, J. A., Cumyn, E. M., Arnott, D. M., Chen, W., Lamont, D. J., Graham, L. C., Hurtado, M. L., Pemberton, A. & Wishart, T. M., 1 Nov 2015, In : Molecular & Cellular Proteomics. 14, 11, p. 3072-3086 15 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
241 Downloads (Pure)

SIMcheck: A toolbox for successful super-resolution structured illumination microscopy

Ball, G., Demmerle, J., Kaufmann, R., Davis, I., Dobbie, I. M. & Schermelleh, L., 3 Nov 2015, In : Scientific Reports. 5, p. 1-12 12 p., 15915.

Research output: Contribution to journalArticle

Open Access
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106 Citations (Scopus)
120 Downloads (Pure)
2002

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

McClue, S. J., Blake, D., Clarke, R., Cowan, A., Cummings, L., Fischer, P. M., MacKenzie, M., Melville, J., Stewart, K., Wang, S., Zhelev, N., Zheleva, D. & Lane, D., Dec 2002, In : International Journal of Cancer. 102, 5, p. 463-468 6 p.

Research output: Contribution to journalArticle

306 Citations (Scopus)
1989

Differences between adult and foetal fibroblasts in the regulation of hyaluronate synthesis: correlation with migratory activity

Chen, W. Y., Grant, M. E., Schor, A. M. & Schor, S. L., Nov 1989, In : Journal of Cell Science. 94, 3, p. 577-84 8 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)