Computational Biology

  • United Kingdom

Research Output

2001

3Dee: a database of protein structural domains

Siddiqui, A. S., Dengler, U. & Barton, G. J., Feb 2001, In : Bioinformatics. 17, 2, p. 200-1 2 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Application of a relativistic accretion disc model to X-ray spectra of LMC X-1 and GRO J1655-40

Gierliński, M., Maciołek-Niedźwiecki, A. & Ebisawa, K., 11 Aug 2001, In : Monthly Notices of the Royal Astronomical Society. 325, 3, p. 1253-1265 13 p.

Research output: Contribution to journalArticle

Open Access
66 Citations (Scopus)

Protein structural domains: analysis of the 3Dee domains database

Dengler, U., Siddiqui, A. S. & Barton, G. J., 15 Feb 2001, In : Proteins: Structure, Function, and Bioinformatics. 42, 3, p. 332-344 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2000

Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 15 Aug 2000, In : Proteins: Structure, Function, and Bioinformatics. 40, 3, p. 502-511 10 p.

Research output: Contribution to journalArticle

617 Citations (Scopus)

ProtEST: protein multiple sequence alignments from expressed sequence tags

Cuff, J. A., Birney, E., Clamp, M. E. & Barton, G. J., Feb 2000, In : Bioinformatics. 16, 2, p. 111-6 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1999

Application of a relativistic accretion disc model to GRO J1655-40 ASCA spectrum

Gierliński, M., Maciołek-Niedźwiecki, A., Magdziarz, P. & Ebisawa, K., 1 Dec 1999, In : Astronomische Nachrichten. 320, 4-5, p. 350 1 p.

Research output: Contribution to journalArticle

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 1 Mar 1999, In : Proteins: Structure, Function, and Bioinformatics. 34, 4, p. 508-19 12 p.

Research output: Contribution to journalArticle

490 Citations (Scopus)

Radiation mechanisms and geometry of cygnus X-1 in the soft state

Gierliński, M., Zdziarski, A. A., Poutanen, J., Coppi, P. S., Ebisawa, K. & Johnson, W. N., 21 Oct 1999, In : Monthly Notices of the Royal Astronomical Society. 309, 2, p. 496-512 17 p.

Research output: Contribution to journalArticle

Open Access
348 Citations (Scopus)

Thermal/non-thermal model of Cyg X-1 in the soft state

Gierliński, M., Zdziarski, A. A., Coppi, P. S., Poutanen, J., Ebisawa, K. & Johnson, W. N., 1 Jan 1999, In : Nuclear Physics B - Proceedings Supplements. 69, 1-3, p. 312-315 4 p.

Research output: Contribution to journalArticle

1998

Broad-band X-ray/γ-ray spectra and binary parameters of GX 339-4 and their astrophysical implications

Zdziarski, A. A., Poutanen, J., Mikołajewska, J., Gierliński, M., Ebisawa, K. & Johnson, W. N., 1 Dec 1998, In : Monthly Notices of the Royal Astronomical Society. 301, 2, p. 435-450 16 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)

Deposition of macromolecular structures

Keller, P. A., Henrick, K., McNeil, P., Moodie, S. & Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

JPred: a consensus secondary structure prediction server

Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M. & Barton, G. J., 1998, In : Bioinformatics. 14, 10, p. 892-3 2 p.

Research output: Contribution to journalArticle

885 Citations (Scopus)

Protein sequence alignment techniques

Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1997

RXTE observations of AGN

Rothschild, R. E., Heindl, W. A., Blanco, P. R., Gruber, D. E., Marsden, D. C., Pelling, M. R., Jahoda, K., Madejski, G., Swank, J. H., Zdziarski, A. A., Gierliński, M. & Hink, P. L., 1 Dec 1997, In : European Space Agency, (Special Publication) ESA SP. 382, p. 393-395 3 p.

Research output: Contribution to journalArticle

Simultaneous X-ray and γ-ray observations of Cyg X-1 in the hard state by Ginga and OSSE

Gierliński, M., Zdziarski, A. A., Done, C., Neil Johnson, W., Ebisawa, K., Ueda, Y., Haardt, F. & Phlips, B. F., 1 Dec 1997, In : Monthly Notices of the Royal Astronomical Society. 288, 4, p. 958-964 7 p.

Research output: Contribution to journalArticle

227 Citations (Scopus)

X-rays and gamma-rays from accretion flows onto black holes in Seyferts and x-ray binaries

Zdziarski, A. A., Johnson, W. N., Poutanen, J., Magdziarz, P. & Gierliński, M., 1 Dec 1997, In : European Space Agency, (Special Publication) ESA SP. 382, p. 373-380 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1996

Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation

Fiser, A., Simon, I. & Barton, G. J., 18 Nov 1996, In : FEBS Letters. 397, 2-3, p. 225-229 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Identification of functional residues and secondary structure from protein multiple sequence alignment

Livingstone, C. D. & Barton, G. J., 1996, In : Methods in Enzymology. 266, p. 497-512 16 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Protein fold recognition by mapping predicted secondary structures

Russell, R. B., Copley, R. R. & Barton, G. J., 14 Jun 1996, In : Journal of Molecular Biology. 259, 3, p. 349-365 17 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

The canonical X-ray/gamma-ray spectrum of Seyfert Is and low-state Galactic black hole candidates

Zdziarski, A. A., Gierlinski, M., Gondek, D. & Magdziarz, P., 1 Dec 1996, In : Astronomy and Astrophysics: Supplement Series. 120, 4, p. 553-558 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
1995

Continuous and discontinuous domains: an algorithm for the automatic generation of reliable protein domain definitions

Siddiqui, A. S. & Barton, G. J., May 1995, In : Protein Science. 4, 5, p. 872-84 13 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Roach, P. L., Clifton, I. J., Fülöp, V., Harlos, K., Barton, G. J., Hajdu, J., Andersson, I., Schofield, C. & Baldwin, J. E., 22 Jun 1995, In : Nature. 375, 6533, p. 700-704 5 p.

Research output: Contribution to journalArticle

357 Citations (Scopus)

Protein fold recognition from secondary structure assignments

Russell, R. B., Copley, R. R. & Barton, G. J., 1995, Proceedings of the 28th Annual Hawaii International Conference on System Sciences (HICSS 1995). IEEE, p. 302-311 10 p. 375326. (Proceedings of the Annual Hawaii International Conference on System Sciences; vol. 5).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Protein secondary structure prediction

Barton, G. J., Jun 1995, In : Current Opinion in Structural Biology. 5, 3, p. 372-376 5 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
1994
130 Citations (Scopus)
149 Citations (Scopus)

Mutational analysis of human papillomavirus E4 proteins: identification of structural features important in the formation of cytoplasmic E4/cytokeratin networks in epithelial cells

Roberts, S., Ashmole, I., Gibson, L. J., Rookes, S. M., Barton, G. J. & Gallimore, P. H., Oct 1994, In : Journal of Virology. 68, 10, p. 6432-6445 14 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

scop: structural classification of proteins

Barton, G. J., Dec 1994, In : Trends in Biochemical Sciences. 19, 12, p. 554-555 2 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
16 Citations (Scopus)
158 Citations (Scopus)

Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ

Matthews, S., Barlow, P., Boyd, J., Barton, G., Russell, R., Mills, H., Cunningham, M., Meyers, N., Burns, N., Clark, N., Kingsman, S., Kingsman, A. & Campbell, I., 25 Aug 1994, In : Nature. 370, 6491, p. 666-668 3 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

The AMPS package for multiple protein sequence alignment

Barton, G. J., 1994, Computer Analysis of Sequence Data Part II . Springer Verlag, Vol. 25. p. 327-47 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)
1993

ALSCRIPT: a tool to format multiple sequence alignments

Barton, G. J., Jan 1993, In : Protein Science. 6, 1, p. 37-40 4 p.

Research output: Contribution to journalArticle

1087 Citations (Scopus)
47 Citations (Scopus)

An SH2-SH3 domain hybrid

Russell, R. B. & Barton, G. J., 26 Aug 1993, In : Nature. 364, 6440, p. 765 1 p.

Research output: Contribution to journalLetter

26 Citations (Scopus)

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation

Livingstone, C. D. & Barton, G. J., Dec 1993, In : Computer Applications in the Biosciences. 9, 6, p. 745-756 12 p.

Research output: Contribution to journalArticle

380 Citations (Scopus)

Protein structure prediction

Barton, G. J. & Russell, R. B., 11 Feb 1993, In : Nature. 361, 6412, p. 505-506 2 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

Secondary structure prediction for modelling by homology

Boscott, P. E., Barton, G. J. & Richards, W. G., Apr 1993, In : Protein Science. 6, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The limits of protein secondary structure prediction accuracy from multiple sequence alignment

Russell, R. B. & Barton, G. J., 20 Dec 1993, In : Journal of Molecular Biology. 234, 4, p. 951-957 7 p.

Research output: Contribution to journalLetter

70 Citations (Scopus)
1992

Computer speed and sequence comparison

Barton, G. J., 18 Sep 1992, In : Science. 257, 5077, p. 1609-1610 2 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

Russell, R. B., Breed, J. & Barton, G. J., 8 Jun 1992, In : FEBS Letters. 304, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Generation and interpretation of protein sequence and structural multiple alignments

Barton, G. J., Russell, R. B. & Livingstone, C. D., 1 Aug 1992, In : Journal of Protein Chemistry. 11, 4, p. 389-389 1 p.

Research output: Contribution to journalArticle

Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase

Barton, G. J., Ponting, C. P., Spraggon, G., Finnis, C. & Sleep, D., May 1992, In : Protein Science. 1, 5, p. 688-90 3 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Mast cell tryptases: examination of unusual characteristics by multiple sequence alignment and molecular modeling

Johnson, D. A. & Barton, G. J., Mar 1992, In : Protein Science. 1, 3, p. 370-7 8 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
536 Citations (Scopus)
1991

Amino acid sequence analysis of the annexin super-gene family of proteins

Barton, G. J., Newman, R. H., Freemont, P. S. & Crumpton, M. J., Jun 1991, In : European Journal of Biochemistry. 198, 3, p. 749-760 12 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)
8 Citations (Scopus)
1990

A knowledge-based architecture for protein sequence analysis and structure prediction

Clark, D. A., Barton, G. J. & Rawlings, C. J., Jun 1990, In : Journal of Molecular Graphics. 8, 2, p. 94-107 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A PROLOG approach to analysing protein structure

Barton, G. J. & Rawlings, C. J., 1 Jan 1990, In : Tetrahedron Computer Methodology. 3, 6 PART C, p. 739-756 18 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)