Computational Biology

  • United Kingdom

Research Output 1987 2019

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1987
387 Citations (Scopus)

A strategy for the rapid multiple alignment of protein sequences: confidence levels from tertiary structure comparisons

Barton, G. J. & Sternberg, M. J. E., 20 Nov 1987, In : Journal of Molecular Biology. 198, 2, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sequence Alignment
Proteins
Globins
Transferrin
Disulfides
107 Citations (Scopus)

Evaluation and improvements in the automatic alignment of protein sequences

Barton, G. J. & Sternberg, M. J., 1 Feb 1987, In : Protein Science. 1, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Sequence Alignment
Secondary Protein Structure
Sequence Homology
Proteins
Testing
18 Citations (Scopus)

Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins

Sternberg, M. J. E., Barton, G. J., Zvelebil, M. J., Cookson, J. & Coates, A. R. M., 29 Jun 1987, In : FEBS Letters. 218, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Viruses
Epitopes
Vaccines
Genes
HIV
1988
18 Citations (Scopus)

LOPAL and SCAMP: techniques for the comparison and display of protein structures

Barton, G. J. & Sternberg, M. J. E., Dec 1988, In : Journal of Molecular Graphics. 6, 4, p. 190-196 7 p.

Research output: Contribution to journalArticle

Display devices
Proteins
Sequence Alignment
Least-Squares Analysis
Dynamic programming
1990
9 Citations (Scopus)

A knowledge-based architecture for protein sequence analysis and structure prediction

Clark, D. A., Barton, G. J. & Rawlings, C. J., Jun 1990, In : Journal of Molecular Graphics. 8, 2, p. 94-107 14 p.

Research output: Contribution to journalArticle

Protein Sequence Analysis
Knowledge based systems
Knowledge engineering
Proteins
Molecular biology
3 Citations (Scopus)

A PROLOG approach to analysing protein structure

Barton, G. J. & Rawlings, C. J., 1 Jan 1990, In : Tetrahedron Computer Methodology. 3, 6 PART C, p. 739-756 18 p.

Research output: Contribution to journalArticle

Proteins
Computer programming languages
PROLOG (programming language)
Sanders
Logic programming
114 Citations (Scopus)

Flexible protein sequence patterns: a sensitive method to detect weak structural similarities

Barton, G. J. & Sternberg, M. J. E., 20 Mar 1990, In : Journal of Molecular Biology. 212, 2, p. 389-402 14 p.

Research output: Contribution to journalArticle

Globins
Proteins
Sequence Alignment
Hemoglobins
Databases
6 Citations (Scopus)

Interaction of synthetic peptides from annexin I and uteroglobin with lipid monolayers and their effect on phospholipase A2 activity

Newman, R. H., Freemont, P. S., Barton, G. J. & Crumpton, M. J., Dec 1990, In : Biochemical Society Transactions. 18, 6, p. 1233-1234 2 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Prediction of domain organisation and secondary structure of thyroid peroxidase, a human autoantigen involved in destructive thyroiditis

Banga, J. P., Mahadevan, D., Barton, G. J., Sutton, B. J., Saldanha, J. W., Odell, E. & McGregor, A. M., 18 Jun 1990, In : FEBS Letters. 266, 1-2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Thyroiditis
Iodide Peroxidase
Autoantigens
Autoimmune Diseases
Thyroid Diseases
178 Citations (Scopus)

Protein multiple sequence alignment and flexible pattern matching

Barton, G. J., 1990, In : Methods in Enzymology. 183, p. 403-28 26 p.

Research output: Contribution to journalArticle

1991
131 Citations (Scopus)

Amino acid sequence analysis of the annexin super-gene family of proteins

Barton, G. J., Newman, R. H., Freemont, P. S. & Crumpton, M. J., Jun 1991, In : European Journal of Biochemistry. 198, 3, p. 749-760 12 p.

Research output: Contribution to journalArticle

Annexins
Protein Sequence Analysis
Genes
Amino Acids
Uteroglobin
8 Citations (Scopus)
Databases
Proteins
Costs and Cost Analysis
1992
88 Citations (Scopus)

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

Russell, R. B., Breed, J. & Barton, G. J., 8 Jun 1992, In : FEBS Letters. 304, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Phosphotyrosine
src Homology Domains
Conservation
Intercellular Signaling Peptides and Proteins
Amino Acids

Generation and interpretation of protein sequence and structural multiple alignments

Barton, G. J., Russell, R. B. & Livingstone, C. D., 1 Aug 1992, In : Journal of Protein Chemistry. 11, 4, p. 389-389 1 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase

Barton, G. J., Ponting, C. P., Spraggon, G., Finnis, C. & Sleep, D., May 1992, In : Protein Science. 1, 5, p. 688-90 3 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Mast cell tryptases: examination of unusual characteristics by multiple sequence alignment and molecular modeling

Johnson, D. A. & Barton, G. J., Mar 1992, In : Protein Science. 1, 3, p. 370-7 8 p.

Research output: Contribution to journalArticle

Tryptases
Molecular modeling
Sequence Alignment
Trypsin
Heparin
530 Citations (Scopus)
Sequence Alignment
Proteins
Globins
Serine Proteases
Oxidoreductases
1993
1083 Citations (Scopus)

ALSCRIPT: a tool to format multiple sequence alignments

Barton, G. J., Jan 1993, In : Protein Science. 6, 1, p. 37-40 4 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
Sequence Deletion
Insertional Mutagenesis
Databases
365 Citations (Scopus)

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation

Livingstone, C. D. & Barton, G. J., Dec 1993, In : Computer Applications in the Biosciences. 9, 6, p. 745-756 12 p.

Research output: Contribution to journalArticle

Sequence Alignment
Proteins
Annexins
Amino Acids
src Homology Domains
18 Citations (Scopus)

Secondary structure prediction for modelling by homology

Boscott, P. E., Barton, G. J. & Richards, W. G., Apr 1993, In : Protein Science. 6, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

Proteins
Secondary Protein Structure
Sequence Alignment
Statistical methods
Composite materials
1994
149 Citations (Scopus)
bis(5'-nucleosyl)tetraphosphatase (asymmetrical)
Phosphoprotein Phosphatases
Escherichia coli
Conservation
Consensus Sequence
54 Citations (Scopus)

Mutational analysis of human papillomavirus E4 proteins: identification of structural features important in the formation of cytoplasmic E4/cytokeratin networks in epithelial cells

Roberts, S., Ashmole, I., Gibson, L. J., Rookes, S. M., Barton, G. J. & Gallimore, P. H., Oct 1994, In : Journal of Virology. 68, 10, p. 6432-6445 14 p.

Research output: Contribution to journalArticle

Papillomaviridae
Keratins
epithelial cells
Epithelial Cells
Human papillomavirus 1
12 Citations (Scopus)

scop: structural classification of proteins

Barton, G. J., Dec 1994, In : Trends in Biochemical Sciences. 19, 12, p. 554-555 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
Factor XIII
Yersinia
Protein Tyrosine Phosphatases
Blood Coagulation Factors
Blood Coagulation
157 Citations (Scopus)
Proteins
Burial
Protein C
Amino Acids
122 Citations (Scopus)

Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ

Matthews, S., Barlow, P., Boyd, J., Barton, G., Russell, R., Mills, H., Cunningham, M., Meyers, N., Burns, N., Clark, N., Kingsman, S., Kingsman, A. & Campbell, I., 25 Aug 1994, In : Nature. 370, 6491, p. 666-668 3 p.

Research output: Contribution to journalArticle

Interferons
env Gene Products
Viruses
Human Immunodeficiency Virus Proteins
gag Gene Products
1995
143 Citations (Scopus)

Continuous and discontinuous domains: an algorithm for the automatic generation of reliable protein domain definitions

Siddiqui, A. S. & Barton, G. J., May 1995, In : Protein Science. 4, 5, p. 872-84 13 p.

Research output: Contribution to journalArticle

Proteins
Protein Databases
Molecular graphics
Databases
Protein Domains
355 Citations (Scopus)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Roach, P. L., Clifton, I. J., Fülöp, V., Harlos, K., Barton, G. J., Hajdu, J., Andersson, I., Schofield, C. & Baldwin, J. E., 22 Jun 1995, In : Nature. 375, 6533, p. 700-704 5 p.

Research output: Contribution to journalArticle

Penicillins
Enzymes
Thiazolidines
Oxygen
Keto Acids
72 Citations (Scopus)

Protein secondary structure prediction

Barton, G. J., Jun 1995, In : Current Opinion in Structural Biology. 5, 3, p. 372-376 5 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Discriminant Analysis
X-Rays
Proteins
Machine Learning
1996
20 Citations (Scopus)

Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation

Fiser, A., Simon, I. & Barton, G. J., 18 Nov 1996, In : FEBS Letters. 397, 2-3, p. 225-229 5 p.

Research output: Contribution to journalArticle

Aspartic Acid
Conservation
Amino Acids
Sequence Alignment
Viperidae
60 Citations (Scopus)

Identification of functional residues and secondary structure from protein multiple sequence alignment

Livingstone, C. D. & Barton, G. J., 1996, In : Methods in Enzymology. 266, p. 497-512 16 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Sequence Alignment
Proteins
Conservation
114 Citations (Scopus)

Protein fold recognition by mapping predicted secondary structures

Russell, R. B., Copley, R. R. & Barton, G. J., 14 Jun 1996, In : Journal of Molecular Biology. 259, 3, p. 349-365 17 p.

Research output: Contribution to journalArticle

Proteins
Imino Acids
Phosphotyrosine
Sequence Alignment
von Willebrand Factor
24 Citations (Scopus)

The canonical X-ray/gamma-ray spectrum of Seyfert Is and low-state Galactic black hole candidates

Zdziarski, A. A., Gierlinski, M., Gondek, D. & Magdziarz, P., 1 Dec 1996, In : Astronomy and Astrophysics: Supplement Series. 120, 4, p. 553-558 6 p.

Research output: Contribution to journalArticle

gamma ray spectra
rays
x rays
cut-off
plasma temperature
1997

RXTE observations of AGN

Rothschild, R. E., Heindl, W. A., Blanco, P. R., Gruber, D. E., Marsden, D. C., Pelling, M. R., Jahoda, K., Madejski, G., Swank, J. H., Zdziarski, A. A., Gierliński, M. & Hink, P. L., 1 Dec 1997, In : European Space Agency, (Special Publication) ESA SP. 382, p. 393-395 3 p.

Research output: Contribution to journalArticle

Proportional counters
X Ray Timing Explorer
proportional counters
active galaxies
Galaxies
224 Citations (Scopus)

Simultaneous X-ray and γ-ray observations of Cyg X-1 in the hard state by Ginga and OSSE

Gierliński, M., Zdziarski, A. A., Done, C., Neil Johnson, W., Ebisawa, K., Ueda, Y., Haardt, F. & Phlips, B. F., 1 Dec 1997, In : Monthly Notices of the Royal Astronomical Society. 288, 4, p. 958-964 7 p.

Research output: Contribution to journalArticle

rays
plasma
x rays
high temperature plasmas
coronas
17 Citations (Scopus)

X-rays and gamma-rays from accretion flows onto black holes in Seyferts and x-ray binaries

Zdziarski, A. A., Johnson, W. N., Poutanen, J., Magdziarz, P. & Gierliński, M., 1 Dec 1997, In : European Space Agency, (Special Publication) ESA SP. 382, p. 373-380 8 p.

Research output: Contribution to journalArticle

x ray binaries
Gamma rays
accretion
gamma rays
X rays
1998
148 Citations (Scopus)

Broad-band X-ray/γ-ray spectra and binary parameters of GX 339-4 and their astrophysical implications

Zdziarski, A. A., Poutanen, J., Mikołajewska, J., Gierliński, M., Ebisawa, K. & Johnson, W. N., 1 Dec 1998, In : Monthly Notices of the Royal Astronomical Society. 301, 2, p. 435-450 16 p.

Research output: Contribution to journalArticle

rays
astrophysics
broadband
x rays
power law
12 Citations (Scopus)

Deposition of macromolecular structures

Keller, P. A., Henrick, K., McNeil, P., Moodie, S. & Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

877 Citations (Scopus)

JPred: a consensus secondary structure prediction server

Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M. & Barton, G. J., 1998, In : Bioinformatics. 14, 10, p. 892-3 2 p.

Research output: Contribution to journalArticle

Structure Prediction
Secondary Structure
Servers
Server
Secondary Protein Structure
10 Citations (Scopus)

Protein sequence alignment techniques

Barton, G. J., 1 Nov 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 6, no. 1, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Sequence Alignment
Protein Sequence Analysis
Proteins
Research Design
1999

Application of a relativistic accretion disc model to GRO J1655-40 ASCA spectrum

Gierliński, M., Maciołek-Niedźwiecki, A., Magdziarz, P. & Ebisawa, K., 1 Dec 1999, In : Astronomische Nachrichten. 320, 4-5, p. 350 1 p.

Research output: Contribution to journalArticle

481 Citations (Scopus)

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 1 Mar 1999, In : Proteins: Structure, Function, and Bioinformatics. 34, 4, p. 508-19 12 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Proteins
World Wide Web
Web services
Sequence Alignment
343 Citations (Scopus)

Radiation mechanisms and geometry of cygnus X-1 in the soft state

Gierliński, M., Zdziarski, A. A., Poutanen, J., Coppi, P. S., Ebisawa, K. & Johnson, W. N., 21 Oct 1999, In : Monthly Notices of the Royal Astronomical Society. 309, 2, p. 496-512 17 p.

Research output: Contribution to journalArticle

Open Access
coronas
corona
accretion
accretion disks
geometry

Thermal/non-thermal model of Cyg X-1 in the soft state

Gierliński, M., Zdziarski, A. A., Coppi, P. S., Poutanen, J., Ebisawa, K. & Johnson, W. N., 1 Jan 1999, In : Nuclear Physics B - Proceedings Supplements. 69, 1-3, p. 312-315 4 p.

Research output: Contribution to journalArticle

2000
603 Citations (Scopus)

Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 15 Aug 2000, In : Proteins: Structure, Function, and Bioinformatics. 40, 3, p. 502-511 10 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Sequence Alignment
Proteins
Computer program listings
Servers
11 Citations (Scopus)

ProtEST: protein multiple sequence alignments from expressed sequence tags

Cuff, J. A., Birney, E., Clamp, M. E. & Barton, G. J., Feb 2000, In : Bioinformatics. 16, 2, p. 111-6 6 p.

Research output: Contribution to journalArticle

Multiple Sequence Alignment
Sequence Alignment
Expressed Sequence Tags
Proteins
Protein
2001
46 Citations (Scopus)

3Dee: a database of protein structural domains

Siddiqui, A. S., Dengler, U. & Barton, G. J., Feb 2001, In : Bioinformatics. 17, 2, p. 200-1 2 p.

Research output: Contribution to journalArticle

Databases
Proteins
Protein
World Wide Web
Internet
65 Citations (Scopus)

Application of a relativistic accretion disc model to X-ray spectra of LMC X-1 and GRO J1655-40

Gierliński, M., Maciołek-Niedźwiecki, A. & Ebisawa, K., 11 Aug 2001, In : Monthly Notices of the Royal Astronomical Society. 325, 3, p. 1253-1265 13 p.

Research output: Contribution to journalArticle

Open Access
accretion disks
accretion
x rays
inclination
radiation pressure
26 Citations (Scopus)

Protein structural domains: analysis of the 3Dee domains database

Dengler, U., Siddiqui, A. S. & Barton, G. J., 15 Feb 2001, In : Proteins: Structure, Function, and Bioinformatics. 42, 3, p. 332-344 13 p.

Research output: Contribution to journalArticle

Databases
Proteins
Protein Domains
Internet
World Wide Web