Computational Biology

  • United Kingdom

Research Output 1987 2019

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Article
1994
16 Citations (Scopus)
Factor XIII
Yersinia
Protein Tyrosine Phosphatases
Blood Coagulation Factors
Blood Coagulation
157 Citations (Scopus)
Proteins
Burial
Protein C
Amino Acids
122 Citations (Scopus)

Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ

Matthews, S., Barlow, P., Boyd, J., Barton, G., Russell, R., Mills, H., Cunningham, M., Meyers, N., Burns, N., Clark, N., Kingsman, S., Kingsman, A. & Campbell, I., 25 Aug 1994, In : Nature. 370, 6491, p. 666-668 3 p.

Research output: Contribution to journalArticle

Interferons
env Gene Products
Viruses
Human Immunodeficiency Virus Proteins
gag Gene Products
1993
1083 Citations (Scopus)

ALSCRIPT: a tool to format multiple sequence alignments

Barton, G. J., Jan 1993, In : Protein Science. 6, 1, p. 37-40 4 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
Sequence Deletion
Insertional Mutagenesis
Databases
365 Citations (Scopus)

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation

Livingstone, C. D. & Barton, G. J., Dec 1993, In : Computer Applications in the Biosciences. 9, 6, p. 745-756 12 p.

Research output: Contribution to journalArticle

Sequence Alignment
Proteins
Annexins
Amino Acids
src Homology Domains
18 Citations (Scopus)

Secondary structure prediction for modelling by homology

Boscott, P. E., Barton, G. J. & Richards, W. G., Apr 1993, In : Protein Science. 6, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

Proteins
Secondary Protein Structure
Sequence Alignment
Statistical methods
Composite materials
1992
88 Citations (Scopus)

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

Russell, R. B., Breed, J. & Barton, G. J., 8 Jun 1992, In : FEBS Letters. 304, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Phosphotyrosine
src Homology Domains
Conservation
Intercellular Signaling Peptides and Proteins
Amino Acids

Generation and interpretation of protein sequence and structural multiple alignments

Barton, G. J., Russell, R. B. & Livingstone, C. D., 1 Aug 1992, In : Journal of Protein Chemistry. 11, 4, p. 389-389 1 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase

Barton, G. J., Ponting, C. P., Spraggon, G., Finnis, C. & Sleep, D., May 1992, In : Protein Science. 1, 5, p. 688-90 3 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Mast cell tryptases: examination of unusual characteristics by multiple sequence alignment and molecular modeling

Johnson, D. A. & Barton, G. J., Mar 1992, In : Protein Science. 1, 3, p. 370-7 8 p.

Research output: Contribution to journalArticle

Tryptases
Molecular modeling
Sequence Alignment
Trypsin
Heparin
530 Citations (Scopus)
Sequence Alignment
Proteins
Globins
Serine Proteases
Oxidoreductases
1991
131 Citations (Scopus)

Amino acid sequence analysis of the annexin super-gene family of proteins

Barton, G. J., Newman, R. H., Freemont, P. S. & Crumpton, M. J., Jun 1991, In : European Journal of Biochemistry. 198, 3, p. 749-760 12 p.

Research output: Contribution to journalArticle

Annexins
Protein Sequence Analysis
Genes
Amino Acids
Uteroglobin
8 Citations (Scopus)
Databases
Proteins
Costs and Cost Analysis
1990
9 Citations (Scopus)

A knowledge-based architecture for protein sequence analysis and structure prediction

Clark, D. A., Barton, G. J. & Rawlings, C. J., Jun 1990, In : Journal of Molecular Graphics. 8, 2, p. 94-107 14 p.

Research output: Contribution to journalArticle

Protein Sequence Analysis
Knowledge based systems
Knowledge engineering
Proteins
Molecular biology
3 Citations (Scopus)

A PROLOG approach to analysing protein structure

Barton, G. J. & Rawlings, C. J., 1 Jan 1990, In : Tetrahedron Computer Methodology. 3, 6 PART C, p. 739-756 18 p.

Research output: Contribution to journalArticle

Proteins
Computer programming languages
PROLOG (programming language)
Sanders
Logic programming
114 Citations (Scopus)

Flexible protein sequence patterns: a sensitive method to detect weak structural similarities

Barton, G. J. & Sternberg, M. J. E., 20 Mar 1990, In : Journal of Molecular Biology. 212, 2, p. 389-402 14 p.

Research output: Contribution to journalArticle

Globins
Proteins
Sequence Alignment
Hemoglobins
Databases
6 Citations (Scopus)

Interaction of synthetic peptides from annexin I and uteroglobin with lipid monolayers and their effect on phospholipase A2 activity

Newman, R. H., Freemont, P. S., Barton, G. J. & Crumpton, M. J., Dec 1990, In : Biochemical Society Transactions. 18, 6, p. 1233-1234 2 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Prediction of domain organisation and secondary structure of thyroid peroxidase, a human autoantigen involved in destructive thyroiditis

Banga, J. P., Mahadevan, D., Barton, G. J., Sutton, B. J., Saldanha, J. W., Odell, E. & McGregor, A. M., 18 Jun 1990, In : FEBS Letters. 266, 1-2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Thyroiditis
Iodide Peroxidase
Autoantigens
Autoimmune Diseases
Thyroid Diseases
178 Citations (Scopus)

Protein multiple sequence alignment and flexible pattern matching

Barton, G. J., 1990, In : Methods in Enzymology. 183, p. 403-28 26 p.

Research output: Contribution to journalArticle

1988
18 Citations (Scopus)

LOPAL and SCAMP: techniques for the comparison and display of protein structures

Barton, G. J. & Sternberg, M. J. E., Dec 1988, In : Journal of Molecular Graphics. 6, 4, p. 190-196 7 p.

Research output: Contribution to journalArticle

Display devices
Proteins
Sequence Alignment
Least-Squares Analysis
Dynamic programming
1987
387 Citations (Scopus)

A strategy for the rapid multiple alignment of protein sequences: confidence levels from tertiary structure comparisons

Barton, G. J. & Sternberg, M. J. E., 20 Nov 1987, In : Journal of Molecular Biology. 198, 2, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sequence Alignment
Proteins
Globins
Transferrin
Disulfides
107 Citations (Scopus)

Evaluation and improvements in the automatic alignment of protein sequences

Barton, G. J. & Sternberg, M. J., 1 Feb 1987, In : Protein Science. 1, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Sequence Alignment
Secondary Protein Structure
Sequence Homology
Proteins
Testing
18 Citations (Scopus)

Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins

Sternberg, M. J. E., Barton, G. J., Zvelebil, M. J., Cookson, J. & Coates, A. R. M., 29 Jun 1987, In : FEBS Letters. 218, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Viruses
Epitopes
Vaccines
Genes
HIV